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Volumn 10, Issue 1, 2011, Pages 178-185

Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; COBROTOXIN; CYCLOPHOSPHAMIDE; EARLY GROWTH RESPONSE FACTOR 1; OBINUTUZUMAB; RITUXIMAB;

EID: 78751564397     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-10-0385     Document Type: Article
Times cited : (113)

References (40)
  • 1
    • 0041736041 scopus 로고    scopus 로고
    • Treatment of low-grade B-cell lymphoma with the monoclonal antibody rituximab
    • Dillman RO. Treatment of low-grade B-cell lymphoma with the monoclonal antibody rituximab. Semin Oncol 2003;30:434-47.
    • (2003) Semin Oncol , vol.30 , pp. 434-447
    • Dillman, R.O.1
  • 2
    • 34249821912 scopus 로고    scopus 로고
    • Rituximab therapy in malignant lymphoma
    • Coiffier B. Rituximab therapy in malignant lymphoma. Oncogene 2007;26:3603-13.
    • (2007) Oncogene , vol.26 , pp. 3603-3613
    • Coiffier, B.1
  • 3
    • 28544435078 scopus 로고    scopus 로고
    • Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: Results of a prospective randomized study of the German Low-Grade Lymphoma Study Group
    • Hiddemann W, Kneba M, Dreyling M, Schmitz N, Lengfelder E, Schmits R, et al. Frontline therapy with rituximab added to the combination of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) significantly improves the outcome for patients with advanced-stage follicular lymphoma compared with therapy with CHOP alone: results of a prospective randomized study of the German Low-Grade Lymphoma Study Group. Blood 2005;106:3725-32.
    • (2005) Blood , vol.106 , pp. 3725-3732
    • Hiddemann, W.1    Kneba, M.2    Dreyling, M.3    Schmitz, N.4    Lengfelder, E.5    Schmits, R.6
  • 4
    • 0042236333 scopus 로고    scopus 로고
    • Rituximab in B-cell chronic lymphocytic leukemia
    • Lin TS, Lucas MS, Byrd JC. Rituximab in B-cell chronic lymphocytic leukemia. Semin Oncol 2003;30:483-92.
    • (2003) Semin Oncol , vol.30 , pp. 483-492
    • Lin, T.S.1    Lucas, M.S.2    Byrd, J.C.3
  • 6
    • 0035169514 scopus 로고    scopus 로고
    • Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: Clinical and molecular evaluation
    • Colombat P, Salles G, Brousse N, Eftekhari P, Soubeyran P, Delwail V, et al. Rituximab (anti-CD20 monoclonal antibody) as single first-line therapy for patients with follicular lymphoma with a low tumor burden: clinical and molecular evaluation. Blood 2001;97:101-6.
    • (2001) Blood , vol.97 , pp. 101-106
    • Colombat, P.1    Salles, G.2    Brousse, N.3    Eftekhari, P.4    Soubeyran, P.5    Delwail, V.6
  • 8
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal anti-body therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
    • McLaughlin P, Grillo-López AJ, Link BK, Levy R, Czuczman MS, Williams ME, et al. Rituximab chimeric anti-CD20 monoclonal anti-body therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 1998;16:2825-33.
    • (1998) J Clin Oncol , vol.16 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-López, A.J.2    Link, B.K.3    Levy, R.4    Czuczman, M.S.5    Williams, M.E.6
  • 9
    • 0033855660 scopus 로고    scopus 로고
    • Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: Safety and efficacy of re-treatment
    • Davis TA, Grillo-Lopez AJ, White CA, McLaughlin P, Czuczman MS, Link BK, et al. Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: safety and efficacy of re-treatment. J Clin Oncol 2000;18:3135-43.
    • (2000) J Clin Oncol , vol.18 , pp. 3135-3143
    • Davis, T.A.1    Grillo-Lopez, A.J.2    White, C.A.3    McLaughlin, P.4    Czuczman, M.S.5    Link, B.K.6
  • 10
    • 11044221218 scopus 로고    scopus 로고
    • Second treatment with rituximab in B-cell non-Hodgkin's lymphoma: Efficacy and toxicity on 41 patients treated at CHU-Lyon Sud
    • Lemieux B, Bouafia F, Thieblemont C, Hequet O, Arnaud P, Tartas S, et al. Second treatment with rituximab in B-cell non-Hodgkin's lymphoma: efficacy and toxicity on 41 patients treated at CHU-Lyon Sud. Hematol J 2004;5:467-71.
    • (2004) Hematol J , vol.5 , pp. 467-471
    • Lemieux, B.1    Bouafia, F.2    Thieblemont, C.3    Hequet, O.4    Arnaud, P.5    Tartas, S.6
  • 11
    • 2942567554 scopus 로고    scopus 로고
    • Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule
    • Ghielmini M, Schmitz SF, Cogliatti SB, Pichert G, Hummerjohann J, Waltzer U, et al. Prolonged treatment with rituximab in patients with follicular lymphoma significantly increases event-free survival and response duration compared with the standard weekly x 4 schedule. Blood 2004;103:4416-23.
    • (2004) Blood , vol.103 , pp. 4416-4423
    • Ghielmini, M.1    Schmitz, S.F.2    Cogliatti, S.B.3    Pichert, G.4    Hummerjohann, J.5    Waltzer, U.6
  • 12
    • 14544276412 scopus 로고    scopus 로고
    • Maximizing therapeutic benefit of rituximab: Maintenance therapy versus re-treatment at progression in patients with indolent non-Hodgkin's lymphoma - A randomized phase II trial of the Minnie Pearl Cancer Research Network
    • Hainsworth JD, Litchy S, Shaffer DW, Lackey VL, Grimaldi M, Greco FA. Maximizing therapeutic benefit of rituximab: maintenance therapy versus re-treatment at progression in patients with indolent non-Hodgkin's lymphoma - a randomized phase II trial of the Minnie Pearl Cancer Research Network. J Clin Oncol 2005;23:1088-95.
    • (2005) J Clin Oncol , vol.23 , pp. 1088-1095
    • Hainsworth, J.D.1    Litchy, S.2    Shaffer, D.W.3    Lackey, V.L.4    Grimaldi, M.5    Greco, F.A.6
  • 13
    • 0642312825 scopus 로고    scopus 로고
    • Rituximab (monoclonal anti-CD20 antibody): Mechanisms of action and resistance
    • Smith MR. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene 2003;22:7359-68.
    • (2003) Oncogene , vol.22 , pp. 7359-7368
    • Smith, M.R.1
  • 14
    • 27244440161 scopus 로고    scopus 로고
    • Immunotherapy for non-Hodgkin's lymphoma: Monoclonal antibodies and vaccines
    • Maloney DG. Immunotherapy for non-Hodgkin's lymphoma: monoclonal antibodies and vaccines. J Clin Oncol 2005;23:6421-8.
    • (2005) J Clin Oncol , vol.23 , pp. 6421-6428
    • Maloney, D.G.1
  • 16
    • 0030926366 scopus 로고    scopus 로고
    • Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma
    • Anderson DR, Grillo-Lopez A, Varns C, Chambers KS, Hanna N. Targeted anti-cancer therapy using rituximab, a chimaeric anti-CD20 antibody (IDEC-C2B8) in the treatment of non-Hodgkin's B-cell lymphoma. Biochem Soc Trans 1997;25:705-8.
    • (1997) Biochem Soc Trans , vol.25 , pp. 705-708
    • Anderson, D.R.1    Grillo-Lopez, A.2    Varns, C.3    Chambers, K.S.4    Hanna, N.5
  • 17
    • 0037306893 scopus 로고    scopus 로고
    • In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas
    • Manches O, Lui G, Chaperot L, Gressin R, Molens JP, Jacob MC, et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood 2003;101:949-54.
    • (2003) Blood , vol.101 , pp. 949-954
    • Manches, O.1    Lui, G.2    Chaperot, L.3    Gressin, R.4    Molens, J.P.5    Jacob, M.C.6
  • 18
    • 0035760902 scopus 로고    scopus 로고
    • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: Further regulation by CD55 and CD59
    • Golay J, Lazzari M, Facchinetti V, Bernasconi S, Borleri G Barbui T, et al. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. Blood 2001;98:3383-9.
    • (2001) Blood , vol.98 , pp. 3383-3389
    • Golay, J.1    Lazzari, M.2    Facchinetti, V.3    Bernasconi, S.4    Borleri, G.5    Barbui, T.6
  • 19
    • 0035525769 scopus 로고    scopus 로고
    • Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspasein-dependent mechanism involving the generation of reactive oxygen species
    • Bellosillo B, Villamor N, López-Guillermo A, Marcé S, Esteve J, Campo E, et al. Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspasein-dependent mechanism involving the generation of reactive oxygen species. Blood 2001;98:2771-7.
    • (2001) Blood , vol.98 , pp. 2771-2777
    • Bellosillo, B.1    Villamor, N.2    López-Guillermo, A.3    Marcé, S.4    Esteve, J.5    Campo, E.6
  • 20
    • 0034660092 scopus 로고    scopus 로고
    • Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59regulatecomplement-mediatedcell lysis
    • Golay J, Zaffaroni L, Vaccari T, et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59regulatecomplement-mediatedcell lysis.Blood2000;95:3900-8.
    • (2000) Blood , vol.95 , pp. 3900-3908
    • Golay, J.1    Zaffaroni, L.2    Vaccari, T.3
  • 21
    • 33644501166 scopus 로고    scopus 로고
    • The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes
    • Golay J, Cittera E, Di Gaetano N, et al. The role of complement in the therapeutic activity of rituximab in a murine B lymphoma model homing in lymph nodes. Hematological 2006;91:176-83.
    • (2006) Hematological , vol.91 , pp. 176-183
    • Golay, J.1    Cittera, E.2    Di Gaetano, N.3
  • 22
    • 0042346042 scopus 로고    scopus 로고
    • Complement activation determines the therapeutic activity of rituximab in vivo
    • Di Gaetano N, Cittera E, Nota R, et al. Complement activation determines the therapeutic activity of rituximab in vivo. J Immunol 2003;171:1581-7.
    • (2003) J Immunol , vol.171 , pp. 1581-1587
    • Di Gaetano, N.1    Cittera, E.2    Nota, R.3
  • 23
    • 0035469885 scopus 로고    scopus 로고
    • Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma
    • Weng WK, Levy R. Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma. Blood 2001;98:1352-7.
    • (2001) Blood , vol.98 , pp. 1352-1357
    • Weng, W.K.1    Levy, R.2
  • 24
    • 0034104375 scopus 로고    scopus 로고
    • Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells
    • Shan D, Ledbetter JA, Press OW. Signaling events involved in anti-CD20-induced apoptosis of malignant human B cells. Cancer Immunol Immunother 2000;48:673-83. (Pubitemid 30146462)
    • (2000) Cancer Immunology Immunotherapy , vol.48 , Issue.12 , pp. 673-683
    • Shan, D.1    Ledbetter, J.A.2    Press, O.W.3
  • 25
    • 0141704595 scopus 로고    scopus 로고
    • CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts
    • Chan HT, Hughes D, French RR, Tutt AL, Walshe CA, Teeling JL, et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts. Cancer Res 2003;63:5480-9.
    • (2003) Cancer Res , vol.63 , pp. 5480-5489
    • Chan, H.T.1    Hughes, D.2    French, R.R.3    Tutt, A.L.4    Walshe, C.A.5    Teeling, J.L.6
  • 26
    • 58149162030 scopus 로고    scopus 로고
    • Type II (tositumomab) anti-CD20 monoclonal antibody out performs Type I (rituximab-like) reagents in B-cell depletion regardless of complement activation
    • Beers SA, Chan CH, James S, French RR, Attfield KE, Brennan CM, et al. Type II (tositumomab) anti-CD20 monoclonal antibody out performs Type I (rituximab-like) reagents in B-cell depletion regardless of complement activation. Blood 2008.
    • (2008) Blood
    • Beers, S.A.1    Chan, C.H.2    James, S.3    French, R.R.4    Attfield, K.E.5    Brennan, C.M.6
  • 27
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes RA, Towers TL, Presta LG, Ravetch JV. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 2000;6: 443-6.
    • (2000) Nat Med , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 28
    • 34249692537 scopus 로고    scopus 로고
    • Rituximab-induced inhibition of antiapoptotic cell survival pathways: Implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions
    • Bonavida B. Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions. Oncogene 2007;26:3629-36.
    • (2007) Oncogene , vol.26 , pp. 3629-3636
    • Bonavida, B.1
  • 29
    • 77951561987 scopus 로고    scopus 로고
    • Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct-and immune effector cell-mediated B-cell cytotoxicity
    • Mössner E, Brünker P, Moser S, Püntener U, Schmidt C, Herter S, et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct-and immune effector cell-mediated B-cell cytotoxicity. Blood 2010; 115:4393-402.
    • (2010) Blood , vol.115 , pp. 4393-4402
    • Mössner, E.1    Brünker, P.2    Moser, S.3    Püntener, U.4    Schmidt, C.5    Herter, S.6
  • 31
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad BM, Irizarry RA, Astrand M, Speed TP. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003;19:185-93.
    • (2003) Bioinformatics , vol.19 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    Astrand, M.3    Speed, T.P.4
  • 32
    • 0037306946 scopus 로고    scopus 로고
    • Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts
    • Cragg MS, Morgan SM, Chan HT, et al. Complement-mediated lysis by anti-CD20 mAb correlates with segregation into lipid rafts. Blood 2003;101:1045-52.
    • (2003) Blood , vol.101 , pp. 1045-1052
    • Cragg, M.S.1    Morgan, S.M.2    Chan, H.T.3
  • 33
    • 37049008917 scopus 로고    scopus 로고
    • Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts
    • Daniel D, Yang B, Lawrence DA, Totpal K, Balter I, Lee WP, et al. Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts. Blood 2007;110:4037-46.
    • (2007) Blood , vol.110 , pp. 4037-4046
    • Daniel, D.1    Yang, B.2    Lawrence, D.A.3    Totpal, K.4    Balter, I.5    Lee, W.P.6
  • 34
    • 34248224220 scopus 로고    scopus 로고
    • The CCL3 family of chemokines and innate immunity cooperate in vivo in the eradication of an established lymphoma xenograft by rituximab
    • Cittera E, Leidi M, Buracchi C, Pasqualini F, Sozzani S, Vecchi A, et al. The CCL3 family of chemokines and innate immunity cooperate in vivo in the eradication of an established lymphoma xenograft by rituximab. J Immunol 2007;178:6616-23.
    • (2007) J Immunol , vol.178 , pp. 6616-6623
    • Cittera, E.1    Leidi, M.2    Buracchi, C.3    Pasqualini, F.4    Sozzani, S.5    Vecchi, A.6
  • 35
    • 16444363534 scopus 로고    scopus 로고
    • Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: Implications in chemosensitization and therapeutic intervention
    • Jazirehi AR, Bonavida B. Cellular and molecular signal transduction pathways modulated by rituximab (rituxan, anti-CD20 mAb) in non-Hodgkin's lymphoma: implications in chemosensitization and therapeutic intervention. Oncogene 2005;24:2121-43.
    • (2005) Oncogene , vol.24 , pp. 2121-2143
    • Jazirehi, A.R.1    Bonavida, B.2
  • 36
    • 38049151149 scopus 로고    scopus 로고
    • PKC zeta mTOR pathway: A newtarget for rituximab therapy in follicular lymphoma
    • Leseux L, Laurent G, Laurent C, Rigo M, Blanc A, Olive D, Bezombes C. PKC zeta mTOR pathway: a newtarget for rituximab therapy in follicular lymphoma. Blood 2008;111:285-91.
    • (2008) Blood , vol.111 , pp. 285-291
    • Leseux, L.1    Laurent, G.2    Laurent, C.3    Rigo, M.4    Blanc, A.5    Olive, D.6    Bezombes, C.7
  • 37
    • 65549146911 scopus 로고    scopus 로고
    • E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells
    • Zheng C, Ren Z, Wang H, Zhang W, Kalvakolanu DV, Tian Z, et al. E2F1 Induces tumor cell survival via nuclear factor-kappaB-dependent induction of EGR1 transcription in prostate cancer cells. Cancer Res 2009;69:2324-31.
    • (2009) Cancer Res , vol.69 , pp. 2324-2331
    • Zheng, C.1    Ren, Z.2    Wang, H.3    Zhang, W.4    Kalvakolanu, D.V.5    Tian, Z.6
  • 38
    • 61349089170 scopus 로고    scopus 로고
    • EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells
    • Zagurovskaya M, Shareef MM, Das A, et al. EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene 2009;28:1121-31.
    • (2009) Oncogene , vol.28 , pp. 1121-1131
    • Zagurovskaya, M.1    Shareef, M.M.2    Das, A.3
  • 39
    • 53949098326 scopus 로고    scopus 로고
    • The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis
    • Wang A, Arantes S, Yan L, Kiguchi K, McArthur MJ, Sahin A, et al. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis. BMC Cancer 2008;8:268.
    • (2008) BMC Cancer , vol.8 , pp. 268
    • Wang, A.1    Arantes, S.2    Yan, L.3    Kiguchi, K.4    McArthur, M.J.5    Sahin, A.6
  • 40
    • 57649178303 scopus 로고    scopus 로고
    • KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3
    • Huang X, Li X, Guo B. KLF6 induces apoptosis in prostate cancer cells through up-regulation of ATF3. J Biol Chem 2008;283:29795-801.
    • (2008) J Biol Chem , vol.283 , pp. 29795-29801
    • Huang, X.1    Li, X.2    Guo, B.3


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