Association between endothelial function (assessed on reactive hyperemia peripheral arterial tonometry) and obstructive sleep apnea, visceral fat accumulation, and serum adiponectin

Circulation Journal

Volumn 79, Issue 6, 2015, Pages 1381-1389

  Azuma, Masanori ^a   Chihara, Yuichi ^b   Yoshimura, Chikara ^c   Murase, Kimihiko ^a   Hamada, Satoshi ^a   Tachikawa, Ryo ^a   Matsumoto, Takeshi ^a   Inouchi, Morito ^a   Tanizawa, Kiminobu ^a   Handa, Tomohiro ^a   Oga, Toru ^a   Mishima, Michiaki ^a   Chin, Kazuo ^a  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Red Cross Hospital   (Japan)

^c KYUSHU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Adiponectin; Continuous positive airway pressure; Endothelial function; Obstructive sleep apnea; Visceral obesity

Indexed keywords

ADIPONECTIN; ADIPOQ PROTEIN, HUMAN;

ADULT; APNEA HYPOPNEA INDEX; ARTERIAL OXYGEN SATURATION; ARTICLE; COMORBIDITY ASSESSMENT; COMPUTER ASSISTED TOMOGRAPHY; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; ENDOTHELIAL DYSFUNCTION; FEMALE; FOLLOW UP; HUMAN; HYPEREMIA; INTRAABDOMINAL FAT; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; PERIPHERAL ARTERIAL TONOMETRY; POLYSOMNOGRAPHY; POSITIVE END EXPIRATORY PRESSURE; REACTIVE HYPEREMIA PERIPHERAL ARTERIAL TONOMETRY; SLEEP DISORDERED BREATHING; AGED; BLOOD; COMORBIDITY; DYSLIPIDEMIAS; HYPERGLYCEMIA; HYPERTENSION; MANOMETRY; METABOLIC SYNDROME X; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; PATHOPHYSIOLOGY; RADIOGRAPHY; RISK FACTOR; SLEEP APNEA, OBSTRUCTIVE; SUBCUTANEOUS FAT; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

ADIPONECTIN; ADULT; AGED; COMORBIDITY; CONTINUOUS POSITIVE AIRWAY PRESSURE; DYSLIPIDEMIAS; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; HYPEREMIA; HYPERGLYCEMIA; HYPERTENSION; INTRA-ABDOMINAL FAT; MALE; MANOMETRY; METABOLIC SYNDROME X; MIDDLE AGED; MULTIDETECTOR COMPUTED TOMOGRAPHY; POLYSOMNOGRAPHY; RISK FACTORS; SLEEP APNEA, OBSTRUCTIVE; SUBCUTANEOUS FAT; TREATMENT OUTCOME;

EID: 84930078879     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-14-1303     Document Type: Article

References (52)

1. Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: A systematic review of cohort studies. Lancet 2006; 368: 666 – 678.
2. Britton KA, Massaro JM, Murabito JM, Kreger BE, Hoffmann U, Fox CS. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. J Am Coll Cardiol 2013; 62: 921 – 925.
3. Matsuzawa Y, Sugiyama S, Sugamura K, Sumida H, Kurokawa H, Fujisue K, et al. Successful diet and exercise therapy as evaluated on self-assessment score significantly improves endothelial function in metabolic syndrome patients. Circ J 2013; 77: 2807 – 2815.
4. Romero-Corral A, Sert-Kuniyoshi FH, Sierra-Johnson J, Orban M, Gami A, Davison D, et al. Modest visceral fat gain causes endothelial dysfunction in healthy humans. J Am Coll Cardiol 2010; 56: 662 – 666.
5. Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000; 102: 1296 – 1301.
6. Torigoe M, Matsui H, Ogawa Y, Murakami H, Murakami R, Cheng XW, et al. Impact of the high-molecular-weight form of adiponectin on endothelial function in healthy young men. Clin Endocrinol (Oxf) 2007; 67: 276 – 281.
7. Frystyk J, Berne C, Berglund L, Jensevik K, Flyvbjerg A, Zethelius B. Serum adiponectin is a predictor of coronary heart disease: A population-based 10-year follow-up study in elderly men. J Clin Endocrinol Metab 2007; 92: 571 – 576.
8. Yamada S, Suzuki H, Kamioka M, Suzuki S, Kamiyama Y, Yoshihisa A, et al. Sleep-disordered breathing increases risk for fatal ventricular arrhythmias in patients with chronic heart failure. Circ J 2013; 77: 1466 – 1473.
9. Floras JS. Sleep apnea and cardiovascular risk. J Cardiol 2014; 63: 3 – 8.
10. Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet 2014; 383: 736 – 747.
11. Kraiczi H, Caidahl K, Samuelsson A, Peker Y, Hedner J. Impairment of vascular endothelial function and left ventricular filling: Association with the severity of apnea-induced hypoxemia during sleep. Chest 2001; 119: 1085 – 1091.
12. Chung S, Yoon IY, Shin YK, Lee CH, Kim JW, Lee T, et al. Endothelial dysfunction and C-reactive protein in relation with the severity of obstructive sleep apnea syndrome. Sleep 2007; 30: 997 – 1001.
13. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 2000; 101: 948 – 954.
14. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coro nary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101: 1899 – 1906.
15. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653 – 658.
16. Bugiardini R, Manfrini O, Pizzi C, Fontana F, Morgagni G. Endothelial function predicts future development of coronary artery disease: A study of women with chest pain and normal coronary angiograms. Circulation 2004; 109: 2518 – 2523.
17. Matsuzawa Y, Sugiyama S, Sumida H, Sugamura K, Nozaki T, Ohba K, et al. Peripheral endothelial function and cardiovascular events in high-risk patients. J Am Heart Assoc 2013; 2: e000426, doi:10.1161/AHA.113.000426.
18. Drager LF, Togeiro SM, Polotsky VY, Lorenzi-Filho G. Obstructive sleep apnea: A cardiometabolic risk in obesity and the metabolic syndrome. J Am Coll Cardiol 2013; 62: 569 – 576.
19. Jelic S, Lederer DJ, Adams T, Padeletti M, Colombo PC, Factor PH, et al. Vascular inflammation in obesity and sleep apnea. Circulation 2010; 121: 1014 – 1021.
20. Namtvedt SK, Hisdal J, Randby A, Agewall S, Stranden E, Somers VK, et al. Impaired endothelial function in persons with obstructive sleep apnoea: Impact of obesity. Heart 2013; 99: 30 – 34.
21. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Washington, DC: National Institutes Health, 1968.
22. Iber C, Ancoli-Israel S, Chesson A, Quan S. The AASM manual for the scoring of sleep and associated events: Rules, terminology and technical specifications. Westchester, IL: American Academy of Sleep Medicine, USA, 2007.
23. Anonymous. EEG arousals: Scoring rules and examples: A preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association. Sleep 1992; 15: 173 – 184.
24. Itzhaki S, Lavie L, Pillar G, Tal G, Lavie P. Endothelial dysfunction in obstructive sleep apnea measured by peripheral arterial tone response in the finger to reactive hyperemia. Sleep 2005; 28: 594 – 600.
25. Yoshizumi T, Nakamura T, Yamane M, Islam AH, Menju M, Yamasaki K, et al. Abdominal fat: Standardized technique for measurement at CT. Radiology 1999; 211: 283 – 286.
26. Examination Committee of Criteria for ‘Obesity Disease’ in Japan; Japan Society for the Study of Obesity. New criteria for ‘obesity disease’ in Japan. Circ J 2002; 66: 987 – 992.
27. Committee on Evaluation of Diagnosis Standards for Metabolic Syndrome. Definition and diagnostic standards for metabolic syndrome. J Jpn Soc Int Med 2005; 94: 794 – 809.
28. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, et al. Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation 2007; 115: 627 – 637.
29. Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR. Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation 2009; 119: 1284 – 1292.
30. Ryan S, Taylor CT, McNicholas WT. Systemic inflammation: A key factor in the pathogenesis of cardiovascular complications in obstructive sleep apnoea syndrome? Thorax 2009; 64: 631 – 636.
31. Hopkins TA, Ouchi N, Shibata R, Walsh K. Adiponectin actions in the cardiovascular system. Cardiovasc Res 2007; 74: 11 – 18.
32. Ouchi N, Kihara S, Funahashi T, Matsuzawa Y, Walsh K. Obesity, adiponectin and vascular inflammatory disease. Curr Opin Lipidol 2003; 14: 561 – 566.
33. Zhang XL, Yin KS, Wang H, Su S. Serum adiponectin levels in adult male patients with obstructive sleep apnea hypopnea syndrome. Respiration 2006; 73: 73 – 77.
34. Yoshikawa M, Yamauchi M, Fujita Y, Koyama N, Fukuoka A, Tamaki S, et al. The impact of obstructive sleep apnea and nasal CPAP on circulating adiponectin levels. Lung 2014; 192: 289 – 295.
35. Kritikou I, Basta M, Vgontzas AN, Pejovic S, Liao D, Tsaoussoglou M, et al. Sleep apnoea, sleepiness, inflammation and insulin resistance in middle-aged males and females. Eur Respir J 2014; 43: 145 – 155.
36. Sánchez-de-la-Torre M, Mediano O, Barceló A, Piérola J, de la Peña M, Esquinas C, et al. The influence of obesity and obstructive sleep apnea on metabolic hormones. Sleep Breath 2012; 16: 649 – 656.
37. Ip MS, Tse HF, Lam B, Tsang KW, Lam WK. Endothelial function in obstructive sleep apnea and response to treatment. Am J Respir Crit Care Med 2004; 169: 348 – 353.
38. Bayram NA, Ciftci B, Keles T, Durmaz T, Turhan S, Bozkurt E, et al. Endothelial function in normotensive men with obstructive sleep apnea before and 6 months after CPAP treatment. Sleep 2009; 32: 1257 – 1263.
39. Patt BT, Jarjoura D, Haddad DN, Sen CK, Roy S, Flavahan NA, et al. Endothelial dysfunction in the microcirculation of patients with obstructive sleep apnea. Am J Respir Crit Care Med 2010; 182: 1540 – 1545.
40. Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, et al. The assessment of endothelial function: From research into clinical practice. Circulation 2012; 126: 753 – 767.
41. Randby A, Namtvedt SK, Hrubos-Strøm H, Einvik G, Somers VK, Omland T. Sex-dependent impact of OSA on digital vascular function. Chest 2013; 144: 915 – 922.
42. Faulx MD, Larkin EK, Hoit BD, Aylor JE, Wright AT, Redline S. Sex influences endothelial function in sleep-disordered breathing. Sleep 2004; 27: 1113 – 1120.
43. Seif F, Patel SR, Walia H, Rueschman M, Bhatt DL, Gottlieb DJ, et al. Association between obstructive sleep apnea severity and endothelial dysfunction in an increased background of cardiovascular burden. J Sleep Res 2013; 22: 443 – 451.
44. Chung S, Yoon IY, Lee CH, Kim JW. The association of nocturnal hypoxemia with arterial stiffness and endothelial dysfunction in male patients with obstructive sleep apnea syndrome. Respiration 2010; 79: 363 – 369.
45. Jelic S, Padeletti M, Kawut SM, Higgins C, Canfield SM, Onat D, et al. Inflammation, oxidative stress, and repair capacity of the vascular endothelium in obstructive sleep apnea. Circulation 2008; 117: 2270 – 2278.
46. Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF Jr, et al. Clinical correlates and heritability of flow-mediated dilation in the community: The Framingham Heart Study. Circulation 2004; 109: 613 – 619.
47. Creager MA, Cooke JP, Mendelsohn ME, Gallagher SJ, Coleman SM, Loscalzo J, et al. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J Clin Invest 1990; 86: 228 – 234.
48. Clarkson P, Celermajer DS, Donald AE, Sampson M, Sorensen KE, Adams M, et al. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol 1996; 28: 573 – 579.
49. Silverberg DS, Oksenberg A. Essential hypertension and abnormal upper airway resistance during sleep. Sleep 1997; 20: 794 – 806.
50. Tishler PV, Larkin EK, Schluchter MD, Redline S. Incidence of sleepdisordered breathing in an urban adult population: The relative importance of risk factors in the development of sleep-disordered breathing. JAMA 2003; 289: 2230 – 2237.
51. West SD, Nicoll DJ, Stradling JR. Prevalence of obstructive sleep apnoea in men with type 2 diabetes. Thorax 2006; 61: 945 – 950.
52. Hamburg NM, Keyes MJ, Larson MG, Vasan RS, Schnabel R, Pryde MM, et al. Cross-sectional relations of digital vascular function to cardiovascular risk factors in the Framingham Heart Study. Circulation 2008; 117: 2467 – 2474.