Pre-exposure to a novel nutritional mixture containing a series of phytochemicals prevents acetaminophen-induced programmed and unprogrammed cell deaths by enhancing BCL-XL expression and minimizing oxidative stress in the liver

Molecular and Cellular Biochemistry

Volumn 293, Issue 1-2, 2006, Pages 119-136

  Ray, Sidhartha D ^a   Patel, Nirav ^a   Shah, Nilank ^a   Nagori, Akila ^a   Naqvi, Anne ^a   Stohs, Sidney J ^b  

^a LONG ISLAND UNIVERSITY   (United States)

^b Research and Development   (United States)

Author keywords

Acetaminophen; Apoptosis; Bcl xL; Caffeine; Cytoprotection; DNA fragmentation; Ephedra; Hepatotoxicity; In vivo; Necrosis; Nutraceutical; Oxidative stress; Phytochemical; Prevention

Indexed keywords

CAFFEINE; CAMELIA SINENSIS EXTRACT; DNA FRAGMENT; ELEUTHEROCOCCUS SENTICOSUS EXTRACT; EPHEDRA SINICA EXTRACT; FLAVONOID; GARCINIA CAMBOGIA EXTRACT; GARLIC EXTRACT; GINKGO BILOBA EXTRACT; GUARANA EXTRACT; GYMNEMA SYLVESTRE EXTRACT; MALONALDEHYDE; NUTRACEUTICAL; OCIMUM BASILICUM EXTRACT; PARACETAMOL; PAULLINIA CUPANA EXTRACT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; POLYPHENOL; PROTEIN BCL XL; SILYBUM MARIANUM EXTRACT; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CAMELIA SINENSIS; CONTROLLED STUDY; DIET; DRUG ACTIVITY; DRUG EXPOSURE; DRUG MECHANISM; DRUG MIXTURE; FEMALE; GARCINIA CAMBOGIA; GUARANA; GYMNEMA; HISTOPATHOLOGY; KIDNEY; LIPID PEROXIDATION; LIVER HOMOGENATE; LIVER INJURY; LIVER TOXICITY; MEDICINAL PLANT; MORTALITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PAULLINIA CUPANA; PROTEIN EXPRESSION;

ACETAMINOPHEN; ANIMALS; APOPTOSIS; BCL-X PROTEIN; CELL PROLIFERATION; DIETARY SUPPLEMENTS; DNA FRAGMENTATION; FEMALE; LIVER; MICE; MICE, INBRED ICR; NECROSIS; OXIDATIVE STRESS; PLANT EXTRACTS;

ALLIUM SATIVUM; ANIMALIA; CITRUS; EPHEDRA; EPHEDRA SINICA; GARCINIA; GYMNEMA; OCIMUM BASILICUM; PAULLINIA CUPANA; SILYBUM;

EID: 33751583377     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-006-9235-2     Document Type: Article

References (45)

1. Ray SD, Lam TS, Rotollo JA, Phadke S, Patel C, Stohs, SJ: Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. Biofactors 21(1-4): 223-232, 2004
2. Lee KW, Lee KJ, Lee CY: Vitamins, phytochemicals, diets, and their implementation in cancer chemoprevention. Crit Rev Food Sci Nutr 44: 437-452, 2004
3. Lampe JW: Spicing up a vCgetarian diet: chemopreventive effects of phytochemicals. Am J Clin Nutr 78(3 Suppl): 579S-583S, 2003
4. Lampe JW: Nutrition and canSer prevention: small-scale human studies for the 21st century. Cancer Epidemiol Biomarkers Prev 13: 1987-1988, 2004
5. Graf BA, Milbury PE, Blumberg JF: Flavonols, flavones, flavanones, and human health: Epidemiological evidence. J Med Food 8(3): 281-290, 2005
6. Ray S, Phadke S, Patel C, Hackman RM, Stohs, S: Short-term and long-term in vivo exposure to an ephedra- and caffeine-containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Arch Toxicol 79: 330-340, 2005
7. Ray SD, Zinkovsky D, Bulku E, Patil BS: Prevention of drug-induced programmed and unprogrammed cell death by citrus flavonoids. ACS Symposium series; AGFD Section entitled "Potential health benefits of Citrus", American Chemical Society Publications, Ed. Patil, B. S. 2006b (In Press).
8. Ray SD, Kumar MA, Bagchi D: A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch Biochem Biophys 369(1): 42-58, 1999
9. Surh YJ: Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3(10): 768-80, 2003
10. Dorai T, Aggarwal BB: Role of chemopreventive agents in cancer therapy. Cancer Lett 215(2): 129-140, 2004
11. Watanabe S, Zhuo XG, KimNra M: Food safety and epidemiology: new database of functional food factors. Biofactors 22(1-4): 213-219, 2004
12. Wroblewski F, Ladue JS: Serum glutamic pyruvic transaminase in cardiac with hepatic disease. Proc Soc Exp Biol Med 91(4): 569-571, 1956
13. Ray SD, Mumaw VR, Raje RR, Fariss MW: Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther 279(3): 1470-1483, 1996
14. Ray SD, Balasubramanian G, Bagchi D, Reddy CS: Ca(2+)-calmodulin antagonist chlorpromazine and poly(ADP-ribose) polymerase modulators 4-aminobenzamide and nicotinamide influence hepatic expression of BCL-XL and P53 and protect against acetaminophen-induced programmed and unprogrammed cell death in mice. Free Radic Biol Med 31(3): 277-291, 2001
15. Ray SD: Oxidative stress orchestrates both apoptosis and necrosis in vivo: A new perspective from molecular toxicology. Proc. Of the Meeting of the Soc. Free Rad. Res. (European Section); Free Radicals and Oxidative stress: Chemistry, Biochemistry and Pathophysiological Implications, In: Galaris, D.; ed., Medimond S.r.l., Monduzzi Editore Int. Proc. Div., Italy, pp. 45-53, 2003
16. 2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB J 7(5): 453-463, 1993
17. Burton K: A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid. Biochem J 62(2): 315-323, 1956
18. Ray SD, Jena N: A hepatotoxic dose of acetaminophen modulates expression of BCL-2, BCL-X(L), and BCL-X(S) during apoptotic and necrotic death of mouse liver cells in vivo. Arch Toxicol 73(10-11): 594-606, 2000
19. Ray SD: Cell Death and apoptosis, Vol 1, Chapter 9, In: General & Applied Toxicology, Ballantyne, B.; Marrs, T.; Turner, P. eds.; Nature Publishing (McMillan), London, Pp. 175-213, 1999
20. Liu J, Li C, Waalkes MP, Clark J, Myers P, Saavedra JE, Keefer LK: The nitric oxide donor, V-PYRRO/NO, protects against acetaminophen-induced hepatotoxicity in mice. Hepatology 37(2): 324-333, 2003
21. Ray SD, Bagchi D: Roles of Polyphenoles, Flavonoids and Oligomeric Proanthocyanidins in Cancer Chemoprevention, Chapter 21, In: Bagchi, D. and Preuss, H. G. Eds., CRC Press, Boca Raton, FL, Pp. 311-348, 2004
22. Moskaug JO, Carlsen H, Myhrstad MC, Blomhoff R: Polyphenols and glutathione synthesis regulation. Am J Clin Nutr 81(1 Suppl): 277S-283S, 2005
23. Hinson JA, Reid AB, McCullough SS, James LP: Acetaminophen-induced hepatotoxicity: Role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition. Drug Metab Rev 36(3-4): 805-822, 2004
24. Dhruva, D.; Ray, S. D. Role of nitric oxide in acetaminophen-induced apoptosis and necrosis and its modulation by 3-aminobenzamide. J Toxicol Clin Toxicol 34: 575, 1996
25. Ray, S. D.; Parikh, H.; Bagchi, D. Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Mutation Res 579(1-2): 81-106, 2005
26. Blazka ME, Wilmer JL, Holladay SD, Wilson RE, Luster MI: Role of proinflammatory cytokines in acetaminophen hepatotoxicity. Toxicol Appl Pharmacol 133(1): 43-52, 1995
27. Gardner CR, Laskin JD, Dubach DM, Sacco M, Durham SK, Bruno MK, et al. Reduced hepatotoxicity of acetaminophen in mice lacking inducible nitric oxide synthase: Potential role of tumor necrosis factor-alpha and interleukin-10. Toxicol Appl Pharmacol 184(1): 27-36, 2002
28. James LP, Makeup PR, Hinson JA: Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 31(12): 1499-506, 2003
29. Zhang H, Cook J, Nickel J, Yu R, Stecker K, Myers K, Dean NM: Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis. Nat Biotechnol 18(8): 862-867, 2000
30. Ishida Y, Kondo T, Ohshima T, Fujiwara H, Iwakura Y, Mukaida N: A pivotal involvement of IFN-gamma in the pathogenesis of acetaminophen-induced acute liver injury. FASEB J 16(10): 1227-1236, 2002
31. Fiorucci S, Antonelli E, Mencarelli A, Palazzetti B, Alvarez-Miller L, Muscara M, del Soldato P, Sanpaolo L, Wallace JL, Morelli A: A NO-releasing derivative of acetaminophen spares the liver by acting at several checkpoints in the Fas pathway. Br J Pharmacol 135(3): 589-599, 2002
32. Ferret PJ, Hammoud R, Tulliez M, Tran A, Trebeden H, Jaffray P, Malassagne B, Calmus Y, Weill B, Batteux F: Detoxification of reactive oxygen species by a nonpeptidyl mimic of superoxide dismutase cures acetaminophen-induced acute liver failure in the mouse. Hepatology 33(5): 1173-180, 2001
33. Esterline RL, Ray SD, Ji S: Reversible and irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Biochem Pharmacol 38(14): 2387-2390, 1989
34. Ramsay RR, Rashed MS, Nelson SD: In vitro effects of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria. Arch Biochem Biophys 273(2): 449-457, 1989
35. Burcham PC, Harman AW: Acetaminophen toxicity results in site-specific mitochondrial damage in isolated mouse hepatocytes. J Biol Chem 266(8): 5049-5054, 1991
36. Jaeschke H, Bajt ML: Intracellular Signaling Mechanisms of Acetaminophen-Induced Liver Cell Death. Toxicol Sci 89(1): 31-41, 2005
37. Gottlieb, E.; Vander Heiden, M. G.; Thompson, C. B. Bcl-xL Prevents the Initial Decrease in Mitochondrial Membrane Potential and Subsequent Reactive Oxygen Species Production during Tumor Necrosis Factor Alpha-Induced Apoptosis. Mol Cell Biol. 20(15): 5680-5689; 2000.
38. Napirei M, Basnakian AG, Apostolov EO, Mannherz HG. Deoxyribonuclease 1 aggravates acetaminophen-induced liver necrosis in male CD-1 mice. Hepatology 43(2): 297-305, 2006
39. Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ, Meyn RE: Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene 15: 1461-1470, 1997
40. Tyurina YT, Tyurin VA, Carta G, Quinn PJ, Schor NF, Kagan VE: Direct evidence for antioxidant effect of Bcl-2 in PC12 rat pheochromocytoma cells. Arch Biochem Biophys 344: 413-423, 1997
41. Molnar D, Torok K, Erhardt E, Jeges S: Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. Int J Obes Relat Metab Disord 24: 1573-1578, 2000
42. Haller CA, Jacob P III., Benowitz NL: Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use. Clin Pharmacol Ther 71: 421-432, 2002
43. Morgenstern LB, Viscoli CM, Kernan WN: Use of Ephedra containing products and risk for hemorrhagic stroke. Neurology 60: 132-135, 2003
44. Shekelle PG, Hardy ML, Morton SC: Efficacy and safety of ephedra and ephedrine for weight loss and athletic performance: A meta-analysis. JAMA 289: 1537-1545, 2003
45. CRN. The CANTOX report on ephedra. Council for Responsible Nutrition, Washington DC; 2002 (see http://www.crnusa.org/cantoxoverview.html).