Sleep apnea and cardiovascular risk

Journal of Cardiology

Volumn 63, Issue 1, 2014, Pages 3-8

  Floras, John S ^a,b  

^a MOUNT SINAI HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Central sleep apnea; Heart failure; Hypertension; Obstructive sleep apnea; Sympathetic nervous system

Indexed keywords

ARTIFICIAL VENTILATION; CARDIOVASCULAR RISK; HUMAN; PATHOPHYSIOLOGY; POSITIVE END EXPIRATORY PRESSURE; REVIEW; SLEEP DISORDERED BREATHING;

CENTRAL SLEEP APNEA; HEART FAILURE; HYPERTENSION; OBSTRUCTIVE SLEEP APNEA; SYMPATHETIC NERVOUS SYSTEM;

CARDIOVASCULAR DISEASES; HUMANS; MEMBRANE PROTEINS; POSITIVE-PRESSURE RESPIRATION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SLEEP APNEA, CENTRAL; SLEEP APNEA, OBSTRUCTIVE; TUMOR SUPPRESSOR PROTEINS;

EID: 84891902751     PISSN: 09145087     EISSN: 18764738     Source Type: Journal    
DOI: 10.1016/j.jjcc.2013.08.009     Document Type: Review

References (62)

1. Bradley T.D., Floras J.F. Obstructive sleep apnoea and its cardiovascular consequences. Lancet 2009, 373:82-93.
2. Kasai T., Floras J.S., Bradley T.D. Sleep apnea and cardiovascular disease: a bidirectional relationship. Circulation 2012, 126:1495-1510.
3. Somers V.K., White D.P., Amin R., Abraham W.T., Costa F., Culebras A., Daniels S., Floras J.S., Hunt C.E., Olson L.J., Pickering T.G., Russell R., Woo M., Young T. Sleep apnea and cardiovascular disease: an American Heart Association/American College of Cardiology Foundation scientific statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. Circulation 2008, 118:1080-1111.
4. Bradley T.D., Floras J.S. Sleep apnea and heart failure: Part I: obstructive sleep apnea. Circulation 2003, 107:1671-1678.
5. Bradley T.D., Floras J.S. Sleep apnea and heart failure: Part II: central sleep apnea. Circulation 2003, 107:1822-1826.
6. American Academy of Sleep Medicine Task Force Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. Sleep 1999, 22:667-689.
7. Young T., Palta M., Dempsey J., Skatrud J., Weber S., Badr S. The occurence of sleep-disordered breathing among middle-aged adults. N Engl J Med 1993, 328:1230-1235.
8. Bradley T.D., Logan A.G., Kimoff R.J., Series F., Morrison D., Ferguson K., Belenkie I., Pfeifer M., Fleetham J., Hanly P., Smilovitch M., Tomlinson G., Floras J.S., CANPAP Investigators Continuous positive airway pressure for central sleep apnea and heart failure. N Engl J Med 2005, 353:2025-2033.
9. Kasai T., Arcand J., Allard J.P., Mak S., Azevedo E.R., Newton G.E., Bradley T.D. Relationship between sodium intake and sleep apnea in patients with heart failure. J Am Coll Cardiol 2011, 58:1970-1974.
10. Bitter T., Faber L., Hering D., Langer C., Horstkotte D., Oldenburg O. Sleep-disordered breathing in heart failure with normal left ventricular ejection fraction. Eur J Heart Fail 2009, 11:602-608.
11. Pedrosa R.P., Drager L.F., Gonzaga C.C., Sousa M.G., de Paula L.K., Amaro A.C., Amodeo C., Bortolotto L.A., Krieger E.M., Bradley T.D., Lorenzi-Filho G. Obstructive sleep apnea: the most common secondary cause of hypertension associated with resistant hypertension. Hypertension 2011, 58:811-817.
12. Gottlieb D.J., Yenokyan G., Newman A.B., O'Connor G.T., Punjabi N.M., Quan S.F., Redline S., Resnick H.E., Tong E.K., Diener-West M., Shahar E. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation 2010, 122:352-360.
13. Marin J.M., Carrizo S.J., Vicente E., Agusti A.G. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005, 365:1046-1053.
14. Young T., Finn L., Peppard P.E., Szklo-Coxe M., Austin D., Nieto F.J., Stubbs R., Hla K. Sleep disordered breathing and mortality: eighteen-year follow-up of the Wisconsin sleep cohort. Sleep 2008, 31:1071-1078.
15. Punjabi N.M., Caffo B.S., Goodwin J.L., Gottlieb D.J., Newman A.B., O'Connor G.T., Rapoport D.M., Redline S., Resnick H.E., Robbins J.A., Shahar E., Unruh M.L., Samet J.M. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Med 2009, 6:e1000132.
16. Young M.E. The circadian clock within the heart: potential influence on myocardial gene expression, metabolism, and function. Am J Physiol Heart Circ Physiol 2006, 290:H1-H16.
17. Drager L.F., Bortolotto L.A., Krieger E.M., Lorenzi-Filho G. Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis. Hypertension 2009, 53:64-69.
18. Jelic S., Lederer D.J., Adams T., Padeletti M., Colombo P.C., Factor P.H., Le Jemtel T.H. Vascular inflammation in obesity and sleep apnea. Circulation 2010, 121:1014-1021.
19. Redline S., Yenokyan G., Gottlieb D.J., Shahar E., O'Connor G.T., Resnick H.E., Diener-West M., Sanders M.H., Wolf P.A., Geraghty E.M., Ali T., Lebowitz M., Punjabi N.M. Obstructive sleep apnea-hypopnea and incident stroke: the sleep heart health study. Am J Respir Crit Care Med 2010, 182:269-277.
20. Floras J.S., Bradley T.D. Treating obstructive sleep apnea: is there more to the story than 2 millimeters of mercuryα. Hypertension 2007, 50:289-291.
21. Drager L.F., Bortolotto L.A., Figueiredo A.C., Silva B.C., Krieger E.M., Lorenzi-Filho G. Obstructive sleep apnea, hypertension, and their interaction on arterial stiffness and heart remodeling. Chest 2007, 131:1379-1386.
22. Bradley T.D., Hall M.J., Ando S., Floras J.S. Hemodynamic effects of simulated obstructive apneas in humans with and without heart failure. Chest 2001, 119:1827-1835.
23. Mehra R., Benjamin E.J., Shahar E., Gottlieb D.J., Nawabit R., Kirchner H.L., Sahadevan J., Redline S., Sleep Heart Health Study Association of nocturnal arrhythmias with sleep-disordered breathing: the Sleep Heart Health Study. Am J Respir Crit Care Med 2006, 173:910-916.
24. Gami A.S., Pressman G., Caples S.M., Kanagala R., Gard J.J., Davison D.E., Malouf J.F., Ammash N.M., Friedman P.A., Somers V.K. Association of atrial fibrillation and obstructive sleep apnea. Circulation 2004, 110:364-367.
25. Kanagala R., Murali N.S., Friedman P.A., Ammash N.M., Gersh B.J., Ballman K.V., Shamsuzzaman A.S., Somers V.K. Obstructive sleep apnea and the recurrence of atrial fibrillation. Circulation 2003, 107:2589-2594.
26. Patel D., Mohanty P., Di Biase L., Shaheen M., Lewis W.R., Quan K., Cummings J.E., Wang P., Al-Ahmad A., Venkatraman P., Nashawati E., Lakkireddy D., Schweikert R., Horton R., Sanchez J., et al. Safety and efficacy of pulmonary vein antral isolation in patients with obstructive sleep apnea: the impact of continuous positive airway pressure. Circ Arrhythm Electrophysiol 2010, 3:445-451.
27. Tkacova R., Hall M.J., Rutherford R., Floras J.S., Bradley T.D. Effect of continuous positive airway pressure on nocturnal blood pressure in patients with heart failure and obstructive sleep apnea. Circulation 1996, 94:I340.
28. Dolan E., Stanton A., Thijs L., Hinedi K., Atkins N., McClory S., Den Hond E., McCormack P., Staessen J.A., O'Brien E. Superiority of ambulatory over clinic blood pressure measurment in predicting mortality: the Dublin outcome study. Hypertension 2005, 46:156-161.
29. Spaak J., Egri Z.J., Kubo T., Yu E., Ando S., Kaneko Y., Usui K., Bradley T.D., Floras J.S. Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea. Hypertension 2005, 46:1327-1332.
30. Floras J.S. Should sleep apnoea be a specific target of therapy in chronic heart failureα. Heart 2009, 95:1041-1046.
31. Sin D.D., Fitzgerald F., Parker J.D., Newton G.E., Logan A.G., Floras J.S., Bradley T.D. Relationship of systolic BP to obstructive sleep apnea in patients with heart failure. Chest 2003, 123:1536-1543.
32. Yumino D., Wang H., Floras J.S., Newton G.E., Mak S., Ruttanaumpawan P., Parker J.D., Bradley T.D. Prevalence and physiological predictors of sleep apnea in heart failure. J Card Fail 2009, 15:279-285.
33. Sin D.D., Logan A.G., Fitzgerald F.S., Liu P.P., Bradley T.D. Effects of continous positive airway pressure on cardiovascular outcomes in heart failure patients with and without Cheyne-Stokes respiration. Circulation 2000, 102:61-66.
34. Wang H., Parker J.D., Newton G.E., Floras J.S., Mak S., Chiu K.L., Ruttanaumpawan P., Tomlinson G., Bradley T.D. Influence of obstructive sleep apnea on mortality in patients with heart failure. J Am Coll Cardiol 2007, 49:1625-1631.
35. Yumino D., Wang H., Floras J.S., Newton G.E., Mak S., Ruttanaumpawan P., Parker J.D., Bradley T.D. Relationship between sleep apnoea and mortality in patients with ischaemic heart failure. Heart 2009, 95:819-824.
36. Floras J.S. Sympathetic nervous system activation in human heart failure: clinical implications of an updated model. J Am Coll Cardiol 2009, 54:375-385.
37. Serizawa N., Yumino D., Kajimoto K., Tagawa Y., Takagi A., Shoda M., Kasanuki H., Hagiwara N. Impact of sleep-disordered breathing on life-threatening ventricular arrhythmia in heart failure patients with implantable cardioverter-defibrillator. Am J Cardiol 2008, 102:1064-1068.
38. Bitter T., Westerheide N., Prinz C., Hassain M.S., Vogt J., Langer C., Horstkotte D., Oldenburg O. Cheyne-Stokes respiration and obstructive sleep apnoea are independent risk factors for malignant ventricular arrhythmias requiring appropriate cardioverter-defibrillator therapies in patients with congestive heart failure. Eur Heart J 2011, 32:61-74.
39. DiBona G.F. Neural control of renal function: cardiovascular implications. Hypertension 1989, 13:539-548.
40. Galiwango P.J., McReynolds A., Ivanov J., Chan C.T., Floras J.S. Activity with ambulation attenuates diuretic responsiveness in chronic heart failure. J Am Coll Cardiol 2011, 17:797-803.
41. Hara K., Floras J.S. After-effects of exercise on haemodynamics and muscle sympathetic nerve activity in young patients with dilated cardiomyopathy. Heart 1996, 75:602-608.
42. Notarius C.F., Ando S., Rongen G.A., Floras J.S. Resting muscle sympathetic nerve activity and peak oxygen uptake in heart failure and normal subjects. Eur Heart J 1999, 20:880-887.
43. Arzt M., Young T., Finn L., Skatrud J.B., Ryan C.M., Newton G.E., Mak S., Parker J.D., Floras J.S., Bradley T.D. Sleepiness and sleep in patients with both systolic heart failure and obstructive sleep apnea. Arch Intern Med 2006, 166:1716-1722.
44. Shiota J.S., Ryan C.M., Chiu K.L., Ruttanaumpawan P., Haight J., Arzt M., Floras J.S., Chan C., Bradley T.D. Alterations in upper airway cross-sectional area in response to lower body positive pressure in healthy subjects. Thorax 2007, 62:868-872.
45. Chiu K.L., Ryan C.M., Shiota S., Ruttanaumpawan P., Arzt M., Haight J.S., Chan C., Floras J.S., Bradley T.D. Fluid shift by lower body positive pressure increases pharyngeal resistance in healthy subjects. Am J Respir Crit Care Med 2006, 174:1378-1383.
46. Redolfi S., Yumino D., Ruttanaumpawan P., Yau B., Su M.C., Lam J., Bradley T.D. Relationship between overnight rostral fluid shift and obstructive sleep apnea in nonobese men. Am J Respir Crit Care Med 2009, 179:241-246.
47. Friedman O., Bradley T.D., Chan C.T., Parkes R., Logan A.G. Relationship between overnight rostral fluid shift and obstructive sleep apnea in drug-resistant hypertension. Hypertension 2010, 56:1077-1082.
48. Witkowski A., Prejbisz A., Florczak E., Kadziela J., Sliwinski P., Bielen P., Michalowska I., Kabat M., Warchot E., Januszewicz M., Narkiewicz K., Somers V.K., Sobotka P.A., Januszewicz A. Effects of renal sympathetic denervation on blood pressure, sleep apnea course, and glycemic control in patients with resistant hypertension and sleep apnea. Hypertension 2011, 58:559-565.
49. Yumino D., Redolfi S., Ruttanaumpawan P., Su M.C., Smith S., Newton G.E., Mak S., Bradley T.D. Nocturnal rostral fluid shift: a unifying concept for the pathogenesis of obstructive and central sleep apnea in men with heart failure. Circulation 2010, 121:1598-1605.
50. Kasai T., Usui Y., Yoshioka T., Yanagisawa N., Takata Y., Narui K., Yamaguchi T., Yamashina A., Momomura S.L., JASV Investigators Effect of flow-triggered adaptive servo-ventilation compared with continuous positive airway pressure in patients with chronic heart failure with coexisting obstructive sleep apnea and Cheyne-Stokes respiration. Circ Heart Fail 2010, 3:140-148.
51. Marin J.M., Agusti A., Villar I., Forner M., Nieto D., Carrizo S.J., Barbe F., Vicente E., Wei Y., Nieto F., Jelic S. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA 2012, 307:2169-2176.
52. Campos-Rodriguez F., Martinez-Garcia M.A., de la Cruz-Moron I., Almeida-Gonzales C., Catalan-Serra P.M.J.M. Cardiovascular mortality in women with obstructive sleep apnea with or without continuous positive airway pressure treatment: a cohort study. Ann Intern Med 2012, 156:115-122.
53. Cassar A., Morgenthaler T.I., Lennon R.J., Rihal C.S., Lerman A. Treatment of obstructive sleep apnea is associated with decreased cardiac death after percutaneous coronary intervention. J Am Coll Cardiol 2007, 50:1310-1314.
54. Kasai T., Naruki K., Dohi T., Yanagisawa N., Ishiwata S., Ohno M., Yamaguchi T., Momomura S. Prognosis of patients with heart failure and obstructive sleep apnea treated with continuous positive airway pressure. Chest 2008, 133:690-696.
55. Logan A.G., Tkacova R., Perlikowski S.M., Leung R.S., Tisler A., Floras J.S., Bradley T.D. Refractory hypertension and sleep apnea: effects of CPAP on blood pressure and baroreflex. Eur Respir J 2013, 21:241-247.
56. Drager L.F., Bortolotto L.A., Figueiredo A.C., Krieger E.M., Lorenzi-Filho G. Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2007, 176:706-712.
57. Barbe F., Duran-Cantolla J., Sanchez-de-la-Torre M., Martinez-Alonso M., Carmona C., Barcelo A., Chiner E., Masa J.F., Gonzalez M., Marin J.M., Garcia-Rio F., Diaz de Atauri J., Teran J., Mayos M., de la Pena M., et al. Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial. JAMA 2012, 307:2161-2168.
58. Kaneko Y., Floras J.S., Usui K., Plante J., Tkacova R., Kubo T., Ando S., Bradlet T.D. Cardiovascular effects of continuous positive airway pressure in patients with heart failure and obstructive sleep apnea. N Engl J Med 2003, 348:1233-1241.
59. Usui K., Bradley T.D., Spaak J., Kubo T., Kaneko Y., Floras J.S. Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure. J Am Coll Cardiol 2005, 45:2008-2011.
60. Taranto Montemurro L., Floras J.S., Millar P.J., Kasai T., Gabriel J.M., Spaak J., Coelho F.M.S., Bradley T.D. Inverse relationship of subjective daytime sleepiness to sympathetic activity in patients with heart failure and obstructive sleep apnea. Chest 2012, 142:1222-1228.
61. Arzt M., Floras J.S., Logan A.G., Kimoff J., Series F., Morrison D., Ferguson K., Belenkie I., Pfeifer M., Fleetham J., Hanly P., Smilovitch M., Ryan C., Tomlinson G., Bradley T.D., et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian Positive Airway Pressure for Patients with Central Sleep Apnea and Heart Failure Trial (CANPAP). Circulation 2007, 115:3173-3180.
62. Joho S., Oda Y., Ushijima R., Hirai T., Inoue H. Effect of adaptive servoventilation on muscle sympathetic nerve activity in patients with chronic obstructive heart failure and central sleep apnea. J Card Fail 2012, 18:769-775.