Stereological methods for estimating the myelin sheaths of the myelinated fibers in white matter

Anatomical Record

Volumn 292, Issue 10, 2009, Pages 1648-1655

  Li, Chen ^a   Yang, Shu ^a   Chen, Lin ^a   Lu, Wei ^a   Qiu, Xuan ^a   Gundersen, Hans Jorgen G ^b   Tang, Yong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Length; Myelin sheaths; Myelinated nerve fibers; Size; Stereology; Volume; White matter

Indexed keywords

ANIMAL TISSUE; ARTICLE; BRAIN SIZE; CONTROLLED STUDY; FEMALE; MYELIN SHEATH; MYELINATED NERVE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; STEREOMETRY; TRANSMISSION ELECTRON MICROSCOPY; WHITE MATTER;

ANIMALS; BIOMETRY; BRAIN; FEMALE; MYELIN SHEATH; RATS; RATS, LONG-EVANS;

RATTUS;

EID: 70449640870     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.20959     Document Type: Article

References (24)

1. Anderson TJ, Schneider A, Barrie JA, Klugmann M, McCulloch MC, Kirkham D, Kyriakides E, Nave KA, Griffiths IR. 1998. Late-onset neurodegeneration in mice with increased dosage of the proteolipid protein gene. J Comp Neurol 394:506-519. (Pubitemid 28183573)
2. Blakemore WF. 1978. Observations on remyelination in the rabbit spinal cord following demyelination induced by lysolecithin. Neuropathol Appl Neurobiol 4:47-59.
3. Blaker WD, Krigman MR, Thomas DJ, Mushak P, Morell P. 1981. Effect of triethyl tin on myelination in the developing rat. J Neurochem 36:44-52. (Pubitemid 11132142)
4. Chang LW. 1990. The neurotoxicology and pathology of organomercury, organolead, and organotin. J Toxicol Sci 4:125-151.
5. Franco-Pons N, Torrente M, Colomina MT, Vilella E. 2007. Behavioral deficits in the cuprizone-induced murine model of demyelination/remyelination. Toxicol Lett 169:205-213. (Pubitemid 46436370)
6. Gundersen HJ. 1977. Notes on the estimation of the numerical density of arbitrary particles: the edge effect. J Microsc 111:219-223.
7. Gundersen HJ. 1979. Estimation of tubule or cylinder Lv, Sv, and Vv on thick sections. J Microsc 117:333-345.
8. Gundersenn HJG, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard JR, Pakkenberg B, Sørensen FB, Vesterby A, West MJ. 1988. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. AMPIS 96:379-394.
9. Irvine KA, Blakemore WF. 2006. Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice. J Neuroimmunol 175:69-76.
10. Irvine KA, Blakemore WF. 2008. Remyelination protects axons from demyelination-associated axon degeneration. Brain 131:1464-1477.
11. Karim SA, Barrie JA, McCulloch MC, Montague P, Edgar JM, Kirkham D, Anderson TJ, Nave KA, Griffiths IR, McLaughlin M. 2007. PLP overexpression perturbs myelin protein composition and myelination in a mouse model of Pelizaeus-Merzbacher disease. Glia 55:341-351. (Pubitemid 46247121)
12. Kuhlmann T, Lassmann H, Brück W. 2008. Diagnosis of inflammatory demyelination in biopsy specimens: a practical approach. Acta Neuropathol 115:275-287.
13. Li C, Yang S, Zhang W, Shi X, Wang W, Nyengaard JR, Tang Y. 2008. Unbiased stereological quantification of unmyelinated fibers in the rat brain white matter. Neurosci Lett 437:38-41.
14. Ludwin SK. 1995. Pathology of the myelin sheath. In: Waxman SG, Kocsis JD, Stys PK, editors. The axon: structure, function, and pathophysiology. New York: Oxford University Press. p 412-437.
15. Ludwin SK. 2000. The neuropathology of multiple sclerosis. Neuroimaging Clin N Am 10:625-648.
16. Malamud N, Hirano A. 1973. Atlas of neuropathology. Berkeley: University of California Press.
17. Monuki ES, Lemke G. 1995. Molecular biology of myelination. In: Waxman SG, Kocsis JD, Stys PK, editors. The axon: structure, function, and pathophysiology. New York: Oxford University Press. p 144-163.
18. Myers SF. 1998. Myelin-sheath abnormalities in the vestibular nerves of chronically diabetic rats. Otolaryngol Head Neck Surg 119:432-438.
19. Nyenggard JR, Gundersen HJG. 1992. The isector: a simple and direct method for generating isotropic, uniform random sections from small specimens. J Microsc 165:427-431.
20. Skripuletz T, Lindner M, Kotsiari A, Garde N, Fokuhl J, Linsmeier F, Trebst C, Stangel M. 2008. Cortical demyelination is prominent in the murine cuprizone model and is strain-dependent. Am J Pathol 172:1053-1061.
21. Tamura E, Parry GJ. 1994. Severe radicular pathology in rats with longstanding diabetes. J Neurol Sci 127:29-35. (Pubitemid 24372520)
22. Tang Y, Nyengaard JR. 1997. A stereological method for estimating the total length and size of myelin fibers in human brain white matter. J Neurosci Meth 73:193-200. (Pubitemid 27244816)
23. Tang Y, Nyengaard JR, Pakkenberg B, Gundersen HJ. 1997. Age-induced white matter changes in the human brain: a stereological investigation. Neurobiol Aging 18:609-615. (Pubitemid 28046413)
24. Yang S, Li C, Zhang W, Wang WW, Tang Y. 2007. Stereological study of the age-related changes of the white matter and the myelinated nerve fibers in the white matter of rat brain. Anat Sin 38:651-656. (Pubitemid 351227768)