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Volumn 81, Issue 11, 2013, Pages 4182-4191

Secreted pyomelanin of legionella pneumophila promotes bacterial iron uptake and growth under iron-limiting conditions

Author keywords

[No Author keywords available]

Indexed keywords

FERROUS ION; HOMOGENTISIC ACID; MELANIN; PYOMELANIN; SIDEROPHORE; UNCLASSIFIED DRUG;

EID: 84886804548     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00858-13     Document Type: Article
Times cited : (48)

References (66)
  • 1
    • 0036314980 scopus 로고    scopus 로고
    • Legionella and Legionnaires' disease: 25 years of investigation
    • Fields BS, Benson RF, Besser RE. 2002. Legionella and Legionnaires' disease: 25 years of investigation. Clin. Microbiol. Rev. 15:506-526.
    • (2002) Clin. Microbiol. Rev. , vol.15 , pp. 506-526
    • Fields, B.S.1    Benson, R.F.2    Besser, R.E.3
  • 2
    • 84886776199 scopus 로고    scopus 로고
    • Legionnaires' disease. In Rosenberg E (ed)
    • 4th ed. Springer-Verlag, Berlin, Germany
    • Cianciotto N, Hilbi H, Buchrieser C. Legionnaires' disease. In Rosenberg E (ed), The prokaryotes, 4th ed. Springer-Verlag, Berlin, Germany.
    • The prokaryotes
    • Cianciotto, N.1    Hilbi, H.2    Buchrieser, C.3
  • 4
    • 84877833716 scopus 로고    scopus 로고
    • Multiple Legionella pneumophila type II secretion substrates, including a novel protein, contribute to differential infection of amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis
    • Tyson JY, Pearce MM, Vargas P, Bagchi S, Mulhern BJ, Cianciotto NP. 2013. Multiple Legionella pneumophila type II secretion substrates, including a novel protein, contribute to differential infection of amoebae Acanthamoeba castellanii, Hartmannella vermiformis, and Naegleria lovaniensis. Infect. Immun. 81:1399-1410.
    • (2013) Infect. Immun. , vol.81 , pp. 1399-1410
    • Tyson, J.Y.1    Pearce, M.M.2    Vargas, P.3    Bagchi, S.4    Mulhern, B.J.5    Cianciotto, N.P.6
  • 5
    • 77954023290 scopus 로고    scopus 로고
    • Biofilms: the environmental playground of Legionella pneumophila
    • Declerck P. 2010. Biofilms: the environmental playground of Legionella pneumophila. Environ. Microbiol. 12:557-566.
    • (2010) Environ. Microbiol. , vol.12 , pp. 557-566
    • Declerck, P.1
  • 6
    • 38849137205 scopus 로고    scopus 로고
    • Transcriptional profiling of Legionella pneumophila biofilm cells and the influence of iron on biofilm formation
    • Hindre T, Bruggemann H, Buchrieser C, Hechard Y. 2008. Transcriptional profiling of Legionella pneumophila biofilm cells and the influence of iron on biofilm formation. Microbiology 154:30-41.
    • (2008) Microbiology , vol.154 , pp. 30-41
    • Hindre, T.1    Bruggemann, H.2    Buchrieser, C.3    Hechard, Y.4
  • 8
    • 84886787294 scopus 로고    scopus 로고
    • Iron assimilation and type II protein secretion, In Hoffman PS, Friedman H, Bendinelli M (ed)
    • Legionella pneumophila: pathogenesis and immunity. Springer, New York, NY
    • Cianciotto NP. 2008. Iron assimilation and type II protein secretion, p 33-48. In Hoffman PS, Friedman H, Bendinelli M (ed), Legionella pneumophila: pathogenesis and immunity. Springer, New York, NY.
    • (2008) , pp. 33-48
    • Cianciotto, N.P.1
  • 9
    • 0033977291 scopus 로고    scopus 로고
    • Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila
    • Liles MR, Aber Scheel T, Cianciotto NP. 2000. Discovery of a nonclassical siderophore, legiobactin, produced by strains of Legionella pneumophila. J. Bacteriol. 182:749-757.
    • (2000) J. Bacteriol. , vol.182 , pp. 749-757
    • Liles, M.R.1    Aber Scheel, T.2    Cianciotto, N.P.3
  • 10
    • 32544436456 scopus 로고    scopus 로고
    • lbtA and lbtB are required for production of the Legionella pneumophila siderophore legiobactin
    • Allard KA, Viswanathan VK, Cianciotto NP. 2006. lbtA and lbtB are required for production of the Legionella pneumophila siderophore legiobactin. J. Bacteriol. 188:1351-1363.
    • (2006) J. Bacteriol. , vol.188 , pp. 1351-1363
    • Allard, K.A.1    Viswanathan, V.K.2    Cianciotto, N.P.3
  • 12
    • 79952796132 scopus 로고    scopus 로고
    • Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore
    • Chatfield CH, Mulhern BJ, Burnside DM, Cianciotto NP. 2011. Legionella pneumophila LbtU acts as a novel, TonB-independent receptor for the legiobactin siderophore. J. Bacteriol. 193:1563-1575.
    • (2011) J. Bacteriol. , vol.193 , pp. 1563-1575
    • Chatfield, C.H.1    Mulhern, B.J.2    Burnside, D.M.3    Cianciotto, N.P.4
  • 13
    • 84857755708 scopus 로고    scopus 로고
    • The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila
    • Chatfield CH, Mulhern BJ, Viswanathan VK, Cianciotto NP. 2012. The major facilitator superfamily-type protein LbtC promotes the utilization of the legiobactin siderophore by Legionella pneumophila. Microbiology 158:721-735.
    • (2012) Microbiology , vol.158 , pp. 721-735
    • Chatfield, C.H.1    Mulhern, B.J.2    Viswanathan, V.K.3    Cianciotto, N.P.4
  • 14
    • 79952254708 scopus 로고    scopus 로고
    • Cytochrome c4 is required for siderophore expression by Legionella pneumophila, whereas cytochromes c1 and c5 promote intracellular infection
    • Yip ES, Burnside DM, Cianciotto NP. 2011. Cytochrome c4 is required for siderophore expression by Legionella pneumophila, whereas cytochromes c1 and c5 promote intracellular infection. Microbiology 157: 868-878.
    • (2011) Microbiology , vol.157 , pp. 868-878
    • Yip, E.S.1    Burnside, D.M.2    Cianciotto, N.P.3
  • 15
    • 0027620344 scopus 로고
    • Ferric reductases of Legionella pneumophila
    • Poch MT, Johnson W. 1993. Ferric reductases of Legionella pneumophila. Biometals 6:107-114.
    • (1993) Biometals , vol.6 , pp. 107-114
    • Poch, M.T.1    Johnson, W.2
  • 16
    • 0036785675 scopus 로고    scopus 로고
    • Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection
    • Robey M, Cianciotto NP. 2002. Legionella pneumophila feoAB promotes ferrous iron uptake and intracellular infection. Infect. Immun. 70:5659- 5669.
    • (2002) Infect. Immun. , vol.70
    • Robey, M.1    Cianciotto, N.P.2
  • 17
    • 0018399823 scopus 로고
    • Aromatic substrate specificity of browning by cultures of the Legionnaires' disease bacterium
    • Baine WB, Rasheed JK. 1979. Aromatic substrate specificity of browning by cultures of the Legionnaires' disease bacterium. Ann. Intern. Med. 90: 619-620.
    • (1979) Ann. Intern. Med. , vol.90 , pp. 619-620
    • Baine, W.B.1    Rasheed, J.K.2
  • 18
    • 0018243287 scopus 로고
    • Effect of supplemental L-tyrosine on pigment production in cultures of the Legionnaires' disease bacterium
    • Baine WB, Rasheed JK, Feeley JC, Gorman GW, Casida LE. 1978. Effect of supplemental L-tyrosine on pigment production in cultures of the Legionnaires' disease bacterium. Curr. Microbiol. 1:93-94.
    • (1978) Curr. Microbiol. , vol.1 , pp. 93-94
    • Baine, W.B.1    Rasheed, J.K.2    Feeley, J.C.3    Gorman, G.W.4    Casida, L.E.5
  • 19
    • 0019379515 scopus 로고
    • Chemically defined medium for Legionella pneumophila growth
    • Ristroph JD, Hedlund KW, Gowda S. 1981. Chemically defined medium for Legionella pneumophila growth. J. Clin. Microbiol. 13:115-119.
    • (1981) J. Clin. Microbiol. , vol.13 , pp. 115-119
    • Ristroph, J.D.1    Hedlund, K.W.2    Gowda, S.3
  • 21
    • 0018758041 scopus 로고
    • Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium
    • Warren WJ, Miller RD. 1979. Growth of Legionnaires disease bacterium (Legionella pneumophila) in chemically defined medium. J. Clin. Microbiol. 10:50-55.
    • (1979) J. Clin. Microbiol. , vol.10 , pp. 50-55
    • Warren, W.J.1    Miller, R.D.2
  • 22
    • 0018381761 scopus 로고
    • Development of a chemically defined liquid medium for growth of Legionella pneumophila
    • Pine L, George JR, Reeves MW, Harrell WK. 1979. Development of a chemically defined liquid medium for growth of Legionella pneumophila. J. Clin. Microbiol. 9:615-626.
    • (1979) J. Clin. Microbiol. , vol.9 , pp. 615-626
    • Pine, L.1    George, J.R.2    Reeves, M.W.3    Harrell, W.K.4
  • 23
    • 0021351369 scopus 로고
    • Clinical laboratory differentiation of Legionellaceae family members with pigment production and fluorescence on media supplemented with aromatic substrates
    • Vickers RM, Yu VL. 1984. Clinical laboratory differentiation of Legionellaceae family members with pigment production and fluorescence on media supplemented with aromatic substrates. J. Clin. Microbiol. 19:583- 587.
    • (1984) J. Clin. Microbiol. , vol.19 , pp. 583-587
    • Vickers, R.M.1    Yu, V.L.2
  • 27
    • 0025858642 scopus 로고
    • Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila
    • Wintermeyer E, Rdest U, Ludwig B, Debes A, Hacker J. 1991. Characterization of legiolysin (lly), responsible for haemolytic activity, colour production and fluorescence of Legionella pneumophila. Mol. Microbiol. 5:1135-1143.
    • (1991) Mol. Microbiol. , vol.5 , pp. 1135-1143
    • Wintermeyer, E.1    Rdest, U.2    Ludwig, B.3    Debes, A.4    Hacker, J.5
  • 30
    • 0028306091 scopus 로고
    • Mutagenesis of Legionella pneumophila using Tn903 dlllacZ: identification of a growth-phaseregulated pigmentation gene
    • Wiater LA, Sadosky AB, Shuman HA. 1994. Mutagenesis of Legionella pneumophila using Tn903 dlllacZ: identification of a growth-phaseregulated pigmentation gene. Mol. Microbiol. 11:641-653.
    • (1994) Mol. Microbiol. , vol.11 , pp. 641-653
    • Wiater, L.A.1    Sadosky, A.B.2    Shuman, H.A.3
  • 31
    • 84866885058 scopus 로고    scopus 로고
    • Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis
    • doi:10.1371/journal.pone.0046209
    • Flydal MI, Chatfield CH, Zheng H, Gunderson FF, Aubi O, Cianciotto NP, Martinez A. 2012. Phenylalanine hydroxylase from Legionella pneumophila is a thermostable enzyme with a major functional role in pyomelanin synthesis. PLoS One 7:e46209. doi:10.1371/journal.pone.0046209.
    • (2012) PLoS One , vol.7
    • Flydal, M.I.1    Chatfield, C.H.2    Zheng, H.3    Gunderson, F.F.4    Aubi, O.5    Cianciotto, N.P.6    Martinez, A.7
  • 32
    • 34547647647 scopus 로고    scopus 로고
    • The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity
    • Chatfield CH, Cianciotto NP. 2007. The secreted pyomelanin pigment of Legionella pneumophila confers ferric reductase activity. Infect. Immun. 75:4062-4070.
    • (2007) Infect. Immun. , vol.75 , pp. 4062-4070
    • Chatfield, C.H.1    Cianciotto, N.P.2
  • 33
    • 33749846938 scopus 로고    scopus 로고
    • Melanin synthesis in microorganisms-biotechnological and medical aspects
    • Plonka PM, Grabacka M. 2006. Melanin synthesis in microorganisms-biotechnological and medical aspects. Acta Biochim. Pol. 53:429-443.
    • (2006) Acta Biochim. Pol. , vol.53 , pp. 429-443
    • Plonka, P.M.1    Grabacka, M.2
  • 34
    • 0031260450 scopus 로고    scopus 로고
    • Biopolymers from marine prokaryotes
    • Weiner RM. 1997. Biopolymers from marine prokaryotes. Trends Biotechnol. 15:390-394.
    • (1997) Trends Biotechnol. , vol.15 , pp. 390-394
    • Weiner, R.M.1
  • 35
    • 0036254876 scopus 로고    scopus 로고
    • Melanin production and use as a soluble electron shuttle for Fe(III) oxide reduction and as a terminal electron acceptor by Shewanella algae BrY
    • Turick CE, Tisa LS, Caccavo F, Jr. 2002. Melanin production and use as a soluble electron shuttle for Fe(III) oxide reduction and as a terminal electron acceptor by Shewanella algae BrY. Appl. Environ. Microbiol. 68: 2436-2444.
    • (2002) Appl. Environ. Microbiol. , vol.68 , pp. 2436-2444
    • Turick, C.E.1    Tisa, L.S.2    Caccavo Jr., F.3
  • 36
    • 0029077898 scopus 로고
    • The Lly protein protects Legionella pneumophila from light but does not directly influence its intracellular survival in Hartmannella vermiformis
    • Steinert M, Engelhard H, Flugel M, Wintermeyer E, Hacker J. 1995. The Lly protein protects Legionella pneumophila from light but does not directly influence its intracellular survival in Hartmannella vermiformis. Appl. Environ. Microbiol. 61:2428-2430.
    • (1995) Appl. Environ. Microbiol. , vol.61 , pp. 2428-2430
    • Steinert, M.1    Engelhard, H.2    Flugel, M.3    Wintermeyer, E.4    Hacker, J.5
  • 37
    • 0019409995 scopus 로고
    • Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens
    • Edelstein PH. 1981. Improved semiselective medium for isolation of Legionella pneumophila from contaminated clinical and environmental specimens. J. Clin. Microbiol. 14:298-303.
    • (1981) J. Clin. Microbiol. , vol.14 , pp. 298-303
    • Edelstein, P.H.1
  • 39
    • 0037400095 scopus 로고    scopus 로고
    • A simple micro-growth assay for enumerating bacteria
    • Brewster JD. 2003. A simple micro-growth assay for enumerating bacteria. J. Microbiol. Methods 53:77-86.
    • (2003) J. Microbiol. Methods , vol.53 , pp. 77-86
    • Brewster, J.D.1
  • 40
    • 79952803738 scopus 로고    scopus 로고
    • Legionella,In Mandell GL, Bennett JE, DolinR(ed)
    • Principles and practice of infectious diseases, 7th ed, Elsevier Churchill Livingstone, Philadelphia, PA
    • Edelstein PH, Cianciotto NP. 2010. Legionella, p 2969-2984. In Mandell GL, Bennett JE, DolinR(ed), Principles and practice of infectious diseases, 7th ed, vol 2. Elsevier Churchill Livingstone, Philadelphia, PA.
    • (2010) , vol.2 , pp. 2969-2984
    • Edelstein, P.H.1    Cianciotto, N.P.2
  • 41
    • 0025813436 scopus 로고
    • Distribution, expression, and long-range mapping of legiolysin gene (lly)- specific DNA sequences in legionellae
    • Bender L, Ott M, Debes A, Rdest U, Heesemann J, Hacker J. 1991. Distribution, expression, and long-range mapping of legiolysin gene (lly)- specific DNA sequences in legionellae. Infect. Immun. 59:3333-3336.
    • (1991) Infect. Immun. , vol.59 , pp. 3333-3336
    • Bender, L.1    Ott, M.2    Debes, A.3    Rdest, U.4    Heesemann, J.5    Hacker, J.6
  • 42
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. 2004. Balancing acts: molecular control of mammalian iron metabolism. Cell 117:285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 43
    • 43949115241 scopus 로고    scopus 로고
    • Highly elevated serum ferritin levels as a diagnostic marker for Legionella pneumonia
    • Cunha BA. 2008. Highly elevated serum ferritin levels as a diagnostic marker for Legionella pneumonia. Clin. Infect. Dis. 46:1789-1791.
    • (2008) Clin. Infect. Dis. , vol.46 , pp. 1789-1791
    • Cunha, B.A.1
  • 44
    • 21044449406 scopus 로고    scopus 로고
    • A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases
    • Challis GL. 2005. A widely distributed bacterial pathway for siderophore biosynthesis independent of nonribosomal peptide synthetases. Chembiochem 6:601-611.
    • (2005) Chembiochem , vol.6 , pp. 601-611
    • Challis, G.L.1
  • 46
    • 37549015583 scopus 로고    scopus 로고
    • Mechanism of formation of the orange-colored sputum in pneumonia caused by Legionella pneumophila
    • Fujita J, Touyama M, Chibana K, Koide M, Haranaga S, Higa F, Tateyama M. 2007. Mechanism of formation of the orange-colored sputum in pneumonia caused by Legionella pneumophila. Intern. Med. 46: 1931-1934.
    • (2007) Intern. Med. , vol.46 , pp. 1931-1934
    • Fujita, J.1    Touyama, M.2    Chibana, K.3    Koide, M.4    Haranaga, S.5    Higa, F.6    Tateyama, M.7
  • 47
    • 84858001166 scopus 로고    scopus 로고
    • Legionella pneumophila transcriptome during intracellular multiplication in human macrophages
    • Faucher SP, Mueller CA, Shuman HA. 2011. Legionella pneumophila transcriptome during intracellular multiplication in human macrophages. Front. Microbiol. 2:60.
    • (2011) Front. Microbiol. , vol.2 , pp. 60
    • Faucher, S.P.1    Mueller, C.A.2    Shuman, H.A.3
  • 48
    • 42149167919 scopus 로고    scopus 로고
    • Pyomelanin is produced by Shewanella algae BrY and affected by exogenous iron
    • Turick CE, Caccavo F, Jr, Tisa LS. 2008. Pyomelanin is produced by Shewanella algae BrY and affected by exogenous iron. Can. J. Microbiol. 54:334-339.
    • (2008) Can. J. Microbiol. , vol.54 , pp. 334-339
    • Turick, C.E.1    Caccavo Jr., F.2    Tisa, L.S.3
  • 50
    • 37449013335 scopus 로고    scopus 로고
    • Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate
    • Keith KE, Killip L, He P, Moran GR, Valvano MA. 2007. Burkholderia cenocepacia C5424 produces a pigment with antioxidant properties using a homogentisate intermediate. J. Bacteriol. 189:9057-9065.
    • (2007) J. Bacteriol. , vol.189 , pp. 9057-9065
    • Keith, K.E.1    Killip, L.2    He, P.3    Moran, G.R.4    Valvano, M.A.5
  • 51
    • 78049415071 scopus 로고    scopus 로고
    • A putative ABC transporter, HatABCDE, is among molecular determinants of pyomelanin production in Pseudomonas aeruginosa
    • Hunter RC, Newman DK. 2010. A putative ABC transporter, HatABCDE, is among molecular determinants of pyomelanin production in Pseudomonas aeruginosa. J. Bacteriol. 192:5962-5971.
    • (2010) J. Bacteriol. , vol.192 , pp. 5962-5971
    • Hunter, R.C.1    Newman, D.K.2
  • 52
    • 65649121900 scopus 로고    scopus 로고
    • Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection
    • Rodriguez-Rojas A, Mena A, Martin S, Borrell N, Oliver A, Blazquez J. 2009. Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection. Microbiology 155:1050-1057.
    • (2009) Microbiology , vol.155 , pp. 1050-1057
    • Rodriguez-Rojas, A.1    Mena, A.2    Martin, S.3    Borrell, N.4    Oliver, A.5    Blazquez, J.6
  • 55
    • 0030933282 scopus 로고    scopus 로고
    • A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture
    • James BW, Mauchline WS, Dennis PJ, Keevil CW. 1997. A study of iron acquisition mechanisms of Legionella pneumophila grown in chemostat culture. Curr. Microbiol. 34:238-243.
    • (1997) Curr. Microbiol. , vol.34 , pp. 238-243
    • James, B.W.1    Mauchline, W.S.2    Dennis, P.J.3    Keevil, C.W.4
  • 56
    • 33750589315 scopus 로고    scopus 로고
    • Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds
    • Nosanchuk JD, Casadevall A. 2006. Impact of melanin on microbial virulence and clinical resistance to antimicrobial compounds. Antimicrob. Agents Chemother. 50:3519-3528.
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3519-3528
    • Nosanchuk, J.D.1    Casadevall, A.2
  • 57
    • 69749095952 scopus 로고    scopus 로고
    • Color me bad: microbial pigments as virulence factors
    • Liu GY, Nizet V. 2009. Color me bad: microbial pigments as virulence factors. Trends Microbiol. 17:406-413.
    • (2009) Trends Microbiol. , vol.17 , pp. 406-413
    • Liu, G.Y.1    Nizet, V.2
  • 58
    • 62649159029 scopus 로고    scopus 로고
    • Surface translocation by Legionella pneumophila: a form of sliding motility that is dependent upon type II protein secretion
    • Stewart CR, Rossier O, Cianciotto NP. 2009. Surface translocation by Legionella pneumophila: a form of sliding motility that is dependent upon type II protein secretion. J. Bacteriol. 191:1537-1546.
    • (2009) J. Bacteriol. , vol.191 , pp. 1537-1546
    • Stewart, C.R.1    Rossier, O.2    Cianciotto, N.P.3
  • 59
    • 0018776750 scopus 로고
    • Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova
    • Brenner DJ, Steigerwalt AG, McDade JE. 1979. Classification of the Legionnaires' disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova. Ann. Intern. Med. 90:656-658.
    • (1979) Ann. Intern. Med. , vol.90 , pp. 656-658
    • Brenner, D.J.1    Steigerwalt, A.G.2    McDade, J.E.3
  • 62
    • 0019224107 scopus 로고
    • Legionella micdadei species nova: classification of a third species of Legionella associated with human pneumonia
    • Hebert GA, Steigerwalt AG, Brenner DJ. 1980. Legionella micdadei species nova: classification of a third species of Legionella associated with human pneumonia. Curr. Microbiol. 3:255-257.
    • (1980) Curr. Microbiol. , vol.3 , pp. 255-257
    • Hebert, G.A.1    Steigerwalt, A.G.2    Brenner, D.J.3
  • 63
    • 0346251028 scopus 로고    scopus 로고
    • Legionella pneumophila type II protein secretion promotes virulence in the A/J mouse model of Legionnaires' disease pneumonia
    • Rossier O, Starkenburg S, Cianciotto NP. 2004. Legionella pneumophila type II protein secretion promotes virulence in the A/J mouse model of Legionnaires' disease pneumonia. Infect. Immun. 72:310-321.
    • (2004) Infect. Immun. , vol.72 , pp. 310-321
    • Rossier, O.1    Starkenburg, S.2    Cianciotto, N.P.3
  • 64
    • 16244414601 scopus 로고    scopus 로고
    • The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection
    • Rossier O, Cianciotto NP. 2005. The Legionella pneumophila tatB gene facilitates secretion of phospholipase C, growth under iron-limiting conditions, and intracellular infection. Infect. Immun. 73:2020-2032.
    • (2005) Infect. Immun. , vol.73 , pp. 2020-2032
    • Rossier, O.1    Cianciotto, N.P.2
  • 65
    • 10444232719 scopus 로고    scopus 로고
    • Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophila
    • Naylor J, Cianciotto NP. 2004. Cytochrome c maturation proteins are critical for in vivo growth of Legionella pneumophila. FEMS Microbiol. Lett. 241:249-256.
    • (2004) FEMS Microbiol. Lett. , vol.241 , pp. 249-256
    • Naylor, J.1    Cianciotto, N.P.2
  • 66
    • 0036176380 scopus 로고    scopus 로고
    • The Dot/Icm type IV secretion system of Legionella pneumophila is essential for the induction of apoptosis in human macrophages
    • Zink SD, Pedersen L, Cianciotto NP, Abu-Kwaik Y. 2002. The Dot/Icm type IV secretion system of Legionella pneumophila is essential for the induction of apoptosis in human macrophages. Infect. Immun. 70:1657- 1663.
    • (2002) Infect. Immun. , vol.70 , pp. 1657-1663
    • Zink, S.D.1    Pedersen, L.2    Cianciotto, N.P.3    Abu-Kwaik, Y.4


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