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Determination of lipophilicity and its use as a predictor of blood–brain barrier penetration of molecular imaging agents
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A rapid vesicle electrokinetic chromatography method for the in vitro prediction of non-specific binding for potential PET ligands
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A biomathematical modeling approach to central nervous system radioligand discovery and development
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Zhang L, Villalobos A, Beck EM, Bocan T, Chappie TA, Chen L, Grimwood S, Heck SD, Helal CJ, Hou X, Humphrey JM, Lu J, Skaddan MB, McCarthy TJ, Verhoest PR, Wager TT, Zasadny K: Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.J Med Chem 2013, 56:4568–4579.
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PID: 19299522, COI: 1:CAS:528:DC%2BD1MXmslamu70%3D
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