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Volumn 308, Issue 9, 2015, Pages E726-E733

Peripheral insulin resistance in obese girls with hyperandrogenism is related to oxidative phosphorylation and elevated serum free fatty acids

Author keywords

Hyperandrogenic syndrome; Hyperandrogenism; Insulin resistance; Mitochondria; Obesity

Indexed keywords

ADENOSINE DIPHOSPHATE; ANDROGEN; ASPARTATE AMINOTRANSFERASE; C REACTIVE PROTEIN; CREATINE KINASE; FATTY ACID; GLUCOSE; HEMOGLOBIN A1C; INSULIN; PHOSPHATE; PHOSPHORUS 31;

EID: 84929662646     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00619.2014     Document Type: Article
Times cited : (40)

References (59)
  • 1
    • 79958029200 scopus 로고    scopus 로고
    • The quantitative insulin sensitivity check index is not able to detect early metabolic alterations in young patients with polycystic ovarian syndrome
    • Angioni S, Sanna S, Magnini R, Melis GB, Fulghesu AM. The quantitative insulin sensitivity check index is not able to detect early metabolic alterations in young patients with polycystic ovarian syndrome. Gynecol Endocrinol 27: 468–474, 2011.
    • (2011) Gynecol Endocrinol , vol.27 , pp. 468-474
    • Angioni, S.1    Sanna, S.2    Magnini, R.3    Melis, G.B.4    Fulghesu, A.M.5
  • 2
    • 0035143773 scopus 로고    scopus 로고
    • Glucose intolerance in obese adolescents with polycystic ovary syndrome: Roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease
    • Arslanian SA, Lewy VD, Danadian K. Glucose intolerance in obese adolescents with polycystic ovary syndrome: roles of insulin resistance and beta-cell dysfunction and risk of cardiovascular disease. J Clin Endocrinol Metab 86: 66–71, 2001.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 66-71
    • Arslanian, S.A.1    Lewy, V.D.2    Danadian, K.3
  • 3
    • 0034136666 scopus 로고    scopus 로고
    • Resistance exercise countermeasures for space flight: Implications of training specificity
    • Bamman MM, Caruso JF. Resistance exercise countermeasures for space flight: implications of training specificity. J Strength Condition Res 14: 45–49, 2000.
    • (2000) J Strength Condition Res , vol.14 , pp. 45-49
    • Bamman, M.M.1    Caruso, J.F.2
  • 4
    • 0029671107 scopus 로고    scopus 로고
    • The android woman—a risky condition
    • Bjorntorp P. The android woman—a risky condition. J Intern Med 239: 105–110, 1996.
    • (1996) J Intern Med , vol.239 , pp. 105-110
    • Bjorntorp, P.1
  • 5
    • 0029972402 scopus 로고    scopus 로고
    • The regulation of adipose tissue distribution in humans
    • Bjorntorp P. The regulation of adipose tissue distribution in humans. Int J Obes Relat Metab Disord 20: 291–302, 1996.
    • (1996) Int J Obes Relat Metab Disord , vol.20 , pp. 291-302
    • Bjorntorp, P.1
  • 6
    • 0028024883 scopus 로고
    • Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production
    • Cara JF. Insulin-like growth factors, insulin-like growth factor binding proteins and ovarian androgen production. Horm Res 42: 49–54, 1994.
    • (1994) Horm Res , vol.42 , pp. 49-54
    • Cara, J.F.1
  • 7
    • 58149383818 scopus 로고    scopus 로고
    • Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance
    • Ciaraldi TP, Aroda V, Mudaliar S, Chang RJ, Henry RR. Polycystic ovary syndrome is associated with tissue-specific differences in insulin resistance. J Clin Endocrinol Metab 94: 157–163, 2009.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 157-163
    • Ciaraldi, T.P.1    Aroda, V.2    Mudaliar, S.3    Chang, R.J.4    Henry, R.R.5
  • 8
    • 33947416676 scopus 로고    scopus 로고
    • Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women
    • Corbould A. Chronic testosterone treatment induces selective insulin resistance in subcutaneous adipocytes of women. J Endocrinol 192: 585–594, 2007.
    • (2007) J Endocrinol , vol.192 , pp. 585-594
    • Corbould, A.1
  • 14
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 18: 774–800, 1997.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 15
    • 0023189131 scopus 로고
    • Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia
    • Dunaif A, Graf M, Mandeli J, Laumas V, Dobrjansky A. Characterization of groups of hyperandrogenic women with acanthosis nigricans, impaired glucose tolerance, and/or hyperinsulinemia. J Clin Endocrinol Metab 65: 499–507, 1987.
    • (1987) J Clin Endocrinol Metab , vol.65 , pp. 499-507
    • Dunaif, A.1    Graf, M.2    Mandeli, J.3    Laumas, V.4    Dobrjansky, A.5
  • 16
    • 0024437305 scopus 로고
    • Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome
    • Dunaif A, Segal KR, Futterweit W, Dobrjansky A. Profound peripheral insulin resistance, independent of obesity, in polycystic ovary syndrome. Diabetes 38: 1165–1174, 1989.
    • (1989) Diabetes , vol.38 , pp. 1165-1174
    • Dunaif, A.1    Segal, K.R.2    Futterweit, W.3    Dobrjansky, A.4
  • 17
    • 0029119085 scopus 로고
    • Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome
    • Dunaif A, Xia J, Book CB, Schenker E, Tang Z. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 96: 801–810, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 801-810
    • Dunaif, A.1    Xia, J.2    Book, C.B.3    Schenker, E.4
  • 18
    • 84908365376 scopus 로고    scopus 로고
    • Testosterone treatment increases androgen receptor and aromatase gene expression in myotubes from patients with PCOS and controls, but does not induce insulin resistance
    • Eriksen MB, Glintborg D, Nielsen MF, Jakobsen MA, Brusgaard K, Tan Q, Gaster M. Testosterone treatment increases androgen receptor and aromatase gene expression in myotubes from patients with PCOS and controls, but does not induce insulin resistance. Biochem Biophys Res Commun 451: 622–626, 2014.
    • (2014) Biochem Biophys Res Commun , vol.451 , pp. 622-626
    • Eriksen, M.B.1    Glintborg, D.2    Nielsen, M.F.3    Jakobsen, M.A.4    Brusgaard, K.5    Tan, Q.6    Gaster, M.7
  • 19
    • 79961233956 scopus 로고    scopus 로고
    • Intact primary mitochondrial function in myotubes established from women with PCOS
    • Eriksen MB, Minet AD, Glintborg D, Gaster M. Intact primary mitochondrial function in myotubes established from women with PCOS. J Clin Endocrinol Metab 96: E1298–E1302, 2011.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. E1298-E1302
    • Eriksen, M.B.1    Minet, A.D.2    Glintborg, D.3    Gaster, M.4
  • 21
    • 0015348189 scopus 로고
    • Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge
    • Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499–502, 1972.
    • (1972) Clin Chem , vol.18 , pp. 499-502
    • Friedewald, W.T.1    Levy, R.I.2    Fredrickson, D.S.3
  • 22
    • 67651124853 scopus 로고    scopus 로고
    • Hyperandrogenemia influences the prevalence of the metabolic syndrome abnormalities in adolescents with the polycystic ovary syndrome
    • Fruzzetti F, Perini D, Lazzarini V, Parrini D, Genazzani AR. Hyperandrogenemia influences the prevalence of the metabolic syndrome abnormalities in adolescents with the polycystic ovary syndrome. Gynecol Endocrinol 25: 335–343, 2009.
    • (2009) Gynecol Endocrinol , vol.25 , pp. 335-343
    • Fruzzetti, F.1    Perini, D.2    Lazzarini, V.3    Parrini, D.4    Genazzani, A.R.5
  • 23
    • 77950916158 scopus 로고    scopus 로고
    • Obesity-related lipid profile and altered insulin incretion in adolescents with polycystic ovary syndrome
    • Fulghesu A, Magnini R, Portoghese E, Angioni S, Minerba L, Melis GB. Obesity-related lipid profile and altered insulin incretion in adolescents with polycystic ovary syndrome. J Adolesc Health 46: 474–481, 2010.
    • (2010) J Adolesc Health , vol.46 , pp. 474-481
    • Fulghesu, A.1    Magnini, R.2    Portoghese, E.3    Angioni, S.4    Minerba, L.5    Melis, G.B.6
  • 24
    • 33747633975 scopus 로고    scopus 로고
    • Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls
    • Glintborg D, Andersen M, Hagen C, Frystyk J, Hulstrom V, Flyvbjerg A, Hermann AP. Evaluation of metabolic risk markers in polycystic ovary syndrome (PCOS). Adiponectin, ghrelin, leptin and body composition in hirsute PCOS patients and controls. Eur J Endocrinol 155: 337–345, 2006.
    • (2006) Eur J Endocrinol , vol.155 , pp. 337-345
    • Glintborg, D.1    Ersen, M.2    Hagen, C.3    Frystyk, J.4    Hulstrom, V.5    Flyvbjerg, A.6    Hermann, A.P.7
  • 25
    • 34548858211 scopus 로고    scopus 로고
    • Intramyocellular lipid kinetics and insulin resistance
    • Guo ZK. Intramyocellular lipid kinetics and insulin resistance. Lipids Health Dis 6: 18, 2007.
    • (2007) Lipids Health Dis , vol.6
    • Guo, Z.K.1
  • 26
    • 84862519734 scopus 로고    scopus 로고
    • Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary syndrome
    • Hutchison SK, Teede HJ, Rachon D, Harrison CL, Strauss BJ, Stepto NK. Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without polycystic ovary syndrome. Diabetologia 55: 1424–1434, 2012.
    • (2012) Diabetologia , vol.55 , pp. 1424-1434
    • Hutchison, S.K.1    Teede, H.J.2    Rachon, D.3    Harrison, C.L.4    Strauss, B.J.5    Stepto, N.K.6
  • 28
    • 77449109099 scopus 로고    scopus 로고
    • Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function
    • Karakelides H, Irving BA, Short KR, O’Brien P, Nair KS. Age, obesity, and sex effects on insulin sensitivity and skeletal muscle mitochondrial function. Diabetes 59: 89–97, 2010.
    • (2010) Diabetes , vol.59 , pp. 89-97
    • Karakelides, H.1    Irving, B.A.2    Short, K.R.3    O’Brien, P.4    Nair, K.S.5
  • 29
    • 0036788293 scopus 로고    scopus 로고
    • Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes
    • Kelley DE, He J, Menshikova EV, Ritov VB. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51: 2944–2950, 2002.
    • (2002) Diabetes , vol.51 , pp. 2944-2950
    • Kelley, D.E.1    He, J.2    Menshikova, E.V.3    Ritov, V.B.4
  • 30
    • 0025340810 scopus 로고
    • In vivo proton spectroscopy in presence of eddy currents
    • Klose U. In vivo proton spectroscopy in presence of eddy currents. Magn Res Med 14: 26–30, 1990.
    • (1990) Magn Res Med , vol.14 , pp. 26-30
    • Klose, U.1
  • 31
    • 0033621867 scopus 로고    scopus 로고
    • Weinsier RL. 31P MRS measurement of mitochondrial function in skeletal muscle: Reliability, force-level sensitivity and relation to whole body maximal oxygen uptake
    • Larson-Meyer DE, Newcomer BR, Hunter GR, Hetherington HP, Weinsier RL. 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake. NMR Biomed 13: 14–27, 2000.
    • (2000) NMR Biomed , vol.13 , pp. 14-27
    • Larson-Meyer, D.E.1    Newcomer, B.R.2    Hunter, G.R.3    Hetherington, H.P.4
  • 33
    • 12344305124 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and type 2 diabetes
    • Lowell BB, Shulman GI. Mitochondrial dysfunction and type 2 diabetes. Science 307: 384–387, 2005.
    • (2005) Science , vol.307 , pp. 384-387
    • Lowell, B.B.1    Shulman, G.I.2
  • 35
    • 33646410148 scopus 로고    scopus 로고
    • The association of obesity and hyperandrogenemia during the pubertal transition in girls: Obesity as a potential factor in the genesis of postpubertal hyperandrogenism
    • McCartney CR, Prendergast KA, Chhabra S, Eagleson CA, Yoo R, Chang RJ, Foster CM, Marshall JC. The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenism. J Clin Endocrinol Metab 91: 1714–1722, 2006.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 1714-1722
    • McCartney, C.R.1    Prendergast, K.A.2    Chhabra, S.3    Eagleson, C.A.4    Yoo, R.5    Chang, R.J.6    Foster, C.M.7    Marshall, J.C.8
  • 36
    • 78049264842 scopus 로고    scopus 로고
    • ATP synthesis is impaired in isolated mitochondria from myotubes established from type 2 diabetic subjects
    • Minet AD, Gaster M. ATP synthesis is impaired in isolated mitochondria from myotubes established from type 2 diabetic subjects. Biochem Biophys Res Commun 402: 70–74, 2010.
    • (2010) Biochem Biophys Res Commun , vol.402 , pp. 70-74
    • Minet, A.D.1    Gaster, M.2
  • 37
    • 77954870760 scopus 로고    scopus 로고
    • Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis
    • Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 16: 347–363, 2010.
    • (2010) Hum Reprod Update , vol.16 , pp. 347-363
    • Moran, L.J.1    Misso, M.L.2    Wild, R.A.3    Norman, R.J.4
  • 38
    • 77954870760 scopus 로고    scopus 로고
    • Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: A systematic review and meta-analysis
    • Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update 16: 347–363, 2010.
    • (2010) Hum Reprod Update , vol.16 , pp. 347-363
    • Moran, L.J.1    Misso, M.L.2    Wild, R.A.3    Norman, R.J.4
  • 43
    • 0031035820 scopus 로고    scopus 로고
    • Adenosine triphosphate production rates, metabolic economy calculations, pH, phosphomonoesters, phosphodiesters, and force output during short-duration maximal isometric plantar flexion exercises and repeated maximal isometric plantar flexion exercises
    • Newcomer BR, Boska MD. Adenosine triphosphate production rates, metabolic economy calculations, pH, phosphomonoesters, phosphodiesters, and force output during short-duration maximal isometric plantar flexion exercises and repeated maximal isometric plantar flexion exercises. Muscle Nerve 20: 336–346, 1997.
    • (1997) Muscle Nerve , vol.20 , pp. 336-346
    • Newcomer, B.R.1    Boska, M.D.2
  • 44
    • 70349264097 scopus 로고    scopus 로고
    • Glucose metabolism in overweight Hispanic adolescents with and without polycystic ovary syndrome
    • Nur MM, Newman IM, Siqueira LM. Glucose metabolism in overweight Hispanic adolescents with and without polycystic ovary syndrome. Pediatrics 124: e496–e502, 2009.
    • (2009) Pediatrics , vol.124 , pp. e496-e502
    • Nur, M.M.1    Newman, I.M.2    Siqueira, L.M.3
  • 49
    • 0345533861 scopus 로고    scopus 로고
    • Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS
    • Rico-Sanz J, Thomas EL, Jenkinson G, Mierisova S, Iles R, Bell JD. Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1H-MRS. J Appl Physiol 87: 2068–2072, 1999.
    • (1999) J Appl Physiol , vol.87 , pp. 2068-2072
    • Rico-Sanz, J.1    Thomas, E.L.2    Jenkinson, G.3    Mierisova, S.4    Iles, R.5    Bell, J.D.6
  • 50
    • 34347238610 scopus 로고    scopus 로고
    • Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic ovary syndrome
    • Romualdi D, Giuliani M, Draisci G, Costantini B, Cristello F, Lanzone A, Guido M. Pioglitazone reduces the adrenal androgen response to corticotropin-releasing factor without changes in ACTH release in hyperinsulinemic women with polycystic ovary syndrome. Fertil Steril 88: 131–138, 2007.
    • (2007) Fertil Steril , vol.88 , pp. 131-138
    • Romualdi, D.1    Giuliani, M.2    Draisci, G.3    Costantini, B.4    Cristello, F.5    Lanzone, A.6    Guido, M.7
  • 52
    • 84918819322 scopus 로고    scopus 로고
    • Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease
    • Shulman GI. Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease. N Engl J Med 371: 1131–1141, 2014.
    • (2014) N Engl J Med , vol.371 , pp. 1131-1141
    • Shulman, G.I.1
  • 53
    • 34547492917 scopus 로고    scopus 로고
    • Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction
    • Sirikul B, Hunter GR, Larson-Meyer DE, Desmond R, Newcomer BR. Relationship between metabolic function and skeletal muscle fatigue during a 90 s maximal isometric contraction. Physiol Appliq Nutr Metab 32: 394–399, 2007.
    • (2007) Physiol Appliq Nutr Metab , vol.32 , pp. 394-399
    • Sirikul, B.1    Hunter, G.R.2    Larson-Meyer, D.E.3    Desmond, R.4    Newcomer, B.R.5
  • 54
    • 34548429745 scopus 로고    scopus 로고
    • Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome
    • Skov V, Glintborg D, Knudsen S, Jensen T, Kruse TA, Tan Q, Brusgaard K, Beck-Nielsen H, Hojlund K. Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome. Diabetes 56: 2349–2355, 2007.
    • (2007) Diabetes , vol.56 , pp. 2349-2355
    • Skov, V.1    Glintborg, D.2    Knudsen, S.3    Jensen, T.4    Kruse, T.A.5    Tan, Q.6    Brusgaard, K.7    Beck-Nielsen, H.8    Hojlund, K.9
  • 55
    • 49249095124 scopus 로고    scopus 로고
    • Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome
    • Skov V, Glintborg D, Knudsen S, Tan Q, Jensen T, Kruse TA, Beck-Nielsen H, Hojlund K. Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome. PLoS One 3: e2466, 2008.
    • (2008) Plos One , vol.3
    • Skov, V.1    Glintborg, D.2    Knudsen, S.3    Tan, Q.4    Jensen, T.5    Kruse, T.A.6    Beck-Nielsen, H.7    Hojlund, K.8
  • 59
    • 0028786656 scopus 로고
    • Serine phosphorylation of human P450c17 increases 17, 20-lyase activity: Implications for adrenarche and the polycystic ovary syndrome
    • Zhang LH, Rodriguez H, Ohno S, Miller WL. Serine phosphorylation of human P450c17 increases 17, 20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci USA 92: 10619–10623, 1995.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 10619-10623
    • Zhang, L.H.1    Rodriguez, H.2    Ohno, S.3    Miller, W.L.4


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