Stereological investigation of the age-related changes of the myelinated fibers in the hippocampus of male rats

Anatomical Record

Volumn 297, Issue 8, 2014, Pages 1490-1497

  Lu, Wei ^a,b   Yang, Shu ^c   Chen, Lin ^a   Qiu, Xuan ^a   Huang, Chun Xia ^a   Wu, Hong ^a   Li, Chen ^a   Yang, Jun Qing ^a   Zhang, Lei ^a   Chao, Feng Lei ^a   Tang, Yong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b NAVY GENERAL HOSPITAL   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Age related change; Hippocampus; Myelinated fiber; Stereology

Indexed keywords

AGE; AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SIZE; CONTROLLED STUDY; ELECTRON MICROSCOPE; HIPPOCAMPUS; MALE; MEMORY; MORRIS WATER MAZE TEST; MYELINATED NERVE; NONHUMAN; PRIORITY JOURNAL; RAT; SPATIAL LEARNING; STEREOLOGY; ANATOMY AND HISTOLOGY; ANIMAL; GROWTH, DEVELOPMENT AND AGING; MAZE TEST; MYELIN SHEATH; ORGAN SIZE; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGING; ANIMALS; HIPPOCAMPUS; MALE; MAZE LEARNING; MICROSCOPY, ELECTRON, TRANSMISSION; MYELIN SHEATH; NERVE FIBERS, MYELINATED; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84904045264     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22936     Document Type: Article

References (33)

1. Calhoun ME, Kurth D, Phinney AL, Long JM, Hengemihle J, Mouton PR, Ingram DK, Jucker M. 1998. Hippocampal neuron and synaptophysin-positive bouton number in aging C57BL/6 mice. Neurobiol Aging 19:599-606.
2. Calhoun ME, Mao Y, Roberts JA, Rapp PR. 2004. Reduction in hippocampal cholinergic innervation is unrelated to recognition memory impairment in aged rhesus monkeys. J Comp Neurol 475:238-246.
3. Chen YC, Lei JL, Chen QS, Wang SL. 1998. Effect of physical training on the age-related changes of acetylcholinesterase-positive fibers in the hippocampal formation and parietal cortex in the C57BL/6J mouse. Mech Ageing Dev 102:81-93.
4. Gaserova Z, Jenege P, Proneyove N, Liptaj T. 2012. Middle-aged rat hippocampus and some early changes accompanying aging. Cent Eur J Biol 7:810-816.
5. Geinisman Y, de Toledo-Morrell L, Morrell F, Heller RE. 1995. Hippocampal markers of age-related memory dysfunction: behavioral, electrophysiological and morphological perspectives. Prog Neurobiol 45:223-252.
6. Geinisman Y, de Toledo-Morrell L, Morrell F, Persina IS, Rossi M. 1992. Age-related loss of axospinous synapses formed by two afferent systems in the rat dentate gyrus as revealed by the unbiased stereological dissector technique. Hippocampus 2:437-444.
7. Geinisman Y, Ganeshina O, Yoshida R, Berry RW, Disterhoft JF, Gallagher M. 2004. Aging, spatial learning, and total synapse number in the rat CA1 stratum radiatum. Neurobiol Aging 25:407-416.
8. Gordon BA, Blazey T, Benzinger TL, Head D. 2013. Effects of aging and Alzheimer's disease along the longitudinal axis of the hippocampus. J Alzheimers Dis 37:41-50.
9. Haug H, Eggers R. 1991. Morphometry of the human cortex cerebri and corus striatum during aging. Neurobiol Aging 12:336-338; discussion 352-355.
10. Howard CV, Reed MG. 1998. Unbiased stereology: three dimensional measurement in microscopy. New York: Springer-Verlag. p 19-37.
11. Huang Q, Zhou D, Chase K, Gusella JF, Aronin N, DiFiglia M. 1992. Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proc Natl Acad Sci USA 89:11988-11992.
12. Juraska JM. 1991. Sex difference in "cognitive" regions of the rat brain. Psychoneuroendocrinology 16:105-109.
13. Liu P, Gupta N, Jing Y, Zhang H. 2008. Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience 155:789-796.
14. Ojo B, Rezaie P, Gabbott PL, Davies H, Colyer F, Cowley TR, Lynch M, Stewart MG. 2012. Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL. Brain Behav Immun 26:778-788.
15. Peters A, Rosene DL, Moss MB, Kemper TL, Abraham CR, Tigges J, Albert MS. 1996. Neurobiological basis of age-related cognitive decline in the rhesus monkey. J Neuropathol Exp Neurol 55:861-874.
16. Peters A, Sethares C. 2002. Aging and the myelinated fibers in prefrontal cortex and corpus callosum of the monkey. J Comp Neurol 442:277-291.
17. Peters A, Sethares C, Killiany RJ. 2001. Effects of age on the thickness of myelin sheaths in monkey primary visual cortex. J Comp Neurol 435:241-248.
18. Porter NM, Landfield PW. 1998. Stress hormones and brain aging: adding injury to insult? Nat Neurosci 1:3-4.
19. Rapp PR, Amaral DG. 1992. Individual differences in cognitive and neurobiological consequences of normal aging. Trends Neurosci 15:340-345.
20. Rapp PR, Gallagher M. 1996. Preserved neuron number in the hippocampus of aged rats with spatial learning deficits. Proc Natl Acad Sci USA 93:9926-9930.
21. Rasmussen T, Schliemann T, Sorensen JC, Zimmer J, West MJ. 1996. Memory impaired aged rats: no loss of principal hippocampal and subicular neurons. Neurobiol Aging 17:143-147.
22. Reinprecht I, Gschanes A, Windisch M, Fachbach G. 1999. Two peptidergic drugs increase the synaptophysin immunoreactivity in brains of 24-month-old rats. Histochem J 31:395-401.
23. Rutten BP, Brasnjevic I, Steinbusch HW, Schmitz C. 2010. Caloric restriction and aging but not overexpression of SOD1 affect hippocampal volumes in mice. Mech Ageing Dev 131:574-579.
24. Sandell JH, Peters A. 2001. Effects of age on nerve fibers in the rhesus monkey optic nerve. J Comp Neurol 429:541-553.
25. Small SA, Chawla MK, Buonocore M, Rapp PR, Barnes CA. 2004. Imaging correlates of brain function in monkeys and rats isolates a hippocampal subregion differentially vulnerable to aging. Proc Natl Acad Sci USA 101:7181-7186.
26. Smith TD, Adams MM, Gallagher M, Morrison JH, Rapp PR. 2000. Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats. J Neurosci 20:6587-6593.
27. Sullivan EV, Adalsteinsson E, Sood R, Mayer D, Bell R, McBride W, Li TK, Pfefferbaum A. 2006. Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. I. Adult brain growth. Alcohol Clin Exp Res 30:1234-1247.
28. Tang Y, Nyengaard JR. 1997. A stereological method for estimating the total length and size of myelin fibers in human brain white matter. J Neurosci Methods 73:193-200.
29. Tang Y, Nyengaard JR. 2004. Length estimation of nerve fibers in human white matter using IUR sections. In: Evans SM, Janson AM, Nyengaard JR, editors. Quantitative methods in neuroscience-a neuroanatomical approach. New York: Oxford University Press. p 249-263.
30. Yang S, Li C, Qiu X, Zhang L, Lu W, Chen L, Zhao YY, Shi XY, Huang CX, Cheng GH, Tang Y. 2013. Effects of an enriched environment on myelin sheaths in the white matter of rats during normal aging: a stereological study. Neuroscience 234:13-21.
31. Yang S, Li C, Zhang W, Wang WW, Nyengaard JR, Tang Y. 2008a. Application of stereological method to study the white matter and myelinated fibers therein of rat brain. Image Anal Stereol 27:125-132.
32. Yang S, Li C, Zhang W, Wang WW, Tang Y. 2008b. Sex differences in the white matter and myelinated nerve fibers of Long-Evans rats. Brain Res 1216:16-23.
33. Yang S, Li C, Zhang W, Wang WW, Tang Y. 2009. The myelinated fiber changes in the white matter of aged female Long-Evans rats. J Neurosci Res 87:1582-1590.