Iron deficiency increases blood concentrations of neurotoxic metals in children

Korean Journal of Pediatrics

Volumn 57, Issue 8, 2014, Pages 345-350

  Kim, Yangho ^a   Park, Sangkyu ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Breast feeding; Deficiency; Iron; Lead; Manganese

Indexed keywords

CADMIUM; FERRITIN; LEAD; MANGANESE; METAL; METALLOTHIONEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NEUROTOXIC METAL; UNCLASSIFIED DRUG;

ATTENTION DEFICIT DISORDER; BREAST FEEDING; COGNITIVE DEFECT; HUMAN; INHALATION; INTELLIGENCE QUOTIENT; IRON ABSORPTION; IRON DEFICIENCY; IRON INTAKE; IRON THERAPY; LEAD BLOOD LEVEL; LIVER CIRRHOSIS; MANGANESE BLOOD LEVEL; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; PORTOSYSTEMIC ANASTOMOSIS; REVIEW; RISK FACTOR; TRACE METAL BLOOD LEVEL;

EID: 84929611984     PISSN: 17381061     EISSN: 20927258     Source Type: Journal    
DOI: 10.3345/kjp.2014.57.8.345     Document Type: Review

References (83)

1. de Benoist B, McLean E, Egli I, Cogswell M. Worldwide prevalence of anaemia 1993-2005: WHO Global Database of Anaemia. Technical Report. Geneva: World Health Organization, 2008.
2. Recommendations to prevent and control iron deficiency in the United States. Centers for Disease Control and Prevention. MMWR Recomm Rep 1998;47(RR-3):1-29.
3. Iron deficency anaemia: assessment, prevention and control: a guide for programme managers. Geneva: World Health Organization, 2001.
4. Cogswell ME, Looker AC, Pfeiffer CM, Cook JD, Lacher DA, Beard JL, et al. Assessment of iron deficiency in US preschool children and nonpregnant females of childbearing age: National Health and Nutrition Examination Survey 2003-2006. Am J Clin Nutr 2009;89:1334-1342.
5. Healthy people 2010. Washington, DC: Department of Health and Human Services, 2000.
6. Lozoff B. Iron deficiency and child development. Food Nutr Bull 2007;28(4 Suppl):S560-S571.
7. Georgieff MK. Long-term brain and behavioral consequences of early iron defciency. Nutr Rev 2011;69 Suppl 1:S43-S48.
8. Logan S, Martins S, Gilbert R. Iron therapy for improving psy-chomotor development and cognitive function in children under the age of three with iron defciency anaemia. Cochrane Database Syst Rev 2001;(2):CD001444.
9. Szajewska H, Ruszczynski M, Chmielewska A. Effects of iron supplementation in nonanemic pregnant women, infants, and young children on the mental performance and psychomotor development of children: a systematic review of randomized controlled trials. Am J Clin Nutr 2010;91:1684-1690.
10. Lozoff B, Beard J, Connor J, Barbara F, Georgieff M, Schallert T. Long-lasting neural and behavioral effects of iron deficiency in infancy. Nutr Rev 2006;64(5 Pt 2):S34-S43.
11. Peirano PD, Algarín CR, Chamorro R, Reyes S, Garrido MI, Duran S, et al. Sleep and neurofunctions throughout child development: lasting effects of early iron defciency. J Pediatr Gastroenterol Nutr 2009;48 Suppl 1:S8-S15.
12. Park S, Sim CS, Lee H, Kim Y. Blood manganese concentration is elevated in infants with iron deficiency. Biol Trace Elem Res 2013; 155:184-189.
13. Park S, Sim CS, Lee H, Kim Y. Effects of iron therapy on blood lead concentrations in infants. J Trace Elem Med Biol 2014;28:56-59.
14. Lucchini RG, Kim Y. Health effects of manganese. In: Vojtisek M, Prakash R, editors. Metals and neurotoxicity. India: Society for Science and Environment, 2009:119-147.
15. Lonnerdal B. Manganese nutrition of infants. In: Klimis-Tavantzis DJ, editor. Manganese in health and disease. Boca Ratonpp: CRC Press,1994:175-191.
16. Hurley LS, Keen CL. Manganese. In: Underwood E, Mertz W, editors. Trace elements in human health and animal nutrition. New York: Academic Press, 1987:185-223.
17. Mackenzie B, Garrick MD. Iron imports. II. Iron uptake at the apical membrane in the intestine. Am J Physiol Gastrointest Liver Physiol 2005;289:G981-G986.
18. Davis CD, Wolf TL, Greger JL. Varying levels of manganese and iron affect absorption and gut endogenous losses of manganese by rats. J Nutr 1992;122:1300-1308.
19. Kim Y, Park JK, Choi Y, Yoo CI, Lee CR, Lee H, et al. Blood manganese concentration is elevated in iron deficiency anemia patients, whereas globus pallidus signal intensity is minimally affected. Neurotoxicology 2005;26:107-111.
20. Kim Y, Lee BK. Iron deficiency increases blood manganese level in the Korean general population according to KNHANES 2008. Neurotoxicology 2011;32:247-254
21. Choi JW, Kim SK. Association between blood lead concentrations and body iron status in children. Arch Dis Child 2003;88:791-792.
22. Watson WS, Hume R, Moore MR. Iron and lead absorption in humans. Am J Clin Nutr 1982;36:823-829.
23. Piasek M, Blanusa M, Kostial K, Laskey JW. Low iron diet and parenteral cadmium exposure in pregnant rats: the effects on trace elements and fetal viability. Biometals 2004;17:1-14.
24. Tallkvist J, Bowlus CL, Lonnerdal B. DMT1 gene expression and cadmium absorption in human absorptive enterocytes. Toxicol Lett 2001;122:171-177.
25. Ryu DY, Lee SJ, Park DW, Choi BS, Klaassen CD, Park JD. Dietary iron regulates intestinal cadmium absorption through iron transporters in rats. Toxicol Lett 2004;152:19-25.
26. Garrick MD, Dolan KG. An expression system for a transporter of iron and other metals. Methods Mol Biol 2002;196:147-154.
27. Zoller H, Koch RO, Theurl I, Obrist P, Pietrangelo A, Montosi G, et al. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Gastroenterology 2001;120:1412-1419.
28. Finley JW. Manganese absorption and retention by young women is associated with serum ferritin concentration. Am J Clin Nutr 1999;70:37-43.
29. Bellinger DC. Prenatal exposures to environmental chemicals and children's neurodevelopment: an update. Staf Health Work 2013;4:1-11.
30. Calne DB, Chu NS, Huang CC, Lu CS, Olanow W. Manganism and idiopathic parkinsonism: similarities and differences. Neurology 1994;44:1583-1586.
31. Olanow CW. Manganese-induced parkinsonism and Parkinson's disease. Ann N Y Acad Sci 2004;1012:209-223.
32. Kim Y, Kim JW. Toxic encephalopathy. Saf Health Work 2012;3: 243-256.
33. Karki P, Lee E, Aschner M. Manganese neurotoxicity: a focus on glu tamate transporters. Ann Occup Environ Med 2013;25:4.
34. Claus Henn B, Ettinger AS, Schwartz J, Tellez-Rojo MM, Lamadrid-Figueroa H, Hernandez-Avila M, et al. Early postnatal blood manganese levels and children's neurodevelopment. Epidemiology 2010;21:433-439.
35. Bouchard MF, Sauve S, Barbeau B, Legrand M, Brodeur ME, Bouffard T, et al. Intellectual impairment in school-age children exposed to manganese from drinking water. Environ Health Per-spect 2011;119:138-143.
36. Bouchard M, Laforest F, Vandelac L, Bellinger D, Mergler D. Hair manganese and hyperactive behaviors: pilot study of school-age children exposed through tap water. Environ Health Perspect 2007;115:122-127.
37. Khan K, Factor-Litvak P, Wasserman GA, Liu X, Ahmed E, Parvez F, et al. Manganese exposure from drinking water and children's classroom behavior in Bangladesh. Environ Health Perspect 2011; 119:1501-1506.
38. Hauser RA, Zesiewicz TA, Rosemurgy AS, Martinez C, Olanow CW. Manganese intoxication and chronic liver failure. Ann Neurol 1994;36:871-875.
39. Butterworth RF, Spahr L, Fontaine S, Layrargues GP. Manganese toxicity, dopaminergic dysfunction and hepatic encephalopathy. Metab Brain Dis 1995;10:259-267.
40. Park NH, Park JK, Choi Y, Yoo CI, Lee CR, Lee H, et al. Whole blood manganese correlates with high signal intensities on T1-weighted MRI in patients with liver cirrhosis. Neurotoxicology 2003;24:909-915.
41. Finley JW, Johnson PE, Johnson LK. Sex affects manganese ab sorption and retention by humans from a diet adequate in manganese. Am J Clin Nutr 1994;60:949-955.
42. Chua AC, Morgan EH. Effects of iron defciency and iron overload on manganese uptake and deposition in the brain and other organs of the rat. Biol Trace Elem Res 1996;55:39-54.
43. Kwik-Uribe CL, Gietzen D, German JB, Golub MS, Keen CL. Chronic marginal iron intakes during early development in mice result in persistent changes in dopamine metabolism and myelin composition. J Nutr 2000;130:2821-2830.
44. Erikson KM, Shihabi ZK, Aschner JL, Aschner M. Manganese accumulates in iron-deficient rat brain regions in a heterogeneous fashion and is associated with neurochemical alterations. Biol Trace Elem Res 2002;87:143-156.
45. Boojar MM, Goodarzi F, Basedaghat MA. Long-term follow-up of workplace and well water manganese effects on iron status indexes in manganese miners. Arch Environ Health 2002;57:519-528.
46. Brna P, Gordon K, Dooley JM, Price V. Manganese toxicity in a child with iron deficiency and polycythemia. J Child Neurol 2011;26:891-894.
47. Sahni V, Leger Y, Panaro L, Allen M, Giffin S, Fury D, et al. Case re port: a metabolic disorder presenting as pediatric manganism. Environ Health Perspect 2007;115:1776-9.
48. Meltzer HM, Brantsaeter AL, Borch-Iohnsen B, Ellingsen DG, Alexander J, Thomassen Y, et al. Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study. Environ Res 2010;110:497-504.
49. Lee BK, Kim Y. Effects of menopause on blood manganese levels in women: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data. Neurotoxicology 2012;33: 401-405.
50. US Centers for Disease Control and Prevention. Low level lead exposure harms children: a renewed call for primary prevention [Internet]. Atlanta (GA): US Centers for Disease Control and Prevention, [c2014] [cited 2012 Dec 1]. Available from: http://www.cdc.gov/nceh/lead/ACCLPP/Final_Document_030712.pdf.
51. Wright RO, Tsaih SW, Schwartz J, Wright RJ, Hu H. Association between iron deficiency and blood lead level in a longitudinal analysis of children followed in an urban primary care clinic. J Pediatr 2003;142:9-14.
52. Wolf AW, Jimenez E, Lozoff B. Effects of iron therapy on infant blood lead levels. J Pediatr 2003;143:789-795.
53. Barany E, Bergdahl IA, Bratteby LE, Lundh T, Samuelson G, Skerfving S, et al. Iron status influences trace element levels in human blood and serum. Environ Res 2005;98:215-223.
54. Hammad TA, Sexton M, Langenberg P. Relationship between blood lead and dietary iron intake in preschool children. A cross-sectional study. Ann Epidemiol 1996;6:30-33.
55. Hershko C, Konijn AM, Moreb J, Link G, Grauer F, Weissenberg E. Iron depletion and blood lead levels in a population with endemic lead poisoning. Isr J Med Sci 1984;20:1039-1043.
56. Rosado JL, Lopez P, Kordas K, Garcia-Vargas G, Ronquillo D, Alatorre J, et al. Iron and/or zinc supplementation did not reduce blood lead concentrations in children in a randomized, placebo-controlled trial. J Nutr 2006;136:2378-2383.
57. Serwint JR, Damokosh AI, Berger OG, Chisolm JJ Jr, Gunter EW, Jones RL, et al. No difference in iron status between children with low and moderate lead exposure. J Pediatr 1999;135:108-110.
58. Wolf AW, Jimenez E, Lozoff B. No evidence of developmental III effects of low-level lead exposure in a developing country. J Dev Behav Pediatr 1994;15:224-231.
59. Clark M, Royal J, Seeler R. Interaction of iron deficiency and lead and the hematologic findings in children with severe lead poisoning. Pediatrics 1988;81:247-254.
60. Yip R, Dallman PR. Developmental changes in erythrocyte pro-toporphyrin: roles of iron deficiency and lead toxicity. J Pediatr 1984;104:710-713.
61. Sim CS, Kim Y, Lee H, Park CY, Ham JO, Lee BK. Iron deficiency increases blood lead levels in boys and pre-menarche girls surveyed in KNHANES 2010-2011. Environ Res 2014;130:1-6.
62. ATSDR. Toxicological profile for cadmium. Atlanta, GA: Agency for Toxic Substances and Disease Registry, 2008.
63. Jarup L, Akesson A. Current status of cadmium as an environmental health problem. Toxicol Appl Pharmacol 2009;238:201-208.
64. Vahter M, Berglund M, Akesson A, Liden C. Metals and women's health. Environ Res 2002;88:145-155.
65. Akesson A, Berglund M, Schutz A, Bjellerup P, Bremme K, Vahter M. Cadmium exposure in pregnancy and lactation in relation to iron status. Am J Public Health 2002;92:284-287.
66. Berglund M, Akesson A, Nermell B, Vahter M. Intestinal absorption of dietary cadmium in women depends on body iron stores and fber intake. Environ Health Perspect 1994;102:1058-1066.
67. Gallagher CM, Chen JJ, Kovach JS. The relationship between body iron stores and blood and urine cadmium concentrations in US never-smoking, non-pregnant women aged 20-49 years. Environ Res 2011;111:702-707.
68. Kippler M, Ekstrom EC, Lonnerdal B, Goessler W, Akesson A, El Arifeen S, et al. Influence of iron and zinc status on cadmium accumulation in Bangladeshi women. Toxicol Appl Pharmacol 2007;222:221-226.
69. Mijal RS, Holzman CB. Blood cadmium levels in women of child-bearing age vary by race/ethnicity. Environ Res 2010;110:505-512.
70. Satarug S, Ujjin P, Vanavanitkun Y, Baker JR, Moore MR. Infuence of body iron store status and cigarette smoking on cadmium body burden of healthy Thai women and men. Toxicol Lett 2004; 148:177-185.
71. Kim SH, Kim Y, Kim NS, Lee BK. Gender difference in blood cadmium concentration in the general population: Can it be explained by iron defciency? J Trace Elem Med Biol 2014;28:322-327.
72. Horiguchi H, Oguma E, Sasaki S, Miyamoto K, Ikeda Y, Machida M, et al. Comprehensive study of the effects of age, iron deficiency, di abetes mellitus, and cadmium burden on dietary cadmium absorption in cadmium-exposed female Japanese farmers. Toxicol Appl Pharmacol 2004;196:114-123.
73. Tsukahara T, Ezaki T, Moriguchi J, Furuki K, Fukui Y, Ukai H, et al. No signifcant effect of iron defciency on cadmium body burden or kidney dysfunction among women in the general population in Japan. Int Arch Occup Environ Health 2003;76:275-281.
74. Olsson IM, Bensryd I, Lundh T, Ottosson H, Skerfving S, Oskarsson A. Cadmium in blood and urine: impact of sex, age, dietary intake, iron status, and former smoking: association of renal effects. Environ Health Perspect 2002;110:1185-1190.
75. Turgut S, Polat A, Inan M, Turgut G, Emmungil G, Bican M, et al. Interaction between anemia and blood levels of iron, zinc, copper, cadmium and lead in children. Indian J Pediatr 2007;74:827-830.
76. Shah F, Kazi TG, Afridi HI, Kazi N, Baig JA, Shah AQ, et al. Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups. Biol Trace Elem Res 2011;141:131-149.
77. Zhao TT, Chen B, Wang HP, Wang R, Zhang H. Evaluation of toxic and essential elements in whole blood from 0- to 6-year-old children from Jinan, China. Clin Biochem 2013;46:612-616.
78. Choi JW, Kim SK. Relationships of lead, copper, zinc, and cadmium levels versus hematopoiesis and iron parameters in healthy adolescents. Ann Clin Lab Sci 2005;35:428-434.
79. Park JH, Park S, Kim Y. Iron deficiency is not associated with increased blood cadmium in infants. Ann Occup Environ Med 2014;26:3.
80. Truska P, Rosival L, Balazova G, Hinst J, Rippel A, Palusova O, et al. Blood and placental concentrations of cadmium, lead, and mercury in mothers and their newborns. J Hyg Epidemiol Microbiol Immunol 1989;33:141-147.
81. Radisch B, Luck W, Nau H. Cadmium concentrations in milk and blood of smoking mothers. Toxicol Lett 1987;36:147-152.
82. Lee BK, Kim Y. Iron defciency is associated with increased levels of blood cadmium in the Korean general population: analysis of 2008-2009 Korean National Health and Nutrition Examination Survey data. Environ Res 2012;112:155-163.
83. US Centers for Disease Control and Prevention. NHANES, Key statistics from NHANES (data are for 2003-2006) [Internet]. Atlanta, GA: US Centers for Disease Control and Prevention; [c2014] [cited 2012 Dec 1]. Available from: http://wwwn.cdc.gov/nchs/nhanes/bibliography/key_statistics.aspx.