Dracorhodin perchlorate induces G1/G0 phase arrest and mitochondria-mediated apoptosis in SK-MES-1 human lung squamous carcinoma cells

Oncology Letters

Volumn 10, Issue 1, 2015, Pages 240-246

  Zhang, Guang Xin ^a   Sun, Mei ^a   Zhang, Yifan ^a   Hua, Peiyan ^a   Li, Xin ^a   Cui, Ranji ^a   Zhang, Xingyi ^a  

^a THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

Apoptosis; Dracorhodin perchlorate; SK MES 1 cells

Indexed keywords

ANTINEOPLASTIC AGENT; APOPTOSIS INDUCING FACTOR; CASPASE 3; DRACORHODIN PERCHLORATE; MATRIX METALLOPROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IC50; IMMUNOCYTOCHEMISTRY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MTT ASSAY; SQUAMOUS CELL LUNG CARCINOMA; UPREGULATION; WESTERN BLOTTING;

EID: 84929920843     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2015.3212     Document Type: Article

References (40)

1. Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Johnson DH: Evolution of cisplatin-based chemotherapy in non-small cell lung cancer: A historical perspective and the eastern cooperative oncology group experience. Chest 117 (4): 133S-137S, 2000.
3. Cragg GM and Newman DJ: Plants as a source of anti-cancer agents. J Ethnopharmacol 100: 72-79, 2005.
4. Amin AR, Kucuk O, Khuri FR and Shin DM: Perspectives for cancer prevention with natural compounds. J Clin Oncol 27: 2712-2725, 2009.
5. Russo M, Palumbo R, Mupo A, et al: Flavonoid quercetin sensitizes a CD95-resistant cell line to apoptosis by activating protein kinase Calpha. Oncogene 22: 3330-3342, 2003.
6. Xia MY, Wang MW, Cui Z, et al: Dracorhodin perchlorate induces apoptosis in HL-60 cells. J Asian Nat Prod Res 8: 335-343, 2006.
7. Ferreira CG, Epping M, Kruyt FA and Giaccone G: Apoptosis: Target of cancer therapy. Clin Cancer Res 8: 2024-2034, 2002
8. Brockmann H and Junge H: Die konstitution des dracorhodins, eines neuen farbstoffes aus dem ?drachenblut?. Eur J Inorg Chem 76: 751-763, 1943 (In German).
9. Rao GS, Gerhart MA, Lee RT III, et al: Antimicrobial agents from higher plants. Dragon's blood resin. J Nat. Prod 45: 646-648, 1982.
10. Gao WF, Zheng H, Wang YS, et al: Synthesis of dracorhodin. Chin J Pharma 20: 247-250, 1989 (In Chinese).
11. Rasul A, Ding C, Li X, et al: Dracorhodin perchlorate inhibits PI3K/Akt and NF-?B activation, up-regulates the expression of p53, and enhances apoptosis. Apoptosis 17: 1104-1119, 2012.
12. Xia M, Wang M, Tashiro S, Onodera S, Minami M and Ikejima T: Dracorhodin perchlorate induces A375-S2 cell apoptosis via accumulation of p53 and activation of caspases. Biol Pharm Bull 28: 226-232, 2005.
13. Yu JH, Zheng GB, Liu CY, Zhang LY, Gao HM, Zhang YH, Dai CY, Huang L, Meng XY, Zhang WY and Yu XF: Dracorhodin perchlorate induced human breast cancer MCF-7 apoptosis through mitochondrial pathways. Int J Med Sci 10: 1149-1156, 2013.
14. Xia M, Wang D, Wang M, Tashiro S, Onodera S, Minami M and Ikejima T: Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species. J Pharmacol Sci 95: 273-283, 2004.
15. Fridman JS and Lowe SW: Control of apoptosis by p53. Oncogene 22: 9030-9040 , 2003.
16. Adams JM and Cory S: Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci 26: 61-66, 2001.
17. Saelens X, Festjens N, Vande Walle L, van Gurp M, van Loo G and Vandenabeele P: Toxic proteins released from mitochondria in cell death. Oncogene 23: 2861-2874, 2004.
18. Porter AG and Jänicke RU: Emerging roles of caspase-3 in apoptosis. Cell Death Differ 6: 99-104, 1999.
19. Araki M, Iida Y, Taketani S, Watanabe K, Ohta T and Saito T: Characterization of photoreceptor cell differentiation in the rat retinal cell culture. Dev Biol 124: 239-247, 1987.
20. King KL and Cidlowski JA: Cell cycle regulation and apoptosis. Annu Rev Physiol 60: 601-617, 1998.
21. Pan J, She M, Xu ZX, et al: Farnesyltransferase inhibitors induce DNA damage via reactive oxygen species in human cancer cells. Cancer Res 65: 3671-3681, 2005.
22. He Y, Ju W, Hao H, Liu Q, Lv L and Zeng F: Dracorhodin perchlorate suppresses proliferation and induces apoptosis in human prostate cancer cell line PC-3. J Huazhong Univ Sci Technolog Med Sci 31: 215-219, 2011.
23. Budram-Mahadeo V, Morris PJ and Latchman DS: The Brn-3a transcription factor inhibits the pro-apoptotic effect of p53 and enhances cell cycle arrest by differentially regulating the activity of the p53 target genes encoding Bax and p21(CIP1/Waf1). Oncogene 21: 6123-6131, 2002.
24. Vogelstein B, Lane D and Levine AJ: Surfing the p53 network. Nature 408: 307-310, 2000.
25. Das SK, Hashimoto T, Shimizu K, et al: Fucoxanthin induces cell cycle arrest at G0/G1 phase in human colon carcinoma cells through up-regulation of p21WAF1/Cip1. Biochim Biophys Acta 1726: 328-335, 2005.
26. Huang DC and Strasser A: BH3-Only proteins-essential initiators of apoptotic cell death. Cell 103: 839-842, 2000.
27. Frenzel A, Grespi F, Chmelewskij W and Villunger A: Bcl2 family proteins in carcinogenesis and the treatment of cancer. Apoptosis 14: 584-596, 2009.
28. Danial NN: BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin Cancer Res 13: 7254-7263, 2007.
29. Schuler M, Bossy-Wetzel E, Goldstein JC, et al: P53 induces apoptosis by caspase activation through mitochondrial cytochrome c release. J Biol Chem 275: 7337-7342, 2000.
30. Toshiyuki M and Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
31. Greiner M, Cárdenas S, Parra C, et al: Adrenalectomy regulates apoptotic-associated genes in rat hippocampus. Endocrine 15: 323-333, 2001.
32. Slee EA, Adrain C and Martin SJ: Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J Biol Chem 276: 7320-7326, 2001.
33. Norberg E, Orrenius S and Zhivotovsky B: Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF). Biochem Biophys Res Commun 396: 95-100, 2010.
34. Candé C, Cohen I, Daugas E, et al: Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria. Biochimie 84: 215-22, 2002.
35. Kroemer G: The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat Med 3: 614-620, 1997.
36. Johnson TM, Yu ZX, Ferrans VJ, et al: Reactive oxygen species are downstream mediators of p53-dependent apoptosis. Proc Natl Acad Sci USA 93: 11848-11852, 1996.
37. Cai J and Jones DP: Mitochondrial redox signaling during apoptosis. J Bioenerg Biomembr 31: 327-334, 1999.
38. Simon HU, Haj-Yehia A and Levi-Schaffer F: Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5: 415-418, 2000.
39. Akgul C, Moulding DA and Edwards SW. Molecular control of neutrophil apoptosis. FEBS Lett 487: 318-322, 2001.
40. Cimino F, Esposito F, Ammendola R and Russo T: Gene regulation by reactive oxygen species. Curr Top Cell Regul 35: 123-148, 1997.