Subunit disassembly and inhibition of TNFα by a semi-synthetic bicyclic peptide

Protein Engineering, Design and Selection

Volumn 28, Issue 2, 2015, Pages 45-52

  Luzi, Stefan ^a   Kondo, Yasushi ^a   Bernard, Elise ^a   Stadler, Lukas K J ^a   Vaysburd, Marina ^a   Winter, Greg ^a   Holliger, Philipp ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

Bicyclic peptide; Phage display; Protein engineering; TNF

Indexed keywords

CELL DEATH; CRYSTAL STRUCTURE; DIMERS; EPITOPES; LIGANDS; PHAGE DISPLAY;

CRYPTIC EPITOPE; DRUG TARGETS; HIGH AFFINITY; INFLAMMATORY DISORDERS; MACROCYCLICS; PROTEIN ENGINEERING; SMALL MOLECULES; TRIMER DISSOCIATION;

PEPTIDES;

EPITOPE; MACROCYCLIC PEPTIDE; SYNTHETIC PEPTIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYCLOPEPTIDE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING SITE; CELL MATURATION; HUMAN; INVERSE POLYMERASE CHAIN REACTION; L929 CELL LINE; MASS SPECTROMETRY; NONHUMAN; PEPTIDE LIBRARY; PHOTON CORRELATION SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN STRUCTURE; PROTEIN SUBUNIT; SIZE EXCLUSION CHROMATOGRAPHY; ULTRACENTRIFUGATION; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; METABOLISM; PROTEIN SECONDARY STRUCTURE;

CELL LINE; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HUMANS; PEPTIDES, CYCLIC; PROTEIN STRUCTURE, SECONDARY; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84929922193     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzu055     Document Type: Article

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