Quercetin ameliorates liver injury induced with Tripterygium glycosides by reducing oxidative stress and inflammation

Canadian Journal of Physiology and Pharmacology

Volumn 93, Issue 6, 2015, Pages 427-433

  Wang, Junming ^a,b   Miao, Mingsan ^a   Zhang, Yueyue ^a   Liu, Ruixin ^c   Li, Xaobing ^a   Cui, Ying ^a   Qu, Lingbo ^b  

^a HENAN UNIVERSITY OF CHINESE MEDICINE   (China)

^b ZHENGZHOU UNIVERSITY   (China)

^c HENAN UNIVERSITY   (China)

Author keywords

Anti inflammatory cytokines; Antioxidant enzymes; Hepatoprotection; Oxidative stress; Pro inflammatory cytokines

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BIFENDATE; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 10; LIVER PROTECTIVE AGENT; MALONALDEHYDE; MESSENGER RNA; PLANT GLYCOSIDE; QUERCETIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIINFLAMMATORY AGENT; BIOLOGICAL MARKER; GLYCOSIDE; PROTECTIVE AGENT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG DOSE COMPARISON; ENZYME ACTIVITY; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIPTERYGIUM WILFORDII; ADVERSE EFFECTS; ANIMAL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; INFLAMMATION; METABOLISM; SERUM; TRIPTERYGIUM;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOMARKERS; DRUG-INDUCED LIVER INJURY; GLYCOSIDES; INFLAMMATION; LIVER; MALE; MICE; OXIDATIVE STRESS; PROTECTIVE AGENTS; QUERCETIN; SERUM; TRIPTERYGIUM;

EID: 84929866124     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2015-0038     Document Type: Article

References (43)

1. Aebi, H. 1984. Catalse in vitro. Methods Enzymol. 105: 121-126. doi: 10. 1016/S0076-6879(84)05016-3. PMID: 6727660.
2. Bocchetti, R., and Regoli, F. 2006. Seasonal variability of oxidative biomarkers, lysosomal parameters, metallothioneins and peroxisomal enzymes in the Mediterranean mussel Mytilus galloprovincialis from Adriatic Sea. Chemosphere, 65(6): 913-921. doi: 10. 1016/j. chemosphere. 2006. 03. 049. PMID: 16678235.
3. Caddeo, C., Díez-Sales, O., Pons, R., Fernàndez-Busquets, X., Fadda, A. M., and Manconi, M. 2014. Topical anti-inflammatory potential of quercetin in lipidbased nanosystems: in vivo and in vitro evaluation. Pharm. Res. 31(4): 959-968. doi: 10. 1007/s11095-013-1215-0. PMID: 24297068.
4. Dai, J., Liu, M., Ai, Q., Lin, L., Wu, K., Deng, X., et al. 2014. Involvement of catalase in the protective benefits of metformin in mice with oxidative liver injury. Chem. Biol. Interact. 216: 34-42. doi: 10. 1016/j. cbi. 2014. 03. 013. PMID: 24717679.
5. Eidi, A., Mortazavi, P., Behzadi, K., Rohani, A. H., and Safi, S. 2013. Hepatoprotective effect of manganese chloride against CCl4-induced liver injury in rats. Biol. Trace Elem. Res. 155(2): 267-275. doi: 10. 1007/s12011-013-9784-7. PMID: 24037643.
6. El Mouatassim, S., Guérin, P., and Ménézo, Y. 1999. Expression of genes encoding antioxidant enzymes in human and mouse oocytes during the final stages of maturation. Mol. Hum. Reprod. 5(8): 720-725. doi: 10. 1093/molehr/5. 8. 720. PMID: 10421798.
7. Girish, C., Koner, B. C., Jayanthi, S., Ramachandra Rao, K., Rajesh, B., and Pradhan, S. C. 2009. Fundam. Clin. Pharmacol. 23(6): 735-745. doi: 10. 1111/j. 1472-8206. 2009. 00722. x. PMID: 19656205.
8. Guo, X. D., Zhang, D. Y., Gao, X. J., Parry, J., Liu, K., Liu, B. L., et al. 2013. Quercetin and quercetin-3-O-glucuronide are equally effective in ameliorating endothelial insulin resistance through inhibition of reactive oxygen speciesassociated inflammation. Mol. Nutr. Food Res. 57(6): 1037-1045. doi: 10. 1002/mnfr. 201200569. PMID: 23504962.
9. Habig, W. H., and Jakoby, W. B. 1981. Assay for differentiation of glutathione S-transferases. Methods Enzymol. 77: 398-405. doi: 10. 1016/S0076-6879(81) 77053-8. PMID: 7329316.
10. Han, D., Shinohara, M., Ybanez, M. D., Saberi, B., and Kaplowitz, N. 2010. Signal transduction pathways involved in drug-induced liver injury. Handb. Exp. Pharmacol. 196: 267-310. doi: 10. 1007/978-3-642-00663-0_10. PMID: 20020266.
11. Hassan, L., Bueno, P., Ferrón-Celma, I., Ramia, J. M., Garrote, D., Muffak, K., et al. 2005. Time course of antioxidant enzyme activities in liver transplant recipients. Transplant. Proc. 37(9): 3932-3935. doi: 10. 1016/j. transproceed. 2005. 10. 088. PMID: 16386589.
12. Hogberg, J., Larson, R. E., Kristoferson, A., and Orrenius, S. 1974. NADPHdependent reductase solubilized from microsomes by peroxidation and its activity. Biochem. Biophys. Res. Commun. 56(3): 836-842. doi: 10. 1016/0006-291X(74)90681-0. PMID: 4151195.
13. Hougardy, B. M., van der Zee, A. G., van den Heuvel, F. A., Timmer, T., de Vries, E. G., and de Jong, S. 2005. Sensitivity to Fas-mediated apoptosis in high-risk HPV-positive human cervical cancer cells: relationship with Fas, caspase-8, and Bid. Gynecol. Oncol. 97(2): 353-364. doi: 10. 1016/j. ygyno. 2005. 01. 036. PMID: 15863130.
14. Houghton, P. J., Hylands, P. J., Mensah, A. Y., Hensel, A., and Deters, A. M. 2005. In vitro tests and ethnopharmacological investigations: wound healing as an example. J. Ethnopharmacol. 100(1-2): 100-107. doi: 10. 1016/j. jep. 2005. 07. 001. PMID: 16040217.
15. Jaeschke, H., McGill, M. R., and Ramachandran, A. 2012. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: lessons learned from acetaminophen hepatotoxicity. Drug Metab. Rev. 44(1): 88-106. doi: 10. 3109/03602532. 2011. 602688. PMID: 22229890.
16. Li, H. G., Ji, W., and Su, J. M. 2012. Literature research of the hepatotoxicity of glucoside tripterygium total and its synergism and toxicity reducing effects. Zhongguo Zhong Xi Yi Jie He Za Zhi, 32(3): 415-418. [Available from http://www. cjim. cn/zxyjhcn/zxyjhcn/ch/reader/view_abstract. aspx?file_no= 20120337&flag=1. 22686096].
17. Li, J., Lu, Y., Xiao, C., Lu, C., Niu, X., He, X., et al. 2011. Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J. Ethnopharmacol. 135(2): 270-277. doi: 10. 1016/j. jep. 2011. 03. 007. PMID: 21397001.
18. Liang, Q. N., Sheng, Y. C., Jiang, P., Ji, L. L., Xia, Y. Y., Min, Y., et al. 2011. The difference of glutathione antioxidant system in newly weaned and young mice liver and its involvement in isoline-induced hepatotoxicity. Arch. Toxicol. 85(10): 1267-1279. doi: 10. 1007/s00204-011-0664-7. PMID: 21327617.
19. Lin, L. M., and Qi, X. M. 2005. Comparative observation on the effects of Radix Tripterygium hypoglaucum tablet and Tripterygium glycosides tablet in treating erosive oral lichen planus. Chin. J. Integr. Med. 11(2): 149-150. [Available from http://d. wanfangdata. com. cn/Periodical_zgzxyjh-e200502017. aspx]. 16150205.
20. Liu, H., Guo, X., Chu, Y., and Lu, S. 2014. Heart protective effects and mechanism of quercetin preconditioning on anti-myocardial ischemia reperfusion (IR) injuries in rats. Gene, 545(1): 149-155. doi: 10. 1016/j. gene. 2014. 04. 043. PMID: 24769323.
21. Lucena, M. I., García-Martín, E., Andrade, R. J., Martínez, C., Stephens, C., Ruiz, J. D., et al. 2010. Mitochondrial superoxide dismutase and glutathione peroxidase in idiosyncratic drug-induced liver injury. Hepatology, 52(1): 303-312. doi: 10. 1002/hep. 23668. PMID: 20578157.
22. Marklund, S. L., and Marklund, G. 1974. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47(3): 469-474. doi: 10. 1111/j. 1432-1033. 1974. tb03714. x. PMID: 4215654.
23. Muriel, P., and Rivera-Espinoza, Y. 2008. Beneficial drugs for liver diseases. J. Appl. Toxicol. 28: 93-103. doi: 10. 1002/jat. 1310. PMID: 17966118.
24. Peng, B., Miao, M. S., and Wang, Y. L. 2003. Initial discussion of mice acute hepatic injury caused by Tripterygium glycosides. Zhongguo Zhong Yao Za Zhi, 28(11): 1067-1070. [Available from http://www. cjcmm. com. cn/cjcmmte/ch/reader/create_pdf. aspx?file_no=10489&flag=1&journal_id=cjcmmte&year_id=2003]. 15615419.
25. Peskin, A. V. 1997. Cu, Zn-superoxide dismutase gene dosage and cell resistance to oxidative stress: a review. Biosci. Rep. 17(1): 85-89. doi: 10. 1023/A: 1027343519591. PMID: 9171924.
26. Ray, S. D., Patel, N., Shah, N., Nagori, A., Naqvi, A., and Stohs, S. J. 2006. Preexposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver. Mol. Cell. Biochem. 293(1-2): 119-136. doi: 10. 1007/s11010-006-9235-2. PMID: 16902808.
27. Rej, R. 1978. Aspartate aminotransferase activity and isoenzymes proportions in human liver tissue. Clin. Chem. 24: 1971-1979. [Available from http://www. clinchem. org/content/24/11/1971. full. pdf]. PMID: 213206.
28. Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., and Hoekstra, W. G. 1973. Selenium: biochemical role as a component of glutathione peroxidase. Science, 179(4073): 588-590. doi: 10. 1126/science. 179. 4073. 588. PMID: 4686466.
29. Song, Q., Lu, J. Z., and Li, J. 2010. Effect of Tripterygium glycosides on serum interleukin-1beta, interleukin-2, tumor necrosis factor alpha, and interferongamma levels in patients with Behcet's disease. Zhongguo Zhong Xi Yi Jie He Za Zhi, 30(6): 598-600. [Available from http://www. cnki. net/KCMS/detail/detail. aspx?QueryID=6&CurRec=1&recid=&filename=ZZXJ201006012&dbname= CJFD2010&dbcode=CJFQ&pr=&urlid=&yx=&v=MDY4Njg3RGgxVDNxVHJXTTFG ckNVUkwrZlp1UnFGeXZtVXIzSlB6ZlRaTEc0SDlITXFZOUVab1I4ZVgxTHV4WVM <26]. 20815274.
30. Tarantino, G., Di Minno, M. N., and Capone, D. 2009. Drug-induced liver injury: is it somehow foreseeable? World J. Gastroenterol. 15(23): 2817-2833. doi: 10. 3748/wjg. 15. 2817. PMID: 19533803.
31. Tilg, H., Kaser, A., and Moschen, A. R. 2006. How to modulate inflammatory cytokines in liver diseases. Liver Int. 26(9): 1029-1039. doi: 10. 1111/j. 1478-3231. 2006. 01339. x. PMID: 17032402.
32. Urban, T. J., Goldstein, D. B., and Watkins, P. B. 2012. Genetic basis of susceptibility to drug-induced liver injury: What have we learned and where do we go from here? Pharmacogenomics, 13: 735-738. doi: 10. 2217/pgs. 12. 45. PMID: 22594502.
33. Verpoorte, R., Choi, Y. H., and Kim, H. K. 2005. Ethnopharmacology and systems biology: a perfect holistic match. J. Ethnopharmacol. 100(1-2): 53-56. doi: 10. 1016/j. jep. 2005. 05. 033. PMID: 16026949.
34. Vidyashankar, S., Sandeep Varma, R., and Patki, P. S. 2013. Quercetin ameliorate insulin resistance and up-regulates cellular antioxidants during oleic acid induced hepatic steatosis in HepG2 cells. Toxicol. In Vitro, 27(2): 945-953. doi: 10. 1016/j. tiv. 2013. 01. 014. PMID: 23348005.
35. Wan, L., Liu, J., Huang, C. B., Wang, Y., Lei, L., Liu, L., et al. 2013. Effect of Tripterygium glycosides on pulmonary function in adjuvant arthritis rats. J. Chin. Med. Assoc. 76(12): 715-723. doi: 10. 1016/j. jcma. 2013. 08. 002. PMID: 24060529.
36. Wan, Y. G., Zhao, Q., Sun, W., Zhang, H. L., Li, M., Wei, Q. X., et al. 2012. Contrasting dose-effects of multi-glycoside of Tripterygium wilfordii Hook. f. on glomerular inflammation and hepatic damage in two types of anti-Thy1. 1 glomerulonephritis. J. Pharmacol. Sci. 118(4): 433-446. doi: 10. 1254/jphs. 11157FP. PMID: 22447300.
37. Wang, J. M., Cui, Y., Shen, L. L., Liu, W. J., and Zhang, T. 2011. Research progress in mechanism based on oxidative stress of liver injury induced by Chinese medicine. Zhongguo Shiyan Fangji Xue Za Zhi, 17(5): 247-249. [Available from http://www. syfjxzz. com/ch/reader/create_pdf. aspx?file_no=20110577&flag= 1&journal_id=zgsyfjxzz].
38. Wang, J., Zhang, Y., Zhang, Y., Cui, Y., Liu, J., and Zhang, B. 2012. Protective effect of Lysimachia christinae against acute alcohol-induced liver injury in mice. Biosci. Trends, 6(2): 89-97. doi: 10. 5582/bst. 2012. v6. 2. 89. PMID: 22621991.
39. Wang, J. M., Liu, J., Cui, Y., Zhang, H. W., and Feng, Z. Y. 2013. Hepatoprotective effects of Lysimachia christinae Hance extracts on acute liver injury induced by Tripterygium glycosides in mice. Chin. Pharm. J. 48(1): 30-34. [Available from http://en. cnki. com. cn/Article_en/CJFDTotal-ZGYX201301010. htm].
40. Yang, T., Kong, B., Gu, J. W., Kuang, Y. Q., Cheng, L., Yang, W. T., et al. 2014. Anti-apoptotic and anti-oxidative roles of quercetin after traumatic brain injury. Cell. Mol. Neurobiol. 34(6): 797-804. doi: 10. 1007/s10571-014-0070-9. PMID: 24846663.
41. Yang, X., Wang, B. C., Zhang, X., Liu, W. Q., Qian, J. Z., Li, W., et al. 2011. Evaluation of Lysimachia christinae Hance extracts as anticholecystitis and cholagogic agents in animals. J. Ethnopharmacol. 137(1): 57-63. doi: 10. 1016/j. jep. 2011. 04. 029. PMID: 21524697.
42. Zelko, I. N., Mariani, T. J., and Folz, R. J. 2002. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radic. Biol. Med. 33(3): 337-349. doi: 10. 1016/S0891-5849(02)00905-X. PMID: 12126755.
43. Zhang, Y., Jiang, Z., Xue, M., Zhang, S., Wang, Y., and Zhang, L. 2012. Toxicogenomic analysis of the gene expression changes in rat liver after a 28-day oral Tripterygium wilfordii multiglycoside exposure. J. Ethnopharmacol. 141(1): 170-177. doi: 10. 1016/j. jep. 2012. 02. 015. PMID: 22366672.