Radiotherapy alone or with concomitant daily low-dose carboplatin in locally advanced, unresectable head and neck cancer: Definitive results of a phase III study with a follow-up period of up to ten years

Tumori

Volumn 96, Issue 2, 2010, Pages 246-253

  Grazia Ruo Redda, Maria ^a   Ragona, Riccardo ^a   Ricardi, Umberto ^a   Beltramo, Giancarlo ^b   Rampino, Monica ^a   Gabriele, Pietro ^c   Allis, Simona ^a   La Porta, Maria Rosa ^d   Moro, Gregorio ^e   Melano, Antonella ^f   Gabriele, Anna Maria ^g   Tessa, Mariella ^h   Fossati, Piero ⁱ   Orecchia, Roberto ⁱ  

^a UNIVERSITY OF TURIN   (Italy)

^b Centro Diagnostico Italiano   (Italy)

^c Ospedale Oncologico A Businco   (Italy)

^d ASL TO 4   (Italy)

^e ASL BI   (Italy)

^f S CROCE E CARLE HOSPITAL   (Italy)

^g MOLINETTE HOSPITAL   (Italy)

^h ASL   (Italy)

ⁱ UNIVERSITY OF MILAN   (Italy)

Author keywords

Chemotherapy; Multicentric trial; Squamous cell carcinoma; Survival

Indexed keywords

CARBOPLATIN;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER CONTROL; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; COBALT THERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG WITHDRAWAL; ELECTRON THERAPY; FEMALE; FIBROSIS; FOLLOW UP; HEAD AND NECK CARCINOMA; HUMAN; JAW OSTEONECROSIS; LEUKOPENIA; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MUCOSA INFLAMMATION; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NECK FIBROSIS; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PARESTHESIA; PHASE 3 CLINICAL TRIAL; PHOTON THERAPY; PROSPECTIVE STUDY; RADIATION SICKNESS; RANDOMIZED CONTROLLED TRIAL; SALVAGE THERAPY; SQUAMOUS CELL CARCINOMA; SURVIVAL RATE; THROMBOCYTOPENIA; VOMITING;

EID: 77952937400     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089161009600210     Document Type: Article

References (41)

1. Ferlay J, Bray F, Pisani P, Parkin DM: GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide, Version 1.0. IARC Cancer Base No. 5. Lyon, France, IARC Press, 2001.
2. Forastiere A, Koch W, Trotti A, Sidransky D: Head and neck cancer. N Engl J Med, 345: 1890-1900, 2001.
3. Calais G, Alfonsi M, Bardet E, Sire C, Germain T, Bergerot P, Rhein B, Tortochaux J, Oudinot P, Bertrand P: Randomized trial of radiation therapy versus concomitant chemotherapy and radiation therapy for advanced-stage oropharynx carcinoma. J Natl Cancer Inst, 91: 2081-2086, 1999. (Pubitemid 30019568)
4. Brizel DM, Albers ME, Fisher SR, Scher RL, Richtsmeier WJ, Hars V, George SL, Huang AT, Prosnitz LR: Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med, 338: 1798 - 1804, 1998.
5. Pignon JP, Bourhis J, Domenge C, Designé L: Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma: Threemeta-analyses of updated individual data - MACH-NC Collaborative Group, Meta-analysis of Chemotherapy on Head and Neck Cancer. Lancet, 355: 949-955, 2000.
6. Pignon JP, Baujat B, Bourhis J: Individual patient data meta-analyses in head and neck carcinoma:What have we learned? Cancer Radiother, 9: 31-36, 2005.
7. Pignon JP, le Maître A, Bourhis J: MACH-NC Collaborative Group. Meta-Analyses of chemotherapy in head and neck cancer (MACH-NC): an update. Int J Radiat Oncol Biol Phys, 69 (2 Suppl): S112-114, 2007.
8. Bourhis J, LeMaître A, Baujat B, Audry H, Pignon JP:Meta-Analysis of Chemotherapy in Head, Neck Cancer Collaborative Group;Meta-Analysis of Radiotherapy in Carcinoma of Head, Neck Collaborative Group; Meta-Analysis of Chemotherapy in Nasopharynx Carcinoma Collaborative Group. Individual patients' data meta-analyses in head and neck cancer. Curr Opin Oncol, 19: 188-194, 2007.
9. Forastiere AA, Goepfert H, Maor M, Pajak TF, Weber R, Morrison W, Glisson B, Trotti A, Ridge JA, Chao C, Peters G, Lee DJ, Leaf A, Ensley J, Cooper J: Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med, 349: 2091-2098, 2003. (Pubitemid 37464533)
10. Garden AS, Asper JA, Morrison WH, Schechter NR, Glisson BS, Kies MS, Myers JN, Ang KK: Is concurrent chemoradiation the treatment of choice for all patients with stage III or IV head and neck carcinoma? Cancer, 100: 1171-1178, 2004.
11. Budach W, Hehr T, Budach V, Belka C, Dietz K: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer, 6: 28-39, 2006.
12. Schwachöfer JH, Crooijmans RP, Hoogenhout J, Kal HB, Theeuwes GM: Effectiveness in inhibition of recovery of cell survival by cisplatin and carboplatin: influence of treatment sequence. Int J Radiat Oncol Biol Phys, 20: 1235-1241, 1991.
13. Stefani S, Eells RW, Abbate J: Hydroxyurea and radiotherapy in head and neck cancer. Radiology, 101: 391-396, 1971.
14. Lo TC, Wiley AL Jr, Ansfield FJ, Brandenburg JH, Davis HL Jr, Gollin FF, Johnson RO, Ramirez G, Vermund H: Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of the oral cavity and oropharynx: a randomized study. Am J Roentgenol, 126: 229-235, 1976.
15. Shanta V, Krishnamurthi S: Combined bleomycin and radiotherapy in oral cancer. Clin Radiol, 31: 617-620, 1980. (Pubitemid 10009378)
16. Fu KK, Phillips TL, Silverberg IJ, Jacobs C, Goffinet DR, Chun C, Friedman MA, Kohler M, McWhirter K, Carter SK: Combined radiotherapy and chemotherapy with bleomycin andmethotrexate for advanced inoperable head and neck cancer: update of a Northern California Oncology Group randomized trial. J Clin Oncol, 5: 1410-1418, 1987. (Pubitemid 18049877)
17. Weissberg JB, Son YH, Papac RJ, Sasaki C, Fischer DB, Lawrence R, Rockwell S, Sartorelli AC, Fischer JJ: Randomized clinical trial of mytomicin C as an adjunct to radiotherapy in head and neck cancer. Int J Radiat Oncol Biol Phys, 17: 3-9, 1989. (Pubitemid 19173231)
18. Vokes EE, Weichselbaum RR: Concomitant chemoradiotherapy: rationale and clinical experience in patients with solid tumors. J Clin Oncol, 8: 911-934, 1990.
19. Douple EB, Richmond RC, O'Hara JA, Coughlin CT: Carboplatin as a potentiator of radiation therapy. Cancer Treat Rev, 12 (suppl A): 111-124, 1985.
20. Al-Sarra fM, Pajak TF, Marcial VA, Mowry P, Cooper JS, Stetz J, Ensley JF, Velez-Garcia E: Concurrent radiotherapy and chemotherapy with cisplatin in inoperable squamous cell carcinoma of the head and neck. An RTOG study. Cancer, 59: 259-265, 1987.
21. Muggia FM: Overview of carboplatin: replacing, complementing, and extending the therapeutic horizons of cisplatin. Semin Oncol, 16 (suppl 5): 7-13, 1989.
22. Eisenberger M, Hornedo J, Silva H, Donehower R, Spaulding M, Van Echo D. Carboplatin (NSC-241-240): An active platinum analog for the treatment of squamous-cell carcinoma of the head and neck. J Clin Oncol, 10: 1506-1509, 1986. (Pubitemid 17183575)
23. Jacobs MC, Eisenberger M, Oh MC, Sinibaldi V, Gray WW, Elias G, Salazar OM: Carboplatin (CBDCA) and radiotherapy for stage IV carcinoma of the head and neck: a phase III study. Int J Radiat Oncol Biol Phys, 17: 361-363, 1989. (Pubitemid 19203084)
24. Zamboglou N, Pape H, Schnabel T, Wurm R, Bannach B, Fürst G, Schmitt G: Kombinierte Radiotherapie mit Cisoder Carboplatin bei fortgesschritten Kopf-Hals-Tumoren. Strahlenther Onkol, 165: 647-651, 1989.
25. Volling P, Staar S, Achterrath W, Muller RP: Carboplatin plus radiation therapy in head and neck cancer. Semin Oncol, 18 (suppl 2): 17-22, 1991.
26. Vermorken JB, Remenar E, van Erpen C, Germa Lluch J, Stewart S, Gorlia T, Degardin M, Schollen K, Bernier J: Standard cisplatin/infusional 5-fluorouracil (PF) vs docetaxel (T) plus PF (TPF) as neoadjuvant chemotherapy for nonresectable locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN): A phase III trial of the EORTC Head and Neck Cancer Group (EORTC #24971). J Clin Oncol, 22 (suppl): 490s (abstr 5508), 2004.
27. Orecchia R, Ragona R, Airoldi M, Gabriele P, Gribaudo S, Grazia Ruo Redda M, Bussi M, Cavalot A, Rampino M, Sannazzari GL: Concomitant radiotherapy and daily low-dose carboplatin in locally advanced, unresectable head and neck cancer. Acta Oncol (Stockolm), 33: 541-545, 1994.
28. th edn Springer-Verlag, Heidelberg, 1987.
29. Dose specification for reporting external beam therapy with photons and electrons. ICRU Report 29. Washington (DC): International Commission on Radiation Units and Measurements, 1978.
30. Fein DA, Lee WR, Amos WR, Hinerman RW, Parsons JT, Mendenhall WM, Stringer SP, Cassisi NJ, Million RR: Oropharyngeal carcinoma treated with radiotherapy: a 30-year experience. Int J Radiat Oncol Biol Phys, 34: 289-296, 1996. (Pubitemid 26031572)
31. Fu KK, Cooper JS, Marcial VA, Laramore GE, Pajak TF, Jacobs J, Al-Sarraf M, Forastiere AA, Cox JD: Evolution of the Radiation Therapy Oncology Group trials for head and neck cancer. Int J Radiat Oncol Biol Phys, 35: 425-438, 1996. (Pubitemid 26242889)
32. Eisenberger M, Van Echo D, Aisner J: Carboplatin: the experience in head and neck cancer. Semin Oncol, 16 (suppl): 34-41, 1989. (Pubitemid 19138344)
33. Bartelink H, Kallman RF, Rapacchietta D, Hart GA: Therapeutic enhancement in mice by clinically relevant dose and fractionation schedules of cis-diamminedichloroplatinum (II) and irradiation. Radiother Oncol, 6: 61-74, 1986. (Pubitemid 16038441)
34. Orecchia R, Urgesi A, Sacco M, Gabriele P, Vasario E, Ricardi U, Gribaudo S, Sola B, Sannazzari GL: Daily low-dose carboplatin and standard radiotherapy in unresectable head and neck and lung cancer: a pilot study. Tumori, 77: 423-425, 1991.
35. Marcial VA, Pajak TF, Mohiuddin M, Cooper JS, al Sarraf M, Mowry PA, Curran W, Crissman J, Rodríguez M, Vélez-García E: Concomitant cisplatin chemotherapy and radiotherapy in advanced mucosal squamous cell carcinoma of the head and neck. Long-term results of the RTOG Study 81-17. Cancer, 66: 1861-1868, 1990.
36. Kanazawa H, Rapacchietta D, Kallman RF: Schedule-dependent therapeutic gain from the combination of fractionated irradiation and cis- diamminedichloroplatinum (II) in C3H/KMmousemodel system. Cancer Res, 48: 3158-3164, 1988.
37. Staar S, Volling P, Achterrath W, Muller RP: Carboplatin and simultaneous accelerated radiation in advanced squamous cell carcinoma of the head and neck. Proc Am Soc Clin Oncol, 11: 246, 1992.
38. Zamboglou N, Schnabel T, Kolotas C, Achterrath W, Strehl H, Dalhäuser S, Vogt HG, Lenaz L, Schmitt G: Carboplatin and radiotherapy in the treatment of head and neck cancer: six years' experience. Semin Oncol, 21 (suppl 12): 45-53, 1994. (Pubitemid 24378886)
39. Jeremic B, Shibamoto Y, Stanisavljevic B, Milojevic L, Milicic B, Nikolic N: Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: a prospective randomized trial. Radiother Oncol, 43: 29-37, 1997. (Pubitemid 27191976)
40. Chitapanarux I, Lorvidhaya V, Kamnerdsupaphon P, Sumitsawan Y, Tharavichitkul E, Sukthomya V, Ford J: Chemoradiation comparing cisplatin versus carboplatin in locally advanced nasopharyngeal cancer: randomised, non-inferiority, open trial. Eur J Cancer, 43: 1399-1406, 2007. (Pubitemid 46874069)
41. Racadot S, Mercier M, Dussart S, Dessard-Diana B, Bensadoun RJ, Martin M, Malaurie E, Favrel V, Housset M, Durdux C, Journel C, Calais G, Huet J, Pillet G, Hennequin C, Haddad E, Diana C, Blaska-Jaulerry B, Henry-Amar M, Géhanno P, Baillet F,Mazeron JJ: Randomized clinical trial of post-operative radiotherapy versus concomitant carboplatin and radiotherapy for head and neck cancers with lymph node involvement. Radiother Oncol, 87: 164-172, 2008.