Phase-vanishing method: Friedel-Crafts acylation of thiophene with tin tetrachloride and its application to convenient parallel synthesis

Synlett

Volumn , Issue 2, 2003, Pages 247-249

  Matsubara, Hiroshi ^a   Yasuda, Shinji ^a   Ryu, Ilhyong ^a  

^a Osaka City University   (Japan)

Author keywords

Fluorous solvent; Friedel Crafts acylation; Parallel synthesis; Phase vanishing; Tin tetrachloride

Indexed keywords

STANNIC CHLORIDE; THIOPHENE;

ACYLATION; ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; SYNTHESIS;

EID: 0037284423     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-36806     Document Type: Article

References (24)

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23. 4, and concentrated. Purification by a short column chromatography on silica gel with benzene gave 2-propionylthiophene (1.43 mmol, 201 mg) in 72% yield.
24. We confirmed that no contamination among products was observed in this parallel experiment under the conditions specified in Scheme 2.