Activating autoantibodies to the β1/2-adrenergic and M2 muscarinic receptors associate with atrial tachyarrhythmias in patients with hyperthyroidism

Endocrine

Volumn 49, Issue 2, 2015, Pages 457-463

  Galloway, Allison ^a   Li, Hongliang ^a   Vanderlinde Wood, Megan ^a   Khan, Muneer ^a   Benbrook, Alexandria ^a   Liles, Campbell ^a   Zillner, Caitlin ^a   Rao, Veitla ^a   Cunningham, Madeleine W ^b   Yu, Xichun ^a   Kem, David C ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Activating autoantibodies; Atrial tachyarrhythmias; Hyperthyroidism; M2 muscarinic receptor; Adrenergic receptors

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; MUSCARINIC M2 RECEPTOR; PROPRANOLOL;

ADULT; AGE; ANTIBODY BLOOD LEVEL; ARTICLE; ATRIAL FIBRILLATION; BETA ADRENERGIC STIMULATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GRAVES DISEASE; HORMONE RELEASE; HUMAN; HYPERTHYROIDISM; IMMUNOASSAY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PREVALENCE; PRIORITY JOURNAL; SINUS RHYTHM; SUBACUTE THYROIDITIS; TOXIC GOITER; AGED; BLOOD; COMPLICATION; IMMUNOLOGY; TACHYCARDIA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ATRIAL FIBRILLATION; AUTOANTIBODIES; FEMALE; GRAVES DISEASE; HUMANS; MALE; MIDDLE AGED; RECEPTOR, MUSCARINIC M2; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; TACHYCARDIA;

EID: 84929956100     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-014-0495-4     Document Type: Article

References (21)

1. A.P. Weetman, Graves’ disease. N. Engl. J. Med. 343, 1236–1248 (2000)
2. C. Selmer, J.B. Olesen, M.L. Hansen, J. Lindhardsen, A.M. Olsen, J.C. Madsen, J. Faber, P.R. Hansen, O.D. Pedersen, C. Torp-Pedersen, G.H. Gislason, The spectrum of thyroid disease and risk of new onset atrial fibrillation: a large population cohort study. BMJ 345, e7895 (2012)
3. I. Klein, K. Ojamaa, Thyroid hormone and the cardiovascular system. N. Engl. J. Med. 344, 501–509 (2001)
4. I. Klein, S. Danzi, Thyroid disease and the heart. Circulation 116, 1725–1735 (2007)
5. C.T. Sawin, A. Geller, P.A. Wolf, A.J. Belanger, E. Baker, P. Bacharach, P.W. Wilson, E.J. Benjamin, R.B. D’Agostino, Low serum thyrotropin concentrations as a risk factor for atrial fibrillation in older persons. N. Engl. J. Med. 331, 1249–1252 (1994)
6. Y.C. Chen, S.A. Chen, Y.J. Chen, M.S. Chang, P. Chan, C.I. Lin, Effects of thyroid hormone on the arrhythmogenic activity of pulmonary vein cardiomyocytes. J. Am. Coll. Cardiol. 39, 366–372 (2002)
7. S. Stavrakis, X. Yu, E. Patterson, S. Huang, S.R. Hamlett, L. Chalmers, R. Pappy, M.W. Cunningham, S.A. Morshed, T.F. Davies, R. Lazzara, D.C. Kem, Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves’ hyperthyroidism. J. Am. Coll. Cardiol. 54, 1309–1316 (2009)
8. J. Perez-Schindler, A. Philp, J. Hernandez-Cascales, Pathophysiological relevance of the cardiac beta2-adrenergic receptor and its potential as a therapeutic target to improve cardiac function. Eur. J. Pharmacol. 698, 39–47 (2013)
9. P.A. Chiale, H.A. Garro, J. Schmidberg, R.A. Sanchez, R.S. Acunzo, M. Lago, G. Levy, M. Levin, Inappropriate sinus tachycardia may be related to an immunologic disorder involving cardiac beta andrenergic receptors. Heart Rhythm 3, 1182–1186 (2006)
10. E.N. Pearce, A.P. Farwell, L.E. Braverman, Thyroiditis. N. Engl. J. Med. 348, 2646–2655 (2003)
11. H. Li, D.C. Kem, S. Reim, M. Khan, M. Vanderlinde-Wood, C. Zillner, D. Collier, C. Liles, M.A. Hill, M.W. Cunningham, C.E. Aston, X. Yu, Agonistic autoantibodies as vasodilators in orthostatic hypotension: a new mechanism. Hypertension 59, 402–408 (2012)
12. H. Li, X. Yu, C. Liles, M. Khan, M. Vanderlinde-Wood, A. Galloway, C. Zillner, A. Benbrook, S. Reim, D. Collier, M.A. Hill, S.R. Raj, L.E. Okamoto, M.W. Cunningham, C.E. Aston, D.C. Kem, Autoimmune basis for postural tachycardia syndrome. J. Am. Heart Assoc. 3, e000755 (2014)
13. P.S. Chen, A.Y. Tan, Autonomic nerve activity and atrial fibrillation. Heart Rhythm 4, S61–S64 (2007)
14. B. Olshansky, Interrelationships between the autonomic nervous system and atrial fibrillation. Prog. Cardiovasc. Dis. 48, 57–78 (2005)
15. S.S. Po, B.J. Scherlag, W.S. Yamanashi, J. Edwards, J. Zhou, R. Wu, N. Geng, R. Lazzara, W.M. Jackman, Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions. Heart Rhythm 3, 201–208 (2006)
16. E. Patterson, S.S. Po, B.J. Scherlag, R. Lazzara, Triggered firing in pulmonary veins initiated by in vitro autonomic nerve stimulation. Heart Rhythm 2, 624–631 (2005)
17. H. Li, B.J. Scherlag, D.C. Kem, C. Zillner, S. Male, S. Thirunavukkarasu, X. Shen, J.V. Pitha, M.W. Cunningham, R. Lazzara, X. Yu, Atrial tachycardia provoked in the presence of activating autoantibodies to beta2-adrenergic receptor in the rabbit. Heart Rhythm 10, 436–441 (2013)
18. H. Li, B.J. Scherlag, D.C. Kem, A. Benbrook, X. Shen, M.W. Cunningham, R. Lazzara, C.E. Aston, X. Yu, Inducible cardiac arrhythmias caused by enhanced beta1-adrenergic autoantibody expression in the rabbit. Am. J. Physiol. Heart Circ. Physiol. 306, H422–H428 (2014)
19. H. Li, B.J. Scherlag, D.C. Kem, C. Zillner, S. Male, S. Thirunavukkarasu, X. Shen, A. Benbrook, J.V. Pitha, R. Lazzara, X. Yu, The propensity for inducing atrial fibrillation: a comparative study on old versus young rabbits. J. Aging Res. 2014, 684918 (2014)
20. H. Li, B.J. Scherlag, D.C. Kem, A. Benbrook, L. Zhang, B. Huang, M.W. Cunningham, R. Lazzara, X. Yu, Atrial tachyarrhythmias induced by the combined effects of beta1/2-adrenergic autoantibodies and thyroid hormone in the rabbit. J. Cardiovasc. Trans. Res. 7, 581–589 (2014)
21. M.D. Rodefeld, S.L. Beau, R.B. Schuessler, J.P. Boineau, J.E. Saffitz, Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density. J. Cardiovasc. Electrophysiol. 7, 1039–1049 (1996)