New binding mode to TNF-alpha revealed by ubiquitin-based artificial binding protein

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Hoffmann, Andreas ^a   Kovermann, Michael ^a   Lilie, Hauke ^a   Fiedler, Markus ^b   Balbach, Jochen ^a   Rudolph, Rainer ^a   Pfeifer, Sven ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b Scil Proteins GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; EPITOPE; POLYSORBATE 20; TUMOR NECROSIS FACTOR ALPHA; UBIQUITIN; AMINO ACID; MUTANT PROTEIN; RECOMBINANT PROTEIN;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; COVALENT BOND; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; HUMAN; ISOTHERMAL TITRATION CALORIMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; RIBOSOME; STOICHIOMETRY; ANIMAL; CALORIMETRY; CELL LINE; CHEMISTRY; CIRCULAR DICHROISM; GEL CHROMATOGRAPHY; METABOLISM; PEPTIDE LIBRARY;

AMINO ACIDS; ANIMALS; CALORIMETRY; CELL LINE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; ENZYME-LINKED IMMUNOSORBENT ASSAY; MAGNETIC RESONANCE SPECTROSCOPY; MUTANT PROTEINS; PEPTIDE LIBRARY; PROTEIN BINDING; RECOMBINANT PROTEINS; TUMOR NECROSIS FACTOR-ALPHA; UBIQUITIN;

EID: 84857424921     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031298     Document Type: Article

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