Inducible cardiac arrhythmias caused by enhanced β1-adrenergic autoantibody expression in the rabbit

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 306, Issue 3, 2014, Pages

  Li, Hongliang ^a   Scherlag, Benjamin J ^a   Kem, David C ^a   Benbrook, Alexandria ^a   Shen, Xiaohua ^a   Cunningham, Madeleine W ^b   Lazzara, Ralph ^a   Aston, Christopher E ^b   Yu, Xichun ^a  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Activating autoantibodies; Tachyarrhythmias

Indexed keywords

AUTOANTIBODY; BETA 1 ADRENERGIC RECEPTOR AUTOANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIGEN BINDING; ARRHYTHMOGENESIS; ARTICLE; CHO CELL; CONCENTRATION (PARAMETERS); CROSS REACTION; FEMALE; HEART ARRHYTHMIA; HEART ATRIOVENTRICULAR NODE; HEART ATRIUM FIBRILLATION; HEART RATE; HEART RIGHT ATRIUM; HEART VENTRICLE TACHYCARDIA; IMMUNIZATION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SINUS RHYTHM; SINUS TACHYCARDIA; SUPERIOR CAVA VEIN; SUPRAVENTRICULAR TACHYCARDIA; TACHYCARDIA;

ACTIVATING AUTOANTIBODIES; TACHYARRHYTHMIAS;

ACETYLCHOLINE; ANIMALS; ARRHYTHMIAS, CARDIAC; AUTOANTIBODIES; HEART RATE; RABBITS; RECEPTORS, ADRENERGIC, BETA-1;

EID: 84893391444     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00551.2013     Document Type: Article

References (20)

1. Baba A, Yoshikawa T, Fukuda Y, Sugiyama T, Shimada M, Akaishi M, Tsuchimoto K, Ogawa S, Fu M. Autoantibodies against M2-muscarinic acetylcholine receptors: new upstream targets in atrial fibrillation in patients with dilated cardiomyopathy. Eur Heart J 25: 1108-1115, 2004.
2. Brodde OE, Leifert FJ, Krehl HJ. Coexistence of beta 1-and beta 2-adrenoceptors in the rabbit heart: quantitative analysis of the regional distribution by (-)-3H-dihydroalprenolol binding. J Cardiovasc Pharmacol 4: 34-43, 1982.
3. Buvall L, Bollano E, Chen J, Shultze W, Fu M. Phenotype of early cardiomyopathic changes induced by active immunization of rats with a synthetic peptide corresponding to the second extracellular loop of the human beta-adrenergic receptor. Clin Exp Immunol 143: 209-215, 2006.
4. Buxton IL, Brunton LL. Beta-adrenergic receptor subtypes and subcellular compartmentation of cyclic AMP and cyclic AMP-dependent protein kinase in rabbit cardiomyocytes. Biochem Int 11: 137-144, 1985.
5. Chiale PA, Ferrari I, Mahler E, Vallazza MA, Elizari MV, Rosenbaum MB, Levin MJ. Differential profile and biochemical effects of antiautonomic membrane receptor antibodies in ventricular arrhythmias and sinus node dysfunction. Circulation 103: 1765-1771, 2001.
6. Chiale PA, Garro HA, Schmidberg J, Sanchez RA, Acunzo RS, Lago M, Levy G, Levin M. Inappropriate sinus tachycardia may be related to an immunologic disorder involving cardiac beta andrenergic receptors. Heart Rhythm 3: 1182-1186, 2006.
7. Chiale PA, Rosenbaum MB, Elizari MV, Hjalmarson A, Magnusson Y, Wallukat G, Hoebeke J. High prevalence of antibodies against beta 1-and beta 2-adrenoceptors in patients with primary electrical cardiac abnormalities. J Am Coll Cardiol 26: 864-869, 1995.
8. 1-adrenoceptor autoantibodies in the pathogenesis of dilated cardiomyopathy. Immunobiology 217: 511-520, 2012.
9. 1-adrenergic receptors induces early afterdepolarization and decreases in K-channel density in rabbits. J Am Coll Cardiol 43: 1090-1100, 2004.
10. Iwata M, Yoshikawa T, Baba A, Anzai T, Mitamura H, Ogawa S. Autoantibodies against the second extracellular loop of beta1-adrenergic receptors predict ventricular tachycardia and sudden death in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 37: 418-424, 2001.
11. 1-adrenergic receptors induces beta-adrenergic receptor desensitization and myocardial hypertrophy in vivo. Circ Res 88: 578-586, 2001.
12. Jahns R, Boivin V, Hein L, Triebel S, Angermann CE, Ertl G, Lohse MJ. Direct evidence for a beta 1-adrenergic receptor-directed autoimmune attack as a cause of idiopathic dilated cardiomyopathy. J Clin Invest 113: 1419-1429, 2004.
13. 1-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. Trends Cardiovasc Med 16: 20-24, 2006.
14. Lazzerini PE, Capecchi PL, Guideri F, Acampa M, Selvi E, Bisogno S, Galeazzi M, Laghi-Pasini F. Autoantibody-mediated cardiac arrhythmias: mechanisms and clinical implications. Basic Res Cardiol 103: 1-11, 2008.
15. Lee HC, Huang KT, Wang XL, Shen WK. Autoantibodies and cardiac arrhythmias. Heart Rhythm 8: 1788-1795, 2011.
16. Li H, Scherlag BJ, Kem DC, Zillner C, Male S, Thirunavukkarasu S, Shen X, Pitha JV, Cunningham MW, Lazzara R, Yu X. Atrial tachycardia provoked in the presence of activating autoantibodies to beta2-adrenergic receptor in the rabbit. Heart Rhythm 10: 436-441, 2013.
17. Matsui S, Larsson L, Hayase M, Katsuda S, Teraoka K, Kurihara T, Murano H, Nishikawa K, Fu M. Specific removal of beta1-adrenoceptor autoantibodies by immunoabsorption in rabbits with autoimmune cardiomyopathy improved cardiac structure and function. J Mol Cell Cardiol 41: 78-85, 2006.
18. Rodefeld MD, Beau SL, Schuessler RB, Boineau JP, Saffitz JE. Beta-adrenergic and muscarinic cholinergic receptor densities in the human sinoatrial node: identification of a high beta 2-adrenergic receptor density. J Cardiovasc Electrophysiol 7: 1039-1049, 1996.
19. Stavrakis S, Yu X, Patterson E, Huang S, Hamlett SR, Chalmers L, Pappy R, Cunningham MW, Morshed SA, Davies TF, Lazzara R, Kem DC. Activating autoantibodies to the beta-1 adrenergic and m2 muscarinic receptors facilitate atrial fibrillation in patients with Graves= hyperthyroidism. J Am Coll Cardiol 54: 1309-1316, 2009.
20. Tenner TE Jr, Young JA, Earley KJ, Yen YC. Functional characterization of beta-adrenoceptor subtypes in rabbit right atria. Life Sci 44: 651-660, 1989.