A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 6, 2015, Pages 3666-3668

  Macuamule, Cristiano J ^a   Tjhin, Erick T ^b   Jana, Collins E ^a   Barnard, Leanne ^a   Koekemoer, Lizbé ^a   De Villiers, Marianne ^a   Saliba, Kevin J ^b   Strauss, Erick ^a  

^a STELLENBOSCH UNIVERSITY   (South Africa)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CHLOROQUINE; COENZYME A; PANTETHEINE; PANTOTHENIC ACID DERIVATIVE; AMIDASE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; PANTETHEINASE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SPECIFICITY; ENZYMATIC DEGRADATION; HUMAN; HUMAN CELL; IC50; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; DRUG EFFECTS; METABOLISM;

AMIDOHYDROLASES; ANTIMALARIALS; CHLOROQUINE; GPI-LINKED PROTEINS; PLASMODIUM FALCIPARUM;

EID: 84929629237     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.04970-14     Document Type: Article

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