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Volumn 10, Issue 5, 2015, Pages 841-851

An update on iron acquisition by Legionella pneumophila: New pathways for siderophore uptake and ferric iron reduction

Author keywords

bacterial virulence; c type cytochromes; FeoB; Gram negative bacteria; iron acquisition; legiobactin siderophore; Legionella pneumophila; Legionnaires' disease; pyomelanin pigment

Indexed keywords

CYTOCHROME; FERRIC ION; IRON; SIDEROPHORE; BACTERIAL PROTEIN; CYTOCHROME C; FERROUS ION; LEGIOBACTIN PROTEIN, LEGIONELLA PNEUMOPHILA; MELANIN; PYOMELANIN;

EID: 84929721464     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.15.21     Document Type: Review
Times cited : (36)

References (81)
  • 1
    • 84922990107 scopus 로고    scopus 로고
    • Legionnnaires' Disease
    • Rosenberg E, DeLong EF, Thompson F, Lory S, Stackebrandt E (Eds). Springer, Berlin, Heidelberg, Germany
    • th Edition). Rosenberg E, DeLong EF, Thompson F, Lory S, Stackebrandt E (Eds). Springer, Berlin, Heidelberg, Germany, 147-217 (2013).
    • (2013) th Edition) , pp. 147-217
    • Cianciotto, N.P.1    Hilbi, H.2    Buchrieser, C.3
  • 2
    • 84920985050 scopus 로고    scopus 로고
    • Current and emerging Legionella diagnostics for laboratory and outbreak investigations
    • Mercante JW, Winchell JM. Current and emerging Legionella diagnostics for laboratory and outbreak investigations. Clin. Microbiol. Rev. 28(1), 95-133 (2015).
    • (2015) Clin. Microbiol. Rev. , vol.28 , Issue.1 , pp. 95-133
    • Mercante, J.W.1    Winchell, J.M.2
  • 4
    • 84927170648 scopus 로고    scopus 로고
    • Legionella norrlandica sp. nov., isolated from the biopurification system of a wood processing plant in northern Sweden
    • Rizzardi K, Winiecka-Krusnell J, Ramliden M, Alm E, Andersson S, Byfors S. Legionella norrlandica sp. nov., isolated from the biopurification system of a wood processing plant in northern Sweden. Int. J. Syst. Evol. Microbiol. 65(Pt 2), 598-603 (2014).
    • (2014) Int. J. Syst. Evol. Microbiol. , vol.65 , pp. 598-603
    • Rizzardi, K.1    Winiecka-Krusnell, J.2    Ramliden, M.3    Alm, E.4    Andersson, S.5    Byfors, S.6
  • 5
    • 84940481302 scopus 로고    scopus 로고
    • Legionellosis on the rise: A review of guidelines for prevention in the United States
    • Epub ahead of print
    • Parr A, Whitney EA, Berkelman RL. Legionellosis on the rise: a review of guidelines for prevention in the United States. J. Public Health Manag. Pract. doi:10.1097/PHH.0000000000000123 (2014) (Epub ahead of print).
    • (2014) J. Public Health Manag. Pract.
    • Parr, A.1    Whitney, E.A.2    Berkelman, R.L.3
  • 6
    • 84908102451 scopus 로고    scopus 로고
    • Legionnaires' disease incidence and risk factors, New York, USA, 2002-2011
    • Farnham A, Alleyne L, Cimini D, Balter S. Legionnaires' disease incidence and risk factors, New York, USA, 2002-2011. Emerg. Infect. Dis. 20, 1795-1802 (2014).
    • (2014) Emerg. Infect. Dis. , vol.20 , pp. 1795-1802
    • Farnham, A.1    Alleyne, L.2    Cimini, D.3    Balter, S.4
  • 7
    • 84856085681 scopus 로고    scopus 로고
    • Legionellae in engineered systems and use of quantitative microbial risk assessment to predict exposure
    • Buse HY, Schoen ME, Ashbolt NJ. Legionellae in engineered systems and use of quantitative microbial risk assessment to predict exposure. Water Res. 46, 921-933 (2012).
    • (2012) Water Res , vol.46 , pp. 921-933
    • Buse, H.Y.1    Schoen, M.E.2    Ashbolt, N.J.3
  • 8
    • 84915819038 scopus 로고    scopus 로고
    • The novel Legionella pneumophila type II secretion substrate NttC contriubtes to infection of amoebae Hartmannella vermiformis and Willaertia magna
    • Tyson JY, Vargas P, Cianciotto NP. The novel Legionella pneumophila type II secretion substrate NttC contriubtes to infection of amoebae Hartmannella vermiformis and Willaertia magna. Microbiology 160(12), 2732-2744 (2014).
    • (2014) Microbiology , vol.160 , Issue.12 , pp. 2732-2744
    • Tyson, J.Y.1    Vargas, P.2    Cianciotto, N.P.3
  • 9
    • 67149086817 scopus 로고    scopus 로고
    • Potentially pathogenic amoeba-associated microorganisms in cooling towers and their control
    • Pagnier I, Merchat M, La Scola B. Potentially pathogenic amoeba-associated microorganisms in cooling towers and their control. Future Microbiol. 4, 615-629 (2009).
    • (2009) Future Microbiol , vol.4 , pp. 615-629
    • Pagnier, I.1    Merchat, M.2    La Scola, B.3
  • 10
    • 77950662773 scopus 로고    scopus 로고
    • Molecular pathogenesis of infections caused by Legionella pneumophila
    • Newton HJ, Ang DK, Van Driel IR, Hartland EL. Molecular pathogenesis of infections caused by Legionella pneumophila. Clin. Microbiol. Rev. 23(2), 274-298 (2010).
    • (2010) Clin. Microbiol. Rev. , vol.23 , Issue.2 , pp. 274-298
    • Newton, H.J.1    Ang, D.K.2    Van Driel, I.R.3    Hartland, E.L.4
  • 11
    • 70349206314 scopus 로고    scopus 로고
    • Many substrates and functions of type II protein secretion: Lessons learned from Legionella pneumophila
    • Cianciotto NP. Many substrates and functions of type II protein secretion: lessons learned from Legionella pneumophila. Future Microbiol. 4, 797-805 (2009).
    • (2009) Future Microbiol , vol.4 , pp. 797-805
    • Cianciotto, N.P.1
  • 12
    • 84915815720 scopus 로고    scopus 로고
    • Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell
    • Rolando M, Buchrieser C. Legionella pneumophila type IV effectors hijack the transcription and translation machinery of the host cell. Trends Cell Biol 24(12), 771-778 (2014).
    • (2014) Trends Cell Biol , vol.24 , Issue.12 , pp. 771-778
    • Rolando, M.1    Buchrieser, C.2
  • 13
    • 34248666720 scopus 로고    scopus 로고
    • Iron acquisition by Legionella pneumophila
    • Cianciotto NP. Iron acquisition by Legionella pneumophila. Biometals 20, 323-331 (2007).
    • (2007) Biometals , vol.20 , pp. 323-331
    • Cianciotto, N.P.1
  • 14
    • 0036785675 scopus 로고    scopus 로고
    • Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection
    • Robey M, Cianciotto NP. Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection. Infect. Immun. 70, 5659-5669 (2002).
    • (2002) Infect. Immun. , vol.70 , pp. 5659-5669
    • Robey, M.1    Cianciotto, N.P.2
  • 15
    • 0033977291 scopus 로고    scopus 로고
    • Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila
    • Liles MR, Aber Scheel T, Cianciotto NP. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila. J. Bacteriol. 182, 749-757 (2000).
    • (2000) J. Bacteriol. , vol.182 , pp. 749-757
    • Liles, M.R.1    Aber Scheel, T.2    Cianciotto, N.P.3
  • 16
    • 32544436456 scopus 로고    scopus 로고
    • lbtA and lbtB are required for production of the Legionella pneumophila siderophore legiobactin
    • Allard KA, Viswanathan VK, Cianciotto NP. lbtA and lbtB are required for production of the Legionella pneumophila siderophore legiobactin. J. Bacteriol. 188(4), 1351-1363 (2006).
    • (2006) J. Bacteriol. , vol.188 , Issue.4 , pp. 1351-1363
    • Allard, K.A.1    Viswanathan, V.K.2    Cianciotto, N.P.3
  • 17
    • 67650093028 scopus 로고    scopus 로고
    • Purification of legiobactin and the importance of this siderophore in lung infection by Legionella pneumophila
    • Allard KA, Dao J, Sanjeevaiah P et al. Purification of legiobactin and the importance of this siderophore in lung infection by Legionella pneumophila. Infect. Immun. 77, 2887-2895 (2009).
    • (2009) Infect. Immun. , vol.77 , pp. 2887-2895
    • Allard, K.A.1    Dao, J.2    Sanjeevaiah, P.3
  • 18
    • 79952796132 scopus 로고    scopus 로고
    • Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore
    • Chatfield CH, Mulhern BJ, Burnside DM, Cianciotto NP. Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore. J. Bacteriol. 193(7), 1563-1575 (2011).
    • (2011) J. Bacteriol. , vol.193 , Issue.7 , pp. 1563-1575
    • Chatfield, C.H.1    Mulhern, B.J.2    Burnside, D.M.3    Cianciotto, N.P.4
  • 19
    • 79952254708 scopus 로고    scopus 로고
    • Cytochrome c4 is required for siderophore expression by Legionella pneumophila, whereas cytochromes c1 and c5 promote intracellular infection
    • Yip ES, Burnside DM, Cianciotto NP. Cytochrome c4 is required for siderophore expression by Legionella pneumophila, whereas cytochromes c1 and c5 promote intracellular infection. Microbiology 157(3), 868-878 (2011).
    • (2011) Microbiology , vol.157 , Issue.3 , pp. 868-878
    • Yip, E.S.1    Burnside, D.M.2    Cianciotto, N.P.3
  • 20
    • 84857755708 scopus 로고    scopus 로고
    • The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila
    • Chatfield CH, Mulhern BJ, Viswanathan VK, Cianciotto NP. The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila. Microbiology 158, 721-735 (2012).
    • (2012) Microbiology , vol.158 , pp. 721-735
    • Chatfield, C.H.1    Mulhern, B.J.2    Viswanathan, V.K.3    Cianciotto, N.P.4
  • 21
    • 34547647647 scopus 로고    scopus 로고
    • The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity
    • Chatfield CH, Cianciotto NP. The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity. Infect. Immun. 75(8), 4062-4070 (2007).
    • (2007) Infect. Immun. , vol.75 , Issue.8 , pp. 4062-4070
    • Chatfield, C.H.1    Cianciotto, N.P.2
  • 22
    • 84886804548 scopus 로고    scopus 로고
    • Secreted pyomelanin of Legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions
    • Zheng H, Chatfield CH, Liles MR, Cianciotto NP. Secreted pyomelanin of Legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions. Infect. Immun. 81, 4182-4191 (2013).
    • (2013) Infect. Immun. , vol.81 , pp. 4182-4191
    • Zheng, H.1    Chatfield, C.H.2    Liles, M.R.3    Cianciotto, N.P.4
  • 23
    • 78049436241 scopus 로고    scopus 로고
    • The genome of Legionella pneumophila strain 130b contains a unique combination of type IV secretion systems and encodes novel Dot/Icm secretion system effector proteins
    • Schroeder GN, Petty NK, Mousnier A et al. The genome of Legionella pneumophila strain 130b contains a unique combination of type IV secretion systems and encodes novel Dot/Icm secretion system effector proteins. J. Bacteriol. 192, 6001-6016 (2010).
    • (2010) J. Bacteriol. , vol.192 , pp. 6001-6016
    • Schroeder, G.N.1    Petty, N.K.2    Mousnier, A.3
  • 24
    • 10044263696 scopus 로고    scopus 로고
    • Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity
    • Cazalet C, Rusniok C, Bruggemann H et al. Evidence in the Legionella pneumophila genome for exploitation of host cell functions and high genome plasticity. Nat. Genet. 36(11), 1165-1173 (2004).
    • (2004) Nat. Genet. , vol.36 , Issue.11 , pp. 1165-1173
    • Cazalet, C.1    Rusniok, C.2    Bruggemann, H.3
  • 25
    • 4644276577 scopus 로고    scopus 로고
    • The genomic sequence of the accidental pathogen Legionella pneumophila
    • Chien M, Morozova I, Shi S et al. The genomic sequence of the accidental pathogen Legionella pneumophila. Science 305(5692), 1966-1968 (2004).
    • (2004) Science , vol.305 , Issue.5692 , pp. 1966-1968
    • Chien, M.1    Morozova, I.2    Shi, S.3
  • 26
    • 85017810674 scopus 로고    scopus 로고
    • National Center for Biotechnology Information (NCBI). www.ncbi.nlm.nih.gov
  • 27
    • 85017798088 scopus 로고    scopus 로고
    • LegioList. http://genolist.pasteur.fr/LegioList
  • 28
    • 84864113215 scopus 로고    scopus 로고
    • Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis
    • Ramakrishnan G, Sen B, Johnson R. Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in Francisella tularensis tularensis. J. Biol. Chem. 287(30), 25191-25202 (2012).
    • (2012) J. Biol. Chem. , vol.287 , Issue.30 , pp. 25191-25202
    • Ramakrishnan, G.1    Sen, B.2    Johnson, R.3
  • 29
    • 84870207309 scopus 로고    scopus 로고
    • Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems
    • Lloubes R, Goemaere E, Zhang X, Cascales E, Duche D. Energetics of colicin import revealed by genetic cross-complementation between the Tol and Ton systems. Biochem. Soc. Trans. 40(6), 1480-1485 (2012).
    • (2012) Biochem. Soc. Trans. , vol.40 , Issue.6 , pp. 1480-1485
    • Lloubes, R.1    Goemaere, E.2    Zhang, X.3    Cascales, E.4    Duche, D.5
  • 30
    • 34248636774 scopus 로고    scopus 로고
    • Bioinformatic analysis of the TonB protein family
    • Chu BC, Peacock RS, Vogel HJ. Bioinformatic analysis of the TonB protein family. Biometals 20(3-4), 467-483 (2007).
    • (2007) Biometals , vol.20 , Issue.3-4 , pp. 467-483
    • Chu, B.C.1    Peacock, R.S.2    Vogel, H.J.3
  • 32
    • 2442485987 scopus 로고    scopus 로고
    • Identification of rhtX and fptX, novel genes encoding proteins that show homology and function in the utilization of the siderophores rhizobactin 1021 by Sinorhizobium meliloti and pyochelin by Pseudomonas aeruginosa, respectively
    • Cuiv PO, Clarke P, Lynch D, O'Connell M. Identification of rhtX and fptX, novel genes encoding proteins that show homology and function in the utilization of the siderophores rhizobactin 1021 by Sinorhizobium meliloti and pyochelin by Pseudomonas aeruginosa, respectively. J. Bacteriol. 186(10), 2996-3005 (2004).
    • (2004) J. Bacteriol. , vol.186 , Issue.10 , pp. 2996-3005
    • Cuiv, P.O.1    Clarke, P.2    Lynch, D.3    O'Connell, M.4
  • 33
    • 34249294573 scopus 로고    scopus 로고
    • Ferripyochelin uptake genes are involved in pyochelin-mediated signalling in Pseudomonas aeruginosa
    • Michel L, Bachelard A, Reimmann C. Ferripyochelin uptake genes are involved in pyochelin-mediated signalling in Pseudomonas aeruginosa. Microbiology 153(5), 1508-1518 (2007).
    • (2007) Microbiology , vol.153 , Issue.5 , pp. 1508-1518
    • Michel, L.1    Bachelard, A.2    Reimmann, C.3
  • 35
    • 53849119555 scopus 로고    scopus 로고
    • Ins and outs of major facilitator superfamily antiporters
    • Law CJ, Maloney PC, Wang DN. Ins and outs of major facilitator superfamily antiporters. Annu. Rev. Microbiol. 62, 289-305 (2008).
    • (2008) Annu. Rev. Microbiol. , vol.62 , pp. 289-305
    • Law, C.J.1    Maloney, P.C.2    Wang, D.N.3
  • 36
    • 0036129789 scopus 로고    scopus 로고
    • The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element
    • Viswanathan VK, Kurtz S, Pedersen LL et al. The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element. Infect. Immun. 70(4), 1842-1852 (2002).
    • (2002) Infect. Immun. , vol.70 , Issue.4 , pp. 1842-1852
    • Viswanathan, V.K.1    Kurtz, S.2    Pedersen, L.L.3
  • 37
    • 10444232719 scopus 로고    scopus 로고
    • Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophila
    • Naylor J, Cianciotto NP. Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophila. FEMS Microbiol. Lett. 241(2), 249-256 (2004).
    • (2004) FEMS Microbiol. Lett. , vol.241 , Issue.2 , pp. 249-256
    • Naylor, J.1    Cianciotto, N.P.2
  • 38
    • 20344383510 scopus 로고    scopus 로고
    • Impact of the bacterial type I cytochrome c maturation system on different biological processes
    • Cianciotto NP, Cornelis P, Baysse C. Impact of the bacterial type I cytochrome c maturation system on different biological processes. Mol. Microbiol. 56(6), 1408-1415 (2005).
    • (2005) Mol. Microbiol. , vol.56 , Issue.6 , pp. 1408-1415
    • Cianciotto, N.P.1    Cornelis, P.2    Baysse, C.3
  • 40
    • 38849191757 scopus 로고    scopus 로고
    • Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa
    • Baert B, Baysse C, Matthijs S, Cornelis P. Multiple phenotypic alterations caused by a c-type cytochrome maturation ccmC gene mutation in Pseudomonas aeruginosa. Microbiology 154(1), 127-138 (2008).
    • (2008) Microbiology , vol.154 , Issue.1 , pp. 127-138
    • Baert, B.1    Baysse, C.2    Matthijs, S.3    Cornelis, P.4
  • 41
    • 77955890343 scopus 로고    scopus 로고
    • Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation
    • Yeterian E, Martin LW, Guillon L, Journet L, Lamont IL, Schalk IJ. Synthesis of the siderophore pyoverdine in Pseudomonas aeruginosa involves a periplasmic maturation. Amino Acids 38(5), 1447-1459 (2010).
    • (2010) Amino Acids , vol.38 , Issue.5 , pp. 1447-1459
    • Yeterian, E.1    Martin, L.W.2    Guillon, L.3    Journet, L.4    Lamont, I.L.5    Schalk, I.J.6
  • 42
    • 34447634995 scopus 로고    scopus 로고
    • Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung
    • Debroy S, Dao J, Soderberg M, Rossier O, Cianciotto NP. Legionella pneumophila type II secretome reveals unique exoproteins and a chitinase that promotes bacterial persistence in the lung. Proc. Natl acad. Sci. USA 103(50), 19146-19151 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.50 , pp. 19146-19151
    • Debroy, S.1    Dao, J.2    Soderberg, M.3    Rossier, O.4    Cianciotto, N.P.5
  • 43
    • 0026035244 scopus 로고
    • Interferon-gamma induced resistance to Legionella pneumophila in susceptible A/J mouse macrophages
    • Klein TW, Yamamoto Y, Brown HK, Friedman H. Interferon-gamma induced resistance to Legionella pneumophila in susceptible A/J mouse macrophages. J. Leuk. Biol. 49(1), 98-103 (1991).
    • (1991) J. Leuk. Biol. , vol.49 , Issue.1 , pp. 98-103
    • Klein, T.W.1    Yamamoto, Y.2    Brown, H.K.3    Friedman, H.4
  • 44
    • 33646593180 scopus 로고    scopus 로고
    • How pathogenic bacteria evade mammalian sabotage in the battle for iron
    • Fischbach MA, Lin H, Liu DR, Walsh CT. How pathogenic bacteria evade mammalian sabotage in the battle for iron. Nat. Chem. Biol. 2(3), 132-138 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , Issue.3 , pp. 132-138
    • Fischbach, M.A.1    Lin, H.2    Liu, D.R.3    Walsh, C.T.4
  • 45
    • 0033963969 scopus 로고    scopus 로고
    • The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence
    • Viswanathan VK, Edelstein PH, Pope CD, Cianciotto NP. The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence. Infect. Immun. 68, 1069-1079 (2000).
    • (2000) Infect. Immun. , vol.68 , pp. 1069-1079
    • Viswanathan, V.K.1    Edelstein, P.H.2    Pope, C.D.3    Cianciotto, N.P.4
  • 46
    • 0030056852 scopus 로고    scopus 로고
    • A Legionella pneumophila gene that promotes hemin binding
    • O'Connell WA, Hickey EK, Cianciotto NP. A Legionella pneumophila gene that promotes hemin binding. Infect. Immun. 64, 842-848 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 842-848
    • O'Connell, W.A.1    Hickey, E.K.2    Cianciotto, N.P.3
  • 47
    • 0031032030 scopus 로고    scopus 로고
    • An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases
    • Hickey EK, Cianciotto NP. An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases. Infect. Immun. 65, 133-143 (1997).
    • (1997) Infect. Immun. , vol.65 , pp. 133-143
    • Hickey, E.K.1    Cianciotto, N.P.2
  • 48
    • 0037221477 scopus 로고    scopus 로고
    • Siderophore-mediated cell signalling in Pseudomonas aeruginosa: Divergent pathways regulate virulence factor production and siderophore receptor synthesis
    • Beare PA, For RJ, Martin LW, Lamont IL. Siderophore-mediated cell signalling in Pseudomonas aeruginosa: divergent pathways regulate virulence factor production and siderophore receptor synthesis. Mol. Microbiol. 47(1), 195-207 (2003).
    • (2003) Mol. Microbiol. , vol.47 , Issue.1 , pp. 195-207
    • Beare, P.A.1    For, R.J.2    Martin, L.W.3    Lamont, I.L.4
  • 49
    • 0037076382 scopus 로고    scopus 로고
    • Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa
    • Lamont IL, Beare PA, Ochsner U, Vasil AI, Vasil ML. Siderophore-mediated signaling regulates virulence factor production in Pseudomonas aeruginosa. Proc. Natl Acad. Sci. USA 99(10), 7072-7077 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , Issue.10 , pp. 7072-7077
    • Lamont, I.L.1    Beare, P.A.2    Ochsner, U.3    Vasil, A.I.4    Vasil, M.L.5
  • 50
    • 33745783491 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity
    • Bredenbruch F, Geffers R, Nimtz M, Buer J, Haussler S. The Pseudomonas aeruginosa quinolone signal (PQS) has an iron-chelating activity. Environ. Microbiol. 8(8), 1318-1329 (2006).
    • (2006) Environ. Microbiol. , vol.8 , Issue.8 , pp. 1318-1329
    • Bredenbruch, F.1    Geffers, R.2    Nimtz, M.3    Buer, J.4    Haussler, S.5
  • 51
    • 0031026577 scopus 로고    scopus 로고
    • Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin
    • Britigan BE, Rasmussen GT, Cox CD. Augmentation of oxidant injury to human pulmonary epithelial cells by the Pseudomonas aeruginosa siderophore pyochelin. Infect. Immun. 65(3), 1071-1076 (1997).
    • (1997) Infect. Immun. , vol.65 , Issue.3 , pp. 1071-1076
    • Britigan, B.E.1    Rasmussen, G.T.2    Cox, C.D.3
  • 52
    • 0018399823 scopus 로고
    • Aromatic substrate specificity of browning by cultures of the Legionnaires' disease bacterium
    • Baine WB, Rasheed JK. Aromatic substrate specificity of browning by cultures of the Legionnaires' disease bacterium. Ann. Int. Med. 90(4), 619-620 (1979).
    • (1979) Ann. Int. Med. , vol.90 , Issue.4 , pp. 619-620
    • Baine, W.B.1    Rasheed, J.K.2
  • 53
    • 0035845641 scopus 로고    scopus 로고
    • The Lly protein is essential for p-hydroxyphenylpyruvate dioxygenase activity in Legionella pneumophila
    • Steinert M, Flugel M, Schuppler M et al. The Lly protein is essential for p-hydroxyphenylpyruvate dioxygenase activity in Legionella pneumophila. FEMS Microbiol. Lett. 203(1), 41-47 (2001).
    • (2001) FEMS Microbiol. Lett. , vol.203 , Issue.1 , pp. 41-47
    • Steinert, M.1    Flugel, M.2    Schuppler, M.3
  • 54
    • 84866885058 scopus 로고    scopus 로고
    • Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis
    • Flydal MI, Chatfield CH, Zheng H et al. Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis. PLoS ONE 7(9), e46209 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.9 , pp. e46209
    • Flydal, M.I.1    Chatfield, C.H.2    Zheng, H.3
  • 55
    • 0029077898 scopus 로고
    • The Lly protein protects Legionella pneumophila from light but does not directly influence its intracellular survival in Hartmannella vermiformis
    • Steinert M, Engelhard H, Flugel M, Wintermeyer E, Hacker J. The Lly protein protects Legionella pneumophila from light but does not directly influence its intracellular survival in Hartmannella vermiformis. Appl. Environ. Microbiol. 61(6), 2428-2430 (1995).
    • (1995) Appl. Environ. Microbiol. , vol.61 , Issue.6 , pp. 2428-2430
    • Steinert, M.1    Engelhard, H.2    Flugel, M.3    Wintermeyer, E.4    Hacker, J.5
  • 56
    • 78049415071 scopus 로고    scopus 로고
    • A putative ABC transporter, HatABCDE, is among molecular determinants of pyomelanin production in Pseudomonas aeruginosa
    • Hunter RC, Newman DK. A putative ABC transporter, HatABCDE, is among molecular determinants of pyomelanin production in Pseudomonas aeruginosa. J. Bacteriol. 192(22), 5962-5971 (2010).
    • (2010) J. Bacteriol. , vol.192 , Issue.22 , pp. 5962-5971
    • Hunter, R.C.1    Newman, D.K.2
  • 57
    • 62449189465 scopus 로고    scopus 로고
    • A role of melanin pigment in expression of Vibrio cholerae virulence factors
    • Valeru SP, Rompikuntal PK, Ishikawa T et al. A role of melanin pigment in expression of Vibrio cholerae virulence factors. Infect. Immun. 77(3), 935-942 (2009).
    • (2009) Infect. Immun. , vol.77 , Issue.3 , pp. 935-942
    • Valeru, S.P.1    Rompikuntal, P.K.2    Ishikawa, T.3
  • 58
    • 79960419185 scopus 로고    scopus 로고
    • Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition
    • Wang Y, Wilks JC, Danhorn T, Ramos I, Croal L, Newman DK. Phenazine-1-carboxylic acid promotes bacterial biofilm development via ferrous iron acquisition. J. Bacteriol. 193(14), 3606-3617 (2011).
    • (2011) J. Bacteriol. , vol.193 , Issue.14 , pp. 3606-3617
    • Wang, Y.1    Wilks, J.C.2    Danhorn, T.3    Ramos, I.4    Croal, L.5    Newman, D.K.6
  • 59
    • 33646950239 scopus 로고    scopus 로고
    • Iron transport in Escherichia coli: All has not been said and done
    • Grass G. Iron transport in Escherichia coli: all has not been said and done. Biometals 19(2), 159-172 (2006).
    • (2006) Biometals , vol.19 , Issue.2 , pp. 159-172
    • Grass, G.1
  • 60
    • 0027620344 scopus 로고
    • Ferric reductases of Legionella pneumophila
    • Poch MT, Johnson W. Ferric reductases of Legionella pneumophila. Biometals 6, 107-114 (1993).
    • (1993) Biometals , vol.6 , pp. 107-114
    • Poch, M.T.1    Johnson, W.2
  • 61
    • 0030933282 scopus 로고    scopus 로고
    • A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture
    • James BW, Mauchline WS, Dennis PJ, Keevil CW. A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture. Curr. Microbiol. 34, 238-243 (1997).
    • (1997) Curr. Microbiol. , vol.34 , pp. 238-243
    • James, B.W.1    Mauchline, W.S.2    Dennis, P.J.3    Keevil, C.W.4
  • 62
    • 34047268399 scopus 로고    scopus 로고
    • Real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in Pseudomonas aeruginosa. A role for ferrous iron
    • Greenwald J, Hoegy F, Nader M et al. Real time fluorescent resonance energy transfer visualization of ferric pyoverdine uptake in Pseudomonas aeruginosa. A role for ferrous iron. J. Biol. Chem. 282(5), 2987-2995 (2007).
    • (2007) J. Biol. Chem. , vol.282 , Issue.5 , pp. 2987-2995
    • Greenwald, J.1    Hoegy, F.2    Nader, M.3
  • 63
    • 34548739613 scopus 로고    scopus 로고
    • Siderophore-based iron acquisition and pathogen control
    • Miethke M, Marahiel MA. Siderophore-based iron acquisition and pathogen control. Microbiol. Mol. Biol. Rev. 71(3), 413-451 (2007).
    • (2007) Microbiol. Mol. Biol. Rev. , vol.71 , Issue.3 , pp. 413-451
    • Miethke, M.1    Marahiel, M.A.2
  • 65
    • 0036032176 scopus 로고    scopus 로고
    • The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition
    • Huston WM, Jennings MP, Mcewan AG. The multicopper oxidase of Pseudomonas aeruginosa is a ferroxidase with a central role in iron acquisition. Mol. Microbiol. 45(6), 1741-1750 (2002).
    • (2002) Mol. Microbiol. , vol.45 , Issue.6 , pp. 1741-1750
    • Huston, W.M.1    Jennings, M.P.2    Mcewan, A.G.3
  • 67
    • 84926415727 scopus 로고    scopus 로고
    • IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages
    • Portier E, Zheng H, Sahr T et al. IroT/mavN, a new iron-regulated gene involved in Legionella pneumophila virulence against amoebae and macrophages. Environ. Microbiol. 17(4), 1338-1350 (2014).
    • (2014) Environ. Microbiol. , vol.17 , Issue.4 , pp. 1338-1350
    • Portier, E.1    Zheng, H.2    Sahr, T.3
  • 68
    • 16244414601 scopus 로고    scopus 로고
    • The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection
    • Rossier O, Cianciotto NP. The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection. Infect. Immun. 73(4), 2020-2032 (2005).
    • (2005) Infect. Immun. , vol.73 , Issue.4 , pp. 2020-2032
    • Rossier, O.1    Cianciotto, N.P.2
  • 69
    • 84886682509 scopus 로고    scopus 로고
    • Type II secretion and Legionella virulence
    • Cianciotto NP. Type II secretion and Legionella virulence. Curr. Top. Microbiol. Immunol. 376, 81-102 (2013).
    • (2013) Curr. Top. Microbiol. Immunol. , vol.376 , pp. 81-102
    • Cianciotto, N.P.1
  • 70
    • 0028275302 scopus 로고
    • Cloning and sequencing of the Legionella pneumophila fur gene
    • Hickey EK, Cianciotto NP. Cloning and sequencing of the Legionella pneumophila fur gene. Gene 143, 117-121 (1994).
    • (1994) Gene , vol.143 , pp. 117-121
    • Hickey, E.K.1    Cianciotto, N.P.2
  • 71
    • 0030033029 scopus 로고    scopus 로고
    • Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection
    • Pope CD, O'Connell W, Cianciotto NP. Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection. Infect. Immun. 64, 629-636 (1996).
    • (1996) Infect. Immun. , vol.64 , pp. 629-636
    • Pope, C.D.1    O'Connell, W.2    Cianciotto, N.P.3
  • 72
    • 33745767998 scopus 로고    scopus 로고
    • Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila
    • Bruggemann H, Hagman A, Jules M et al. Virulence strategies for infecting phagocytes deduced from the in vivo transcriptional program of Legionella pneumophila. Cell. Microbiol. 8(8), 1228-1240 (2006).
    • (2006) Cell. Microbiol. , vol.8 , Issue.8 , pp. 1228-1240
    • Bruggemann, H.1    Hagman, A.2    Jules, M.3
  • 73
    • 84858001166 scopus 로고    scopus 로고
    • Legionella pneumophila transcriptome during intracellular multiplication in human macrophages
    • Faucher SP, Mueller CA, Shuman HA. Legionella pneumophila transcriptome during intracellular multiplication in human macrophages. Front. Microbiol. 2, 215158 (2011).
    • (2011) Front. Microbiol. , vol.2 , pp. 215158
    • Faucher, S.P.1    Mueller, C.A.2    Shuman, H.A.3
  • 74
  • 76
    • 41849151739 scopus 로고    scopus 로고
    • Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis
    • Stirrett KL, Ferreras JA, Jayaprakash V, Sinha BN, Ren T, Quadri LE. Small molecules with structural similarities to siderophores as novel antimicrobials against Mycobacterium tuberculosis and Yersinia pestis. Bioorg. Med. Chem. Lett. 18(8), 2662-2668 (2008).
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , Issue.8 , pp. 2662-2668
    • Stirrett, K.L.1    Ferreras, J.A.2    Jayaprakash, V.3    Sinha, B.N.4    Ren, T.5    Quadri, L.E.6
  • 77
    • 35648991971 scopus 로고    scopus 로고
    • Strategic paradigm shifts in the antimicrobial drug discovery process of the 21st century
    • st century. Infect. Disord. Drug Targets 7(3), 230-237 (2007).
    • (2007) Infect. Disord. Drug Targets , vol.7 , Issue.3 , pp. 230-237
    • Quadri, L.E.1
  • 78
    • 70349680258 scopus 로고    scopus 로고
    • Mucosal immunization with iron receptor antigens protects against urinary tract infection
    • Alteri CJ, Hagan EC, Sivick KE, Smith SN, Mobley HLT. Mucosal immunization with iron receptor antigens protects against urinary tract infection. PLoS Pathog. 5, e1000586 (2009).
    • (2009) PLoS Pathog. , vol.5 , pp. e1000586
    • Alteri, C.J.1    Hagan, E.C.2    Sivick, K.E.3    Smith, S.N.4    Mobley, H.L.T.5
  • 79
    • 65549163793 scopus 로고    scopus 로고
    • FvtA is the receptor for the siderophore vanchrobactin in Vibrio anguillarum: Utility as a route of entry for vanchrobactin analogues
    • Balado M, Osorio CR, Lemos ML. FvtA is the receptor for the siderophore vanchrobactin in Vibrio anguillarum: utility as a route of entry for vanchrobactin analogues. Appl. Environ. Microbiol. 75(9), 2775-2783 (2009).
    • (2009) Appl. Environ. Microbiol. , vol.75 , Issue.9 , pp. 2775-2783
    • Balado, M.1    Osorio, C.R.2    Lemos, M.L.3
  • 80
    • 67651222492 scopus 로고    scopus 로고
    • Iron trafficking as an antimicrobial target
    • Frederick RE, Mayfield JA, Dubois JL. Iron trafficking as an antimicrobial target. Biometals 22(4), 583-593 (2009).
    • (2009) Biometals , vol.22 , Issue.4 , pp. 583-593
    • Frederick, R.E.1    Mayfield, J.A.2    Dubois, J.L.3
  • 81
    • 67651247638 scopus 로고    scopus 로고
    • Siderophores as drug delivery agents: Application of the "Trojan Horse" strategy
    • Mollmann U, Heinisch L, Bauernfeind A, Kohler T, Ankel-Fuchs D. Siderophores as drug delivery agents: application of the "Trojan Horse" strategy. Biometals 22(4), 615-624 (2009).
    • (2009) Biometals , vol.22 , Issue.4 , pp. 615-624
    • Mollmann, U.1    Heinisch, L.2    Bauernfeind, A.3    Kohler, T.4    Ankel-Fuchs, D.5


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