Running exercise reduces myelinated fiber loss in the dentate gyrus of the hippocampus in APP/PS1 transgenic mice

Current Alzheimer Research

Volumn 12, Issue 4, 2015, Pages 377-383

  Chao, Fenglei ^a   Zhang, Lei ^a   Luo, Yanmin ^a   Xiao, Qian ^a   Lv, Fulin ^a   He, Qi ^a   Zhou, Chunni ^a   Zhang, Yi ^a   Jiang, Lin ^a   Jiang, Rong ^a   Gu, Hengwei ^a   Tang, Yong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer s disease; APP PS1 transgenic mouse; Dentate gyrus; Exercise; Hippocampus; Myelinated fiber

Indexed keywords

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CONTROLLED STUDY; DEMYELINATION; DENTATE GYRUS; ELECTRON MICROSCOPY; HIPPOCAMPUS; MALE; MORRIS WATER MAZE TEST; MOUSE; MYELIN SHEATH; MYELINATED NERVE; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; RUNNING; SPATIAL LEARNING; SPATIAL MEMORY; STEREOMETRY; TRANSGENIC MOUSE; ANIMAL; DISEASE MODEL; GENETICS; HUMAN; MAZE TEST; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; TRANSMISSION ELECTRON MICROSCOPY;

AMYLOID PRECURSOR PROTEIN; APP PROTEIN, HUMAN; PRESENILIN 1; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DENTATE GYRUS; DISEASE MODELS, ANIMAL; HUMANS; MALE; MAZE LEARNING; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; NERVE FIBERS, MYELINATED; ORGAN SIZE; PHYSICAL CONDITIONING, ANIMAL; PRESENILIN-1; RANDOM ALLOCATION; RUNNING; SPATIAL MEMORY;

EID: 84929611875     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205012666150325183011     Document Type: Article

References (35)

1. Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science 278(5337): 412-419 (1997).
2. Morrison JH, Hof PR. Selective vulnerability of cortical and hippocampal circuits in aging and Alzheimer's disease. Prog Brain Res 136: 467-486 (2002).
3. Jacobsen JS, Wu CC, Redwine JM, Comery TA, Arias R, Bowlby M, et al. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 103: 5161- 5166 (2006) .
4. Kövari E, Gold G, Herrmann FR, Canuto A, Hof PR, Bouras C, et al. Cortical microinfarcts and demyelination affect cognition in cases at high risk for dementia. Neurology 68(12): 927-931 (2007).
5. Peters A. The effects of normal aging on myelinated nerve fibers in monkey central nervous system. Front Neuroanat 3:11 (2009).
6. Bartzokis G. Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer's disease. Neurobiol Aging 25(1): 5-18 (2004).
7. Noble M. The possible role of myelin destruction as a precipitating event in Alzheimer's disease. Neurobiol Aging 25(1): 25-31 (2004).
8. Tang Y, Nyengaard JR, Pakkenberg B, Gundersen HJ. Ageinduced white matter changes in the human brain: A stereological investigation. Neurobiol Aging 18(6): 609-615 (1997).
9. Marner L, Nyengaard JR, Tang Y, Pakkenberg B. Marked loss of myelinated fiber in the human brain with age. J Comp Neurol 462: 144-152.16 (2003).
10. Bartzokis G, Cummings JL, Sultzer D, Henderson VW, Nuechterlein KH, Mintz J. White matter structural integrity in healthy aging adults and patients with Alzheimer disease: a magnetic resonance imaging study. Arch Neurol 60(3): 393-398 (2003).
11. de Leeuw FE, Barkhof F, Scheltens P. White matter lesions and hippocampal atrophy in Alzheimer's disease. Neurology 62(2): 310-312 (2004).
12. van Norden AG, Fick WF, de Laat KF, van Uden IW, van Oudheusden LJ, Tendolkar I, et al. Subjective cognitive failures and hippocampal volume in elderly with white matter lesions. Neurology 71(15): 1152-1159 (2008).
13. Barnes J, Fox NC. The search for early markers of AD: hippocampal atrophy and memory deficits. Int Psychogeriatr 26(7): 1065- 1066 (2014).
14. Redwine JM, Kosofsky B, Jacobs RE, Games D, Reilly JF, Morrison JH, et al. Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis. Proc Natl Acad Sci USA 100(3):1381-1386 (2003).
15. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K. Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol. 58(3): 498-504 (2001).
16. Hirsch C. ACP Journal Club. A 12-month, in-home exercise program delayed functional deterioration in Alzheimer disease. Ann Intern Med 159(4): JC10 (2013).
17. Nichol KE, Deeny SP, Seif J, Camaclang K, Cotman CW. Exercise improves cognition and hippocampal plasticity in APOE epsilon4 mice. Alzheimers Dement 5(4): 287-294 (2009).
18. Yuede CM, Zimmerman SD, Dong H, Kling MJ, Bero AW, Holtzman DM, et al. Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease. Neurobiol Dis 35(3): 426-432 (2009).
19. Kitazawa M, Medeiros R, Laferla FM. Transgenic mouse models of Alzheimer disease: Developing a better model as a tool for therapeutic interventions. Curr Pharm Des 18: 1131-1147 (2012).
20. Morris RG, Garrud P, Rawlins JN, O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 297(5868): 681- 683 (1982).
21. Tanila H. Wading pools, fading memories-place navigation in transgenic mouse models of Alzheimer's disease. Front Aging Neurosci 4:11 (2012).
22. Hao J, Janssen WG, Tang Y, Roberts JA, McKay H, Lasley B, et al. Estrogen increases number of spinophilin-immunoreactive spines in the hippocampus of young and aged female rhesus monkeys. J Comp Neurol 465: 540-550 (2003).
23. Gundersen HJ, Bendtsen TF, Korbo L, Marcussen N, Moller A, Nielsen K, et al. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96: 379-394 (1988).
24. Nyengaard JR, Gundersen HJ. The isector: A simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 165: 427-431 (1992).
25. Lu W, Yang S, Chen L, Qiu X, Huang CX, Wu H, et al. Stereological investigation of the age-related changes of the myelinated fibers in the hippocampus of male rats. Anat Rec (Hoboken) 297(8): 1490-1497 (2014).
26. Li C, Yang S, Chen L, Lu W, Qiu X, Gundersen HJ, et al. Stereological methods for estimating the myelin sheaths of the myelinated fibers in white matter. Anat Rec (Hoboken) 292(10):1648- 1655 (2009).
27. Gundersen HJ, Jensen EB, Kiêu K, Nielsen J. The efficiency of systematic sampling in stereology--reconsidered. J Microsc 193(Pt 3):199-211 (1999).
28. Daviglus ML, Bell CC, Berrettini W, Bowen PE, Connolly ES Jr, Cox NJ, et al. National Institutes of Health State-of-the-Science Conference statement: preventing Alzheimer disease and cognitive decline. Ann Intern Med 153: 176-181 (2010).
29. Norton S, Matthews FE, Barnes DE, Yaffe K, Brayne C. Potential for primary prevention of Alzheimer's disease: an analysis of population- based data. Lancet Neurol 13(8): 788-794 (2014).
30. Wolf SA, Kronenberg G, Lehmann K, Blankenship A, Overall R, Staufenbiel M, et al. Cognitive and physical activity differently modulate disease progression in the amyloid precursor protein (APP)-23 model of Alzheimer's disease. Biol Psychiatry 60(12):1314-1323 (2006).
31. Richter H, Ambrée O, Lewejohann L, Herring A, Keyvani K, Paulus W, et al. Wheel-running in a transgenic mouse model of Alzheimer's disease: protection or symptom? Behav Brain Res 190(1):74-84 (2008).
32. Wang PN, Liu HC, Lirng JF, Lin KN, Wu ZA. Accelerated hippocampal atrophy rates in stable and progressive amnestic mild cognitive impairment. Psychiatry Res 171(3): 221-231 (2009).
33. Smith JC, Nielson KA, Woodard JL, Seidenberg M, Durgerian S, Hazlett KE, et al. Physical activity reduces hippocampal atrophy in elders at genetic risk for Alzheimer's disease. Front Aging Neurosci 6: 61 (2014).
34. Shing YL, Rodrigue KM, Kennedy KM, Fandakova Y, Bodammer N, Werkle-Bergner M, et al. Hippocampal subfield volumes: age, vascular risk, and correlation with associative memory. Front Aging Neurosci 3: 2 (2011).
35. Yassa MA, Stark SM, Bakker A, Albert MS, Gallagher M, Stark CE. High-resolution structural and functional MRI of hippocampal CA3 and dentate gyrus in patients with amnestic Mild Cognitive Impairment. Neuroimage 51(3): 1242-1252 (2010).