메뉴 건너뛰기




Volumn 15, Issue 6, 2015, Pages 883-893

Brodalumab-An IL-17RA monoclonal antibody for psoriasis and psoriatic arthritis

Author keywords

Autoimmune disease; Brodalumab; IL 17 therapy; Psoriasis; Psoriatic arthritis; Rheumatoid arthritis

Indexed keywords

BRODALUMAB; ETANERCEPT; INFLIXIMAB; INTERLEUKIN 17; PLACEBO; USTEKINUMAB; IL17RA PROTEIN, HUMAN; INTERLEUKIN 17 RECEPTOR; MONOCLONAL ANTIBODY;

EID: 84929899736     PISSN: 14712598     EISSN: 17447682     Source Type: Journal    
DOI: 10.1517/14712598.2015.1045410     Document Type: Article
Times cited : (24)

References (45)
  • 1
    • 14244267601 scopus 로고    scopus 로고
    • Psoriatic arthritis and psoriasis: Classification, clinical features, pathophysiology, immunology, genetics
    • Langley RGB, Krueger GG, Griffiths CEM. Psoriatic arthritis and psoriasis: classification, clinical features, pathophysiology, immunology, genetics. Ann Rheum Dis 2005;64:18-23
    • (2005) Ann Rheum Dis , vol.64 , pp. 18-23
    • Rgb, L.1    Krueger, G.G.2    Cem, G.3
  • 2
    • 25844490095 scopus 로고    scopus 로고
    • Epidemiology of psoriatic arthritis in the population of the United States
    • Gelfand JM, Gladman DD, Mease PJ, et al. Epidemiology of psoriatic arthritis in the population of the United States. J Am Acad Dermatol 2005;53(4):573
    • (2005) J Am Acad Dermatol , vol.53 , Issue.4 , pp. 573
    • Gelfand, J.M.1    Gladman, D.D.2    Mease, P.J.3
  • 3
    • 36549001139 scopus 로고    scopus 로고
    • The prevalence and geographic distribution of Crohns disease and ulcerative colitis in the United States
    • Kappelman MD, Rifas-shiman SL, Kleinman K, et al. The prevalence and geographic distribution of Crohns disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol 2007;5(12):1424-9
    • (2007) Clin Gastroenterol Hepatol , vol.5 , Issue.12 , pp. 1424-1429
    • Kappelman, M.D.1    Rifas-Shiman, S.L.2    Kleinman, K.3
  • 4
    • 84866752292 scopus 로고    scopus 로고
    • Trends in asthma prevalence health care use and mortality in the United States 2001 -2010
    • Akinbami LJ, Moorman JE, Bailey C, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001-2010. NCHS Data Brief 2012(94):1-8
    • (2012) NCHS Data Brief , vol.94 , pp. 1-8
    • Akinbami, L.J.1    Moorman, J.E.2    Bailey, C.3
  • 5
    • 79951743212 scopus 로고    scopus 로고
    • Functional specialization of interleukin-17 family members
    • Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity 2011;34(2):149-62
    • (2011) Immunity , vol.34 , Issue.2 , pp. 149-162
    • Iwakura, Y.1    Ishigame, H.2    Saijo, S.3    Nakae, S.4
  • 6
    • 79954414473 scopus 로고    scopus 로고
    • Signaling of interleukin-17 family cytokines in immunity and inflammation
    • Chang SH, Dong C. Signaling of interleukin-17 family cytokines in immunity and inflammation. Cell Signal 2011;23(7):1069-75
    • (2011) Cell Signal , vol.23 , Issue.7 , pp. 1069-1075
    • Chang, S.H.1    Dong, C.2
  • 7
    • 84957564791 scopus 로고    scopus 로고
    • IL-17 cytokines in immunity and inflammation
    • Jin W, Dong C. IL-17 cytokines in immunity and inflammation. Emer Microbes Infect 2013;2:e60
    • (2013) Emer Microbes Infect , vol.2 , pp. e60
    • Jin, W.1    Dong, C.2
  • 8
    • 84886067284 scopus 로고    scopus 로고
    • Th17 cells and IL-17 a: Focus on immunopathogenesis and immunotherapeutics
    • Van den berg WB, Mcinnes IB. Th17 cells and IL-17 a: focus on immunopathogenesis and immunotherapeutics. Semin Arthritis Rheum 2013;43(2):158-70
    • (2013) Semin Arthritis Rheum , vol.43 , Issue.2 , pp. 158-170
    • Van Den Berg, W.B.1    McInnes, I.B.2
  • 9
    • 33751521013 scopus 로고    scopus 로고
    • Th17 functions as an osteoclastic helper T cell subset that links T cell activation and bone destruction
    • Sato K, Suematsu A, Okamoto K, et al. Th17 functions as an osteoclastic helper T cell subset that links T cell activation and bone destruction. J Exp Med 2006;203:2673-82
    • (2006) J Exp Med , vol.203 , pp. 2673-2682
    • Sato, K.1    Suematsu, A.2    Okamoto, K.3
  • 10
    • 70349173249 scopus 로고    scopus 로고
    • IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: Implications for bone remodeling
    • Huang H, Kim HJ, Chang EJ, et al. IL-17 stimulates the proliferation and differentiation of human mesenchymal stem cells: implications for bone remodeling. Cell Death Differ 2009;16:1332-43
    • (2009) Cell Death Differ , vol.16 , pp. 1332-1343
    • Huang, H.1    Kim, H.J.2    Chang, E.J.3
  • 11
    • 84929922540 scopus 로고    scopus 로고
    • Review: Th17 cells
    • Maddur S, et al. Review: Th17 cells. Am J Pathol 2012;181(1):03-44
    • (2012) Am J Pathol , vol.181 , Issue.1 , pp. 03-44
    • Maddur, S.1
  • 12
    • 84898688169 scopus 로고    scopus 로고
    • Small-molecule RORgt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms
    • Xiao S, Yosef N, Yang J, et al. Small-molecule RORgt antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity 2014;40(4):477-89
    • (2014) Immunity , vol.40 , Issue.4 , pp. 477-489
    • Xiao, S.1    Yosef, N.2    Yang, J.3
  • 13
    • 42149087160 scopus 로고    scopus 로고
    • Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells
    • Lowes MA, Kikuchi T, Fuentes-duculan J, et al. Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 2008;128(5):1207-11
    • (2008) J Invest Dermatol , vol.128 , Issue.5 , pp. 1207-1211
    • Lowes, M.A.1    Kikuchi, T.2    Fuentes-Duculan, J.3
  • 14
    • 84864856809 scopus 로고    scopus 로고
    • What have genomewide studies told us about psoriatic arthritis?
    • Bluett J, Barton A. What have genomewide studies told us about psoriatic arthritis? Curr Rheumatol Rep 2012;14(4):364-8
    • (2012) Curr Rheumatol Rep , vol.14 , Issue.4 , pp. 364-368
    • Bluett, J.1    Barton, A.2
  • 15
    • 83555174764 scopus 로고    scopus 로고
    • IL-17 receptor and its functional significance in psoriatic arthritis
    • Raychaudhuri SP, Raychaudhuri SK, Genovese MC. IL-17 receptor and its functional significance in psoriatic arthritis. Mol Cell Biochem 2012;359(1-2):419-29
    • (2012) Mol Cell Biochem , vol.359 , Issue.1-2 , pp. 419-429
    • Raychaudhuri, S.P.1    Raychaudhuri, S.K.2    Genovese, M.C.3
  • 16
    • 0030917573 scopus 로고    scopus 로고
    • Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage
    • Attur MG, Patel RN, Abramson SB, Amin AR. Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage. Arthritis Rheum 1997;40(6):1050-3
    • (1997) Arthritis Rheum , vol.40 , Issue.6 , pp. 1050-1053
    • Attur, M.G.1    Patel, R.N.2    Abramson, S.B.3    Amin, A.R.4
  • 17
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut 2003;52(1):65-70
    • (2003) Gut , vol.52 , Issue.1 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 19
    • 43549110961 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by IL-17F
    • Yang XO, Chang SH, Park H, et al. Regulation of inflammatory responses by IL-17F. J Exp Med 2008; 205(5):1063-75
    • (2008) J Exp Med , vol.205 , Issue.5 , pp. 1063-1075
    • Yang, X.O.1    Chang, S.H.2    Park, H.3
  • 20
    • 84877603562 scopus 로고    scopus 로고
    • Efficacy and safety of secukinumab in patients with rheumatoid arthritis: A phase II dose-finding double-blind randomised placebo controlled study
    • Genovese MC, Durez P, Richards HB, et al. Efficacy and safety of secukinumab in patients with rheumatoid arthritis: a phase II, dose-finding, double-blind, randomised, placebo controlled study. Ann Rheum Dis 2013;72(6): 863-9
    • (2013) Ann Rheum Dis , vol.72 , Issue.6 , pp. 863-869
    • Genovese, M.C.1    Durez, P.2    Richards, H.B.3
  • 21
    • 84859073115 scopus 로고    scopus 로고
    • Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis
    • Leonardi C, Matheson R, Zachariae C, et al. Anti-interleukin-17 monoclonal antibody ixekizumab in chronic plaque psoriasis. N Engl J Med 2012;366(13):1190-9
    • (2012) N Engl J Med , vol.366 , Issue.13 , pp. 1190-1199
    • Leonardi, C.1    Matheson, R.2    Zachariae, C.3
  • 22
    • 84929928555 scopus 로고    scopus 로고
    • Exposure-response modeling of phase 1 data to inform phase 2 dose selection: A case study using AMG 827 in psoriasis
    • 11 -13 September 2011; Chicago, IL . Initial investigation of pharmacokinetics for brodalumab
    • Salinger DH, Martin DA, Gibbs M. Exposure-response modeling of phase 1 data to inform phase 2 dose selection: a case study using AMG 827 in psoriasis. 40th Annual Meeting of the American College of Clinical Pharmacology; 11 -13 September 2011; Chicago, IL . Initial investigation of pharmacokinetics for brodalumab.
    • 40th Annual Meeting of the American College of Clinical Pharmacology
    • Salinger, D.H.1    Martin, D.A.2    Gibbs, M.3
  • 23
    • 84886226230 scopus 로고    scopus 로고
    • A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
    • Martin DA, Churchill M, Flores-suarez L, et al. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis. Arthritis Res Ther 2013;15(5):R164
    • (2013) Arthritis Res Ther , vol.15 , Issue.5 , pp. R164
    • Martin, D.A.1    Churchill, M.2    Flores-Suarez, L.3
  • 24
    • 84904983689 scopus 로고    scopus 로고
    • Clinical pharmacology of the anti-IL-17 receptor antibody brodalumab (KHK4827) in Japanese normal healthy volunteers and Japanese subjects with moderate to severe psoriasis: A randomized, dose-escalation, placebocontrolled study
    • Osamu N, Hirotaka N, Koji S, Kenji T. Clinical pharmacology of the anti-IL-17 receptor antibody brodalumab (KHK4827) in Japanese normal healthy volunteers and Japanese subjects with moderate to severe psoriasis: a randomized, dose-escalation, placebocontrolled study. J Dermatol Sci 2014;75(3):201-4
    • (2014) J Dermatol Sci , vol.75 , Issue.3 , pp. 201-204
    • Osamu, N.1    Hirotaka, N.2    Koji, S.3    Kenji, T.4
  • 25
    • 84904577871 scopus 로고    scopus 로고
    • Population pharmacokinetics of brodalumab in healthy adults and adults with psoriasis from single and multiple dose studies
    • Endres CJ, Salinger DH, Köck K, et al. Population pharmacokinetics of brodalumab in healthy adults and adults with psoriasis from single and multiple dose studies. J Clin Pharmacol 2014;54(11):1230-8
    • (2014) J Clin Pharmacol , vol.54 , Issue.11 , pp. 1230-1238
    • Endres, C.J.1    Salinger, D.H.2    Köck, K.3
  • 26
    • 84859017988 scopus 로고    scopus 로고
    • Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis
    • Papp KA, Leonardi C, Menter A, et al. Brodalumab, an anti-interleukin-17-receptor antibody for psoriasis. N Engl J Med 2012;366(13):1181-9
    • (2012) N Engl J Med , vol.366 , Issue.13 , pp. 1181-1189
    • Papp, K.A.1    Leonardi, C.2    Menter, A.3
  • 27
    • 84925226246 scopus 로고    scopus 로고
    • Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment
    • Papp K, Leonardi C, Menter A, et al. Safety and efficacy of brodalumab for psoriasis after 120 weeks of treatment. J Am Acad Dermatol 2014;71(6):1183-90
    • (2014) J Am Acad Dermatol , vol.71 , Issue.6 , pp. 1183-1190
    • Papp, K.1    Leonardi, C.2    Menter, A.3
  • 28
    • 84976531046 scopus 로고    scopus 로고
    • Amgen AstraZenecas brodalumab meets primary endpoints of third Phase III trial in moderate-Tosevere-plaque psoriasis
    • Web. 2015
    • Barber, J. Amgen, AstraZenecas brodalumab meets primary endpoints of third Phase III trial in moderate-Tosevere-plaque psoriasis. First Word Pharma, 2014. Web. 2015
    • (2014) First Word Pharma
    • Barber, J.1
  • 29
    • 84902209516 scopus 로고    scopus 로고
    • Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis
    • Mease PJ, Genovese MC, Greenwald MW, et al. Brodalumab, an anti-IL17RA monoclonal antibody, in psoriatic arthritis. N Engl J Med 2014;370(24):2295-306
    • (2014) N Engl J Med , vol.370 , Issue.24 , pp. 2295-2306
    • Mease, P.J.1    Genovese, M.C.2    Greenwald, M.W.3
  • 30
    • 84887412452 scopus 로고    scopus 로고
    • A randomized, double-blind, placebocontrolled, multiple-dose study to evaluate the safety, tolerability and efficacy of Brodalumab (AMG 827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate
    • Pavelka K, Chon Y, Newmark R, et al. A randomized, double-blind, placebocontrolled, multiple-dose study to evaluate the safety, tolerability and efficacy of Brodalumab (AMG 827) in subjects with rheumatoid arthritis and an inadequate response to methotrexate. Arthrit Rheum 2012;64(10
    • (2012) Arthrit Rheum , vol.64 , pp. 10
    • Pavelka, K.1    Chon, Y.2    Newmark, R.3
  • 32
    • 84886226230 scopus 로고    scopus 로고
    • A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis
    • Martin DA, Churchill M, Flores-suarez L, et al. A phase Ib multiple ascending dose study evaluating safety, pharmacokinetics, and early clinical response of brodalumab, a human anti-IL-17R antibody, in methotrexate-resistant rheumatoid arthritis. Arthritis Res Ther 2013;15(5):R164
    • (2013) Arthritis Res Ther , vol.15 , Issue.5 , pp. R164
    • Martin, D.A.1    Churchill, M.2    Flores-Suarez, L.3
  • 33
    • 84929890544 scopus 로고    scopus 로고
    • 2012 randomized, double-blind, placebocontrolled study to evaluate the safety, tolerability, and efficacy of AMG 827 in subjects with moderate to severe Crohns disease
    • Targan SR, Feagan BG, Vermeire S, et al. 2012 randomized, double-blind, placebocontrolled study to evaluate the safety, tolerability, and efficacy of AMG 827 in subjects with moderate to severe Crohns disease. Gastroenterology 2012;143
    • Gastroenterology , vol.2012 , pp. 143
    • Targan, S.R.1    Feagan, B.G.2    Vermeire, S.3
  • 34
    • 84889083869 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG 827) in subjects with moderate to severe asthma
    • Trial suggestive that further studies of brodalumab may be warranted in asthma
    • Busse WW, Holgate ST, Kerwin EM, et al. A randomized, double-blind, placebo-controlled, multiple-dose study to evaluate the safety, tolerability, and efficacy of brodalumab (AMG 827) in subjects with moderate to severe asthma. J Allergy Clin Immun 2013;131(2):AB230. . Trial suggestive that further studies of brodalumab may be warranted in asthma.
    • (2013) J Allergy Clin Immun , vol.131 , Issue.2 , pp. AB230
    • Busse, W.W.1    Holgate, S.T.2    Kerwin, E.M.3
  • 35
    • 84877060491 scopus 로고    scopus 로고
    • The efficacy and safety of etanercept when used with as-needed adjunctive topical therapy in a randomised, double-blind study in subjects with moderate-To-severe psoriasis (the PRISTINE trial)
    • Strohal R, Puig L, Chouela E, et al. The efficacy and safety of etanercept when used with as-needed adjunctive topical therapy in a randomised, double-blind study in subjects with moderate-To-severe psoriasis (the PRISTINE trial). J Dermatolog Treat 2013;24(3): 169-78
    • (2013) J Dermatolog Treat , vol.24 , Issue.3 , pp. 169-178
    • Strohal, R.1    Puig, L.2    Chouela, E.3
  • 36
    • 84856302095 scopus 로고    scopus 로고
    • Efficacy and safety of infliximab vs. Methotrexate in patients with moderate-To-severe plaque psoriasis: Results of an open-label, active-controlled, randomized trial (RESTORE1)
    • Barker J, Hoffmann M, Wozel G, et al. Efficacy and safety of infliximab vs. methotrexate in patients with moderate-To-severe plaque psoriasis: results of an open-label, active-controlled, randomized trial (RESTORE1). Br J Dermatol 2011;165(5):1109-17
    • (2011) Br J Dermatol , vol.165 , Issue.5 , pp. 1109-1117
    • Barker, J.1    Hoffmann, M.2    Wozel, G.3
  • 37
    • 84883134297 scopus 로고    scopus 로고
    • Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3 multicentre double-blind placebo-controlled PSUMMIT 1 trial
    • Mcinnes IB, Kavanaugh A, Gottlieb AB, et al. Efficacy and safety of ustekinumab in patients with active psoriatic arthritis: 1 year results of the phase 3, multicentre, double-blind, placebo-controlled PSUMMIT 1 trial. Lancet 2013;382(9894):780-9
    • (2013) Lancet , vol.382 , Issue.9894 , pp. 780-789
    • McInnes, I.B.1    Kavanaugh, A.2    Gottlieb, A.B.3
  • 38
    • 3042649266 scopus 로고    scopus 로고
    • Etanercept treatment of psoriatic arthritis: Safety, efficacy, and effect on disease progression
    • Mease PJ, Kivitz AJ, Burch FX, et al. Etanercept treatment of psoriatic arthritis: safety, efficacy, and effect on disease progression. Arthritis Rheum 2004;50(7):2264-72
    • (2004) Arthritis Rheum , vol.50 , Issue.7 , pp. 2264-2272
    • Mease, P.J.1    Kivitz, A.J.2    Burch, F.X.3
  • 39
    • 26844432745 scopus 로고    scopus 로고
    • Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: Results of a double-blind, randomized, placebocontrolled trial
    • Mease PJ, Gladman DD, Ritchlin CT, et al. Adalimumab for the treatment of patients with moderately to severely active psoriatic arthritis: Results of a double-blind, randomized, placebocontrolled trial. Arthritis Rheum 2013;52:3279-89
    • (2013) Arthritis Rheum , vol.52 , pp. 3279-3289
    • Mease, P.J.1    Gladman, D.D.2    Ritchlin, C.T.3
  • 40
    • 60249084148 scopus 로고    scopus 로고
    • Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: Randomised, double-blind, placebo-controlled, crossover trial
    • Gottlieb A, Menter A, Mendelsohn A, et al. Ustekinumab, a human interleukin 12/23 monoclonal antibody, for psoriatic arthritis: randomised, double-blind, placebo-controlled, crossover trial. Lancet 2009;373(9664):633-40
    • (2009) Lancet , vol.373 , Issue.9664 , pp. 633-640
    • Gottlieb, A.1    Menter, A.2    Mendelsohn, A.3
  • 41
    • 0033574147 scopus 로고    scopus 로고
    • Etanercept therapy in rheumatoid arthritis A randomized, controlled trial
    • Moreland LW, Schiff MH, Baumgartner SW, et al. Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial. Ann Intern Med 1999;130(6): 478-86
    • (1999) Ann Intern Med , vol.130 , Issue.6 , pp. 478-486
    • Moreland, L.W.1    Schiff, M.H.2    Baumgartner, S.W.3
  • 42
    • 67650379733 scopus 로고    scopus 로고
    • Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): A multicentre, randomised, double-blind, placebocontrolled, phase III trial
    • Smolen JS, Kay J, Doyle MK, et al. Golimumab in patients with active rheumatoid arthritis after treatment with tumour necrosis factor alpha inhibitors (GO-AFTER study): a multicentre, randomised, double-blind, placebocontrolled, phase III trial. Lancet 2009;374(9685):210-21
    • (2009) Lancet , vol.374 , Issue.9685 , pp. 210-221
    • Smolen, J.S.1    Kay, J.2    Doyle, M.K.3
  • 43
    • 55849112632 scopus 로고    scopus 로고
    • Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty-Two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallelgroup study
    • Keystone E, Heijde Dv, Mason D, et al. Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: findings of a fifty-Two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallelgroup study. Arthritis Rheum 2008;58(11):3319-29
    • (2008) Arthritis Rheum , vol.58 , Issue.11 , pp. 3319-3329
    • Keystone, E.1    Dv, H.2    Mason, D.3
  • 44
    • 0348109372 scopus 로고    scopus 로고
    • Adalimumab, a fully human anti tumor necrosis factor-Alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: Results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis)
    • Furst DE, Schiff MH, Fleischmann RM, et al. Adalimumab, a fully human anti tumor necrosis factor-Alpha monoclonal antibody, and concomitant standard antirheumatic therapy for the treatment of rheumatoid arthritis: results of STAR (Safety Trial of Adalimumab in Rheumatoid Arthritis). J Rheumatol 2003;30(12):2563-71
    • (2003) J Rheumatol , vol.30 , Issue.12 , pp. 2563-2571
    • Furst, D.E.1    Schiff, M.H.2    Fleischmann, R.M.3
  • 45
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therpay in rheumatoid arthritis and the risk of serious infections and malignancies: A systemic review and meta-Analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton A, Sweeting MJ, et al. Anti-TNF antibody therpay in rheumatoid arthritis and the risk of serious infections and malignancies: A systemic review and meta-Analysis of rare harmful effects in randomized controlled trials. JAMA 2006;295(19):2275-85
    • (2006) JAMA , vol.295 , Issue.19 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.2    Sweeting, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.