HIF-1A and C/EBPs transcriptionally regulate adipogenic differentiation of bone marrow-derived MSCs in hypoxia

Stem Cell Research and Therapy

Volumn 6, Issue 1, 2015, Pages

  Jiang, Chen ^a,b,c   Sun, Jun ^a,b,c   Dai, Yafei ^a,b,c   Cao, Pengfei ^a,b,c   Zhang, Liyang ^a   Peng, Shuping ^a,b   Zhou, Yanhong ^a,b   Li, Guiyuan ^a,b,c   Tang, Jingqun ^d   Xiang, Juanjuan ^a,b,c  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b The First People s Hospital of Changde City)   (China)

^c Hunan Key Laboratory of Nonresolving Inflammation and Cancer   (China)

^d CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CCAAT ENHANCER BINDING PROTEIN; CCAAT ENHANCER BINDING PROTEIN DELTA; COMPLEMENT FACTOR D; FAT DROPLET; HYPOXIA INDUCIBLE FACTOR 1ALPHA; LEPTIN; LIPOPROTEIN LIPASE; OSTEOCALCIN; OSTEOPONTIN; OXYGEN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; CEBPD PROTEIN, HUMAN; CELL SURFACE RECEPTOR; ENDOGLIN; ENG PROTEIN, HUMAN; HERMES ANTIGEN; HIF1A PROTEIN, HUMAN; LEUKOCYTE ANTIGEN; SMALL INTERFERING RNA;

ADIPOCYTE; ADIPOGENESIS; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL HYPOXIA; CELL SPECIFICITY; CFD GENE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME REGULATION; GENE; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; HIG2 GENE; HUMAN; HUMAN CELL; IN VIVO STUDY; LEPTIN GENE; LIPID STORAGE; LPL GENE; OSTEOCYTE; OXYGEN CONCENTRATION; PGAR GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; TUMOR MICROENVIRONMENT; UPREGULATION; ANTAGONISTS AND INHIBITORS; BONE DEVELOPMENT; BONE MARROW CELL; CELL CULTURE; CHONDROCYTE; CYTOLOGY; GENETICS; MESENCHYMAL STROMA CELL; METABOLISM; RNA INTERFERENCE;

ADIPOCYTES; ADIPOGENESIS; ALKALINE PHOSPHATASE; ANTIGENS, CD; ANTIGENS, CD44; BONE MARROW CELLS; CCAAT-ENHANCER-BINDING PROTEIN-DELTA; CCAAT-ENHANCER-BINDING PROTEINS; CELL HYPOXIA; CELLS, CULTURED; CHONDROCYTES; ENDOGLIN; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MESENCHYMAL STROMAL CELLS; OSTEOGENESIS; RECEPTORS, CELL SURFACE; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84930001331     PISSN: None     EISSN: 17576512     Source Type: Journal    
DOI: 10.1186/s13287-015-0014-4     Document Type: Article

References (20)

1. Park YK, Park H. Prevention of CCAAT/enhancer-binding protein beta DNA binding by hypoxia during adipogenesis. J Biol Chem. 2010;285:3289-99.
2. Brahimi-Horn MC, Pouyssegur J. Oxygen, a source of life and stress. FEBS Lett. 2007;581:3582-91.
3. Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med. 2012;18:883-91.
4. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, et al. VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438:820-7.
5. Kaplan RN, Psaila B, Lyden D. Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev. 2006;25:521-9.
6. Li Q, Xia J, Yao Y, Gong DW, Shi H, Zhou Q. Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells. Breast Cancer Res Treat. 2013;141:317-24.
7. Xiang J, Tang J, Song C, Yang Z, Hirst DG, Zheng QJ, et al. Mesenchymal stem cells as a gene therapy carrier for treatment of fibrosarcoma. Cytotherapy. 2009;11:516-26.
8. TFSEARCH (predicts TF binding sites based on TRANSFAC data). http://www.cbrc.jp/research/db/TFSEARCH.html. Submitted on June, 2014.
9. Mamlouk S, Wielockx B. Hypoxia-inducible factors as key regulators of tumor inflammation. Int J Cancer. 2012;132:2721-9.
10. Fehrer C, Brunauer R, Laschober G, Unterluggauer H, Reitinger S, Kloss F, et al. Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan. Aging Cell. 2007;6:745-57.
11. Holzwarth C, Vaegler M, Gieseke F, Pfister SM, Handgretinger R, Kerst G, et al. Low physiologic oxygen tensions reduce proliferation and differentiation of human multipotent mesenchymal stromal cells. BMC Cell Biol. 2010;11:11.
12. Valorani MG, Montelatici E, Germani A, Biddle A, D'Alessandro D, Strollo R, et al. Pre-culturing human adipose tissue mesenchymal stem cells under hypoxia increases their adipogenic and osteogenic differentiation potentials. Cell Prolif. 2012;45:225-38.
13. Fink T, Abildtrup L, Fogd K, Abdallah BM, Kassem M, Ebbesen P, et al. Induction of adipocyte-like phenotype in human mesenchymal stem cells by hypoxia. Stem Cells. 2004;22:1346-55.
14. Fajas L, Schoonjans K, Gelman L, Kim JB, Najib J, Martin G, et al. Regulation of peroxisome proliferator-activated receptor gamma expression by adipocyte differentiation and determination factor 1/sterol regulatory element binding protein 1: implications for adipocyte differentiation and metabolism. Mol Cell Biol. 1999;19:5495-503.
15. Hu CJ, Wang LY, Chodosh LA, Keith B, Simon MC. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74.
16. Miller SG, De Vos P, Guerre-Millo M, Wong K, Hermann T, Staels B, et al. The adipocyte specific transcription factor C/EBPalpha modulates human ob gene expression. Proc Natl Acad Sci U S A. 1996;93:5507-11.
17. Melzner I, Scott V, Dorsch K, Fischer P, Wabitsch M, Bruderlein S, et al. Leptin gene expression in human preadipocytes is switched on by maturation-induced demethylation of distinct CpGs in its proximal promoter. J Biol Chem. 2002;277:45420-7.
18. Huang AM, Montagna C, Sharan S, Ni Y, Ried T, Sterneck E. Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. Oncogene. 2004;23:1549-57.
19. Ramji DP, Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002;365:561-75.
20. Do-Umehara HC, Chen C, Urich D, Zhou L, Qiu J, Jang S, et al. Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-delta. Nat Immunol. 2013;14:461-9.