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Volumn 17, Issue 10, 2015, Pages 2354-2357

Phase-Vanishing Method with Acetylene Evolution and Its Utilization in Several Organic Syntheses

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EID: 84929629871     PISSN: 15237060     EISSN: 15237052     Source Type: Journal    
DOI: 10.1021/acs.orglett.5b00827     Document Type: Article
Times cited : (45)

References (49)
  • 21
    • 84929636275 scopus 로고    scopus 로고
    • note
    • Galden HT135 and HT200 are polyether-type perfluorinated solvents, which are commercially available from Solvay Solexis Inc. The kinetic viscosities of Galden HT135 and HT200 at 25°C are 1.0 and 2.4 cSt, respectively.
  • 27
    • 84929612951 scopus 로고    scopus 로고
    • Paquette, L. A.; Crich, D.; Fuchs, P. L.; Molander, G. A., Eds.; John Wiley & Sons: Chichester, UK
    • Arrington, K. L. In Encyclopedia of Reagents for Organic Synthesis, 2nd ed.; Paquette, L. A.; Crich, D.; Fuchs, P. L.; Molander, G. A., Eds.; John Wiley & Sons: Chichester, UK, 2009; Vol. 1, p 97.
    • (2009) Encyclopedia of Reagents for Organic Synthesis, 2nd ed. , vol.1 , pp. 97
    • Arrington, K.L.1
  • 31
    • 84929636277 scopus 로고    scopus 로고
    • note
    • When this procedure was omitted, the evolution of acetylene was not efficient, resulting in slightly (<5%) lower yields.
  • 47
    • 84929636278 scopus 로고    scopus 로고
    • note
    • No oxidative coupling products of the alkynes were observed.
  • 48
    • 84929636279 scopus 로고    scopus 로고
    • note
    • A significant decrease of isolated yields was caused by the difficulty in the separation of unreacted substrates from the products.
  • 49
    • 84929636280 scopus 로고    scopus 로고
    • note
    • To examine the scalability of the PV system with acetylene gas evolution, Sonogashira coupling with 4.08 g (20 mmol) of iodobenzene was carried out in a larger test tube (30 mm φ x 150 mm) to afford diphenylacetylene in 78% yield, indicating that the Sonogashira reaction can be safely performed at the gram scale using the PV method.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.