The Effect of Prophylactic Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement on Swallowing and Swallow-Related Outcomes in Patients Undergoing Radiotherapy for Head and Neck Cancer: A Systematic Review

Dysphagia

Volumn 30, Issue 2, 2015, Pages 152-175

  Shaw, Stephanie M ^a   Flowers, Heather ^a   O’Sullivan, Brian ^b   Hope, Andrew ^b   Liu, Louis W C ^c   Martino, Rosemary ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c TORONTO WESTERN HOSPITAL   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Deglutition and deglutition disorders; Feeding tube; Head and neck cancer; Percutaneous endoscopic gastrostomy (PEG); Prophylactic; Radiotherapy

Indexed keywords

ARTICLE; CANCER RADIOTHERAPY; CASE CONTROL STUDY; COHORT ANALYSIS; DEHYDRATION; DISEASE SEVERITY; DYSPHAGIA; HEAD AND NECK CANCER; HUMAN; MALNUTRITION; OBSERVATIONAL STUDY; PATIENT RISK; PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; PRIORITY JOURNAL; PROPHYLACTIC PERCUTANEOUS ENDOSCOPIC GASTROSTOMY; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; SYSTEMATIC REVIEW; TREATMENT DURATION; TREATMENT OUTCOME; WEIGHT REDUCTION; ADVERSE EFFECTS; DEGLUTITION DISORDERS; ENTERIC FEEDING; GASTROSCOPY; GASTROSTOMY; HEAD AND NECK NEOPLASMS; PHYSIOLOGY; PROCEDURES; SWALLOWING;

DEGLUTITION; DEGLUTITION DISORDERS; DEHYDRATION; ENTERAL NUTRITION; GASTROSCOPY; GASTROSTOMY; HEAD AND NECK NEOPLASMS; HUMANS; MALNUTRITION; QUALITY OF LIFE;

EID: 84929963266     PISSN: 0179051X     EISSN: 14320460     Source Type: Journal    
DOI: 10.1007/s00455-014-9592-z     Document Type: Article

References (123)

1. Forte T, Niu J, Lockwood GA, Bryant HE. Incidence trends in head and neck cancers and human papillomavirus (HPV)-associated oropharyngeal cancer in Canada, 1992–2009. Cancer Causes Control. 2012;23(8):1343–8. doi:10.1007/s10552-012-0013-z.
2. Argiris A, Karamouzis MV, Raben D, Ferris RL. Head and neck cancer. Lancet. 2008;371(9625):1695–709. doi:10.1016/s0140-6736(08)60728-x.
3. Bourhis J, Overgaard J, Audry H, Ang KK, Saunders M, Bernier J, Horiot J-C, et al. Hyperfractionated or accelerated radiotherapy in head and neck cancer: a meta-analysis. Lancet. 2006;368(9538):843–54. doi:10.1016/s0140-6736(06)69121-6.
4. Chin D, Boyle GM, Porceddu S, Theile DR, Parsons PG, Coman WB. Head and neck cancer: past, present and future. Expert Rev Anticancer Ther. 2006;6:1111–8. doi:10.1586/14737140.6.7.1111.
5. Nguyen NP, Frank C, Moltz CC, Vos P, Smith HJ, Bhamidipati PV, Karlsson U, et al. Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence. Radiother Oncol. 2006;80(3):302–6. doi:10.1016/j.radonc.2006.07.031.
6. Bachaud J-M, Cohen-Jonathan E, Alzieu C, David J-M, Serrano E, Daly-Schveitzer N. Combined postoperative radiotherapy and weekly cisplatin infusion for locally advanced head and neck carcinoma: final report of a randomized trial. Int J Radiat Oncol Biol Phys. 1996;36(5):999–1004. doi:10.1016/S0360-3016(96)00430-0.
7. Fu KK. Combined-modality therapy for head and neck cancer. Oncology. 1997;11(12):1781.
8. Redda MGR, Ragona R, Ricardi U, Beltramo G, Rampino M, Gabriele P, Allis S, et al. Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: definitive results of a phase III study with a follow-up period of up to ten years. Tumori. 2010;96:246–53. doi:10.1700/488.5774.
9. Zackrisson B, Mercke C, Strander H, Wennerberg J, Cavallin-Ståhl E. A systematic overview of radiation therapy effects in head and neck cancer. Acta Otolaryngol. 2003;42(5–6):443–61. doi:10.1080/02841860310014886.
10. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, et al. Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. 2003;349(22):2091–8. doi:10.1056/NEJMoa031317.
11. Cooper JS, Pajak TF, Forastiere AA, Jacobs J, Campbell BH, Saxman SB, Kish JA, et al. Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck. N Engl J Med. 2004;350(19):1937–44. doi:10.1056/NEJMoa032646.
12. Al-Sarraf M, Leblanc M, Giri P, Fu K, Cooper J, Vuong T, Forastiere A, et al. Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol. 1998;16(4):1310–7.
13. Adelstein DJ, Li Y, Adams GL, Wagner H, Kish JA, Ensley JF, Schuller DE, et al. An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer. J Clin Oncol. 2003;21(1):92–8. doi:10.1200/jco.2003.01.008.
14. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, et al. Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. N Engl J Med. 2006;354(6):567–78. doi:10.1056/NEJMoa053422.
15. Alkureishi LWT, De Bree R, Ross GL. RADPLAT: an alternative to surgery? Oncologist. 2006;11(5):469–80. doi:10.1634/theoncologist.11-5-469.
16. Trotti A. Toxicity in head and neck cancer: a review of trends and issues. Int J Radiat Oncol Biol Phys. 2000;47(1):1–12. doi:10.1016/S0360-3016(99)00558-1.
17. Rosenthal DI, Mendoza TR, Chambers MS, Asper JA, Gning I, Kies MS, Weber RS, et al. Measuring head and neck cancer symptom burden: the development and validation of the M. D. Anderson symptom inventory, head and neck module. Head Neck. 2007;29(10):923–31. doi:10.1002/hed.20602.
18. Henk JM. Controlled trials of synchronous chemotherapy with radiotherapy in head and neck cancer: overview of radiation morbidity. Clin Oncol. 1997;9(5):308–12. doi:10.1016/S0936-6555(05)80064-0.
19. Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, Komaroff E, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiat Oncol. 2003;66(3):253–62. doi:10.1016/S0167-8140(02)00404-8.
20. Bentzen SM, Saunders MI, Dische S, Bond SJ. Radiotherapy-related early morbidity in head and neck cancer: quantitative clinical radiobiology as deduced from the CHART trial. Radiother Oncol. 2001;60(2):123–35. doi:10.1016/s0167-8140(01)00358-9.
21. Piquet M-A, Ozsahin M, Larpin I, Zouhair A, Coti P, Monney M, Monnier P, et al. Early nutritional intervention in oropharyngeal cancer patients undergoing radiotherapy. Support Care Cancer. 2002;10(6):502–4. doi:10.1007/s00520-002-0364-1.
22. Chen AM, Li B-Q, Lau DH, Farwell DG, Luu Q, Stuart K, Newman K, et al. Evaluating the role of prophylactic gastrostomy tube placement prior to definitive chemoradiotherapy for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(4):1026–32. doi:10.1016/j.ijrobp.2009.09.036.
23. Newman LA, Vieira F, Schwiezer V, Samant S, Murry T, Woodson G, Kumar P, et al. Eating and weight changes following chemoradiation therapy for advanced head and neck cancer. Arch Otolaryngol Head Neck Surg. 1998;124(5):589–92. doi:10.1001/archotol.124.5.589.
24. Beaver ME, Matheny KE, Roberts DB, Myers JN. Predictors of weight loss during radiation therapy. Otolaryngol Head Neck Surg. 2001;125(6):645–8. doi:10.1067/mhn.2001.120428.
25. Colasanto JM, Prasad P, Nash MA, Decker RH, Wilson LD. Nutritional support of patients undergoing radiation therapy for head and neck cancer. Oncology. 2005;19(3):371–9.
26. Lee JH, Machtay M, Unger LD, Weinstein GS, Weber RS, Chalian AA, Rosenthal DI. Prophylactic gastrostomy tubes in patients undergoing intensive irradiation for cancer of the head and neck. Arch Otolaryngol Head Neck Surg. 1998;124(8):871–5. doi:10.1001/archotol.124.8.871.
27. Nayel H, El-Ghoneimy E, El-Haddad S. Impact of nutritional supplementation on treatment delay and morbidity in patients with head and neck tumors treated with irradiation. Nutrition. 1992;8(1):13–8.
28. Haydock DA, Hill GL. Impaired wound healing in surgical patients with varying degrees of malnutrition. JPEN J Parenter Enteral Nutr. 1986;10(6):550–4. doi:10.1177/0148607186010006550.
29. Haydock DA, Hill GL. Improved wound healing response in surgical patients receiving intravenous nutrition. Br J Surg. 1987;74(4):320–3. doi:10.1002/bjs.1800740432.
30. Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clin Nutr. 2008;27(1):5–15. doi:10.1016/j.clnu.2007.10.007.
31. Andreyev HJN, Norman AR, Oates J, Cunningham D. Why do patients with weight loss have a worse outcome when undergoing chemotherapy for gastrointestinal malignancies? Eur J Cancer. 1998;34(4):503–9. doi:10.1016/S0959-8049(97)10090-9.
32. Norman K, Schütz T, Kemps M, Lübke HJ, Lochs H, Pirlich M. The Subjective Global Assessment reliably identifies malnutrition-related muscle dysfunction. Clin Nutr. 2005;24(1):143–50. doi:10.1016/j.clnu.2004.08.007.
33. Correia MITD, Waitzberg DL. The impact of malnutrition on morbidity, mortality, length of hospital stay and costs evaluated through a multivariate model analysis. Clin Nutr. 2003;22(3):235–9. doi:10.1016/S0261-5614(02)00215-7.
34. Norman K, Kirchner H, Lochs H, Pirlich M. Malnutrition affects quality of life in gastroenterology patients. World J Gastroenterol. 2006;12(21):3380. doi:10.3748/wjg.v12.i21.3385.
35. Marín Caro MM, Laviano A, Pichard C. Impact of nutrition on quality of life during cancer. Curr Opin Clin Nutr Metab Care. 2007;10(4):480–7. doi:10.1097/MCO.0b013e3281e2c983.
36. Ravasco P, Monteiro-Grillo I, Camilo ME. Does nutrition influence quality of life in cancer patients undergoing radiotherapy? Radiat Oncol. 2003;67(2):213–20. doi:10.1016/S0167-8140(03)00040-9.
37. Lees J. Nasogastric and percutaneous endoscopic gastrostomy feeding in head and neck cancer patients receiving radiotherapy treatment at a regional oncology unit: a two year study. Eur J Cancer Care. 1997;6(1):45–9. doi:10.1111/j.1365-2354.1997.tb00268.x.
38. Magné N, Marcy P, Foa C, Falewee M, Schneider M, Demard F, Bensadoun R. Comparison between nasogastric tube feeding and percutaneous fluoroscopic gastrostomy in advanced head and neck cancer patients. Eur Arch Otorhinolaryngol. 2001;258(2):89–92. doi:10.1007/s004050000311.
39. Raykher A, Correa L, Russo L, Brown P, Lee N, Pfister D, Gerdes H, et al. The role of pretreatment percutaneous endoscopic gastrostomy in facilitating therapy of head and neck cancer and optimizing the body mass index of the obese patient. JPEN J Parenter Enteral Nutr. 2009;33(4):404–10. doi:10.1177/0148607108327525.
40. ®): head and neck cancers version 1.2012, 2012. http://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf. Accessed April 8, 2013.
41. Nguyen N, Frank C, Moltz C, Vos P, Smith H, Nguyen P, Martinez T, et al. Analysis of factors influencing aspiration risk following chemoradiation for oropharyngeal cancer. Br J Radiol. 2009;82(980):675–80. doi:10.1259/bjr/72852974.
42. Lee H, Havrila C, Bravo V, Shantz K, Diaz K, Larner J, Read P. Effect of oral nutritional supplementation on weight loss and percutaneous endoscopic gastrostomy tube rates in patients treated with radiotherapy for oropharyngeal carcinoma. Support Care Cancer. 2008;16(3):285–9. doi:10.1007/s00520-007-0313-0.
43. Wiggenraad RGJ, Flierman L, Goossens A, Brand R, Verschuur HP, Croll GA, Moser LEC, et al. Prophylactic gastrostomy placement and early tube feeding may limit loss of weight during chemoradiotherapy for advanced head and neck cancer, a preliminary study. Clin Otolaryngol. 2007;32(5):384–90. doi:10.1111/j.1749-4486.2007.01533.x.
44. Berlach DM, Nguyen N, Cury F, Al Halabi H, Shenouda G. Comparison of prophylactic and emergent percutaneous endoscopic gastrostomy tube placement in patients treated with chemotherapy and radiation for head and neck cancer. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):437.
45. Paccagnella A, Morello M, Da Mosto MC, Baruffi C, Marcon ML, Gava A, Baggio V, et al. Early nutritional intervention improves treatment tolerance and outcomes in head and neck cancer patients undergoing concurrent chemoradiotherapy. Support Care Cancer. 2010;18(7):837–45. doi:10.1007/s00520-009-0717-0.
46. Hughes BGM, Jain VK, Brown T, Spurgin A-L, Hartnett G, Keller J, Tripcony L, et al. Decreased hospital stay and significant cost savings after routine use of prophylactic gastrostomy for high-risk patients with head and neck cancer receiving chemoradiotherapy at a tertiary cancer institution. Head Neck. 2013;35(3):436–42. doi:10.1002/hed.22992.
47. George A, Abhyankar A, Hari C. Percutaneous endoscopic gastrostomy (PEG) tube insertion in head and neck cancer (HNC) patients: a cause for delay. Otorhinolaryngologist. 2011;3(3):125–6.
48. Cady J. Nutritional support during radiotherapy for head and neck cancer: the role of prophylactic feeding tube placement. Clin J Oncol Nurs. 2007;11(6):875–80. doi:10.1188/07.cjon.875-880.
49. Moor JW, Patterson J, Kelly C, Paleri V. Prophylactic gastrostomy before chemoradiation in advanced head and neck cancer: a multiprofessional web-based survey to identify current practice and to analyse decision making. Clin Oncol. 2010;22(3):192–8. doi:10.1016/j.clon.2010.01.008.
50. Back M, Raymond B, Ko F, Chin S, Veivers D, Wignall A, Eade T. Impact of prophylactic PEG tubes on nutritional outcomes at 12 months following IMRT for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A199.
51. Huang DT, Thomas G, Wilson WR. Stomal seeding by percutaneous endoscopic gastrostomy in patients with head and neck cancer. Arch Otolaryngol Head Neck Surg. 1992;118(6):658–9. doi:10.1001/archotol.1992.01880060108022.
52. Bushnell L, White TW, Hunter JG. Metastatic implantation of laryngeal carcinoma at a PEG exit site. Gastrointest Endosc. 1991;37(4):480–2. doi:10.1016/S0016-5107(91)70787-6.
53. Meurer MF, Kenady DE. Metastatic head and neck carcinoma in a percutaneous gastrostomy site. Head Neck. 1993;15(1):70–3. doi:10.1002/hed.2880150116.
54. Preyer S, Thul P. Gastric metastasis of squamous cell carcinoma of the head and neck after percutaneous endoscopic gastrostomy: report of a case. Endoscopy. 1989;21(6):295. doi:10.1055/s-2007-1012974.
55. Laccoureye O, Merite-Drancy A, Chabardes E, Carnot FO. Implantation metastasis following percutaneous endoscopic gastrostomy. J Laryngol Otol. 1993;107:946–9. doi:10.1017/S0022215100124879.
56. Sharma P, Berry S, Wilson K, Neale H, Fink A. Metastatic implantation of an oral squamous-cell carcinoma at a percutaneous endoscopic gastrostomy site. Surg Endosc. 1994;8(10):1232–5. doi:10.1007/BF00591059.
57. Thorburn D, Karim SN, Soutar DS, Mills PR. Tumour seeding following percutaneous endoscopic gastrostomy placement in head and neck cancer. Postgrad Med J. 1997;73(861):430–2. doi:10.1136/pgmj.73.861.430.
58. Schiano T, Pfister D, Harrison L, Shike M. Neoplastic seeding as a complication of percutaneous endoscopic gastrostomy. Am J Gastroenterol. 1994;89(1):131–3.
59. Schneider AM, Loggie BW. Metastatic head and neck cancer to the percutaneous endoscopic gastrostomy exit site: a case report and review of the literature. Am Surg. 1997;63(6):481.
60. Riera L, Sandiumenge A, Calvo C, Bordas J, Alobid I, Llach J, Bernal M. Percutaneous endoscopic gastrostomy in head and neck cancer patients. J Otorhinolaryngol. 2002;64(1):32–4. doi:10.1159/000049265.
61. Corry J, Poon W, Mcphee N, Milner AD, Cruickshank D, Porceddu SV, Rischin D, et al. Prospective study of percutaneous endoscopic gastrostomy tubes versus nasogastric tubes for enteral feeding in patients with head and neck cancer undergoing (chemo)radiation. Head Neck. 2009;31(7):867–76. doi:10.1002/hed.21044.
62. Rustom IK, Jebreel A, Tayyab M, England RJA, Stafford ND. Percutaneous endoscopic, radiological and surgical gastrostomy tubes: a comparison study in head and neck cancer patients. J Laryngol Otol. 2006;120(6):463–6. doi:10.1017/S0022215106000661.
63. Grant D, Bradley P, Pothier D, Bailey D, Caldera S, Baldwin D, Birchall M. Complications following gastrostomy tube insertion in patients with head and neck cancer: a prospective multi-institution study, systematic review and meta-analysis. Clin Otolaryngol. 2009;34(2):103–12. doi:10.1111/j.1749-4486.2009.01889.x.
64. Pruthi D, Duerksen DR, Singh H. The practice of gastrostomy tube placement across a Canadian regional health authority. Am J Gastroenterol. 2010;105(7):1541–50. doi:10.1038/ajg.2009.756.
65. Callahan CM, Buchanan NN, Stump TE. Healthcare costs associated with percutaneous endoscopic gastrostomy among older adults in a defined community. J Am Geriatr Soc. 2001;49(11):1525–9. doi:10.1046/j.1532-5415.2001.4911248.x.
66. Madhoun MF, Blankenship MM, Blankenship DM, Krempl GA, Tierney WM. Prophylactic PEG placement in head and neck cancer: how many feeding tubes are unused (and unnecessary)? World J Gastroenterol. 2011;17(8):1004–1008. doi: 10.3748/wjg.v17.i8.1004
67. Langmore S, Krisciunas GP, Miloro KV, Evans SR, Cheng DM. Does PEG use cause dysphagia in head and neck cancer patients? Dysphagia. 2012;27(2):251–9. doi:10.1007/s00455-011-9360-2.
68. Carnaby-Mann G, Crary MA, Schmalfuss I, Amdur R. Pharyngocise: randomized controlled trial of preventative exercises to maintain muscle structure and swallowing function during head-and-neck chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2012;83(1):210–9. doi:10.1016/j.ijrobp.2011.06.1954.
69. Koyfman SA, Adelstein DJ. Enteral feeding tubes in patients undergoing definitive chemoradiation therapy for head-and-neck cancer: a critical review. Int J Radiat Oncol Biol Phys. 2012;84(3):581–9. doi:10.1016/j.ijrobp.2012.03.053.
70. Robbins J, Butler SG, Daniels SK, Diez Gross R, Langmore S, Lazarus CL, Martin-Harris B, et al. Swallowing and dysphagia rehabilitation: translating principles of neural plasticity into clinically oriented evidence. J Speech Lang Hear Res. 2008;51(1):S276–300. doi:10.1044/1092-4388(2008/021).
71. Silander E, Jacobsson I, Berteus-Forslund H, Hammerlid E. Energy intake and sources of nutritional support in patients with head and neck cancer-a randomised longitudinal study. Eur J Clin Nutr. 2013;67(1):47–52. doi:10.1038/ejcn.2012.172.
72. Silander E, Nyman J, Bove M, Johansson L, Larsson S, Hammerlid E. Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study. Head Neck. 2012;34(1):1–9. doi:10.1002/hed.21700.
73. Langmore S, Vasquez Miloro K, Kriscuinas G. Prophylactic vs late PEG placement in head and neck cancer patients. Dysphagia. 2009;24(4):449.
74. Paleri V, Patterson J. Use of gastrostomy in head and neck cancer: a systematic review to identify areas for future research. Clin Otolaryngol. 2010;35(3):177–89. doi:10.1111/j.1749-4486.2010.02128.x.
75. Locher JL, Bonner JA, Carroll WR, Caudell JJ, Keith JN, Kilgore ML, Ritchie CS, et al. Prophylactic percutaneous endoscopic gastrostomy tube placement in treatment of head and neck cancer: a comprehensive review and call for evidence-based medicine. JPEN J Parenter Enteral Nutr. 2011;35(3):365–74. doi:10.1177/0148607110377097.
76. Orphanidou C, Biggs K, Johnston M, Wright J, Bowman A, Hotte S, Esau A, et al. Prophylactic feeding tubes for patients with locally advanced head-and-neck cancer undergoing combined chemotherapy and radiotherapy: systematic review and recommendations for clinical practice. Curr Oncol. 2011;18(4):e191–201. doi:10.3747/co.v18i4.749.
77. Nugent B, Lewis S, O’sullivan JM. Enteral feeding methods for nutritional management in patients with head and neck cancers being treated with radiotherapy and/or chemotherapy. Cochrane Database Syst Rev. 2013;1:1–18. doi:10.1002/14651858.CD007904.pub3.
78. Raber-Durlacher J, Brennan M, Verdonck-De Leeuw I, Gibson R, Eilers J, Waltimo T, Bots C, et al. Swallowing dysfunction in cancer patients. Support Care Cancer. 2012;20(3):433–43. doi:10.1007/s00520-011-1342-2.
79. Cheng SS, Terrell JE, Bradford CR, Ronis DL, Fowler KE, Prince ME, Teknos TN, et al. Variables associated with feeding tube placement in head and neck cancer. Arch Otolaryngol Head Neck Surg. 2006;132(6):655–61. doi:10.1001/archotol.132.6.655.
80. Higgins JPT, Altman DG. Chapter 8: Assessing risk of bias in included studies. In: Higgins JPT, Green S, editors. Cochrane handbook for systematic reviews of interventions. Chichester: Wiley; 2008. p. 187–241.
81. Berlach D, Nguyen NT, Al Halabi H, Cury F, Shenouda G. Comparison of prophylactic and urgent percutaneous gastrostomy tube placement in patients treated with combined radiation and chemotherapy for head and neck cancer. Radiother Oncol. 2010;96:S53.
82. Romesser PT, Setton M, Schupak J, Gelblum K, Rao D, Sherman S, Lee E. Dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2014;88(2):470.
83. Oozeer NB, Corsar K, Glore RJ, Penney S, Patterson J, Paleri V. The impact of enteral feeding route on patient-reported long term swallowing outcome after chemoradiation for head and neck cancer. Oral Oncol. 2011;47(10):980–3. doi:10.1016/j.oraloncology.2011.07.011.
84. Quon HCM, Martens C, Butler A, Stimpson J, Duerksen R, Campbell-Enns D. Impact of feeding tubes on prospective functional outcomes in patients with locally-advanced head-and-neck cancer undergoing radiation therapy. Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S143.
85. Sanguineti GR, Gunn N, Ricchetti B, Fiorino F. Predictors of PEG dependence after IMRT±chemotherapy for oropharyngeal cancer. Radiat Oncol. 2013;107(3):300–4. doi:10.1016/j.radonc.2013.05.021.
86. Chin S, Raymond B, Ko F, Eade T, Back M. Understanding the patient experience with prophylactic PEG tubes during intensity modulated radiation therapy for locoregionally advanced head and neck cancer. J Med Imaging Radiat Oncol. 2009;53:A100.
87. Romesser PB, Romanyshyn JC, Schupak KD, Setton J, Riaz N, Wolden SL, Gelblum DY, et al. Percutaneous endoscopic gastrostomy in oropharyngeal cancer patients treated with intensity-modulated radiotherapy with concurrent chemotherapy. Cancer. 2012;118(24):6072–8. doi:10.1002/cncr.27633.
88. Williams GF, Teo MTW, Sen M, Dyker KE, Coyle C, Prestwich RJD. Enteral feeding outcomes after chemoradiotherapy for oropharynx cancer: a role for a prophylactic gastrostomy? Oral Oncol. 2012;48(5):434–40. doi:10.1016/j.oraloncology.2011.11.022.
89. Beer KT, Krause KB, Zuercher T, Stanga Z. Early percutaneous endoscopic gastrostomy insertion maintains nutritional state in patients with aerodigestive tract cancer. Nutr Cancer. 2005;52(1):29–34. doi:10.1207/s15327914nc5201_4.
90. Olson R, Karam I, Wilson G, Bowman A, Lee C, Wong F. Population-based comparison of two feeding tube approaches for head and neck cancer patients receiving concurrent systemic-radiation therapy: is a prophylactic feeding tube approach harmful or helpful? Support Care Cancer. 2013;21(12):3433–9. doi:10.1007/s00520-013-1936-y.
91. Rutter CE, Yovino S, Taylor R, Wolf J, Cullen KJ, Ord R, Athas M, et al. Impact of early percutaneous endoscopic gastrostomy tube placement on nutritional status and hospitalization in patients with head and neck cancer receiving definitive chemoradiation therapy. Head Neck. 2011;33(10):1441–7. doi:10.1002/hed.21624.
92. Prestwich RJD, Teo MTW, Gilbert A, Williams G, Dyker KE, Sen M. Long-term swallow function after chemoradiotherapy for oropharyngeal cancer: the influence of a prophylactic gastrostomy or reactive nasogastric tube. Clin Oncol. 2014;26(2):103–9. doi:10.1016/j.clon.2013.10.005.
93. Romesser PB, Tam MM, Zhang Z, Setton J, Spratt DE, Schupak KD, Gelblum DY, et al. Prospective dysphagia quality of life scores and treatment outcomes in oropharyngeal cancer patients: is it time to reconsider the prophylactic percutaneous endoscopic gastrostomy? Int J Radiat Oncol Biol Phys. 2013;87(2 Suppl. 1):S131.
94. Morton RP, Crowder VL, Mawdsley R, Ong E, Izzard M. Elective gastrostomy, nutritional status and quality of life in advanced head and neck cancer patients receiving chemoradiotherapy. Aust N Z J Surg. 2009;79(10):713–8. doi:10.1111/j.1445-2197.2009.05056.x.
95. Pohar SS, Demarcantonio M, Crandley E, Wadsworth JT, Karakla D. Prophylactic PEG tube and swallowing following chemoradiation. Int J Radiat Oncol Biol Phys. 2010;78(3 Suppl. 1):S456.
96. Chen AM, Chen LM, Vaughan A, Farwell DG, Luu Q, Purdy JA, Vijayakumar S. Head and neck cancer among lifelong never-smokers and ever-smokers: matched-pair analysis of outcomes after radiation therapy. Am J Clin Oncol. 2010;34(3):270–5. doi:10.1097/COC.0b013e3181dea40b.
97. Tracy JF, Logemann JA, Kahrilas PJ, Jacob P, Kobara M, Krugler C. Preliminary observations on the effects of age on oropharyngeal deglutition. Dysphagia. 1989;4(2):90–4. doi:10.1007/BF02407151.
98. Ekberg O, Feinberg M. Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. Am J Roentgenol. 1991;156(6):1181–4.
99. Jager-Wittenaar HT, Dijkstra PU, Vissink A, Van Der Laan BF, Van Oort RP, Roodenburg JL. Critical weight loss in head and neck cancer-prevalence and risk factors at diagnosis: an explorative study. Support Care Cancer. 2007;15(9):1045–50. doi:10.1007/s00520-006-0212-9.
100. Caudell JJ, Schaner PE, Meredith RF, Locher JL, Nabell LM, Carroll WR, Magnuson JS, et al. Factors associated with long-term dysphagia after definitive radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2009;73(2):410–5. doi:10.1016/j.ijrobp.2008.04.048.
101. Dirix P, Abbeel S, Vanstraelen B, Hermans R, Nuyts S. Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures. Int J Radiat Oncol Biol Phys. 2009;75(2):385–92. doi:10.1016/j.ijrobp.2008.11.041.
102. Machtay M, Moughan J, Trotti A, Garden AS, Weber RS, Cooper JS, Forastiere A, et al. Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: an RTOG analysis. J Clin Oncol. 2008;26(21):3582–9. doi:10.1200/jco.2007.14.8841.
103. McRackan TR, Watkins JM, Herrin AE, Garrett-Mayer EM, Sharma AK, Day TA, Gillespie MB. Effect of body mass index on chemoradiation outcomes in head and neck cancer. Laryngoscope. 2008;118(7):1180–5. doi:10.1097/MLG.0b013e31816fca5c.
104. Pildal J, Hróbjartsson A, Jørgensen K, Hilden J, Altman D, Gøtzsche P. Impact of allocation concealment on conclusions drawn from meta-analyses of randomized trials. Int J Epidemiol. 2007;36(4):847–57. doi:10.1093/ije/dym087.
105. Hewitt C, Hahn S, Torgerson DJ, Watson J, Bland JM. Adequacy and reporting of allocation concealment: review of recent trials published in four general medical journals. BMJ. 2005;330(7499):1057–8. doi:10.1136/bmj.38413.576713.AE.
106. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias: dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273(5):408–12. doi:10.1001/jama.1995.03520290060030.
107. Schulz KF, Grimes DA. Allocation concealment in randomised trials: defending against deciphering. Lancet. 2002;359(9306):614–8. doi:10.1016/S0140-6736(02)07750-4.
108. Wood L, Egger M, Gluud LL, Schulz KF, Jüni P, Altman DG, Gluud C, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ. 2008;336(7644):601–5. doi:10.1136/bmj.39465.451748.AD.
109. Roe JWG, Carding PN, Dwivedi RC, Kazi RA, Rhys-Evans PH, Harrington KJ, Nutting CM. Swallowing outcomes following Intensity Modulated Radiation Therapy (IMRT) for head and neck cancer: a systematic review. Oral Oncol. 2010;46(10):727–33. doi:10.1016/j.oraloncology.2010.07.012.
110. Logemann JA, Rademaker AW, Pauloski BR, Lazarus CL, Mittal BB, Brockstein B, Maccracken E, et al. Site of disease and treatment protocol as correlates of swallowing function in patients with head and neck cancer treated with chemoradiation. Head Neck. 2006;28(1):64–73. doi:10.1002/hed.20299.
111. Lowery SD. Assessment and measurement tools used in the evaluation of swallowing. Curr Opin Otolaryngol Head Neck Surg. 2001;9(3):134–8.
112. Eisbruch A, Lyden T, Bradford CR, Dawson LA, Haxer MJ, Miller AE, Teknos TN, et al. Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2002;53(1):23–8. doi:10.1016/S0360-3016(02)02712-8.
113. Jensen K, Bonde Jensen A, Grau C. The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires. Radiother Oncol. 2006;78(3):298–305. doi:10.1016/j.radonc.2006.02.005.
114. Lazarescu A, Karamanolis G, Aprile L, De Oliveira RB, Dantas R, Sifrim D. Perception of dysphagia: lack of correlation with objective measurements of esophageal function. Neurogastroenterol Motil. 2010;22(12):1292-e1337. doi:10.1111/j.1365-2982.2010.01578.x.
115. Nguyen NP, Moltz CC, Frank C, Vos P, Smith HJ, Karlsson U, Dutta S, et al. Dysphagia following chemoradiation for locally advanced head and neck cancer. Ann Oncol. 2004;15(3):383–8. doi:10.1093/annonc/mdh101.
116. Lewis SL, Brody R, Touger-Decker R, Parrott JS, Epstein J. Feeding tube use in patients with head and neck cancer. Head Neck. 2013;. doi:10.1002/hed.23538.
117. Kramer S, Newcomb M, Hessler J, Siddiqui F. Prophylactic versus reactive PEG tube placement in head and neck cancer. Otolaryngol Head Neck Surg. 2014;150(3):407–12. doi:10.1177/0194599813517081.
118. Amin N, Reddy K, Westerly D, Raben D, Dewitt P, Chen C. Sparing the larynx and esophageal inlet expedites feeding tube removal in patients with stage III–IV oropharyngeal squamous cell carcinoma treated with intensity-modulated radiotherapy. Laryngoscope. 2012;122(12):2736–42. doi:10.1002/lary.23597.
119. Bhayani MK, Hutcheson KA, Barringer DA, Lisec A, Alvarez CP, Roberts DB, Lai SY, et al. Gastrostomy tube placement in patients with oropharyngeal carcinoma treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1634–40. doi:10.1002/hed.23200.
120. Bhayani MK, Hutcheson KA, Barringer DA, Roberts DB, Lewin JS, Lai SY. Gastrostomy tube placement in patients with hypopharyngeal cancer treated with radiotherapy or chemoradiotherapy: factors affecting placement and dependence. 2013;35(11):1641–46. doi:10.1002/hed.23199.
121. Magnuson JS, Durst J, Rosenthal EL, Carroll WR, Ritchie CS, Kilgore ML, Locher JL. Increased likelihood of long-term gastrostomy tube dependence in head and neck cancer survivors without partners. Head Neck. 2013;35(3):420–5. doi:10.1002/hed.22996.
122. Kiss NK, Krishnasamy M, Loeliger J, Granados A, Dutu G, Corry J. A dietitian-led clinic for patients receiving (chemo)radiotherapy for head and neck cancer. Support Care Cancer. 2012;20(9):2111–20. doi:10.1007/s00520-011-1321-7.
123. Bjordal K, Hammerlid E, Ahlner-Elmqvist M, De Graeff A, Boysen M, Evensen JF, Biörklund A, et al. Quality of life in head and neck cancer patients: validation of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-H&N35. J Clin Oncol. 1999;17(3):1008.