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Volumn 283, Issue , 2015, Pages 11-16

The role of laquinimod in modulation of the immune response in relapsing-remitting multiple sclerosis: Lessons from gene expression signatures

Author keywords

Gene expression microarray; Laquinimod; Multiple sclerosis; Peripheral blood mononuclear cells

Indexed keywords

ALPHA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON ALPHA 10; INTERFERON ALPHA 17; INTERFERON ALPHA 4; INTERFERON ALPHA 8; INTERLEUKIN 11; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 12P70; INTERLEUKIN 20; INTERLEUKIN 36; INTERLEUKIN 9; INTERLEUKIN RECEPTOR; LAQUINIMOD; OSTEOPROTEGERIN; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CYTOKINE; IMMUNOLOGIC FACTOR; MESSENGER RNA; QUINOLONE DERIVATIVE;

EID: 84929598546     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2015.04.007     Document Type: Article
Times cited : (8)

References (48)
  • 1
    • 33947363967 scopus 로고    scopus 로고
    • The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease
    • Adams R.A., Bauer J., Flick M.J., Sikorski S.L., Nuriel T., Lassmann H., Degen J.L., Akassoglou K. The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. J. Exp. Med. 2007, 204:571-582.
    • (2007) J. Exp. Med. , vol.204 , pp. 571-582
    • Adams, R.A.1    Bauer, J.2    Flick, M.J.3    Sikorski, S.L.4    Nuriel, T.5    Lassmann, H.6    Degen, J.L.7    Akassoglou, K.8
  • 2
    • 36749051730 scopus 로고    scopus 로고
    • Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis
    • Adams R.A., Schachtrup C., Davalos D., Tsigelny I., Akassoglou K. Fibrinogen signal transduction as a mediator and therapeutic target in inflammation: lessons from multiple sclerosis. Curr. Med. Chem. 2007, 14:2925-2936.
    • (2007) Curr. Med. Chem. , vol.14 , pp. 2925-2936
    • Adams, R.A.1    Schachtrup, C.2    Davalos, D.3    Tsigelny, I.4    Akassoglou, K.5
  • 3
    • 84922106382 scopus 로고    scopus 로고
    • Coagulation takes center stage in inflammation
    • Akassoglou K. Coagulation takes center stage in inflammation. Blood 2015, 125:419-420.
    • (2015) Blood , vol.125 , pp. 419-420
    • Akassoglou, K.1
  • 4
    • 0037075577 scopus 로고    scopus 로고
    • Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation
    • Akassoglou K., Yu W.M., Akpinar P., Strickland S. Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron 2002, 33:861-875.
    • (2002) Neuron , vol.33 , pp. 861-875
    • Akassoglou, K.1    Yu, W.M.2    Akpinar, P.3    Strickland, S.4
  • 5
    • 2342570412 scopus 로고    scopus 로고
    • Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis
    • Akassoglou K., Adams R.A., Bauer J., Mercado P., Tseveleki V., Lassmann H., Probert L., Strickland S. Fibrin depletion decreases inflammation and delays the onset of demyelination in a tumor necrosis factor transgenic mouse model for multiple sclerosis. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:6698-6703.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 6698-6703
    • Akassoglou, K.1    Adams, R.A.2    Bauer, J.3    Mercado, P.4    Tseveleki, V.5    Lassmann, H.6    Probert, L.7    Strickland, S.8
  • 6
    • 0037237822 scopus 로고    scopus 로고
    • Rapid up-regulation of alpha4 integrin-mediated leukocyte adhesion by transforming growth factor-beta1
    • Bartolome R.A., Sanz-Rodriguez F., Robledo M.M., Hidalgo A., Teixido J. Rapid up-regulation of alpha4 integrin-mediated leukocyte adhesion by transforming growth factor-beta1. Mol. Biol. Cell 2003, 14:54-66.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 54-66
    • Bartolome, R.A.1    Sanz-Rodriguez, F.2    Robledo, M.M.3    Hidalgo, A.4    Teixido, J.5
  • 7
    • 0034775840 scopus 로고    scopus 로고
    • Regulation of T-cell interaction with fibronectin by transforming growth factor-beta is associated with altered Pyk2 phosphorylation
    • Brill A., Franitza S., Lider O., Hershkoviz R. Regulation of T-cell interaction with fibronectin by transforming growth factor-beta is associated with altered Pyk2 phosphorylation. Immunology 2001, 104:149-156.
    • (2001) Immunology , vol.104 , pp. 149-156
    • Brill, A.1    Franitza, S.2    Lider, O.3    Hershkoviz, R.4
  • 8
    • 84890126970 scopus 로고    scopus 로고
    • Multiple sclerosis: oral laquinimod for MS-bringing the brain into focus
    • Bruck W., Vollmer T. Multiple sclerosis: oral laquinimod for MS-bringing the brain into focus. Nat. Rev. Neurol. 2013, 9:664-665.
    • (2013) Nat. Rev. Neurol. , vol.9 , pp. 664-665
    • Bruck, W.1    Vollmer, T.2
  • 9
    • 79958770585 scopus 로고    scopus 로고
    • Insight into the mechanism of laquinimod action
    • Brück W., Wegner C. Insight into the mechanism of laquinimod action. J. Neurol. Sci. 2011, 306:173-179.
    • (2011) J. Neurol. Sci. , vol.306 , pp. 173-179
    • Brück, W.1    Wegner, C.2
  • 11
    • 0036710356 scopus 로고    scopus 로고
    • The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis
    • Brunmark C., Runstrom A., Ohlsson L., Sparre B., Brodin T., Astrom M., Hedlund G. The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2002, 130:163-172.
    • (2002) J. Neuroimmunol. , vol.130 , pp. 163-172
    • Brunmark, C.1    Runstrom, A.2    Ohlsson, L.3    Sparre, B.4    Brodin, T.5    Astrom, M.6    Hedlund, G.7
  • 12
    • 45249107267 scopus 로고    scopus 로고
    • Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study
    • Comi G., Pulizzi A., Rovaris M., Abramsky O., Arbizu T., Boiko A., Gold R., Havrdova E., Komoly S., Selmaj K., Sharrack B., Filippi M., Group L.A.Q.S. Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study. Lancet 2008, 371:2085-2092.
    • (2008) Lancet , vol.371 , pp. 2085-2092
    • Comi, G.1    Pulizzi, A.2    Rovaris, M.3    Abramsky, O.4    Arbizu, T.5    Boiko, A.6    Gold, R.7    Havrdova, E.8    Komoly, S.9    Selmaj, K.10    Sharrack, B.11    Filippi, M.12    Group, L.A.Q.S.13
  • 13
    • 84859715302 scopus 로고    scopus 로고
    • Fibrinogen as a key regulator of inflammation in disease
    • Davalos D., Akassoglou K. Fibrinogen as a key regulator of inflammation in disease. Semin. Immunopathol. 2012, 34:43-62.
    • (2012) Semin. Immunopathol. , vol.34 , pp. 43-62
    • Davalos, D.1    Akassoglou, K.2
  • 15
    • 40149098058 scopus 로고    scopus 로고
    • Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation
    • East E., Gverić D., Baker D., Pryce G., Lijnen H., ML., C. Chronic relapsing experimental allergic encephalomyelitis (CREAE) in plasminogen activator inhibitor-1 knockout mice: the effect of fibrinolysis during neuroinflammation. Neuropathol. Appl. Neurobiol. 2008, 34:16-30.
    • (2008) Neuropathol. Appl. Neurobiol. , vol.34 , pp. 16-30
    • East, E.1    Gverić, D.2    Baker, D.3    Pryce, G.4    Lijnen, H.5    ML, C.6
  • 17
    • 84860475865 scopus 로고    scopus 로고
    • Emerging oral treatments in multiple sclerosis - clinical utility of cladribine tablets
    • Gasperini C., Ruggieri S., Pozzilli C. Emerging oral treatments in multiple sclerosis - clinical utility of cladribine tablets. Ther. Clin. Risk Manag. 2010, 6:391-399.
    • (2010) Ther. Clin. Risk Manag. , vol.6 , pp. 391-399
    • Gasperini, C.1    Ruggieri, S.2    Pozzilli, C.3
  • 19
    • 77951218761 scopus 로고    scopus 로고
    • Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study
    • Gurevich, M.; Gritzman, T.; Orbach, R.; Tuller, T.; Feldman, A.; Achiron, A. Laquinimod suppress antigen presentation in relapsing-remitting multiple sclerosis: in-vitro high-throughput gene expression study. J. Neuroimmunol. 2010, 221:87-94.
    • (2010) J. Neuroimmunol. , vol.221 , pp. 87-94
    • Gurevich, M.1    Gritzman, T.2    Orbach, R.3    Tuller, T.4    Feldman, A.5    Achiron, A.6
  • 20
    • 79952771167 scopus 로고    scopus 로고
    • Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation
    • Gutcher I., Donkor M.K., Ma Q., Rudensky A.Y., Flavell R.A., Li M.O. Autocrine transforming growth factor-beta1 promotes in vivo Th17 cell differentiation. Immunity 2011, 34:396-408.
    • (2011) Immunity , vol.34 , pp. 396-408
    • Gutcher, I.1    Donkor, M.K.2    Ma, Q.3    Rudensky, A.Y.4    Flavell, R.A.5    Li, M.O.6
  • 21
    • 0038157213 scopus 로고    scopus 로고
    • Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors
    • Gveric D., Herrera B., Petzold A., Lawrence D., Cuzner M. Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain 2003, 126.
    • (2003) Brain , vol.126
    • Gveric, D.1    Herrera, B.2    Petzold, A.3    Lawrence, D.4    Cuzner, M.5
  • 22
    • 0347361653 scopus 로고    scopus 로고
    • The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets
    • Horwitz D.A., Zheng S.G., Gray J.D. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8+ regulatory T cell subsets. J. Leukoc. Biol. 2003, 74:471-478.
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 471-478
    • Horwitz, D.A.1    Zheng, S.G.2    Gray, J.D.3
  • 23
    • 34447523607 scopus 로고    scopus 로고
    • Isolation and solubilization of proteins after TRIzol extraction of RNA and DNA from patient material following prolonged storage
    • Hummon A.B., Lim S.R., Difilippantonio M.J., Ried T. Isolation and solubilization of proteins after TRIzol extraction of RNA and DNA from patient material following prolonged storage. Biotechniques 2007, 42(467-470):472.
    • (2007) Biotechniques , vol.42 , Issue.467-470 , pp. 472
    • Hummon, A.B.1    Lim, S.R.2    Difilippantonio, M.J.3    Ried, T.4
  • 24
    • 79958721221 scopus 로고    scopus 로고
    • Th17 cell, the new player of neuroinflammatory process in multiple sclerosis
    • (Jul;74(1):1-13., S.J.I.)
    • Jadidi-Niaragh F., Mirshafiey A. Th17 cell, the new player of neuroinflammatory process in multiple sclerosis. Scand. J. Immunol. 2011, 74:1-13. (Jul;74(1):1-13., S.J.I.).
    • (2011) Scand. J. Immunol. , vol.74 , pp. 1-13
    • Jadidi-Niaragh, F.1    Mirshafiey, A.2
  • 27
    • 84928826568 scopus 로고    scopus 로고
    • Analysis of TGF-beta1 and TGF-beta3 as regulators of encephalitogenic Th17 cells: implications for multiple sclerosis
    • Lee P.W., Yang Y., Racke M.K., Lovett-Racke A.E. Analysis of TGF-beta1 and TGF-beta3 as regulators of encephalitogenic Th17 cells: implications for multiple sclerosis. Brain Behav. Immun. 2014, 10.1016/j.bbi.2014.12.007.
    • (2014) Brain Behav. Immun.
    • Lee, P.W.1    Yang, Y.2    Racke, M.K.3    Lovett-Racke, A.E.4
  • 28
    • 0035949745 scopus 로고    scopus 로고
    • Downregulation of transforming growth factor-beta1 in interferon-beta1a-treated MS patients
    • Lunemann J.D., Aktas O., Gniadek P., Zschenderlein R., Zipp F. Downregulation of transforming growth factor-beta1 in interferon-beta1a-treated MS patients. Neurology 2001, 57:1132-1134.
    • (2001) Neurology , vol.57 , pp. 1132-1134
    • Lunemann, J.D.1    Aktas, O.2    Gniadek, P.3    Zschenderlein, R.4    Zipp, F.5
  • 29
    • 69249112562 scopus 로고    scopus 로고
    • Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling
    • Luo D.D., Fielding C., Phillips A., Fraser D. Interleukin-1 beta regulates proximal tubular cell transforming growth factor beta-1 signalling. Nephrol. Dial. Transplant. 2009, 24:2655-2665.
    • (2009) Nephrol. Dial. Transplant. , vol.24 , pp. 2655-2665
    • Luo, D.D.1    Fielding, C.2    Phillips, A.3    Fraser, D.4
  • 32
    • 84885457151 scopus 로고    scopus 로고
    • TGF-beta: guardian of T cell function
    • Oh S.A., Li M.O. TGF-beta: guardian of T cell function. J. Immunol. 2013, 191:3973-3979.
    • (2013) J. Immunol. , vol.191 , pp. 3973-3979
    • Oh, S.A.1    Li, M.O.2
  • 33
    • 34247177988 scopus 로고    scopus 로고
    • Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans
    • Ponighaus C., Ambrosius M., Casanova J.C., Prante C., Kuhn J., Esko J.D., Kleesiek K., Gotting C. Human xylosyltransferase II is involved in the biosynthesis of the uniform tetrasaccharide linkage region in chondroitin sulfate and heparan sulfate proteoglycans. J. Biol. Chem. 2007, 282:5201-5206.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5201-5206
    • Ponighaus, C.1    Ambrosius, M.2    Casanova, J.C.3    Prante, C.4    Kuhn, J.5    Esko, J.D.6    Kleesiek, K.7    Gotting, C.8
  • 35
    • 68849126246 scopus 로고    scopus 로고
    • Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity
    • Sanjabi S., Zenewicz L.A., Kamanaka M., Flavell R.A. Anti-inflammatory and pro-inflammatory roles of TGF-beta, IL-10, and IL-22 in immunity and autoimmunity. Curr. Opin. Pharmacol. 2009, 9:447-453.
    • (2009) Curr. Opin. Pharmacol. , vol.9 , pp. 447-453
    • Sanjabi, S.1    Zenewicz, L.A.2    Kamanaka, M.3    Flavell, R.A.4
  • 39
    • 84860320611 scopus 로고    scopus 로고
    • TGF-beta converts apoptotic stimuli into the signal for Th9 differentiation
    • Takami M., Love R.B., Iwashima M. TGF-beta converts apoptotic stimuli into the signal for Th9 differentiation. J. Immunol. 2012, 188:4369-4375.
    • (2012) J. Immunol. , vol.188 , pp. 4369-4375
    • Takami, M.1    Love, R.B.2    Iwashima, M.3
  • 41
    • 84908655755 scopus 로고    scopus 로고
    • Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis
    • Varrin-Doyer M., Zamvil S.S., Schulze-Topphoff U. Laquinimod, an up-and-coming immunomodulatory agent for treatment of multiple sclerosis. Exp. Neurol. 2014, 262(PA):66-71.
    • (2014) Exp. Neurol. , vol.262 , Issue.PA , pp. 66-71
    • Varrin-Doyer, M.1    Zamvil, S.S.2    Schulze-Topphoff, U.3
  • 43
    • 33746111852 scopus 로고    scopus 로고
    • The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
    • Wan Y.Y., Chi H., Xie M., Schneider M.D., Flavell R.A. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 2006, 7:851-858.
    • (2006) Nat. Immunol. , vol.7 , pp. 851-858
    • Wan, Y.Y.1    Chi, H.2    Xie, M.3    Schneider, M.D.4    Flavell, R.A.5
  • 44
    • 77956649428 scopus 로고    scopus 로고
    • Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis
    • Wegner C., Stadelmann C., Pfortner R., Raymond E., Feigelson S., Alon R., Timan B., Hayardeny L., Bruck W. Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis. J. Neuroimmunol. 2010, 227:133-143.
    • (2010) J. Neuroimmunol. , vol.227 , pp. 133-143
    • Wegner, C.1    Stadelmann, C.2    Pfortner, R.3    Raymond, E.4    Feigelson, S.5    Alon, R.6    Timan, B.7    Hayardeny, L.8    Bruck, W.9
  • 45
    • 4744340401 scopus 로고    scopus 로고
    • Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats
    • Yang J.S., Xu L.Y., Xiao B.G., Hedlund G., Link H. Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-beta in Lewis rats. J. Neuroimmunol. 2004, 156:3-9.
    • (2004) J. Neuroimmunol. , vol.156 , pp. 3-9
    • Yang, J.S.1    Xu, L.Y.2    Xiao, B.G.3    Hedlund, G.4    Link, H.5
  • 48
    • 0036240732 scopus 로고    scopus 로고
    • Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue
    • Zou L.P., Abbas N., Volkmann I., Nennesmo I., Levi M., Wahren B., Winblad B., Hedlund G., Zhu J. Suppression of experimental autoimmune neuritis by ABR-215062 is associated with altered Th1/Th2 balance and inhibited migration of inflammatory cells into the peripheral nerve tissue. Neuropharmacology 2002, 42:731-739.
    • (2002) Neuropharmacology , vol.42 , pp. 731-739
    • Zou, L.P.1    Abbas, N.2    Volkmann, I.3    Nennesmo, I.4    Levi, M.5    Wahren, B.6    Winblad, B.7    Hedlund, G.8    Zhu, J.9


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