Swallowing dysfunction in cancer patients

Supportive Care in Cancer

Volumn 20, Issue 3, 2012, Pages 433-443

  Raber Durlacher, Judith E ^a,o   Brennan, Mike T ^b   Verdonck De Leeuw, Irma M ^c   Gibson, Rachel J ^d   Eilers, June G ^e   Waltimo, Tuomas ^f   Bots, Casper P ^g   Michelet, Marisol ^h   Sollecito, Thomas P ⁱ   Rouleau, Tanya S ^b   Sewnaik, Aniel ^j   Bensadoun, Rene Jean ^k   Fliedner, Monica C ^l   Silverman Jr , Sol ^m   Spijkervet, Fred K L ⁿ  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CAROLINAS MEDICAL CENTER   (United States)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f UNIVERSITY OF BASEL   (Switzerland)

^g UNIVERSITY OF AMSTERDAM   (Netherlands)

^h Fundacion para Combatir La Leucemia   (Argentina)

ⁱ UNIVERSITY OF PENNSYLVANIA SCHOOL OF DENTAL MEDICINE   (United States)

^j ERASMUS MEDICAL CENTER   (Netherlands)

^k POITIERS UNIVERSITY HOSPITAL   (France)

^l UNIVERSITY OF BERN   (Switzerland)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^o VU UNIVERSITY AMSTERDAM   (Netherlands)

more..

Author keywords

Aspiration; Cancer; Chemoradiation; Deglutition disorders; Dysphagia; Head and neck neoplasms; Swallowing dysfunction

Indexed keywords

AMIFOSTINE; CARBOPLATIN; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; PACLITAXEL; PANITUMUMAB; RADIOACTIVE IODINE;

CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CLINICAL ASSESSMENT TOOL; DISEASE ASSOCIATION; DYSPHAGIA; FUNCTIONAL ASSESSMENT; GRAFT VERSUS HOST REACTION; HEAD AND NECK CANCER; HEAD AND NECK SURGERY; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MUCOSA INFLAMMATION; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; PULMONARY ASPIRATION; QUALITY OF LIFE; RADIATION INJURY; REVIEW; SYSTEMATIC REVIEW; THYROID CANCER; XEROSTOMIA;

ANTINEOPLASTIC AGENTS; CAUSALITY; CHEMORADIOTHERAPY; COMORBIDITY; DEGLUTITION DISORDERS; HEAD AND NECK NEOPLASMS; HUMANS; NEOPLASMS; POSTOPERATIVE COMPLICATIONS; PREVALENCE; QUALITY OF LIFE; RECEPTOR, EPIDERMAL GROWTH FACTOR; XEROSTOMIA;

EID: 84857659438     PISSN: 09414355     EISSN: 14337339     Source Type: Journal    
DOI: 10.1007/s00520-011-1342-2     Document Type: Review

References (107)

1. JA Logemann 1997 Role of the modified barium swallow in management of patients with dysphagia Otolaryngol Head Neck Surg 116 335 338 9121786 1:STN:280:DyaK2s3ksVClug%3D%3D (Pubitemid 27163688)
2. AS Garden JS Lewin MS Chambers 2006 How to reduce radiation-related toxicity in patients with cancer of the head and neck Curr Oncol Rep 8 140 145 16507224
3. JA Logemann 2007 Swallowing disorders Best Pract Res Clin Gastroenterolog 21 563 573 (Pubitemid 47074365)
4. S Cheng CR Bradford DL Ronis 2006 Variables associated with feeding tube placement in patients with head and neck cancer Arch Otolaryngol Head Neck Surg 132 655 661 16785412 (Pubitemid 43927044)
5. EC Ward AL Conroy 1999 Validity, reliability and responsiveness of the Royal Brisbane Hospital Outcome Measure for Swallowing Asia Pac J Speech Lang Hear 4 109 129
6. JA Logemann AW Rademaker BR Pauloski, et al. 1998 Normal swallowing physiology as viewed by videofluoroscopy and videoendoscopy Folia Phoniatr Logop 50 311 319 9925954 1:STN:280:DyaK1M7is1artA%3D%3D (Pubitemid 128707093)
7. MP Karnell E McCracken 1994 A data base information storage and reporting system for videofluorographic oropharyngeal motility (OPM) swallowing evaluations Am J Speech Language Pathol 3 54 60
8. KH O'Neil M Purdy J Falk, et al. 1999 The dysphagia outcome and severity scale Dysphagia 14 139 145 10341109 (Pubitemid 29263844)
9. JC Rosenbek JA Robbins EB Roecker JL Coyle JL Wood 1996 A penetration-aspiration scale Dysphagia 11 93 98 8721066 1:STN:280: DyaK28zjvFShsw%3D%3D (Pubitemid 26107509)
10. PH Kahrilas S Lin AW Rademaker JA Logemann 1997 Impaired deglutive airway protection Gastroenterology 113 1457 1464 9352847 1:STN:280: DyaK1c%2Fht1yqtA%3D%3D
11. JA Langendijk P Doornaert DHF Rietveld IM Verdonck-de Leeuw CR Leemans BJ Slotman 2009 A predictive model for swallowing dysfunction after curative radiotherapy in head and neck cancer Radiother Oncol 90 189 195 19167120
12. CA McHorney J Robbins K Lomax, et al. 2002 The SWAL-QOL and SWAL-CARE outcomes tool for oropharyngeal dysphagia in adults: III. Documentation of reability and validity Dysphagia 17 97 114 11956835 (Pubitemid 36919838)
13. RN Rinkel IM Verdonck-de Leeuw JA Langendijk, et al. 2009 The psychometric and clinical validity of the SWAL-QOL questionnaire in evaluating swallow problems experienced by patients with oral and oropharyngeal cancer Oral Oncol 45 e67 e71 19442567
14. M List L D'Antonio D Cella, et al. 1996 The Performance Status Scale for head and neck cancer patients and the Functional Assessment of Cancer Therapy-Head and Neck Scale: a study of utility and validity Cancer 77 2294 2301 8635098 1:STN:280:DyaK283isVyqtA%3D%3D (Pubitemid 26162422)
15. DF Cella I Wiklund SA Shumaker NK Aaronson 1993 Integrating health-related quality of life into cross-national clinical trials Qual Life Res 2 433 440 8161977 1:STN:280:DyaK2c3hsVeqsg%3D%3D (Pubitemid 24035215)
16. EA Weymuller R Alsarraf B Yueh FW Deleyiannis MD Coltrera 2001 Analysis of the performance characteristics of the University of Washington Quality of Life instrument and its modification (UW-QOL-R) Arch Otolaryngol Head Neck Surg 127 489 493 11346422 (Pubitemid 32434043)
17. GF Funk LH Karnell AJ Christenen PJ Moan J Ricks 2003 Comprehensive head and neck oncology health status assessment Head Neck 25 561 567 12808660
18. JE Terrell KA Nanavati RM Esclamado JK Bishop CR Bradford GT Wolf 1997 Head and neck cancer-specific quality of life: instrument validation Arch Otolaryngol Head Neck Surg 123 1125 1132 9339991 1:STN:280:DyaK2svnvF2isg%3D%3D
19. PJ Stiff EH Bensinger C Emmanoullides, et al. 2006 Reliability and validity of a patient self-administered daily questionnaire to assess impact of oral mucositis (OM) on pain and daily functioning in patients undergoing autologous hematopoietic stem cell transplantation (HSCT) Bone Marrow Transplant 37 393 401 16415901 1:STN:280:DC%2BD28%2FnvVeisQ%3D%3D (Pubitemid 43250474)
20. JB Epstein JL Beaumont CK Gwede, et al. 2007 Longitudinal evaluation of the oral mucositis weekly questionnaire-head neck cancer, a patient-reported outcomes questionnaire Cancer 109 1914 1922 17377917 (Pubitemid 46668558)
21. BA Murphy MS Dietrich N Wells, et al. 2010 Reliability and validity of the Vanderbilt Head and Neck Symptom Survey: a tool to assess symptom burden in patients treated with chemoradiation Head Neck 32 26 37 19626644
22. RC Dwivedi SST Rose JWG Roe, et al. 2010 Validation of the Sydney Swallow Questionnaire (SSQ) in a cohort of head and neck cancer patients Oral Oncol 46 e10 e14 20219415
23. PM Enderby A John 1999 Therapy outcome measures in speech and language therapy: comparing performance between different providers Int J Lang Commun Disord 34 417 429 10884909 1:STN:280:DC%2BD3czktlehsQ%3D%3D (Pubitemid 29488006)
24. MA List C Ritter-Sterr SB Lansky 1990 A performance status scale for head and neck cancer patients Cancer 66 564 569 2364368 1:STN:280: DyaK3czgsVOmsA%3D%3D (Pubitemid 20233457)
25. BR Pauloski AW Rademaker JA Logemann, et al. 2002 Swallow function and perception of dysphagia in patients with head and neck cancer Head Neck 24 555 565 12112553 (Pubitemid 34568557)
26. K Jensen JA Bonde C Grau 2006 The relationship between observer-based toxicity scoring and patient assessed symptom severity after treatment for head and neck cancer. A correlative cross sectional study of the DAHANCA toxicity scoring system and the EORTC quality of life questionnaires Radiother Oncol 78 298 305 16524633
27. JS Lewin 2007 Dysphagia after chemoradiation: prevention and treatment Int J Radiat Onc Biol Phys 69 S86 S87
28. R Speyer L Baijens M Heijnen I Zwijnenberg 2010 Effects of therapy in oropharyngeal dysphagia by speech and language therapists: a systematic review Dysphagia 25 40 65 19760458
29. WHO (2001) The international classification of functioning disability and health (ICF). WHO, Geneva
30. JJ Frowen AR Perry 2006 Swallowing outcomes after radiotherapy for head and neck cancer: a systematic review Head Neck 28 932 944 16906517 (Pubitemid 44497870)
31. JA Logemann AW Rademaker BR Paulowski, et al. 2006 Site of disease and treatment protocol as correlates of swallow function in patients with head and neck cancer treated with chemoradiation Head Neck 28 64 73 16302193 (Pubitemid 43099637)
32. BR Pauloski AW Rademaker JA Logemann, et al. 2000 Pretreatment swallowing function in patients with head and neck cancer Head Neck 22 474 482 10897107 1:STN:280:DC%2BD3cvpsFyjsA%3D%3D (Pubitemid 30483056)
33. KM Stenson E MacCracken M List, et al. 2000 Swallowing function in patients with head and neck cancer prior to treatment Arch Otolaryngol Head Neck Surg 126 371 377 10722011 1:STN:280:DC%2BD3c7osFSrtA%3D%3D (Pubitemid 30140393)
34. NP Nguyen CC Moltz C Frank, et al. 2004 Dysphagia following chemoradiation for locally advanced head and neck cancer Ann Oncol 15 383 388 14998839 1:STN:280:DC%2BD2c7gvVeltg%3D%3D (Pubitemid 38444540)
35. NP Nguyen P Vos CC Moltz, et al. 2008 Analysis of the factors influencing dysphagia severity upon diagnosis of head and neck cancer Br J Radiol 81 706 710 18508871 1:STN:280:DC%2BD1crnvVCquw%3D%3D
36. B Martin-Harris MB Brodsky Y Michel, et al. 2005 Breathing and swallowing dynamics across the adult life span Arch Otolaryngol Head Neck Surg 131 762 770 16172351 (Pubitemid 41366087)
37. P Dirix S Abbeel B Vansraelen R Hermans S Nuyts 2009 Dysphagia after chemoradiotherapy for head-and-neck squamous cell carcinoma: dose-effect relationships for the swallowing structures Int J Radiat Oncol Biol Phys 75 385 392 19553033 1:CAS:528:DC%2BD1MXhtV2ktrjF
38. MB Kronenberger AD Meijers 1994 Dysphagia following head and neck surgery Dysphagia 9 236 244 7805423 1:STN:280:DyaK2M7gtl2nsw%3D%3D (Pubitemid 24305709)
39. BA Murphy J Gilbert 2009 Dysphagia in head and neck cancer patients treated with radiation: assessment, sequelae and rehabilitation Semin Radiat Oncol 19 35 42 19028344
40. BR Pauloski AW Rademaker JA Logemann LA Colangelo 1998 Speech and swallowing in irradiated and non-irradiated post surgical oral cancer patients Otolaryngol Head Neck Surg 118 616 624 9591859 1:STN:280:DyaK1c3lt1GmtA%3D%3D (Pubitemid 28222203)
41. DM Denk W Schima K Eibenberger 1997 Prognostic factors for swallowing rehabilitation following head and neck cancer surgery Acta Otolaryngol 117 769 774 9349879 1:STN:280:DyaK1c%2FhtVOhsw%3D%3D (Pubitemid 27418212)
42. F McConnel AW Rademaker BR Pauloski, et al. 1994 Surgical variables affecting postoperative swallow efficiency in oral cancer patients: a pilot study Laryngoscope 104 87 90 8295463 1:STN:280:DyaK2c7isFyntw%3D%3D (Pubitemid 24028041)
43. DV Martini FE Lucente DH Slavit 1997 Swallow and pharyngeal function in post-operative cancer patients Ear Nose Throat J 76 450 456 9248138 1:STN:280:DyaK2szptFegsw%3D%3D (Pubitemid 27327143)
44. BB Mittal BR Pauloski DJ Haraf, et al. 2003 Swallowing dysfunction-preventative and rehabilitation strategies in patients with head-and-neck cancers treated with surgery, radiotherapy, and chemotherapy: a critical review Int J Radiation Oncol Biol Phys 57 1219 1230 (Pubitemid 37443958)
45. PA Borggreven I Verdonck-de Leeuw RN Rinkel, et al. 2007 Swallowing after major surgery of the oral cavity or oropharynx: a prospective and longitudinal assessment of patients treated by microvascular soft tissue reconstruction Head Neck 29 638 647 17274054 (Pubitemid 47168234)
46. MC Jacobson E Franssen DM Fliss, et al. 1995 Free forearm flap in oral reconstruction Arch Otolaryngol Head Neck Surg 121 959 964 7646863 1:STN:280:DyaK2MznsVOgsA%3D%3D
47. M Hirano Y Kuroiwa S Tanaka, et al. 1992 Dysphagia following various degrees of surgical resection for oral cancer Ann Otol Rhinol Laryngol 101 138 141 1739258 1:STN:280:DyaK387lt1yitw%3D%3D
48. Manikantan K, Khode S, Sayed SI et al (2009) Dysphagia in head and neck cancer. Cancer Treat Rev. doi: 10:10,1016/j.ctrv.2009.08.008
49. R de Bree CR Leemans 2010 Recent advances in surgery for head and neck cancer Curr Opin Oncol 22 186 193 20173640
50. S Nuyts P Dirix PM Clement, et al. 2008 Impact of adding concomitant chemotherapy to hyperfractionated radiotherapy for advanced head and neck cancer squamous cell carcinoma Int J Radiat Oncol Biol Phys 73 1088 1095 18707823
51. JP Pignon A Le Maitre J Bourhis 2007 Meta-analyses of chemotherapy in head and neck cancer (MACH-NC): an update Int J Radiol Oncol Biol Phys 69 2 Suppl S112 S114
52. D Rosenthal J Lewin A Eisbruch 2006 Prevention and treatment of dysphagia and aspiration after chemoradiation for head and neck cancer J Clin Oncol 24 2636 2643 16763277 (Pubitemid 46622085)
53. N Platteaux P Dirix E Dejaeger S Nuyts 2010 Dysphagia in head and neck cancer patients treated with chemoradiotherapy Dysphagia 25 139 152 19711127
54. JK Salama KM Stenson MA List 2008 Characteristics associated with swallowing changes after concurrent chemotherapy and radiotherapy in patients with head and neck cancer Arch Otolaryngol Head Neck Surg 134 1060 1065 18936351
55. WT Lee LM Akst DJ Adelstein, et al. 2006 Risk factors for hypopharyngeal/upper esophageal stricture formation after concurrent chemoradiation Head Neck 28 808 812 16732601 (Pubitemid 44320534)
56. A Eisbruch M Schwartz C Rasch, et al. 2004 Dysphagia and aspiration after chemoradiotherapy for head and neck cancer: which anatomic structures are effected and can they be spared by IMRT? Int J Radiol Oncol Biol Phys 60 1425 1439 (Pubitemid 39601860)
57. M Feng A Eisbruch 2007 Future issues in highly conformal radiotherapy for the head and neck cancer J Clin Oncol 8 1009 1013 (Pubitemid 350002868)
58. TF Fua J Corry AD Milner, et al. 2007 Intensity-modulated radiotherapy for nasopharyngeal carcinoma: clinical correlation of dose to the pharyngo-esophageal axis and dysphagia Int J Radiat Oncol Bio Phys 67 976 981
59. A Eisbruch PC Levendag FY Feng D Teguh, et al. 2007 Can IMRT or brachytherapy reduce dysphagia associated with chemoradiotherapy of head and neck cancer? The Michigan and Rotterdam experiences Int J Radiat Oncol Biol Phys 69 2 Suppl S40 S42 17848291
60. J Werbrouck K De Ruyck F Duprez, et al. 2009 Acute normal tissue reactions in head-and-neck cancer patients treated with IMRT: influence of dose and association with genetic polymorphisms in DNA DSB repair genes Int J Radiat Oncol Biol Phys 73 1187 1195 19251090 1:CAS:528:DC%2BD1MXisVOgsbg%3D
61. JJ Caudell PE Schaner DA Desmond, et al. 2010 Dosimetric factors associated with long-term dysphagia after definitive radiotherapy for squamous cell carcinoma of the head and neck Int J Radiat Oncol Biol Phys 76 403 409 19467801
62. JC Roe PN Carding R Dwivedi, et al. 2010 Swallowing outcomes following intensity modulated radiation therapy Oral Oncol 46 727 733 20850370
63. FY Feng HM Kim T Lyden, et al. 2010 Intensity-modulated chemoradiotherapy aiming to reduce dysphagia in patients with oropharyngeal cancer: clinical and functional results J Clin Oncol 28 2732 2738 20421546
64. DL Schwartz K Hutcheson D Barringer SL Tucker M Kies FC Holsinger KK Ang WH Morrison DI Rosenthal AS Garden L Dong JS Lewin 2010 Candidate dosimetric predictors of long-term swallowing dysfunction after oropharyngeal intensity-modulated radiotherapy Int J Radiat Oncol Biol Phys 78 1356 1365 20646872
65. JA Bonner PM Harari J Giralt, et al. 2010 Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival Lancet Oncol 11 21 28 19897418 1:CAS:528:DC%2BC3cXjslKktA%3D%3D
66. D Curran J Giralt PM Harari, et al. 2007 Quality of life in head and neck cancer patients after treatment with high dose radiotherapy alone or in combination with cetuximab J Clin Oncol 25 2191 2197 17538164 1:CAS:528:DC%2BD2sXnsVSht7c%3D (Pubitemid 46954642)
67. DI Pryor SV Porceddu BH Burmeister, et al. 2008 Enhanced toxicity with concurrent cetuximab and radiotherapy in head and neck cancer Radiother Oncol 90 172 176 18976827
68. LJ Wirth AM Allen MR Posner, et al. 2010 Phase I dose-finding study of paclitaxel with panituzemab, carboplatin and intensity-modulated radiotherapy in patients with locally advanced squamous cell cancer of the head and neck Ann Oncol 21 342 347 19892746 1:STN:280:DC%2BC3c%2FlslOhsg%3D%3D
69. AM Pedersen A Bardow S Beier Jensen B Nauntofte 2002 Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion Oral Dis 8 117 129 12108756 1:STN:280:DC%2BD38zmtlCrsg%3D%3D (Pubitemid 34535060)
70. JF Prinz PW Lucas 1995 Swallow thresholds in human mastication Arch Oral Biol 40 401 403 7639643 1:STN:280:DyaK2Mzms1yqsw%3D%3D
71. S Hamlet J Faull B Klein, et al. 1997 Mastication and swallowing in patients with postirradiation xerostomia Int J Radiat Oncol Biol Phys 37 789 796 9128953 1:STN:280:DyaK2s3nsFSmuw%3D%3D (Pubitemid 27181310)
72. NL Rhodus K Moller S Colby J Bereuter 1995 Dysphagia in patients with three different etiologies of salivary dysfunction Ear Nose Throat J 74 45 48
73. DN Teguh PC Levendag I Noever P van Rooij P Voet H van der Est D Sipkema A Sewnaik RJ Baatenburg de Jong D de la Bije PI Schmitz 2008 Treatment techniques and site considerations regarding dysphagia-related quality of life in cancer of the oropharynx and nasopharynx Int J Radiat Oncol Biol Phys 15 1119 1127
74. JA Logemann BR Pauloski AW Rademaker CL Lazarus B Mittal J Gaziano L Stachowiak EM MacCracken LA Newman 2003 Xerostomia: 12-month changes in saliva production and its relationship to perception and performance of swallow function, oral intake, and diet after chemoradiation Head Neck 25 432 437 12784234 (Pubitemid 36577026)
75. AD Sasse EC Sasse ACC Alark 2005 Amifostine reduces side effects and improves complete response rate during radiotherapy: results of a meta-analysis Int J Radiat Oncol Biol Phy 64 784 794
76. J Brizel M Glatzel R Muecke O Micke F Bruns 2007 Influence of amifostine on late radiation-toxicity in head and neck cancer-a follow-up study Anticancer Res 27 1953 1956 (Pubitemid 46954706)
77. D De Ruysscher C Dehing RH Bremer, et al. 2007 Maximal neutropenia during chemotherapy and radiotherapy is significantly associated with the development of acute radiation-induced dysphagia in lung cancer patients Ann Oncol 18 909 916 17322546 (Pubitemid 47054090)
78. C Dehing-Oberije D De Ruysscher S Petit, et al. 2010 Development, external validation and clinical usefulness of a practical prediction model for radiation-induced dysphagia in lung cancer patients Radiother Oncol 79 455 461
79. S Sonis N Treister S Chawla, et al. 2010 Preliminary characterization of oral lesions associated with inhibitors of mammalian target of rapamycin in cancer patients Cancer 116 210 215 19862817 1:CAS:528:DC%2BC3cXitFGiurw%3D
80. DR Camidge 2001 The causes of dysphagia in carcinoma of the lung JR Soc Med 94 567 672 1:STN:280:DC%2BD3MnktVyktA%3D%3D
81. J Nazareno D Taves HG Preiksaitis 2006 Metastatic breast cancer to the gastrointestinal tract: a case series and review of the literature World J Gastroenterol 12 6219 6224 17036400 (Pubitemid 44688177)
82. N Varsamidakis M Kanakis T Thomas 2009 Dysphagia as the presenting symptom of thyroid cancer Exp Clin Endocrinol Diabet 117 511 513 1:CAS:528:DC%2BD1MXhsFWisLjN
83. Almeida JP, Sanabria AE, Lima EN, Kowalski LP (2011) Late side effects of radioactive iodine on salivary gland function in patients with thyroid cancer. Head Neck (in press)
84. G Akpek W Chinratanalab LA Lee M Torbenson JP Hallick V Anders GB Vogelsang 2003 Gastrointestinal Involvement in chronic graft-versus-host disease: a clinicopathologic study Biol Blood Marrow Transpl 9 46 51 (Pubitemid 41123053)
85. W Schima P Pokieser C Fordtinger, et al. 1994 Videofluoroscopy of the pharynx and esophagus in chronic graft-versus-host disease Abdom Imaging 19 191 194 8019340 1:STN:280:DyaK2c3ptVagtw%3D%3D (Pubitemid 24126412)
86. FY Feng HM Kim TH Lyden, et al. 2007 Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: early dose-effect relationships for the swallowing structures Int J Radiat Oncol Biol Phys 68 1289 1298 17560051 (Pubitemid 47176817)
87. NP Nguyen CC Moltz C Frank, et al. 2007 Effectiveness of the cough reflex in patients with aspiration following radiation for head and neck cancer Lung 185 243 248 17661135 (Pubitemid 47397483)
88. A Eisbruch T Lyden CR Bradford, et al. 2002 Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head and neck cancer Int J Radiat Oncol Biol Phys 53 23 38 12007937
89. NP Nguyen C Frank CC Moltz U Karlsson PD Nguyen HW Ward P Vos HJ Smith S Huang LM Nguyen C Lemanski A Ludin S Sallah 2009 Analysis of factors influencing dysphagia severity following treatment of head and neck cancer Anticancer Res 29 3299 3304 19661348
90. TM Mekhail DJ Adelstein LA Rybicki, et al. 2001 Enteral nutrition during the treatment of head and neck carcinoma: is a percutaneous endoscopic gastronomy tube preferable to a nasogastric tube? Cancer 91 1785 1790 11335904 1:STN:280:DC%2BD3M3jvFOqtw%3D%3D (Pubitemid 32377965)
91. BA Murphy 2007 Clinical and economic consequences of mucositis induced by chemotherapy and/or radiotherapy J Support Oncol 5 Suppl 4 13 21 18046994 (Pubitemid 350041363)
92. MB Gillespie MB Brodsky TA Day FS Lee B Martin-Harris 2004 Swallowing-related quality of life after head and neck cancer treatment Laryngoscope 114 1362 1367 15280708 (Pubitemid 39045503)
93. JA Langendijk P Doornaert I Verdonck-de Leeuw CR Leemans NK Aronson BJ Slotman 2008 Impact of late treatment-related toxicity on quality of life among patients with head and neck cancer treated with radiotherapy J Clin Oncol 26 3770 3776 18669465
94. MR Vergeer PAH Doornaert DHF Rietveld CR Leemans BJ Slotman JA Langendijk 2009 Intensity-modulated radiotherapy reduces radiation-induced morbidity and improves health related quality of life: results of a nonrandomized prospective study using a standardized follow-up program Int J Radiat Oncol Biol Phys 74 1 8 19111400
95. PA Borggreven NK Aaronson IM Verdonck-de Leeuw, et al. 2007 Quality of life after surgical treatment for oral and oropharyngeal cancer: a prospective longitudinal assessment of patients reconstructed by a microvascular flap Oral Oncol 43 1034 1042 17307019 (Pubitemid 47532780)
96. IM Verdonck-de Leeuw SE Eerenstein MH Van der Linden DJ Kuik R de Bree CR Leemans 2007 Distress in spouses and patients after treatment for head and neck cancer Laryngoscope 117 238 241 17277616 (Pubitemid 46207879)
97. IM Verdonck-de Leeuw WJ van Bleek CR Leemans R de Bree 2010 Employment and return to work in head and neck cancer survivors Oral Oncol 46 56 60 20004135
98. KA Hutcheson DA Barringer DI Rosenthal AH May DB Roberts JS Lewin 2008 Swallowing outcomes after radiotherapy for laryngeal carcinoma Arch Otolaryngol Head Neck Surg 134 178 183 18283161 (Pubitemid 351287499)
99. M Pijls-Johannesma R Houben L Boersma J Grutters K Seghers R Wanders D De Ruysscher 2009 High-dose radiotherapy or concurrent chemotherapy in lung cancer patients only induces a temporary, reversible decline in QoL Radiother Oncol 91 443 448 19297049
100. I Gluck FY Feng T Lyden, et al. 2010 Evaluating and reporting dysphagia in trials of chemoirradiation for head-and-neck cancer Int J Radiat Oncol Biol Phys 77 727 733 19783380
101. Pauloski BR, Rademaker AW, Logemann JA et al (2010) Relation of mucous membrane alterations to oral intake during the first year after treatment for head and neck cancer. Head Neck. doi: 10.1002/hed.21542
102. LA Murray MS Kramer DP Hesson, et al. 2010 Serum amyloid P ameliorates radiation-induced oral mucositis and fibrosis Fibrogenesis Tissue Repair 3 11 20602770 At: http://www.fibrogenesis.com/content/3/1/11
103. BA Murphy 2009 Advances in quality of life and symptom management for head and neck cancer patients Curr Opin Oncol 21 242 247 19322081
104. ST Sonis 2010 New thoughts on the initiation of mucositis Oral Dis 16 597 600 20846150 1:STN:280:DC%2BC3cfivF2luw%3D%3D
105. G Aprile M Ranoni D Keefe ST Sonis 2009 Links between regimen-related toxicities in patients being treated for colorectal cancer Curr Opin Support Palliat Care 3 50 54 19365161
106. A Rosen TH Rhee R Kaufman 2001 Prediction of aspiration in patients with newly diagnosed untreated advanced head and neck cancer Arch Otolaryngol Head Neck Surg 127 975 979 11493209 1:STN:280:DC%2BD3MvovFWmuw%3D%3D (Pubitemid 32717738)
107. NP Nguyen C Frank CC Moltz, et al. 2006 Aspiration rate following chemoradiation for head and neck cancer: an underreported occurrence Radiother Oncol 80 302 306 16890314 (Pubitemid 44397205)