The cytochrome C maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element

Infection and Immunity

Volumn 70, Issue 4, 2002, Pages 1842-1852

  Viswanathan, V K ^a   Kurtz, Sherry ^a   Pedersen, Lisa L ^a   Abu Kwaik, Yousef ^a   Krcmarik, Kevin ^a   Mody, Sejal ^a   Cianciotto, Nicholas P ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; CYTOCHROME C; LEGIOBACTIN; SIDEROPHORE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIUM MUTANT; BIOGENESIS; CELL STRAIN U937; CONTROLLED STUDY; GENE INSERTION SEQUENCE; GENE MUTATION; GENETIC COMPLEMENTATION; HUMAN; HUMAN CELL; INFECTION; IRON CHELATION; IRON STORAGE; LEGIONELLA PNEUMOPHILA; MACROPHAGE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOUTHERN BLOTTING; STRAIN DIFFERENCE; TRANSPOSON;

ACANTHAMOEBA; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; CHROMOSOME MAPPING; DNA TRANSPOSABLE ELEMENTS; GENETIC COMPLEMENTATION TEST; IRON; LEGIONELLA PNEUMOPHILA; MACROPHAGES; MEMBRANE PROTEINS; OPEN READING FRAMES; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC;

EID: 0036129789     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.70.4.1842-1852.2002     Document Type: Article

References (87)

1. Fatal attraction of mammalian cells to Legionella pneumophila
2. Temporal pore formation-mediated egress from macrophages and alveolar epithelial cells by Legionella pneumophila
3. Secreted enzymatic activities of wild-type and pilD-deficient Legionella pneumophila
4. Legionella: From environmental habitats to disease pathology, detection and control
5. Legionella pneumophila serogroup 14 isolated from patients with fatal pneumonia
6. Conserved structure of IS 200 elements in Salmonella
7. Isolation and characterization of a seventh serogroup of Legionella pneumophila
8. Isolation of a Rhodobacter capsulatus mutant that lacks c-type cytochromes and excretes porphyrins
9. New serogroup of Legionella pneumophila, serogroup 8
10. Bactericidal effect of lactoferrin on Legionella pneumophila: Effect of the physiological state of the organism
11. Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova
12. Intrapulmonary Hartmannella vermiformis: A potential niche for Legionella pneumophila replication in a murine model of legionellosis
13. Nucleotide sequence of IS110, an insertion sequence of Streptomyces coelicolor A3(2)
14. Aberrantly low transferrin receptor expression on human monocytes is associated with nonpermissiveness for Legionella pneumophila growth
15. Interferon gamma-activated human monocytes downregulate transferrin receptors and inhibit the intracellular multiplication of Legionella pneumophila by limiting the availability of iron
16. Lactoferrin inhibits or promotes Legionella pneumophila intracellular multiplication in nonactivated and interferon gamma-activated human monocytes depending upon its degree of iron saturation. Iron-lactoferrin and nonphysiologic iron chelates reverse monocyte activation against Legionella pneumophila
17. c-type cytochromes and manganese oxidation in Pseudomonas putida MnB1
18. Virulence conversion of Legionella pneumophila: A one-way phenomenon
19. New shuttle vectors for Haemophilus influenzae and Escherichia coli: P15A-derived plasmids replicate in H. influenzae Rd
20. A Legionella pneumophila gene encoding a species-specific surface protein potentiates initiation of intracellular infection
21. Legionella pneumophila mip gene potentiates intracellular infection of protozoa and human macrophages
22. Iron requirements of and acquisition of iron by Legionella pneumophila
23. Mycobacterium tuberculosis and Legionella pneumophila phagosomes exhibit arrested maturation despite acquisition of Rab7
24. The cytochrome c maturation operon is involved in manganese oxidation in Pseudomonas putida GB-1
25. Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens
26. A fifth serogroup of Legionella pneumophila
27. Cloning and expression of Legionella pneumophila antigens in Escherichia coli
28. Characterization of the Legionella pneumophila gene ligA
29. The molecular ecology of legionellae
30. Specific indication of hemoproteins in polyacrylamide gels using a double-staining process
31. Different residues in periplasmic domains of the CcmC inner membrane protein of Pseudomonas fluorescens ATCC 17400 are critical for cytochrome c biogenesis and pyoverdine-mediated iron uptake
32. A cytochrome c biogenesis gene involved in pyoverdine production in Pseudomonas fluorescens ATCC 17400
33. Utilization of similar mechanisms by Legionella pneumophila to parasitize two evolutionarily distant host cells, mammalian macrophages and protozoa
34. Identification of macrophage-specific infectivity loci (mil) of Legionella pneumophila that are not required for infectivity of protozoa
35. Macrophage permissiveness for Legionella pneumophila growth modulated by iron
36. Metal complexes of lactoferrin and their effect on the intracellular multiplication of Legionella pneumophila
37. The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii
38. From protozoa to mammalian cells: A new paradigm in the life cycle of intracellular bacterial pathogens
39. Cloning and sequencing of the Legionella pneumophila fur gene
40. An iron- and fur-repressed Legionella pneumophila gene that promotes intracellular infection and encodes a protein with similarity to the Escherichia coli aerobactin synthetases
41. Respiratory physiology and cytochrome content of Legionella pneumophila
42. cis/trans isomerase of unsaturated fatty acids of Pseudomonas putida P8: Evidence for a heme protein of the cytochrome c type
43. Cytotoxicity of extracellular Legionella pneumophila
44. A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture
45. Influence of iron-limited continuous culture on physiology and virulence of Legionella pneumophila
46. Acquisition of iron by Legionella pneumophila: Role of iron reductase
47. Novel sequence organization and insertion specificity of IS 605 and IS 606: Chimaeric transposable elements of Helicobacter pylori
48. Evidence for pore-forming ability by Legionella pneumophila
49. Elucidation of the complete Azorhizobium nicotinate catabolism pathway
50. Legionellosis: Ecological factors of an environmentally "new" disease
51. Molecular mechanisms of cytochrome c biogenesis: Three distinct systems
52. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila
53. The prepilin peptidase is required for protein secretion by and the virulence of the intracellular pathogen Legionella pneumophila
54. Identification and temperature regulation of Legionella pneumophila genes involved in type IV pilus biogenesis and type II protein secretion
55. Thirteenth serogroup of Legionella pneumophila isolated from patients with pneumonia
56. Insertion sequences
57. Identification and subcellular localization of the Legionella pneumophila IcmX protein: A factor essential for establishment of a replicative organelle in eukaryotic host cells
58. Four serogroups of Legionnaires' disease bacteria defined by direct immunofluorescence
59. Legionella pneumophila serogroup six: Isolation from cases of legionellosis, identification by immunofluorescence staining, and immunological response to infection
60. DNA sequence of IS91 and identification of the transposase gene
61. A series of widehost-range low-copy-number vectors that allow direct screening for recombinants
62. Characterization of a Legionella micdadei mip mutant
63. A Legionella pneumophila gene that promotes hemin binding
64. Mutants of Methylobacterium extorquens and Paracoccus denitrificans deficient in c-type cytochrome biogenesis synthesise the methylamine-dehydrogenase polypeptides but cannot assemble the tryptophan-tryptophylquinone group
65. The Paracoccus denitrificans ccmA, B and C genes: Cloning and sequencing, and analysis of the potential of their products to form a haem or apo- c-type cytochrome transporter
66. Identification of the contiguous Paracoccus denitrificans ccmF and ccmH genes: Disruption of ccmF, encoding a putative transporter, results in formation of an unstable apocytochrome c and deficiency in siderophore production
67. Ferric reductases of Legionella pneumophila
68. Identification of Legionella pneumophila genes important for infection of amoebas by signature-tagged mutagenesis
69. Legionella pneumophila mutants that are defective for iron acquisition and assimilation and intracellular infection
70. Genetic and biochemical characterization of the pathway in Pantoea citrea leading to pink disease of pineapple
71. Killing of Legionella pneumophila by human serum and iron-binding agents
72. Metal requirements of Legionella pneumophila
73. Type II protein secretion is a subset of the PilD-dependent processes that facilitate intracellular infection by Legionella pneumophila
74. Trafficking of the Legionella pneumophila phagosome
75. New insights into the role of CcmC, CcmD and CcmE in the haem delivery pathway during cytochrome c maturation by a complete mutational analysis of the conserved tryptophan-rich motif of CcmC
76. A periplasmic and extracellular c-type cytochrome of Geobacter sulfurreducens acts as a ferric iron reductase and as an electron carrier to other acceptors or to partner bacteria
77. Legionella pneumophila utilizes the same genes to multiply within Acanthamoeba castellanii and human macrophages
78. Intracellular multiplication of Legionella pneumophila: Human pathogen or accidental tourist?
79. Natural competence for DNA transformation by Legionella pneumophila and its association with expression of type IV pili
80. Legionella pneumophila pathogenesis: A fateful journey from amoebae to macrophages
81. Biogenesis of respiratory cytochromes in bacteria
82. Role of iron acquisition in Legionella pneumophila virulence
83. The Legionella pneumophila iraAB locus is required for iron assimilation, intracellular infection, and virulence
84. Cell biology of Legionella pneumophila
85. Legionnaires disease: Historical perspective
86. A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens
87. High affinity iron acquisition in Rhizobium leguminosarum requires the cycHJKL operon and the feuPQ gene products, which belong to the family of two-component transcriptional regulators