The discovery of potent and selective non-steroidal glucocorticoid receptor modulators, suitable for inhalation

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 11, 2014, Pages 2571-2577

  Edman, Karl ^a   Ahlgren, Ragnhild ^a   Bengtsson, Malena ^a   Bladh, Håkan ^a   Bäckström, Stefan ^a   Dahmén, Jan ^a   Henriksson, Krister ^a   Hillertz, Per ^a   Hulikal, Vijakumar ^a   Jerre, Anders ^a   Kinchin, Liz ^a   Kåse, Charlotte ^a   Lepistö, Matti ^a   Mile, Irene ^a   Nilsson, Stinabritt ^a   Smailagic, Amir ^a   Taylor, John ^a   Tjörnebo, Ann ^a   Wissler, Lisa ^a   Hansson, Thomas ^a  

^a ASTRAZENECA R AND D   (Sweden)

Author keywords

Glucocorticoid receptor; Indazoles; Inhalation; Non steroidal selective glucocorticoid receptor modulators

Indexed keywords

ANDROGEN RECEPTOR; ANTIINFLAMMATORY AGENT; BUDESONIDE; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUTICASONE PROPIONATE; GLUCOCORTICOID RECEPTOR; HORMONE RECEPTOR AFFECTING AGENT; INDAZOLE DERIVATIVE; PROGESTERONE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; LIGAND; NONSTEROID ANTIINFLAMMATORY AGENT; SULFONAMIDE;

ANDROGEN RELEASE; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG CLEARANCE; DRUG RECEPTOR BINDING; DRUG SOLUBILITY; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER MICROSOME; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMA CONCENTRATION-TIME CURVE; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, GLUCOCORTICOID; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 84899983917     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2014.03.070     Document Type: Article

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