Glycan structure and serum half-life of recombinant CTLA4Ig, an immunosuppressive agent, expressed in suspension-cultured rice cells with coexpression of human β1,4-galactosyltransferase and human CTLA4Ig

Glycoconjugate Journal

Volumn 32, Issue 3-4, 2015, Pages 161-172

  Kang, Seung Hoon ^a   Jung, Hahn Sun ^a   Lee, Song Jae ^a   Park, Cheon Ik ^a   Lim, Sang Min ^a   Park, Heajin ^b   Kim, Byung Sun ^b   Na, Kwang Heum ^b   Han, Gyeong Jin ^b   Bae, Jae Woo ^b   Park, Hyun Joo ^b   Bang, Keuk Chan ^b   Park, Byung Tae ^b   Hwang, Hye Seong ^b   Jung, In Soo ^c   Kim, Jae Il ^d   Oh, Doo Byung ^e   Kim, Dong Il ^f   Yagi, Hirokazu ^g   Kato, Koichi ^g,h   Kim, Dae Kyong ^b   Kim, Ha Hyung ^b   more..

^a Boryung Pharm Co Ltd   (South Korea)

^b Chung Ang University   (South Korea)

^c Korea University   (South Korea)

^d Gwangju Institute of Science and Technology (GIST)   (South Korea)

^e Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^f Inha University   (South Korea)

^g NAGOYA CITY UNIVERSITY   (Japan)

^h OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

Author keywords

Clearance; CTLA4Ig; Half life; Human 1,4 galactosyltransferase; N glycan; Plant cell culture

Indexed keywords

ABATACEPT; ALPHA 1,3 FUCOSE; BETA 1,2 XYLOSE; BETA 1,4 GALACTOSYLTRANSFERASE; FUCOSE; GALACTOSYLTRANSFERASE; GENOMIC DNA; GLYCAN; UNCLASSIFIED DRUG; XYLOSE; BETA1,4-GALACTOSYLTRANSFERASE, HUMAN; HYBRID PROTEIN; IMMUNOSUPPRESSIVE AGENT; POLYSACCHARIDE;

ANIMAL EXPERIMENT; ARTICLE; CARBOHYDRATE ANALYSIS; CHO CELL LINE; CONTROLLED STUDY; DNA ISOLATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; HUMAN; IMMUNOBLOTTING; IN VITRO STUDY; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PLANT CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RICE; RICE CELL; SIALYLATION; SPRAGUE DAWLEY RAT; ANIMAL; BLOOD; CELL CULTURE TECHNIQUE; CHEMISTRY; CRICETULUS; CYTOLOGY; GENETICS; HALF LIFE TIME; METABOLISM; MOLECULAR GENETICS; ORYZA; PROCEDURES; TRANSGENIC PLANT;

CRICETULUS GRISEUS; RATTUS;

ABATACEPT; ANIMALS; CARBOHYDRATE SEQUENCE; CELL CULTURE TECHNIQUES; CHO CELLS; CRICETULUS; GALACTOSYLTRANSFERASES; HALF-LIFE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; MALE; MOLECULAR SEQUENCE DATA; ORYZA; PLANTS, GENETICALLY MODIFIED; POLYSACCHARIDES; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS;

EID: 84929963973     PISSN: 02820080     EISSN: 15734986     Source Type: Journal    
DOI: 10.1007/s10719-015-9590-x     Document Type: Article

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