메뉴 건너뛰기




Volumn 9, Issue 1, 2014, Pages 4093-4105

Multiwalled carbon nanotubes induce altered morphology and loss of barrier function in human bronchial epithelium at noncytotoxic doses

Author keywords

Bronchial epithelium; Cytoskeleton; Human; Morphology; Multiwalled carbon nanotubes; Transepithelial electrical resistance

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ALPHA TUBULIN; FIBRONECTIN; LACTATE DEHYDROGENASE; MULTI WALLED NANOTUBE; OCCLUDIN; PHALLOIDIN; PROTEIN ZO1; UVOMORULIN; VIMENTIN; CARBON NANOTUBE; CYTOSKELETON PROTEIN;

EID: 84930009430     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S65567     Document Type: Article
Times cited : (26)

References (31)
  • 1
    • 84940351509 scopus 로고    scopus 로고
    • Nanotechproject.org. Project on Emerging Nanotechnologies; Updated 2013 October 28. Available from, Accessed May 6
    • Nanotechproject.org. Project on Emerging Nanotechnologies; Updated 2013 October 28. Available from: http://www.nanotechproject.org/cpi/about/analysis/. Accessed May 6, 2014.
    • (2014)
  • 2
    • 0037008487 scopus 로고    scopus 로고
    • Carbon nanotubes - the route toward applications
    • Baughman RH, Zakhidov AA, de Heer WA. Carbon nanotubes - the route toward applications. Science. 2002;297(5582):787-792.
    • (2002) Science , vol.297 , Issue.5582 , pp. 787-792
    • Baughman, R.H.1    Zakhidov, A.A.2    de Heer, W.A.3
  • 3
    • 27744504244 scopus 로고    scopus 로고
    • Applications of carbon nanotubes in drug delivery
    • Bianco A, Kostarelos K, Prato M. Applications of carbon nanotubes in drug delivery. Curr Opin Chem Biol. 2005;9(6):674-679.
    • (2005) Curr Opin Chem Biol , vol.9 , Issue.6 , pp. 674-679
    • Bianco, A.1    Kostarelos, K.2    Prato, M.3
  • 4
    • 23844531202 scopus 로고    scopus 로고
    • Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
    • Kam NWS, O'Connell M, Wisdom JA, Dai HJ. Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction. Proc Natl Acad Sci U S A. 2005;102(33): 11600-11605.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.33 , pp. 11600-11605
    • Kam, N.W.S.1    O'Connell, M.2    Wisdom, J.A.3    Dai, H.J.4
  • 6
    • 33745597580 scopus 로고    scopus 로고
    • Carbon nanotubes: A review of their properties in relation to pulmonary toxicology and workplace safety
    • Donaldson K, Aitken R, Tran L, et al. Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci. 2006;92(1):5-22.
    • (2006) Toxicol Sci , vol.92 , Issue.1 , pp. 5-22
    • Donaldson, K.1    Aitken, R.2    Tran, L.3
  • 7
    • 80052699285 scopus 로고    scopus 로고
    • A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice
    • Park EJ, Roh J, Kim SN, et al. A single intratracheal instillation of single-walled carbon nanotubes induced early lung fibrosis and subchronic tissue damage in mice. Arch Toxicol. 2011;85(9):1121-1131.
    • (2011) Arch Toxicol , vol.85 , Issue.9 , pp. 1121-1131
    • Park, E.J.1    Roh, J.2    Kim, S.N.3
  • 8
    • 24944566939 scopus 로고    scopus 로고
    • Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice
    • Shvedova AA, Kisin ER, Mercer R, et al. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol. 2005;289(5):L698-L708.
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289 , Issue.5
    • Shvedova, A.A.1    Kisin, E.R.2    Mercer, R.3
  • 9
    • 1542726626 scopus 로고    scopus 로고
    • Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation
    • Lam CW, James JT, McCluskey R, Hunter RL. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci. 2004;77(1):126-134.
    • (2004) Toxicol Sci , vol.77 , Issue.1 , pp. 126-134
    • Lam, C.W.1    James, J.T.2    McCluskey, R.3    Hunter, R.L.4
  • 11
    • 34548165334 scopus 로고    scopus 로고
    • Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells
    • Sharma CS, Sarkar S, Periyakaruppan A, et al. Single-walled carbon nanotubes induces oxidative stress in rat lung epithelial cells. J Nanosci Nanotechnol. 2007;7(7):2466-2472.
    • (2007) J Nanosci Nanotechnol , vol.7 , Issue.7 , pp. 2466-2472
    • Sharma, C.S.1    Sarkar, S.2    Periyakaruppan, A.3
  • 12
    • 79959246775 scopus 로고    scopus 로고
    • Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells
    • Tsukahara T, Haniu H. Cellular cytotoxic response induced by highly purified multi-wall carbon nanotube in human lung cells. Mol Cell Biochem. 2011;352(1-2):57-63.
    • (2011) Mol Cell Biochem , vol.352 , Issue.1-2 , pp. 57-63
    • Tsukahara, T.1    Haniu, H.2
  • 13
    • 84864006786 scopus 로고    scopus 로고
    • Different cellular response mechanisms contribute to the length-dependent cytotoxicity of multi-walled carbon nanotubes
    • Liu D, Wang LJ, Wang ZG, Cuschieri A. Different cellular response mechanisms contribute to the length-dependent cytotoxicity of multi-walled carbon nanotubes. Nanoscale Res Lett. 2012;7(1):361.
    • (2012) Nanoscale Res Lett , vol.7 , Issue.1 , pp. 361
    • Liu, D.1    Wang, L.J.2    Wang, Z.G.3    Cuschieri, A.4
  • 14
    • 84055177567 scopus 로고    scopus 로고
    • Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-kappa B signaling, and promoting fibroblast-to-myofibroblast transformation
    • He XQ, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q. Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-kappa B signaling, and promoting fibroblast-to-myofibroblast transformation. Chem Res Toxicol. 2011;24(12):2237-2248.
    • (2011) Chem Res Toxicol , vol.24 , Issue.12 , pp. 2237-2248
    • He, X.Q.1    Young, S.H.2    Schwegler-Berry, D.3    Chisholm, W.P.4    Fernback, J.E.5    Ma, Q.6
  • 15
    • 84878457573 scopus 로고    scopus 로고
    • Interlaboratory evaluation of cytotoxicity and inflammatory responses to engineered nanomaterials: The NIEHS Nano Go Consortium
    • Xia T, Hamilton RF Jr, Bonner JC, et al. Interlaboratory evaluation of cytotoxicity and inflammatory responses to engineered nanomaterials: the NIEHS Nano Go Consortium. Environ Health Perspect. 2013; 121(6):683-690.
    • (2013) Environ Health Perspect , vol.121 , Issue.6 , pp. 683-690
    • Xia, T.1    Hamilton Jr., R.F.2    Bonner, J.C.3
  • 16
    • 84861080030 scopus 로고    scopus 로고
    • Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines
    • Haniu H, Saito N, Matsuda Y, et al. Elucidation mechanism of different biological responses to multi-walled carbon nanotubes using four cell lines. Int J Nanomedicine. 2011;6:3487-3497.
    • (2011) Int J Nanomedicine , vol.6 , pp. 3487-3497
    • Haniu, H.1    Saito, N.2    Matsuda, Y.3
  • 17
    • 80051788917 scopus 로고    scopus 로고
    • Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice
    • Wang X, Katwa P, Podila R, et al. Multi-walled carbon nanotube instillation impairs pulmonary function in C57BL/6 mice. Part Fibre Toxicol. 2011;8:24.
    • (2011) Part Fibre Toxicol , vol.8 , pp. 24
    • Wang, X.1    Katwa, P.2    Podila, R.3
  • 18
    • 0030924467 scopus 로고    scopus 로고
    • Human airway epithelial tight junctions
    • Godfrey RW. Human airway epithelial tight junctions. Microsc Res Tech. 1997;38(5):488-499.
    • (1997) Microsc Res Tech , vol.38 , Issue.5 , pp. 488-499
    • Godfrey, R.W.1
  • 19
    • 0026738687 scopus 로고
    • Electrical method for detection of endothelial cell shape change in real time: Assessment of endothelial barrier function
    • Tiruppathi C, Malik AB, Del Vecchio PJ, Keese CR, Giaever I. Electrical method for detection of endothelial cell shape change in real time: assessment of endothelial barrier function. Proc Natl Acad Sci U S A. 1992;89(17):7919-7923.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , Issue.17 , pp. 7919-7923
    • Tiruppathi, C.1    Malik, A.B.2    Vecchio, D.P.J.3    Keese, C.R.4    Giaever, I.5
  • 20
    • 84869199214 scopus 로고    scopus 로고
    • Noncardiogenic pulmonary edema
    • Bachmann M, Waldrop JE. Noncardiogenic pulmonary edema. Compendium. 2012;34(11):E1.
    • (2012) Compendium , vol.34 , Issue.11
    • Bachmann, M.1    Waldrop, J.E.2
  • 21
    • 84862851582 scopus 로고    scopus 로고
    • Understanding and correcting for carbon nanotube interferences with a commercial LDH cytotoxicity assay
    • Wang G, Zhang J, Dewilde AH, et al. Understanding and correcting for carbon nanotube interferences with a commercial LDH cytotoxicity assay. Toxicology. 2012;299(2-3):99-111.
    • (2012) Toxicology , vol.299 , Issue.2-3 , pp. 99-111
    • Wang, G.1    Zhang, J.2    Dewilde, A.H.3
  • 22
    • 84859195390 scopus 로고    scopus 로고
    • The mechanism of pleural inflammation by long carbon nanotubes: Interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells
    • Murphy FA, Schinwald A, Poland CA, Donaldson K. The mechanism of pleural inflammation by long carbon nanotubes: interaction of long fibres with macrophages stimulates them to amplify pro-inflammatory responses in mesothelial cells. Part Fibre Toxicol. 2012;9:8.
    • (2012) Part Fibre Toxicol , vol.9 , pp. 8
    • Murphy, F.A.1    Schinwald, A.2    Poland, C.A.3    Donaldson, K.4
  • 23
    • 84875305657 scopus 로고    scopus 로고
    • Understanding the toxicity of carbon nanotubes
    • Liu Y, Zhao Y, Sun B, Chen C. Understanding the toxicity of carbon nanotubes. Acc Chem Res. 2013;46(3):702-713.
    • (2013) Acc Chem Res , vol.46 , Issue.3 , pp. 702-713
    • Liu, Y.1    Zhao, Y.2    Sun, B.3    Chen, C.4
  • 24
    • 70349498079 scopus 로고    scopus 로고
    • Airway barrier dysfunction induced by exposure to carbon nanotubes in vitro: Which role for fiber length?
    • Rotoli BM, Bussolati O, Barilli A, et al. Airway barrier dysfunction induced by exposure to carbon nanotubes in vitro: which role for fiber length? Hum Exp Toxicol. 2009;28(6-7):361-368.
    • (2009) Hum Exp Toxicol , vol.28 , Issue.6-7 , pp. 361-368
    • Rotoli, B.M.1    Bussolati, O.2    Barilli, A.3
  • 25
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, et al. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133(4): 704-715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3
  • 26
    • 0025000007 scopus 로고
    • Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor beta-1 as squamous differentiation-inducing agents
    • Ke Y, Gerwin BI, Ruskie SE, Pfeifer AM, Harris CC, Lechner JF. Cell density governs the ability of human bronchial epithelial cells to recognize serum and transforming growth factor beta-1 as squamous differentiation-inducing agents. Am J Pathol. 1990;137(4):833-843.
    • (1990) Am J Pathol , vol.137 , Issue.4 , pp. 833-843
    • Ke, Y.1    Gerwin, B.I.2    Ruskie, S.E.3    Pfeifer, A.M.4    Harris, C.C.5    Lechner, J.F.6
  • 27
    • 0020466499 scopus 로고
    • Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium
    • Lechner JF, Haugen A, McClendon IA, Pettis EW. Clonal growth of normal adult human bronchial epithelial cells in a serum-free medium. In Vitro. 1982;18(7):633-642.
    • (1982) In Vitro , vol.18 , Issue.7 , pp. 633-642
    • Lechner, J.F.1    Haugen, A.2    McClendon, I.A.3    Pettis, E.W.4
  • 28
    • 80052624717 scopus 로고    scopus 로고
    • Cytoskeleton in motion: The dynamics of keratin intermediate filaments in epithelia
    • Windoffer R, Beil M, Magin TM, Leube RE. Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol. 2011;194(5):669-678.
    • (2011) J Cell Biol , vol.194 , Issue.5 , pp. 669-678
    • Windoffer, R.1    Beil, M.2    Magin, T.M.3    Leube, R.E.4
  • 29
    • 60949091201 scopus 로고    scopus 로고
    • Tubulin encapsulation of carbon nanotubes into functional hybrid assemblies
    • Dinu CZ, Bale SS, Zhu G, Dordick JS. Tubulin encapsulation of carbon nanotubes into functional hybrid assemblies. Small. 2009;5(3): 310-315.
    • (2009) Small , vol.5 , Issue.3 , pp. 310-315
    • Dinu, C.Z.1    Bale, S.S.2    Zhu, G.3    Dordick, J.S.4
  • 30
    • 84865612779 scopus 로고    scopus 로고
    • Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization
    • Rodriguez-Fernandez L, Valiente R, Gonzalez J, Villegas JC, Fanarraga ML. Multiwalled carbon nanotubes display microtubule biomimetic properties in vivo, enhancing microtubule assembly and stabilization. ACS Nano. 2012;6(8):6614-6625.
    • (2012) ACS Nano , vol.6 , Issue.8 , pp. 6614-6625
    • Rodriguez-Fernandez, L.1    Valiente, R.2    Gonzalez, J.3    Villegas, J.C.4    Fanarraga, M.L.5
  • 31
    • 33746413027 scopus 로고    scopus 로고
    • Epithelial stem cells of the lung: Privileged few or opportunities for many?
    • Rawlins EL, Hogan BL. Epithelial stem cells of the lung: privileged few or opportunities for many? Development. 2006;133(13):2455-2465.
    • (2006) Development , vol.133 , Issue.13 , pp. 2455-2465
    • Rawlins, E.L.1    Hogan, B.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.