PF-4708671 activates AMPK independently of p70S6K1 inhibition

PLoS ONE

Volumn 9, Issue 9, 2014, Pages

  Vainer, Gilad W ^a   Saada, Ann ^b   Kania Almog, Juliane ^a   Amartely, Adir ^b   Bar Tana, Jacob ^c   Hertz, Rachel ^c  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c HEBREW UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; P70 RIBOSOMAL PROTEIN S6 KINASE 1; PF 4708671; S6 KINASE; UNCLASSIFIED DRUG; IMIDAZOLE DERIVATIVE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PF-4708671; PIPERAZINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ARTICLE; AUTOPHAGY; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DETERMINATION; EMBRYO; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; FIBROBLAST; IMMORTALIZED CELL LINE; METABOLIC REGULATION; MOUSE; NONHUMAN; PROTEIN SYNTHESIS; RESPIRATORY CHAIN; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; FIBROBLASTS; IMIDAZOLES; MICE; MULTIPROTEIN COMPLEXES; PHOSPHORYLATION; PIPERAZINES; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84929941964     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0107364     Document Type: Article

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