Essential hypertension and abnormal upper airway resistance during sleep

Sleep

Volumn 20, Issue 9, 1997, Pages 794-806

  Silverberg, Donald S ^a   Oksenberg, Arie ^a  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

Author keywords

Essential hypertension; Obstructive sleep apnea; Sleep; Upper airway resistance

Indexed keywords

ATRIAL NATRIURETIC FACTOR; RENIN; URIC ACID;

AIRWAY RESISTANCE; BLOOD EXAMINATION; BLOOD PRESSURE; ESSENTIAL HYPERTENSION; HEREDITY; HUMAN; NONHUMAN; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; REVIEW; SLEEP APNEA SYNDROME; SNORING; UPPER RESPIRATORY TRACT; WEIGHT REDUCTION;

EID: 0030712338     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/20.9.794     Document Type: Review

References (187)

1. Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndrome. Ann Rev Med 1976;27:465-84.
2. Strohl KP, Redline S. Recognition of obstructive sleep apnea. Am J Respir Crit Care Med 1997;154:279-89.
3. Guilleminault C, Simmons FB, Motta J, et al. Obstructive sleep apnea syndrome and tracheostomy: long-term follow-up experience. Arch Intern Med 1981;141:985-8.
4. Lavie P. Incidence of sleep apnea in a presumably healthy working population: a significant relationship with excessive daytime sleepiness. Sleep 1983;6:312-8.
5. Burack B. The hypersomnia sleep-apnea syndrome: its recognition in clinical cardiology. Am Heart J 1984;107:543-8.
6. Lavie P, Yoffe N, Berger J, Peled R. The relationship between the severity of sleep apnea syndrome and 24-hour blood pressure values in patients with obstructive sleep apnea. Chest 1993;103:717-21.
7. Hypertension Detection and Follow-Up Program. The hypertension detection and follow-up program: a progress report. Circulation Res 1977;40(Suppl 1):106-9.
8. Lavie P, Ben-Yosef R, Rubin AE. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am Heart J 1984;108:373-6.
9. Kales A, Cadieux RJ, Shaw LC, et al. Sleep apnea in a hypertensive population. Lancet 1984;2:1005-8.
10. Fletcher EC, DeBehnke RD, Lovoi MS, Gorin AB. Undiagnosed sleep apnea in patients with essential hypertension. Ann Intern Med 1985;103:190-5.
11. Williams AJ, Houston D, Finberg S, Lam CHI, Kinney JL, Santiago S. Sleep apnea syndrome and essential hypertension. Am J Cordiol 1985;55:1019-22.
12. Scharf SM, Garshick E, Brown R, Tishler PV, Tosteson T, McCarley R. Screening for subclinical sleep-disordered breathing. Sleep 1990;13:344-53.
13. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Bard S. The occurrence of sleep-disordered breathing among middle-aged adults. New Engl J Med 1993;328:1230-5.
14. Stoohs RA, Gingold J, Cohrs F, Harter R, Finlayson E, Guilleminault C. Sleep-disordered breathing and systemic hypertension in the elderly. J Am Geriatr Soc 1996;44:1295-1300.
15. Stradling JR. Sleep apnea and hypertension. Thorax 1989;44: 974-82.
16. Carlson J, Davies R, Klaus E, et al. Obstructive sleep apnea and blood pressure elevation: what is the relationship? Blood Press 1993;2:166-82.
17. Silverberg DS, Oksenberg A. Essential and secondary hypertension and sleep-disordered breathing: a unifying hypothesis. J Human Hypertens 1996;10:353-63.
18. Brooks D, Homer RL, Kozar LF, Render-Teixera CL, Phillipson EA. Obstructive sleep apnea as a cause of systemic hypertension. Evidence from a canine model. J Clin Invest 1997; 99:106-9.
19. Hoffstein V, Mateika S, Rubinstein I, Slutsky AS. Determinants of blood pressure in snorers. Lancet 1988;2:992-4.
20. Millman RP, Redline S, Carlisle SS, Assaf AR, Levinson PD. Daytime hypertension in obstructive sleep apnea. Chest 1991; 99:861-6.
21. Rajala R, Partinen M, Sane T, Pelkinen R, Huikur K, Seppalainen AM. Obstructive sleep apnea syndrome in morbidly obese patients. J Intern Med 1991;230:125-9.
22. Mendelson WB. Sleepiness and hypertension in obstructive sleep apnea. Chest 1992;101:903-9.
23. Gleadhill IC, McCrum EE, Patterson CC, Johnston CG, Evans A, MacMahon J. Sleep-related hypoxaemia in hypertensive and normotensive men. Thorax 1993;48:534-6.
24. Tehindrazanarivelo A, Romejko P, Essalhi M, Valty J, Fleury B. Prevalence of hypertension in obstructive sleep apnea: a prospective continuous monitoring of blood pressure study. Am Rev Respir Dis 1993;147:A1016 (abstract).
25. Bearpark H, Elliot L, Grunstein R, et al. Occurrence and correlates of sleep disordered breathing in the Australian town of Busselton: a preliminary analysis. Sleep 1993;16:S3-5.
26. Kiselak J, Clark M, Pera V, Rosenberg C, Redline S. The association between hypertension and sleep apnea in obese patients. Chest 1993;104:775-80.
27. Grunstein R, Wilcox L, Yang T-S, Could Y, Hedner J. Snoring and sleep apnea in men: association with central obesity and hypertension. Int J Obesity 1993;17:533-40.
28. Carlson JT, Hedner JA, Ejnell H, Peterson LE. High prevalence of hypertension in sleep apnea patients independent of obesity. Am J Respir Crit Care Med 1994;150:72-7.
29. Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB, Dempsey J. Sleep apnea and hypertension: a population-based study. Ann Intern Med 1994;120:382-8.
30. Hoffstein V. Blood pressure, snoring, obesity, and nocturnal hypoxaemia. Lancet 1994;344:643-5.
31. Strohl KP, Novak RD, Singer W, et al. Insulin levels, blood pressure and sleep apnea. Sleep 1994;17:614-8.
32. Bartel PR, Loock M, van der Mayden C, Robinson E, Becker P. Hypertension and sleep apnea in black South Africans. Am J Hypertens 1995;8:1200-5.
33. Mendelson WB. The relationship of sleepiness and blood pressure to respiratory variables in obstructive sleep apnea. Chest 1995;108:966-72.
34. Guilleminault C, Stoohs R, Young-Do K, Chervin R, Black J, Clerk A. Upper airway sleep-disordered breathing in women. Ann Intern Med 1995;122:493-501.
35. Grunstein RR, Stenlof K, Hedner J, Sjostrom L. Impact of obstructive sleep apnea and sleepiness on metabolic and cardiovascular risk factors in the Swedish obese (SOS) study. Int J Obesity 1995;19:410-8.
36. Pankow W, Nabe B, Lies A, Kohl FV, Lohmann FW. Influence of obstructive sleep apnea on circadian blood pressure profile. Sleep Res 1995;4 (Suppl 1):102-6.
37. Fischer J, Raschke F. Glucose tolerance, insulin resistance and arterial hypertension in patients with obstructive sleep apnea. Pneumologie 1995;49:131-5.
38. Sforza E, Lugaresi E. Determinants of the awakening rise in systemic blood pressure in obstructive sleep apnea syndrome. Blood Press 1995;4:218-25.
39. Akashiba T, Kurashina K, Minemura H, Yamamoto H, Hore T. Daytime hypertension and the effects of short-term nasal continuous positive airway pressure treatment in obstructive sleep apnea syndrome. Intern Med 1995;34:528-35.
40. Suzuki M, Guilleminault C, Otsuka K, Shiomi T. Blood pressure "dipping" and "non-dipping" in obstructive sleep apnea syndrome patients. Sleep 1996,19:382-7.
41. Coy TV, Dimsdale JE, Ancoli-Israel S, Clausen JL. The role of sleep-disordered breathing in essential hypertension. Chest 1996;108:890-5.
42. McGinty D, Beahn E, Stern N, Littner M, Sowers J, Reige W. Nocturnal hypertension in older men with sleep-related breathing disorders. Chest 1988;94:305-11.
43. Warley ARH, Mitchell JH, Stradling JR. Prevalence of nocturnal hypoxaemia amongst men with mild to moderate hypertension. Quart J Med 1988;256;637-44.
44. Stradling JR, Crosby JH. Relation between systemic hypertension and sleep hypoxaemia or snoring: analysis in 748 men drawn from general practice. Brit Med J 1990;300:75-8.
45. Escourrou P, Kirani A, Nedelcoux H, Duroux P, Gaultier C. Systemic hypertension in sleep apnea syndrome: relationship with sleep architecture and breathing abnormalities. Chest 1990;98:1362-5.
46. Rauscher H, Popp W, Zwich H. Systemic hypertension in snorers with and without sleep apnea. Chest 1992;102:367-71.
47. Jennum P, Sjøl A. Snoring, sleep apnea and cardiovascular risk factors: the Monica II study. Int J Epidemiol 1993;22:439-44.
48. Worsnop CJ, Pierce RJ, Naughton M. Systemic hypertension and obstructive sleep apnea. Sleep 1993;16:5148-9.
49. Davies RJO, Crosby J, Prothero O, Stradling JR. Ambulatory blood pressure and left ventricular hypertrophy in subjects with untreated obstructive sleep apnea and snoring, compared with matched control subjects and their response to treatment. Clin Sci 1994;86:417-24.
50. Olson LG, King MT, Kensley MJ, Saunders NA. A community study of snoring and sleep-disordered breathing. Am J Respir Crit Care Med 1995;152:717-20.
51. Nabe B, Lies A, Pankow W, Kohl FV, Lohmann FW. Determinants of circadian blood pressure rhythm and blood pressure variability in obstructive sleep apnea. J Sleep Res 1995;4 (Suppl 1):97-101.
52. Stoohs RA, Bingham LA, Itoi A, Guilleminault C, Dement WC. Sleep and sleep-disordered breathing in commercial long-haul truck drivers. Chest 1995;107:1275-82.
53. Coccagna G, Mantovani M, Brignani F, Parchi C, Lugaresi E. Tracheostomy in hypersomnia with periodic breathing. Bull Physiopathol Respir 1972;8:1217-27.
54. Motta J, Guilleminault C, Schroeder JS, Dement WC. Tracheostomy and hemodynamic changes in sleep-induced apnea. Ann Intern Med 1978;89:454-8.
55. Dickson RI, Blokmanis A. Treatment of obstructive sleep apnea by uvulopalatopharyngoplasty. Laryngoscope 1987;97: 1054-9.
56. Rolfe I, Olsen LG, Saunders NA. Longterm nasal CPAP does not ameliorate obstructive sleep apnea. Aust NZ Med J 1991; 21:235-8.
57. Jennum P, Wildschiodtz G, Christensen NJ, Schwartz T. Blood pressure, catecholamines and pancreatic polypeptide in obstructive sleep apnea with and without nasal continuous positive airway (nCPAP) treatment. Am J Hypertens 1989;2:847-52.
58. Lund-Johansen P, White WB. Central hemodynamics and 24-hour blood pressure in obstructive sleep apnea syndrome: effects of corrective surgery. Am J Med 1990;88:678-82.
59. Naughton M, Pierce R. Effects of nasal continuous positive airway pressure on blood pressure and body mass index in obstructive sleep apnea. Aust NZ J Med 1991;21:917-9.
60. Mayer J, Becker H, Brandenburg U, Penzel T, Peter JH, Wichert PV. Blood pressure and sleep apnea: results of long-term nasal continuous positive airway pressure therapy. Cardiology 1991;79:84-92.
61. Guilleminault C, Suzuki M. Sleep-related hemodynamics and hypertension with partial or complete upper airway obstruction during sleep. Sleep 1992;15:520-4.
62. Wilcox I, Grunstein RR, Hedner JA, et al. Effects of nasal continuous positive airway pressure during sleep on 24-hour blood pressure in obstructive sleep apnea. Sleep 1993;16:539-44.
63. Suzuki M, Otsuka K, Guilleminault C. Long-term nasal continuous positive airway pressure on administration can normalize hypertension in obstructive sleep apnea patients. Sleep 1993;16:545-9.
64. Rauscher H, Formanek D, Popp W, Zwich H. Nasal CPAP and weight loss in hypertensive patients with obstructive sleep apnea. Thorax 1993;48:529-33.
65. Akashiba T, Minemura H, Horie T. The influence of nasal continuous positive airway pressure (CPAP) on nocturnal hypertension in obstructive sleep apnea (OSA) patients. Sleep 1993; 16:S35-6.
66. Pryzbylowski T, Lapinski M, Byskiniewicz K, et al. The effect of nCPAP therapy on 24-hour arterial blood pressure profile in obstructive sleep apnea syndrome (OSAS) patients. J Sleep Res 1994;3:212 (abstract).
67. Fernandez-Pinilla C, Martin P, Espina J, et al. Effect of suppression of apnea on arterial pressure and plasma catecholamines in normotensive patients with sleep apnea. Med Clin Bar 1994;103:165-8.
68. Schwartz M, Scharf SM, Greenberg H. The effect of nasal continuous positive airway pressure on hypertension in patients with obstructive sleep apnea. Am J Respir Dis Crit Care Med 1994;149:A493 (abstract).
69. Hedner J, Darpo B, Ejnell H, Carlson J, Caidahl K. Reduction in sympathetic activity after long-term CPAP treatment in sleep apnoea: cardiovascular implications. Eur Respir J 1995;8:222-9.
70. Voogel AJ, van Steenwijk RP, Karemaker JM, van Montfrans GA. Effect of treatment with continuous positive airway pressure on circadian hemodynamics in obstructive sleep apnea. Biol Rhythm Res 1995;26:454 (abstract).
71. Thalhofer S, Dorow P, Meissner S, Heinemann S. Circadian blood pressure rhythm in severe obstructive sleep apnea syndrome before and after onset of nCPAP therapy. Pneumologie 1995;49:167-9.
72. Lies A, Nabe B, Pankow W, Kohl FV, Lohmann FW. Hypertension and obstructive sleep apnea. Ambulatory blood pressure monitoring before and with nCPAP therapy. Z Kardiol 1996,85:3 (Suppl):140-2.
73. Berger M, Oksenberg A, Silverberg DS, Arons A, Radwan H, Iaina A. Avoiding the supine position during sleep in obstructive sleep apnea (OSA) patients: the effect on 24-hour blood pressure. Sleep Res 1996;25:200 (abstract).
74. Engelman HM, Gough K, Martin SE, Kingshott RN, Padfield PL, Douglas NJ. Ambulatory blood pressure on and off continuous positive airway pressure therapy for the sleep apnea/ hypopnea syndrome: effects in "non-dippers". Sleep 1996;19: 378-81.
75. Saarelainen S, Hasan J, Siitonen S, Seppala E. Effect of nasal CPAP treatment on plasma volume, aldosterone and 24-h blood pressure in obstructive sleep apnea. J Sleep Res 1996;5: 181-5.
76. Stradline JR, Partlett J, Davies RJO, Siegwart D, Tarassenko L. Effect of short-term graded withdrawal of nasal continuous positive airway pressure on systemic blood pressure in patients with obstructive sleep apnea. Blood Press 1996;5:234-40.
77. Hoffstein V. Is snoring dangerous to your health? Sleep 1996; 19:506-16.
78. Young T, Finn L, Hla M, Morgan B, Palta M. Snoring as a part of a dose-resonse relationship between sleep-disordered breathing and blood pressure. Sleep 1996;19:5202-5.
79. Lofaso F, Coste A, Gilain L, Harf A, Guilleminault C, Goldenberg F. Sleep fragmentation as a risk factor for hypertension in middle-aged non-apneic snorers. Chest 1996;109:896-900.
80. Guilleminault C, Stoohs R, Duncan S. Snoring (1). Daytime sleepiness in regular heavy snorers. Chest 1991;99:40-8.
81. Guilleminault C, Stoohs R, Clerk A, Cetel M, Maistros P. A cause of excessive daytime sleepiness: the upper airway resistance syndrome. Chest 1993;104:781-7.
82. Stoohs R, Skrobal A, Guilleminault C. Does snoring intensity predict flow limitation or respiratory effort during sleep? Respir Physiol 1993;92:27-38.
83. Mateika JK, Mateika S, Slutsky AS, Hoffstein V. The effect of snoring on mean arterial blood pressure during non-REM sleep. Am Rev Respir Dis 1992;145:141-6.
84. Davies RJO, Crosby J, Vardy-Visy K, Clarke M, Stradling J. Non-invasive beat to beat arterial blood pressure during non-REM sleep in obstructive sleep apnea and snoring. Thorax 1994;49:335-9.
85. Rees E, Faris JE, Calverley PMA. Pleural pressure and blood pressure chagnes during sleep in heavy snorers and obstructive sleep apnoea. Am Rev Respir Dis 1993;147 (Suppl):A1019.
86. Frohberg V, Naples RJ, Jones DL. Cephalometric comparison of characteristics in chronically snoring patients with and without sleep apnea syndrome. Oral Surg Oral Med Oral Pathol 1995;80:28-33.
87. Hillerdal G, Helta J, Lindholm CE, Hultcrantz E, Boman G. Symptoms in heavy snorers with and without obstructive sleep apnea. Acta Otolaryngol 1991;111:574-81.
88. Zucconi M, Oldani A, Ferini-Strambi L, Calori G, Castonovo C, Smirne S. EEG arousal pattern in habitual snorers with and without obstructive sleep apnoea (OSA). J Sleep Res 1995;4: 107-12.
89. Woodson BT, Garancis JC, Toohill RJ. Histopathologic changes in snoring and obstructive sleep apnea syndrome. Laryngoscope 1991;101;1318-22.
90. Guilleminault C, Stoohs R, Shiomi T, Kushida C, Schnittinger I. Upper airway resistance syndrome, nocturnal blood pressure monitoring and borderline hypertension. Chest 1996;109:901-8.
91. Guilleminault C, Kim Y-D, Stoohs R. Upper airway resistance syndrome. Oral Maxillofacial Surg Clin N Am 1995;7:243-56.
92. Pedulla M, Silvestri R, Lasco A, Mento G, Lanuzza B, Sofia L, Fresina N. Sleep structure in essential hypertensive patients: differences between dippers and non-dippers. Blood Press 1995;4:232-7.
93. Verdecchia P, Schillaci G, Porcellati C. Dippers versus non-dippers. J Hypertens 1991;9 (Suppl 8):S42-4.
94. Guilleminault C, Partinen M, Hollman K, Powell N, Stoohs R. Familial aggregates in obstructive sleep apnea. Chest 1995; 107:1545-51.
95. Kushida CA, Guilleminault C, Ahmed O Jr, Clerk AA. Clinical prediction of obstructive sleep apnea by a morphometric model. Neurology 1996;46:A485 (abstract).
96. Gadkary C, Kushida CA, Clerk AA, Guilleminault C. Daytime sleepiness measured by the Epworth sleepiness scale and the multiple sleep latency test in patients with sleep disorders. Neurology 1996;46:A485 (abstract).
97. Blair D, Habicht JP, Sims EAH, Sylvester D, Abraham S. Evidence for increased risk for hypertension with centrally located body fat and the effect of race and sex on their risk. Am J Epidemiol 1984;119:526-40.
98. Larsson B, Svardsudd K, Welin L, Wilhelmsen L, Bjorntorp P, Tibblin G. Abdominal adipose distribution, obesity and risk of cardiovascular disease and death: 13-year follow-up of participants in the study of men born in 1913. Brit Med J 1984;288: 1401-4.
99. Landsberg L. Obesity and hypertension: experimental data. J Hypertens 1992;10 (Suppl 7):S195-201.
100. Strobel RJ, Rosen RC. Obesity and weight loss in obstructive sleep apnea: a critical review. Sleep 1996;192:104-15.
101. Kaplan NM. Clinical hypertension. 6th edition. Baltimore, MD: Williams and Wilkins, 1994:5.
102. Kaplan NM. The treatment of hypertension in women. Arch Intern Med 1995;155:563-7.
103. Burt VL, Cutler JA, Higgins M, et al. Trends in the prevalence, awareness, treatment and control of hypertension in the adult US population. Hypertension 1995;26:60-9.
104. Redline S, Kump K, Tishler PV, Browner I, Ferrette V. Gender differences in sleep disordered breathing in a community-based sample. Am J Respir Crit Care Med 1994;149:722-6.
105. Ancoli-Israel S, Klauber MR, Stepnowsky C, Esteine E, Chinn A, Fell R. Sleep-disordered breathing in African-American elderly. Am J Respir Crit Care Med 1995;152:1946-9.
106. Reisin E, Abel R, Modan M, Silverberg DS, Eliahou HE, Modan B. Effect of weight loss without salt restriction on the reduction of blood pressure in overweight hypertensive patients. New Engl J Med 1978;298:1-6.
107. Verdecchia P, Schillacci G, Boldrini F, et al. Risk stratification of left ventricular hypertrophy using noninvasive ambulatory blood pressure monitoring. Am J Cardiol 1990;66:583-90.
108. MacMahon S, Peto R, Cutler R, et al. Blood pressure, stroke and coronary heart disease. Part 1. Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990;335:765-74.
109. Partinen M, Jamieson A, Guilleminault C. Long-term outcome for obstructive sleep apnea syndrome patients: mortality. Chest 1988;94:1200-4.
110. Hung J, Whitford EG, Parsons RW, Hillman DR. Association of sleep apnea with myocardial infarction in men. Lancet 1990; 336:261-4.
111. Lavie P, Herer P, Peled R, et al. Mortality in sleep apnea patients: a multivariate analysis of risk factors. Sleep 1995;18: 141-57.
112. Hedner J, Ejnell H, Caidahl K. Left ventricular hypertrophy independent of hypertension in patients with obstructive sleep apnea. J Hypertens 1990;8:941-6.
113. Noda A, Okada T, Yasuma F, Nakashima N, Yokota M. Cardiac hypertrophy in obstructive sleep apnea syndrome. Chest 1995; 107:1538-43.
114. Takasake Y, Orr D, Popkin J, Rutherford R, Liu P, Bradley TB. Effect of nasal continuous airway pressure in sleep apnea in congestive heart failure. Am Rev Respir Dis 1989;140:1578-84.
115. Naughton MT, Liu PP, Benard DC, Goldstein RS, Bradley TD. Treatment of congestive heart failure and Cheyne-Stokes respiration during sleep by continuous positive airway pressure. Am J Respir Crit Care Med 1995;151:92-7.
116. Loui WS, Blackshear JL, Fredrickson PA, Kaplan J. Obstructive sleep apnea manifesting as suspected angina: report of three cases. Mayo Clin Proc 1994;69:244-8.
117. Franklin KA, Nilsson JB, Sahlin C, Naslund U. Sleep apnea and nocturnal angina. Lancet 1995;345:1085-7.
118. Guilleminault C, Connolly SJ, Winkle RA. Cardiac arrhythmia and conduction disturbances during sleep in 400 patients with sleep apnea syndrome. Am J Cardiol 1984;52:490-4.
119. Becker H, Brandenburg U, Peter JH, Von-Wichert P. Reversal of sinus arrest and atrioventricular conduction block in patients with sleep apnea during nasal continuous positive airway pressure. Am J Respir Crit Care Med 1995;151:215-8.
120. Harvey JM, Howie AJ, Lee SJ, et al. Renal biopsy findings in hypertensive patients with proteinuria. Lancet 1992;340:1435-6.
121. Gerber LM, Shmukler C, Alderman MH. Differences in urinary albumin excretion rate between normotensive and hypertensive white and non-white subjects. Arch Intern Med 1992; 152:373-7.
122. Chaudhary BA, Sklar AH, Chaudhary TK, Kolbeck RC, Speir WA Jr. Sleep apnea, proteinuria and nephrotic syndrome. Sleep 1988;11:69-74.
123. Sklar AH, Chaudhary BA. Reversible proteinuria in obstructive sleep apnea syndrome. Arch Intern Med 1988;149:87-9.
124. Fletcher EC. Obstructive sleep apnea and the kidney. J Am Soc Nephrol 1993;4:1111-21.
125. Siegel WC, Appelbaum M. Hypertension affects neurobehavioral functioning. Psychosocial Med 1993;55:44-50.
126. Wyss JM, Van Groen T. Neurologic consequences of hypertension and antihypertensive drug therapy. Curr Opin Nephrol Hypertens 1994;3:228-35.
127. Engelman HM, Martin ES, Deary IJ, Douglas NJ. Effect of continuous positive airway pressure on the daytime function in sleep apnoea/hypopnea syndrome. Lancet 1994;343:572-5.
128. Naegele B, Thouvard V, Pepin JL, et al. Deficits of cognitive executive functions in patients with sleep apnea syndrome. Sleep 1995;18:43-52.
129. Cooper WD, Glover DR, Hormbrey JM, Kimber AR. Headache and blood pressure: evidence of a close relationship. J Human Hypertens 1989;3:41-4.
130. Ulfberg J. Snoring and headache: an important association. Arch Neurol 1995;52:1043.
131. Bansal S. Sexual dysfunction in hypertensive men: a critical review of the literature. Hypertension 1988;12:1-10.
132. Prisant LM, Carr A, Bottin PB, Solursh DS, Solursh LP. Sexual dysfunction with antihypertensive drugs. Arch Intern Med 1994;154:730-6.
133. Hirshkowitz M, Karacan I, Gurakar A, Williams RL. Hypertension, erectile dysfunction and occult sleep apnea. Sleep 1989;12:223-32.
134. Hirshkowitz M, Karacan I, Arcasay MO, Acik G, Narter EM, Williams RL. Prevalence of sleep apnea in men with erectile dysfunction. Urology 1990;36:232-4.
135. Karacan I, Karatas M. Erectile function in patients with sleep apnea and response to CPAP. J Sex Marital Ther 1995;21:239-47.
136. Beilin LJ. Alcohol, hypertension, and cardiovascular disease. J Hypertens 1995;13:939-42.
137. Chan CS, Grunstein RR, Bye PTP, Woolcock AJ, Sullivan CE. Obstructive sleep apnea with severe chronic airflow limitation - comparison of hypercapneic and eucapneic patients. Am Rev Respir Dis 1989;140:1274-8.
138. Taasan VC, Block AJ, Boysen PG, Wynne J, White C, Lindsey S. Alcohol increases sleep apnea and oxygen desaturation in asymptomatic men. Am J Med 1981;71:240-5.
139. De Fronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome for NIDDM, obesity, hypertension, dyslipidemia and atherosclerotic cardiovascular disease. Diab Care 1991;14: 173-94.
140. Levinson PD, McGarvey ST, Carlisle CC, Eveloff SE, Herbert PN, Millman RP. Adiposity and cardiovascular risk factors in men with obstructive sleep apnea. Chest 1993;103:1336-42.
141. Katsumata K, Okada T, Miyao M, Katsumata Y. High incidence of sleep apnea syndrome in a male diabetic population. Diab Res Clin Prac 1991;13:45-52.
142. Brooks B, Cistulli PA, Borkman M, et al. Obstructive sleep apnea in obese noninsulin-dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin-responsiveness. J Clin Endocrinol Metab 1994;79:1681-5.
143. Palatini P, Perizo M, Racioppa A, Zugno E, Guzzardi G, Anaderio M. Clinical relevance of nighttime blood pressure and of daytime blood pressure variability. Arch Intern Med 1992; 152:1855-60.
144. Parati G, Omboni S, Rienzo MD, Frattola A, Albini F, Mancia G. Twenty-four hour blood pressure variability: clinical implications. Kidney Int 1992;41 (Suppl 37):S24-8.
145. Isaksson H, Svanborg E. Obstructive sleep apnea syndrome in male hypertensives refractory to drug therapy. Nocturnal automatic blood pressure measurements - an aid to diagnosis? Clin Exper Hypertens - Theory Prac 1991T3:1198-1212.
146. Cirillo M, Laurenzi M, Trevisan M, Stamler J. Hematocrit, blood pressure and hypertension: the Gubbio population study. Hypertension 1992;20:319-26.
147. Carlson JT, Hedner J, Fagenberg B, Ejnell H, Magnussen B, Fyhrquist F. Secondary polycthemia associated with nocturnal apnoea - a relationship not mediated by erthropoietin. J Intern Med 1992;231:381-7.
148. Krieger J, Sforza E, Delanoe C, Petiau C. Decrease in hematocrit with continuous positive airway pressure treatment in obstructive sleep apnea patients. Eur Respir J 1992;5:228-33.
149. Hoffstein V, Herridge M, Mateika S, Redline S, Strohl KP. Hematocrit levels in sleep apnea. Chest 1994;106:787-91.
150. Cannon PJ, Stason WB, Demartini FE, Sommers SC, Laragh JH. Hyperuricemia in primary and renal hypertension. New Engl J Med 1966;275:457-64.
151. Grunstein RR, Stewart D, Handelsman DJ, Sullivan CE. Plasma uric acid and lipid levels in men with sleep apnea. Sleep Res 1989;18:221 (abstract).
152. Braghiroli A, Sacco C, Erbetta M, Ruga V, Donner CF. Overnight urinary uric acid: creatinine ratio for detection of sleep hypoxemia. Am Rev Respir Dis 1993;148:173-8.
153. Stern N, Sowers JR, McGinty D, et al. Circadian rhythm of plasma renin in older normal and essential hypertensive men: relation with inactive renin, aldosterone, cortisol, and REM sleep. J Hypertens 1986;4:543-50.
154. Follenius M, Krieger J, Krauth MO, Sforza E, Brandenberger G. Obstructive sleep apnea treatment: peripheral and central effects on plasma renin activity and aldosterone. Sleep 1991; 14:211-7.
155. Yamada Y, Myajima E, Toohikubo O, Matsukowa T, Ishii M. Age related changes in muscle sympathetic nerve activity in essential hypertension. Hypertension 1989;13:870-7.
156. Anderson EA, Sinkey CA, Lawton WL, Mark AL. Elevated sympathetic nerve activity in borderline hypertensive humans. Hypertension 1989;14:177-83.
157. Saruta T, Kumagai H. The sympathetic nervous system in hypertension and renal disease. Curr Opin Nephrol Hypertens 1995;4:72-9.
158. Waravdekar NV, Sinoway LI, Zwillich CW, Levenberger VA. Influence of treatment on muscle sympathetic nerve activity in sleep apnea. Am J Respir Crit Care Med 1995;153:1333-8.
159. Baruzzi A, Riva R, Cirignotta F, Zucconi M, Cappelli M, Lugaresi E. Atrial natriuretic peptide and catecholamines in obstructive sleep apnea syndrome. Sleep 1991;14:83-6.
160. Marrone O, Riccobono L, Salvaggio A, Mirabella A, Bonanno A, Bonsignore MR. Catecholamines and blood pressure in obstructive sleep apnea syndrome. Chest 1993;103:722-7.
161. Sagnella GA, Markandu ND, Buckley MG, et al. Plasma atrial natriuretic peptide in essential hypertension. Comparison with normotensive subjects and effects of changes in sodium intake. Am J Hypertens 1988;1:112-8.
162. Sagnella GA, MacGregor GA. Atrial natriuretic peptides. In: Swales JD, ed. Textbook of Hypertension. Oxford: Blackwell Scientific Publishers, 1994:272-86.
163. Krieger J, Follenius M, Sforza E, Brandenberger G, Peter J. Effect of treatment with nasal continuous airway pressure on atrial natriuretic peptide and argenin vasopressin with obstructive sleep apnea. Clin Sci 1991;80:443-9.
164. Minuz P, Barrow SE, Cockcroft JR, Ritter JM. Prostacyclin and thromboxane biosynthesis in mild hypertension. Hypertension 1990;15:469-74.
165. Krieger J, Benzoni D, Sforza E, Sassard J. Urinary excretion of prostanoids during sleep in obstructive sleep apnea patients. Clin Exp Pharmacol Physiol 1991;18:551-5.
166. Barrett-Connor E, Khan K-T. Endogenous sex hormones and cardiovascular disease in men. Circulation 1988;78:539-45.
167. Santamaria JD, Prior JC, Fleetham JA. Reversible reproduction dysfunction in men with obstructive sleep apnea. Clin Endocrinol 1988;28:461-70.
168. Grunstein RR, Handelsman DJ, Lawrence SJ, Blackwell CR, Caterson ID, Sullivan CE. Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airway pressure therapy. J Clin Endocrinol Metab 1989;68:352-8.
169. Panza JA, Cesino PR, Kilcoyne CM, Quyyumi AA. Role of endothelium-derived nitric oxide in the abnormal endothelium-dependent vascular relaxation of patients with essential hypertension. Circulation 1993;87:1468-74.
170. Carlson JT, Rangemark C, Hedner JA. Attenuated endothelium-dependent vasular relaxation in patients with sleep apnea. J Hypertens 1996;14:577-84.
171. Jansson JH, Johansson B, Boman K, Nilsson TK. Hypofibrinolysis in patients with hypertension and elevated cholesterol. J Intern Med 1991;229:309-16.
172. Nordby G, Haaland A, Os I. Evidence of decreased fibrinolytic activity in hypertensive premenopausal women. Scand J Clin Lab Invest 1992;52:275-81.
173. Rangemark C, Hedner JA, Carlson JT, Gleerup G, Winther K. Platelet function and fibrinolytic activity in hypertensive and normotensive sleep apnea patients. Sleep 1995;18:188-94.
174. Letcher RI, Chien S, Pickering TG, Laragh JH. Elevated blood viscosity in patients with borderline essential hypertension. Hypertension 1983;15:757-62.
175. Chin K, Ohi M, Kita H, et al. Effects of nCPAP therapy on fibrinogen levels in obstructive sleep apnea. Am J Respir Crit Care Med 1996;153:1972-6.
176. Islim IF, Bareford D, Ebanks M, Beevers DG. The role of platelets in essential hypertension. Blood Press 1995;4:199-214.
177. Bokensky G, Miller M, Avit K, Husband P, Mitchell J. Spontaneous platelet activation and aggregation during obstructive sleep apnea and its resonse to therapy with nasal continuous positive airway pressure: a preliminary investigation. Chest 1995;108:625-9.
178. Trzebski A, Tafil M, Zoltowski M, Przybylski J. Increased sensitivity of arterial chemoreceptor drive in young men with mild hypertension. Cardiovasc Res 1982;16:163-72.
179. Hedner JA, Wilcox I, Laks L, Grunstein R, Sillivan CE. A specific and potent pressor effect of hypoxia in patients with sleep apnea. Am Rev Respir Dis 1992;146:1240-5.
180. Wilcox I, Collins FL, Grunstein RR, Hedner J, Kelly DT, Sullivan CE. Relationship between chemosensitivity, obesity and blood pressure in obstructive sleep apnea. Blood Press 1994; 3:47-54.
181. Matsukawa T, Gotoh E, Hasegawa O, et al. Reduced arterial baroreflex control of muscle sympathetic activity in young borderline hypertensives. Fund Neurol 1991;6:113-20.
182. Parmer RJ, Cervenka JH, Stone RA. Baroreflex sensitivity and heredity in essential hypertension. Circulation 1992;85:497-503.
183. Sforza E, Parchi P, Contin M, Cortelli P, Lugaresi E. Do autonomic cardiovascular reflexes predict the nocturnal rise in blood pressure in obstructive sleep apnea? Blood Press 1994; 3:295-302.
184. Ziegler MG, Neleson RA, Mills PJ, et al. The effect of hypoxia on baroreflexes and pressor sensitivity in sleep apnea and hypertension. Sleep 1995;18:859-65.
185. Williams RR, Hunt SC, Hasstedt SJ, et al. Are there interactions and relations between genetic and environmental factors predisposing to high blood pressure? Hypertension 1991;18 (Suppl 1):29-37.
186. Redline S, Tischler PV, Tosteson TR, et al. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med 1995;151:682-7.
187. Mathur R, Douglas NJ. Family studies in patients with sleep apnea-hypopnea syndrome. Ann Intern Med 1995;122:174-8.