Oxidation of the aromatic amino acids tryptophan and tyrosine disrupts their anabolic effects on bone marrow mesenchymal stem cells

Molecular and Cellular Endocrinology

Volumn 410, Issue , 2015, Pages 87-96

  El Refaey, Mona ^a,b   Watkins, Christopher P ^c   Kennedy, Eileen J ^c   Chang, Andrew ^a   Zhong, Qing ^a,b   Ding, Ke Hong ^a,b   Shi, Xing ming ^a,b   Xu, Jianrui ^a,b   Bollag, Wendy B ^a,b,d   Hill, William D ^a,b,d   Johnson, Maribeth ^a   Hunter, Monte ^b   Hamrick, Mark W ^a,b   Isales, Carlos M ^a,b  

^a AUGUSTA UNIVERSITY   (United States)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Amino acids; BMMSCs; Differentiation; Kynurenine; Oxidized nutrients; Proliferation

Indexed keywords

ALKALINE PHOSPHATASE; AROMATIC AMINO ACID; KYNURENINE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCALCIN; OXYGEN; RAF PROTEIN; TRANSCRIPTION FACTOR RUNX2; TRYPTOPHAN; TYROSINE; ANABOLIC AGENT;

ANIMAL CELL; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVITY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CELL CULTURE; CHEMISTRY; DRUG EFFECTS; MESENCHYMAL STROMA CELL; OSTEOPOROSIS; OXIDATION REDUCTION REACTION;

AMINO ACIDS, AROMATIC; ANABOLIC AGENTS; ANIMALS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; MAP KINASE SIGNALING SYSTEM; MESENCHYMAL STROMAL CELLS; MICE; OSTEOPOROSIS; OXIDATION-REDUCTION; TRYPTOPHAN; TYROSINE;

EID: 84930081227     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2015.01.034     Document Type: Review

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