Microneedle-iontophoresis combinations for enhanced transdermal drug delivery

Methods in Molecular Biology

Volumn 1141, Issue , 2014, Pages 121-132

  Donnelly, Ryan F ^a   Garland, Martin J ^a   Alkilani, Ahlam Zaid ^a  

^a NONE

Author keywords

Iontophoresis; Microneedles; Transdermal drug delivery

Indexed keywords

IBUPROFEN;

ANIMAL EXPERIMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; IONTOPHORESIS; MICRONEEDLE; MOLECULAR WEIGHT; NONHUMAN; RAT; TRANSDERMAL DRUG DELIVERY SYSTEM;

EID: 84929940884     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-0363-4_7     Document Type: Chapter

References (22)

1. Prausnitz MR (2004) Microneedles for transdermal drug delivery. Adv Drug Deliv Rev 56(5):581–587.
2. Banga A (2007) Transdermal delivery of proteins. Pharm Res 24:1357–1359.
3. Migalska K, Morrow DI, Garland MJ, Thakur R, Woolfson AD, Donnelly RF (2011) Laserengineered dissolving microneedle arrays for transdermal macromolecular drug delivery. Pharm Res 28(8):1919–1930.
4. Kaushik S, Allen H, Donald D et al (2001) Lack of pain associated with microfabricated microneedles. Anesth Analg 92:5024.
5. Bal SM, Caussin J, Pavel S, Bouwstra JA (2008) In vivo assessment of safety of microneedle arrays in human skin. Eur J Pharm Sci 35(3): 193–202.
6. Van Damme P, Oosterhuis-Kafeja F, Van der Wielen M et al (2009) Safety and effi cacy of a novel microneedle device for dose sparing intradermal infl uenza vaccination in healthy adults. Vaccine 27(3):454–459.
7. Wilke N, Mulcahy A, Ye S, Morrissey A (2005) Process optimization and characterization of silicon microneedles fabricated by wet etch technology. Microelectron J 36:650–656.
8. McAllister DV, Wang PM, Davis SP et al (2003) Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc Natl Acad Sci U S A 100(24):13755–13760.
9. Cormier M, Johnson B, Ameri M et al (2004) Transdermal delivery of desmopressin using a coated microneedle array patch system. J Control Release 97(3):503–511.
10. Sullivan SP, Murthy N, Prausnitz MR (2008) Minimally invasive protein delivery with rapidly dissolving polymer microneedles. Adv Mater 20(5):933–938.
11. Chu LY, Choi SO, Prausnitz MR (2010) Fabrication of dissolving polymer microneedles for controlled drug encapsulation and delivery: bubble and pedestal microneedle designs. J Pharm Sci 99(10):4228–4238.
12. Donnelly RF, Majithiya R, Singh TR et al (2011) Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm Res 28(1):41–57.
13. Lanke SS, Kolli CS, Strom JG, Banga AK (2009) Enhanced transdermal delivery of low molecular weight heparin by barrier perturbation. Int J Pharm 365(1–2):26–33.
14. Wang Y, Thakur R, Fan Q, Michniak B (2005) Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur J Pharm Biopharm 60(2):179–191.
15. Katikaneni S, Badkar A, Nema S, Banga AK (2009) Molecular charge mediated transport of a 13 kD protein across microporated skin. Int J Pharm 378(1–2):93–100.
16. Wu XM, Todo H, Sugibayashi K (2007) Enhancement of skin permeation of high molecular compounds by a combination of microneedle pretreatment and iontophoresis. J Control Release 118(2):189–195.
17. Chen H, Zhu H, Zheng J et al (2009) Iontophoresis-driven penetration of nanovesicles through microneedle-induced skin microchannels for enhancing transdermal delivery of insulin. J Control Release 139(1):63–72.
18. Vemulapalli V, Yang Y, Friden PM, Banga AK (2008) Synergistic effect of iontophoresis and soluble microneedles for transdermal delivery of methotrexate. J Pharm Pharmacol 60(1): 27–33.
19. Kalluri H, Banga AK (2011) Formation and closure of microchannels in skin following microporation. Pharm Res 28(1):82–94.
20. Williams AC (2003) Transdermal and topical drug delivery. Pharmaceutical Press, London.
21. Garland MJ, Singh TR, Woolfson AD, Donnelly RF (2011) Electrically enhanced solute permeation across poly(ethylene glycol)-crosslinked poly(methyl vinyl ether-co-maleic acid) hydrogels: effect of hydrogel crosslink density and ionic conductivity. Int J Pharm 406(1–2): 91–98.
22. Mukerjee EV, Collins SD, Isseroff RR, Smith RL (2004) Microneedle array for transdermal biological fl uid extraction and in situ analysis. Sens Actuat A Phys 114:267–275.