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Volumn 12, Issue 1, 2012, Pages 62-73

CDC25 phosphatase inhibitors: An update

Author keywords

Antiproliferative agents; Cancer; CDC25 inhibitors; Cell cycle; Dual specificity phosphatases

Indexed keywords

AMINO ACID; ARGININE; CDC25A PHOSPHATASE; CDC25B PHOSPHATASE; CDC25C PHOSPHATASE; CYCLIN DEPENDENT KINASE; CYSTEINE; ELECTROPHILE; HISTIDINE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; PYRIMIDINE DERIVATIVE; QUINONE DERIVATIVE; REGULATOR PROTEIN; SCAFFOLD PROTEIN; SIGNAL PEPTIDE; UNCLASSIFIED DRUG;

EID: 84855849159     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955712798868940     Document Type: Review
Times cited : (71)

References (82)
  • 2
    • 0029780526 scopus 로고    scopus 로고
    • The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications
    • Fauman, E.B.; Yuvaniyama, C.; Schubert, H.L.; Stuckey, J.A.; Saper, M.A. The X-ray crystal structures of Yersinia tyrosine phosphatase with bound tungstate and nitrate. Mechanistic implications. J. Biol. Chem., 1996, 271(31), 18780-18788.
    • (1996) J. Biol. Chem. , vol.271 , Issue.31 , pp. 18780-18788
    • Fauman, E.B.1    Yuvaniyama, C.2    Schubert, H.L.3    Stuckey, J.A.4    Saper, M.A.5
  • 3
    • 0030296869 scopus 로고    scopus 로고
    • Molecular mechanisms of the protein serine/threonine phosphatases
    • Barford, D. Molecular mechanisms of the protein serine/threonine phosphatases. Trends Biochem. Sci., 1996, 21(11), 407-412.
    • (1996) Trends Biochem. Sci. , vol.21 , Issue.11 , pp. 407-412
    • Barford, D.1
  • 4
    • 0031860103 scopus 로고    scopus 로고
    • The structure and mechanism of protein phosphatases: Insights into catalysis and regulation
    • Barford, D.; Das, A.K.; Egloff, M.P. The structure and mechanism of protein phosphatases: insights into catalysis and regulation. Annu. Rev. Biophys. Biomol. Struct., 1998, 27, 133-164.
    • (1998) Annu. Rev. Biophys. Biomol. Struct , vol.27 , pp. 133-164
    • Barford, D.1    Das, A.K.2    Egloff, M.P.3
  • 5
    • 0030297891 scopus 로고    scopus 로고
    • Form and function in protein dephosphorylation
    • Denu, J.M.; Stuckey, J.A.; Saper, M.A.; Dixon, J.E. Form and function in protein dephosphorylation. Cell, 1996, 87(3), 365-368.
    • (1996) Cell , vol.87 , Issue.3 , pp. 365-368
    • Denu, J.M.1    Stuckey, J.A.2    Saper, M.A.3    Dixon, J.E.4
  • 6
    • 0029583122 scopus 로고
    • Crystal structure of the catalytic subunit of human protein phosphatase and its complex with tungstate
    • Egloff, M.P.; Cohen, P.T.; Reinemer, P.; Barford, D. Crystal structure of the catalytic subunit of human protein phosphatase and its complex with tungstate. J. Mol. Biol., 1995, 254(5), 942-959.
    • (1995) J. Mol. Biol. , vol.254 , Issue.5 , pp. 942-959
    • Egloff, M.P.1    Cohen, P.T.2    Reinemer, P.3    Barford, D.4
  • 8
    • 60549090245 scopus 로고    scopus 로고
    • Is Cdc25 a Druggable Target? Anticancer Agents
    • Lazo, J.S.; Wipf, P. Is Cdc25 a Druggable Target? Anticancer Agents Med. Chem., 2008, 8(8), 837-842.
    • (2008) Med. Chem. , vol.8 , Issue.8 , pp. 837-842
    • Lazo, J.S.1    Wipf, P.2
  • 9
    • 34848812587 scopus 로고    scopus 로고
    • What if higher plants lack a CDC25 phosphatase?
    • Boudolf, V., Inze, D.; De Veylder, L. What if higher plants lack a CDC25 phosphatase? Trends Plant Sci., 2006, 11(10), 474-479.
    • (2006) Trends Plant Sci. , vol.11 , Issue.10 , pp. 474-479
    • Boudolf, V.1    Inze, D.2    de Veylder, L.3
  • 10
    • 0026319225 scopus 로고
    • Specific activation of Cdc25 tyrosine phosphatases by B-type cyclins: Evidence for multiple roles of mitotic cyclins
    • Galaktionov, K.; Beach, D. Specific activation of Cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. Cell, 1991, 67(6), 1181-1194.
    • (1991) Cell , vol.67 , Issue.6 , pp. 1181-1194
    • Galaktionov, K.1    Beach, D.2
  • 11
    • 0025324692 scopus 로고
    • Human homolog of fission yeast Cdc25 mitotic inducer is predominantly expressed in G2
    • Sadhu, K.; Reed, S.I.; Richardson, H.; Russell, P. Human homolog of fission yeast Cdc25 mitotic inducer is predominantly expressed in G2. Proc. Natl. Acad. Sci. USA, 1990, 87(13), 5139-5143.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , Issue.13 , pp. 5139-5143
    • Sadhu, K.1    Reed, S.I.2    Richardson, H.3    Russell, P.4
  • 12
    • 0026234297 scopus 로고
    • An additional homolog of the fission yeast Cdc25 gene occurs in humans and is highly expressed in some cancer cells
    • Nagata, A.; Igarashi, M.; Jinno, S.; Suto, K.; Okayama, H. An additional homolog of the fission yeast Cdc25 gene occurs in humans and is highly expressed in some cancer cells. New Biol. 1991, 3(10), 959-968.
    • (1991) New Biol , vol.3 , Issue.10 , pp. 959-968
    • Nagata, A.1    Igarashi, M.2    Jinno, S.3    Suto, K.4    Okayama, H.5
  • 13
    • 0033646929 scopus 로고    scopus 로고
    • Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C
    • Wegener, S.; Hampe, W.; Herrmann, D.; Schaller, H.C. Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C. Eur. J. Cell Biol., 2000, 79(11), 810-815.
    • (2000) Eur. J. Cell Biol. , vol.79 , Issue.11 , pp. 810-815
    • Wegener, S.1    Hampe, W.2    Herrmann, D.3    Schaller, H.C.4
  • 14
    • 0030919764 scopus 로고    scopus 로고
    • Alternative splicing of the human CDC25B tyrosine phoshatase. Possible implications for growth control?
    • Baldin, V.; Cans, C.; Superti-Furga, G.; Ducommun, B. Alternative splicing of the human CDC25B tyrosine phoshatase. Possible implications for growth control? Oncogene, 1997, 14(20), 2485-2495.
    • (1997) Oncogene , vol.14 , Issue.20 , pp. 2485-2495
    • Baldin, V.1    Cans, C.2    Superti-Furga, G.3    Ducommun, B.4
  • 16
    • 60549094422 scopus 로고    scopus 로고
    • Cell Cycle Control by the CDC25 Phosphatases. Anti-Cancer Agents
    • Aressy, B.; Ducommun B. Cell Cycle Control by the CDC25 Phosphatases. Anti-Cancer Agents Med. Chem., 2008, 8(8), 818-824.
    • (2008) Med. Chem. , vol.8 , Issue.8 , pp. 818-824
    • Aressy, B.1    Ducommun, B.2
  • 17
    • 0034543444 scopus 로고    scopus 로고
    • An additional transcript of the cdc25C gene from A431 cells encodes a functional protein
    • Bureik, M.; Rief, N.; Drescher, R.; Jungbluth, A.; Montenarh, M.; Wagner, P. An additional transcript of the cdc25C gene from A431 cells encodes a functional protein. Int. J. Oncol., 2000, 17(6), 1251-1258.
    • (2000) Int. J. Oncol. , vol.17 , Issue.6 , pp. 1251-1258
    • Bureik, M.1    Rief, N.2    Drescher, R.3    Jungbluth, A.4    Montenarh, M.5    Wagner, P.6
  • 18
    • 27644480747 scopus 로고    scopus 로고
    • Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer
    • Ozen M, Ittmann M. Increased expression and activity of CDC25C phosphatase and an alternatively spliced variant in prostate cancer. Clin. Cancer Res., 2005, 11(13), 4701-4706
    • (2005) Clin. Cancer Res. , vol.11 , Issue.13 , pp. 4701-4706
    • Ozen, M.1    Ittmann, M.2
  • 19
  • 20
    • 34250865564 scopus 로고    scopus 로고
    • CDC25 phosphatases in cancer cells:Key players? Good targets?
    • Boutros, R.; Lobjois V.; Ducommun, B. CDC25 phosphatases in cancer cells:key players? Good targets? Nat. Rev. Cancer, 2007, 7(7), 495-507.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.7 , pp. 495-507
    • Boutros, R.1    Lobjois, V.2    Ducommun, B.3
  • 21
    • 33947646873 scopus 로고    scopus 로고
    • Cdc25 phosphatases: Structure, specificity, and mechanism
    • Rudolph, J. Cdc25 phosphatases: structure, specificity, and mechanism. Biochemistry, 2007, 46(12), 3595-3604.
    • (2007) Biochemistry , vol.46 , Issue.12 , pp. 3595-3604
    • Rudolph, J.1
  • 22
    • 0033538847 scopus 로고    scopus 로고
    • Cdc25b and Cdc25c Differ Markedly in Their Properties as Initiators of Mitosis
    • Karlsson, C.; Katich, S.; Hagting, A.; Hoffmann, I.; Pines, J.J. Cdc25b and Cdc25c Differ Markedly in Their Properties as Initiators of Mitosis. Cell Biol., 1999, 146(3), 573-584.
    • (1999) Cell Biol. , vol.146 , Issue.3 , pp. 573-584
    • Karlsson, C.1    Katich, S.2    Hagting, A.3    Hoffmann, I.4    Pines, J.J.5
  • 23
    • 0034232093 scopus 로고    scopus 로고
    • Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis
    • Molinari, M.; Mercurio, C.; Dominguez, J.; Goubin, F.; Draetta, G.F. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep., 2000, 1, 71-79.
    • (2000) EMBO Rep , vol.1 , pp. 71-79
    • Molinari, M.1    Mercurio, C.2    Dominguez, J.3    Goubin, F.4    Draetta, G.F.5
  • 24
  • 25
    • 33344476097 scopus 로고    scopus 로고
    • DNA damage checkpoints in mammals
    • Niida, H.; Nakanishi, M. DNA damage checkpoints in mammals. Mutagenesis, 2006, 21, 3-9.
    • (2006) Mutagenesis , vol.21 , pp. 3-9
    • Niida, H.1    Nakanishi, M.2
  • 26
    • 4344718628 scopus 로고    scopus 로고
    • Cdc25 phosphatases and cancer
    • Kristjánsdóttir, K.; Rudolph, J. Cdc25 phosphatases and cancer. Chem. Biol., 2004, 11(8), 1043-1051.
    • (2004) Chem. Biol. , vol.11 , Issue.8 , pp. 1043-1051
    • Kristjánsdóttir, K.1    Rudolph, J.2
  • 27
    • 0037421958 scopus 로고    scopus 로고
    • Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer
    • Ngan, E.S.; Hashimoto, Y.; Ma, Z.Q.; Tsai, M.J.; Tsai, S.Y. Overexpression of Cdc25B, an androgen receptor coactivator, in prostate cancer. Oncogene, 2003, 22(5), 734-739.
    • (2003) Oncogene , vol.22 , Issue.5 , pp. 734-739
    • Ngan, E.S.1    Hashimoto, Y.2    Ma, Z.Q.3    Tsai, M.J.4    Tsai, S.Y.5
  • 29
    • 77952484477 scopus 로고    scopus 로고
    • Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes
    • Wang, Z.; Trope, C.G.; Flørenes, V.A.; Suo, Z.; Nesland, J.M.; Holm, R. Overexpression of CDC25B, CDC25C and phospho-CDC25C (Ser216) in vulvar squamous cell carcinomas are associated with malignant features and aggressive cancer phenotypes. BMC Cancer, 2010, 10, 233.
    • (2010) BMC Cancer , vol.10 , pp. 233
    • Wang, Z.1    Trope, C.G.2    Flørenes, V.A.3    Suo, Z.4    Nesland, J.M.5    Holm, R.6
  • 31
    • 0027423987 scopus 로고
    • Amino acid sequence similarity between CL100, a dual-specificity MAP kinase phosphatase and Cdc25
    • Keyse S.M.; Ginsburg, M. Amino acid sequence similarity between CL100, a dual-specificity MAP kinase phosphatase and Cdc25. Trends Biochem. Sci., 1993, 18(10), 377-378.
    • (1993) Trends Biochem. Sci. , vol.18 , Issue.10 , pp. 377-378
    • Keyse, S.M.1    Ginsburg, M.2
  • 32
    • 33846388965 scopus 로고    scopus 로고
    • Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase
    • Sohn, J.; Buhrman, G.; Rudolph, J. Kinetic and structural studies of specific protein-protein interactions in substrate catalysis by Cdc25B phosphatase. Biochemistry, 2007, 46(3), 807-818.
    • (2007) Biochemistry , vol.46 , Issue.3 , pp. 807-818
    • Sohn, J.1    Buhrman, G.2    Rudolph, J.3
  • 33
    • 16844367916 scopus 로고    scopus 로고
    • Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond
    • Buhrman, G.K.; Parker, B.; Sohn, J.; Rudolph, J.; Mattos, C. Structural mechanism of oxidative regulation of the phosphatase Cdc25B via an intramolecular disulfide bond. Biochemistry, 2005, 44(20), 5307-5316.
    • (2005) Biochemistry , vol.44 , Issue.20 , pp. 5307-5316
    • Buhrman, G.K.1    Parker, B.2    Sohn, J.3    Rudolph, J.4    Mattos, C.5
  • 35
    • 0032738102 scopus 로고    scopus 로고
    • Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle
    • Reynolds, R. A.; Yem, A. W.; Wolfe, C. L.; Deibel, M. R. Jr; Chidester, C. G.; Watenpaugh, K. D. Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle. J. Mol. Biol., 1999, 293(3), 559-68.
    • (1999) J. Mol. Biol. , vol.293 , Issue.3 , pp. 559-568
    • Reynolds, R.A.1    Yem, A.W.2    Wolfe, C.L.3    Deibel Jr., M.R.4    Chidester, C.G.5    Watenpaugh, K.D.6
  • 36
  • 37
    • 0036773411 scopus 로고    scopus 로고
    • Quantification of protein surfaces, volumes and atom-atom contacts using a constrained Voronoi procedure
    • McConkey, B.J.; Sobolev, V.; Edelman, M. Quantification of protein surfaces, volumes and atom-atom contacts using a constrained Voronoi procedure. Bioinformatics, 2002, 18(10), 1365-1373.
    • (2002) Bioinformatics , vol.18 , Issue.10 , pp. 1365-1373
    • McConkey, B.J.1    Sobolev, V.2    Edelman, M.3
  • 38
    • 58149250722 scopus 로고    scopus 로고
    • Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening
    • Bakan, A.; Lazo J.S.; Wipf, P.; Brummond, K.M.; Bahar, I. Toward a Molecular Understanding of the Interaction of Dual Specificity Phosphatases with Substrates: Insights from Structure-Based Modeling and High Throughput Screening. Curr. Med. Chem. 2008, 15(25), 2536-2544.
    • (2008) Curr. Med. Chem , vol.15 , Issue.25 , pp. 2536-2544
    • Bakan, A.1    Lazo, J.S.2    Wipf, P.3    Brummond, K.M.4    Bahar, I.5
  • 39
    • 77957946203 scopus 로고    scopus 로고
    • Flexibility and inhibitor binding in Cdc25 phosphatases
    • Arantes, G.M. Flexibility and inhibitor binding in Cdc25 phosphatases. Proteins, 2010, 78(14), 3017-3032.
    • (2010) Proteins , vol.78 , Issue.14 , pp. 3017-3032
    • Arantes, G.M.1
  • 40
    • 0035935711 scopus 로고    scopus 로고
    • Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25
    • Lazo, J.S.; Aslan, D.C.; Southwick, E.C.; Cooley, K.A.; Ducruet, A.P.; Joo, B.; Vogt, A.; Wipf, P. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J. Med. Chem., 2001, 44(24), 4042-4049.
    • (2001) J. Med. Chem. , vol.44 , Issue.24 , pp. 4042-4049
    • Lazo, J.S.1    Aslan, D.C.2    Southwick, E.C.3    Cooley, K.A.4    Ducruet, A.P.5    Joo, B.6    Vogt, A.7    Wipf, P.8
  • 42
    • 0035935711 scopus 로고    scopus 로고
    • Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25
    • Lazo, J.S.; Aslan, D.C.; Southwick, E.C.; Cooley, K.A.; Ducruet, A.P.; Joo, B.; Vogt, A.; Wipf, P. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J. Med. Chem., 2001, 44(24), 4042-4049.
    • (2001) J. Med. Chem. , vol.44 , Issue.24 , pp. 4042-4049
    • Lazo, J.S.1    Aslan, D.C.2    Southwick, E.C.3    Cooley, K.A.4    Ducruet, A.P.5    Joo, B.6    Vogt, A.7    Wipf, P.8
  • 43
    • 33847235757 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases
    • Brault, L.; Denancé, M.; Banaszak, E.; Maadidi, S. E.; Battaglia, E.; Bagrel, D.; Samadi, M. Synthesis and biological evaluation of dialkylsubstituted maleic anhydrides as novel inhibitors of Cdc25 dual specificity phosphatases. Eur. J. Med. Chem., 2007, 42(2), 243-247.
    • (2007) Eur. J. Med. Chem. , vol.42 , Issue.2 , pp. 243-247
    • Brault, L.1    Denancé, M.2    Banaszak, E.3    Maadidi, S.E.4    Battaglia, E.5    Bagrel, D.6    Samadi, M.7
  • 46
    • 33646776011 scopus 로고    scopus 로고
    • Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism
    • Lavecchia, A.; Cosconati, S.; Limongelli, V.; Novellino, E. Modeling of Cdc25B dual specifity protein phosphatase inhibitors: docking of ligands and enzymatic inhibition mechanism. Chem. Med. Chem. 2006, 1(5), 540-550.
    • (2006) Chem. Med. Chem , vol.1 , Issue.5 , pp. 540-550
    • Lavecchia, A.1    Cosconati, S.2    Limongelli, V.3    Novellino, E.4
  • 47
    • 52449110024 scopus 로고    scopus 로고
    • Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening
    • Park, H.; Bahn, Y. J.; Jung, S.-K.; Jeong, D. G.; Lee, S.-H.; Seo, I.; Yoon, T.-S.; Kim, S. J.; Ryu, S. E. Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening. J. Med. Chem. 2008, 51(18), 5533-5541.
    • (2008) J. Med. Chem , vol.51 , Issue.18 , pp. 5533-5541
    • Park, H.1    Bahn, Y.J.2    Jung, S.-K.3    Jeong, D.G.4    Lee, S.-H.5    Seo, I.6    Yoon, T.-S.7    Kim, S.J.8    Ryu, S.E.9
  • 48
    • 60549090062 scopus 로고    scopus 로고
    • Cdc25B phosphatase inhibitors in cancer therapy: Latest developments, trends and medicinal chemistry perspective
    • Lavecchia A, Coluccia A, Di Giovanni C, Novellino E. Cdc25B phosphatase inhibitors in cancer therapy: latest developments, trends and medicinal chemistry perspective. Anticancer Agents Med. Chem., 2008, 8(8), 843-856.
    • (2008) Anticancer Agents Med. Chem. , vol.8 , Issue.8 , pp. 843-856
    • Lavecchia, A.1    Coluccia, A.2    Di Giovanni, C.3    Novellino, E.4
  • 49
    • 68449102462 scopus 로고    scopus 로고
    • CDC25A and B dualspecificity phosphatase inhibitors: Potential agents for cancer therapy
    • Lavecchia A, Di Giovanni C, Novellino E. CDC25A and B dualspecificity phosphatase inhibitors: potential agents for cancer therapy. Curr. Med. Chem. 2009, 16(15):1831-1849.
    • (2009) Curr. Med. Chem , vol.16 , Issue.15 , pp. 1831-1849
    • Lavecchia, A.1    Di Giovanni, C.2    Novellino, E.3
  • 50
    • 77649085550 scopus 로고    scopus 로고
    • Inhibitors of Cdc25 phosphatases as anticancer agents: A patent review. Expert Opin
    • Lavecchia A, Di Giovanni C, Novellino E. Inhibitors of Cdc25 phosphatases as anticancer agents: a patent review. Expert Opin. Ther. Pat., 2010, 20(3), 405-425.
    • (2010) Ther. Pat. , vol.20 , Issue.3 , pp. 405-425
    • Lavecchia, A.1    Di Giovanni, C.2    Novellino, E.3
  • 51
    • 70249108449 scopus 로고    scopus 로고
    • LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation
    • Zhou, Y.B.; Feng, X.; Wang, L.N.; Du, J.Q.; Zhou, Y.Y.; Yu, H.P.; Zang, Y.; Li, J.Y.; Li, J. LGH00031, a novel ortho-quinonoid inhibitor of cell division cycle 25B, inhibits human cancer cells via ROS generation. Acta Pharmacol. Sin., 2009, 30(9):1359-1368.
    • (2009) Acta Pharmacol. Sin. , vol.30 , Issue.9 , pp. 1359-1368
    • Zhou, Y.B.1    Feng, X.2    Wang, L.N.3    Du, J.Q.4    Zhou, Y.Y.5    Yu, H.P.6    Zang, Y.7    Li, J.Y.8    Li, J.9
  • 52
    • 67649934675 scopus 로고    scopus 로고
    • Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors
    • Park, H.;. Bahn, Y.J.; Ryu, S.E. Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors. Bioorg. Med. Chem. Lett., 2009, 19(15), 4330-4334.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.15 , pp. 4330-4334
    • Park, H.1    Bahn, Y.J.2    Ryu, S.E.3
  • 53
    • 52449110024 scopus 로고    scopus 로고
    • Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening
    • Park, H.; Bahn, Y. J.; Jung, S.-K.; Jeong, D. G.; Lee, S.-H.; Seo, I.; Yoon, T.-S.; Kim, S. J.; Ryu, S. E. Discovery of novel Cdc25 phosphatase inhibitors with micromolar activity based on the structure-based virtual screening. J. Med. Chem., 2008, 51(18), 5533-5541.
    • (2008) J. Med. Chem. , vol.51 , Issue.18 , pp. 5533-5541
    • Park, H.1    Bahn, Y.J.2    Jung, S.-K.3    Jeong, D.G.4    Lee, S.-H.5    Seo, I.6    Yoon, T.-S.7    Kim, S.J.8    Ryu, S.E.9
  • 56
    • 70449435021 scopus 로고    scopus 로고
    • Rapid Discovery of Triazolobenzylidene-Thiazolopyrimidines (TBTP) as CDC25 Phosphatase Inhibitors by Parallel Click Chemistry and in Situ screening
    • Duval, R.; Kolb, S.; Braud, E.; Genest, D.; Garbay, C. Rapid Discovery of Triazolobenzylidene-Thiazolopyrimidines (TBTP) as CDC25 Phosphatase Inhibitors by Parallel Click Chemistry and in Situ screening. J. Comb. Chem., 2009, 11(6), 947-950.
    • (2009) J. Comb. Chem. , vol.11 , Issue.6 , pp. 947-950
    • Duval, R.1    Kolb, S.2    Braud, E.3    Genest, D.4    Garbay, C.5
  • 57
    • 77957590019 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases
    • Valente, S.; Bana, E.; Viry, E.; Bagrel, D.; Kirsch, G. Synthesis and biological evaluation of novel coumarin-based inhibitors of Cdc25 phosphatases. Bioorg. Med. Chem. Lett., 2010, 20(19), 5827-5830.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.19 , pp. 5827-5830
    • Valente, S.1    Bana, E.2    Viry, E.3    Bagrel, D.4    Kirsch, G.5
  • 58
    • 43949126193 scopus 로고    scopus 로고
    • Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells
    • Deep, G.; Oberlies, N. H.; Kroll, D. J.; Agarwal, R. Identifying the differential effects of silymarin constituents on cell growth and cell cycle regulatory molecules in human prostate cancer cells. Int. J. Cancer, 2008, 123(1), 41-50.
    • (2008) Int. J. Cancer , vol.123 , Issue.1 , pp. 41-50
    • Deep, G.1    Oberlies, N.H.2    Kroll, D.J.3    Agarwal, R.4
  • 59
  • 60
    • 77950860029 scopus 로고    scopus 로고
    • Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B
    • Chen, H.J.; Liu, Y.; Wang, L.N.; Shen, Q.; Li, J.; Nan, F.J. Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. Bioorg. Med. Chem. Lett., 2010, 20(9), 2876-2879.
    • (2010) Bioorg. Med. Chem. Lett , vol.20 , Issue.9 , pp. 2876-2879
    • Chen, H.J.1    Liu, Y.2    Wang, L.N.3    Shen, Q.4    Li, J.5    Nan, F.J.6
  • 61
    • 0035010504 scopus 로고    scopus 로고
    • Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
    • Wardman, P. Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia. Curr. Med. Chem., 2001, 8(7) 739-761.
    • (2001) Curr. Med. Chem , vol.8 , Issue.7 , pp. 739-761
    • Wardman, P.1
  • 63
    • 3042594182 scopus 로고    scopus 로고
    • Fluorinated quinoid inhibitor: Possible "pure" arylator predicted by the simple theoretical calculation
    • Ham, S. W.; Choe, J. I.; Wang, M. F.; Peyregne, V.; Carr, B. I. Fluorinated quinoid inhibitor: possible "pure" arylator predicted by the simple theoretical calculation. Bioorg. Med. Chem. Lett. 2004, 14(15), 4103-4105.
    • (2004) Bioorg. Med. Chem. Lett , vol.14 , Issue.15 , pp. 4103-4105
    • Ham, S.W.1    Choe, J.I.2    Wang, M.F.3    Peyregne, V.4    Carr, B.I.5
  • 64
    • 33750215412 scopus 로고    scopus 로고
    • Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK
    • Kar, S.; Wang, M.; Ham, S. W.; Carr, B. I. Fluorinated Cpd 5, a pure arylating K-vitamin derivative, inhibits human hepatoma cell growth by inhibiting Cdc25 and activating MAPK. Biochem. Pharmacol., 2006, 72(10), 1217-1227.
    • (2006) Biochem. Pharmacol. , vol.72 , Issue.10 , pp. 1217-1227
    • Kar, S.1    Wang, M.2    Ham, S.W.3    Carr, B.I.4
  • 65
    • 33947582226 scopus 로고    scopus 로고
    • Fluorinated NSC as a Cdc25 inhibitor
    • 2354
    • Park, H.; Carr, B. I.; Li, M.; Ham, S. W. Fluorinated NSC as a Cdc25 inhibitor. Bioorg. Med. Chem. Lett., 2007, 17(8), 2351-2354.-2354
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , Issue.8 , pp. 2351-2354
    • Park, H.1    Carr, B.I.2    Li, M.3    Ham, S.W.4
  • 72
    • 84855849987 scopus 로고    scopus 로고
    • Anthraquinonic derivatives having an antitumor activity and applications thereof
    • February 10
    • Avendano Lopez C.; Garcia Gravalos, D. Anthraquinonic derivatives having an antitumor activity and applications thereof. U.S. Patent 5,716,963, February 10, 1998.
    • (1998) U.S. Patent 5,716,963
    • Avendano Lopez, C.1    Garcia Gravalos, D.2
  • 75
    • 84855824134 scopus 로고    scopus 로고
    • Method for obtaining human CDC25 phosphatases and method for identifying human CDC25 phosphatase modulators
    • June 21
    • Goubin-Gramatica, F.; Ducommun, B.; Prevost, G.; Method for obtaining human CDC25 phosphatases and method for identifying human CDC25 phosphatase modulators. W.O. Patent 0, 144, 467, June 21, 2001.
    • (2001) W.O. Patent 0, 144, 467
    • Goubin-Gramatica, F.1    Ducommun, B.2    Prevost, G.3
  • 78
    • 43049129579 scopus 로고    scopus 로고
    • Targeting PTPs with small molecule inhibitors in cancer treatment
    • Jiang, Z.X.; Zhang, Z.Y. Targeting PTPs with small molecule inhibitors in cancer treatment. Cancer Metastasis Rev., 2008, 27(2), 263-272.
    • (2008) Cancer Metastasis Rev. , vol.27 , Issue.2 , pp. 263-272
    • Jiang, Z.X.1    Zhang, Z.Y.2
  • 81
    • 33845878529 scopus 로고    scopus 로고
    • Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone
    • Brisson, M.; Foster, C.; Wipf, P.; Joo, B.; Tomko, R.J. Jr.; Nguyen, T.; Lazo, J.S. Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone. Mol. Pharmacol. 2007, 71(1), 184-192.
    • (2007) Mol. Pharmacol , vol.71 , Issue.1 , pp. 184-192
    • Brisson, M.1    Foster, C.2    Wipf, P.3    Joo, B.4    Tomko Jr., R.J.5    Nguyen, T.6    Lazo, J.S.7
  • 82
    • 52749098453 scopus 로고    scopus 로고
    • Computational design, synthesis and biological evaluation of para-quinone based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B
    • Keinan, S.; Paquette, W.D.; Skoko, J.J.; Beratan, D.N.; Yang, W.; Shinde, S.; Johnston, P.A.; Lazo J.S.; Wipf, P. Computational design, synthesis and biological evaluation of para-quinone based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Org. Biomol. Chem., 2008, 6(18), 3256-3263.
    • (2008) Org. Biomol. Chem. , vol.6 , Issue.18 , pp. 3256-3263
    • Keinan, S.1    Paquette, W.D.2    Skoko, J.J.3    Beratan, D.N.4    Yang, W.5    Shinde, S.6    Johnston, P.A.7    Lazo, J.S.8    Wipf, P.9


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