Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 12, 2015, Pages 2810-2818

  George Rosenker, Kara M ^a   Paquette, William D ^a   Johnston, Paul A ^a   Sharlow, Elizabeth R ^b   Vogt, Andreas ^c,e   Bakan, Ahmet ^c   Lazo, John S ^b   Wipf, Peter ^a,d  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d University of Pittsburgh   (United States)

^e Kabbage Inc   (United States)

Author keywords

3 Amino 1,2 dihydro 1 isoquinolinone; Cdc25B; Checkpoint bypass; Molecular docking; Palladium cross coupling

Indexed keywords

3 (1H [1,2,4] TRIAZOL 3 YLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (2 CHLOROPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (2 FLUOROPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (2 HYDROXYPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (2,5 DIMETHOXYPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (4 FLUOROPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (4 METHOXYBENZYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (4 METHOXYPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (6 HYDROXYHEXYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (BENZYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (BENZYLMETHYLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (BIPHENYL 2 YLAMINO) 2H ISOQUINOLIN 1 ONE; 3 (PYRIDIN 2 YLAMINO) 2H ISOQUINOLIN 1 ONE; 3 PARA TOLYLAMINO 2H ISOQUINOLIN 1 ONE; 3 PIPERIDIN 1 YL 2H ISOQUINOLIN 1 ONE; 3 [(2 BROMOBENZYL)METHYLAMINO] 2H ISOQUINOLIN 1 ONE; 4 (1 OXO 1,2 DIHYDROISOQUINOLIN 3 YLAMINO)BENZOIC ACID ETHYL ESTER; 4 BENZOYL 3 PARA TOLYLAMINO 2H ISOQUINOLIN 1 ONE; 4 BROMO 2 CYANOMETHYLBENZOIC ACID; 5 (2 FLUOROPHENYL) 3H ISOBENZOFURAN 1 ONE; 5 (4 TRIFLUOROMETHOXYPHENYL) 3H ISOBENZOFURAN 1 ONE; 5 THIOPHEN 3 YL 3H ISOBENZOFURAN 1 ONE; 5H BENZO[4,5]IMIDAZO[1,2 B]ISOQUINOLIN 1 ONE; 6 (3 AMINOPHENYL) 3 (PHENYLAMINO)ISOQUINOLIN 1(2H) ONE; 6 BROMO 3 (2 METHOXYPHENYLAMINO) 2H ISOQUINOLIN 1 ONE; 6 BROMO 3 PHENYLAMINO 2H ISOQUINOLIN 1 ONE; CDC25B PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; 1-AMINOISOQUINOLINE; ANTINEOPLASTIC AGENT; CDC25B PROTEIN, HUMAN; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; MELTING POINT; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; THIN LAYER CHROMATOGRAPHY; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HUMAN; METABOLISM; MOLECULAR DOCKING; NEOPLASMS; SYNTHESIS; TUMOR CELL LINE;

MAMMALIA;

ANTINEOPLASTIC AGENTS; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; MOLECULAR DOCKING SIMULATION; NEOPLASMS;

EID: 84930081935     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.01.043     Document Type: Article

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