메뉴 건너뛰기




Volumn 30, Issue 3, 2015, Pages 343-347

Rat Pig-a mutation assay responds to the genotoxic carcinogen ethyl carbamate but not the non-genotoxic carcinogen methyl carbamate

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMIC ACID METHYL ESTER; CARCINOGEN; EPOXIDE; URETHAN; CARBAMIC ACID DERIVATIVE; MEMBRANE PROTEIN; MUTAGENIC AGENT; PHOSPHATIDYLINOSITOL GLYCAN-CLASS A PROTEIN;

EID: 84929584348     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/geu084     Document Type: Article
Times cited : (23)

References (32)
  • 1
    • 30344443429 scopus 로고    scopus 로고
    • accessed December 3, 2014
    • U.S. EPA. (2005) Guidelines for Carcinogen Risk Assessment. http://www. epa.gov/ttnatw01/cancer-guidelines-final-3-25-05.pdf (accessed December 3, 2014).
    • (2005) Guidelines for Carcinogen Risk Assessment
  • 2
    • 84928809223 scopus 로고    scopus 로고
    • IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk
    • in press
    • MacGregor, J.T., Frötschl, R., White, P.A et al.. (2014) IWGT Report on Quantitative Approaches to Genotoxicity Risk Assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk. Mutat. Res., in press. doi: 10.1016/j.mrgentox. 2014.10.008.
    • (2014) Mutat. Res.
    • Macgregor, J.T.1    Frötschl, R.2    Et Al.., A.W.P.3
  • 4
    • 0025297041 scopus 로고
    • Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane
    • Holmstrom, M. (1990) Induction of micronuclei in bone marrow of mice exposed to 1, 2 or 3 daily doses of urethane. Mutat. Res., 234, 147-154.
    • (1990) Mutat. Res. , vol.234 , pp. 147-154
    • Holmstrom, M.1
  • 5
    • 0035070535 scopus 로고    scopus 로고
    • Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: Summary of the 13th collaborative study by the Colloborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS)
    • Hamada, S., Sutou, S., Morita, T. et al. (2001) Evaluation of the rodent micronucleus assay by a 28-day treatment protocol: summary of the 13th collaborative study by The Colloborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS). Environ. Mol. Mutagen., 37, 93-110.
    • (2001) Environ. Mol. Mutagen. , vol.37 , pp. 93-110
    • Hamada, S.1    Sutou, S.2    Et Al., M.T.3
  • 7
    • 0141785156 scopus 로고    scopus 로고
    • In vivo transgenic mutation assays
    • Thybaud, V., Dean, S., Nohmi, T. et al. (2003) In vivo transgenic mutation assays. Mutat. Res., 540, 141-151.
    • (2003) Mutat. Res. , vol.540 , pp. 141-151
    • Thybaud, V.1    Dean, S.2    Et Al., N.T.3
  • 8
    • 0025091492 scopus 로고
    • The in vivo erythrocyte micronucleus test: Measurement at steady state increases assay efficiency and permits integration with toxicity studies
    • MacGregor, J. T., Wehr, C. M., Henika, P. R. and Shelby, M. D. (1990) The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fundam. Appl. Toxicol., 14, 513-522.
    • (1990) Fundam. Appl. Toxicol. , vol.14 , pp. 513-522
    • Macgregor, J.T.1    Wehr, C.M.2    Henika, P.R.3    Shelby, M.D.4
  • 9
    • 0025193585 scopus 로고
    • 1,N6-ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate
    • Leithauser, M. T., Liem, A., Stewart, B. C., Miller, E. C. and Miller, J. A. (1990) 1,N6-ethenoadenosine formation, mutagenicity and murine tumor induction as indicators of the generation of an electrophilic epoxide metabolite of the closely related carcinogens ethyl carbamate (urethane) and vinyl carbamate. Carcinogenesis, 11, 463-473.
    • (1990) Carcinogenesis , vol.11 , pp. 463-473
    • Leithauser, M.T.1    Liem, A.2    Stewart, B.C.3    Miller, E.C.4    Miller, J.A.5
  • 10
    • 0025340017 scopus 로고
    • Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate
    • Park, K. K., Surh, Y. J., Stewart, B. C. and Miller, J. A. (1990) Synthesis and properties of vinyl carbamate epoxide, a possible ultimate electrophilic and carcinogenic metabolite of vinyl carbamate and ethyl carbamate. Biochem. Biophys. Res. Commun., 169, 1094-1098.
    • (1990) Biochem. Biophys. Res. Commun. , vol.169 , pp. 1094-1098
    • Park, K.K.1    Surh, Y.J.2    Stewart, B.C.3    Miller, J.A.4
  • 11
    • 84929583457 scopus 로고    scopus 로고
    • Integration of Pig-A, micronucleus, chromosome aberration, and comet assay endpoints in a 28-day rodent toxicity study with urethane
    • Stankowski, L.F. Jr., Aardema, M.J., Lawlor, T.E., Pant, K., Roy, S., Xu, Y. and Elbekai, R. (2015) Integration of Pig-a, micronucleus, chromosome aberration, and comet assay endpoints in a 28-day rodent toxicity study with urethane. Mutagenesis, 30, 335-342.
    • (2015) Mutagenesis , vol.30 , pp. 335-342
    • Stankowski, L.F.1    Aardema, M.J.2    Lawlor, T.E.3    Pant, K.4    Roy, S.5    Xu, Y.6    Elbekai, R.7
  • 12
    • 84929584724 scopus 로고
    • Toxicology and carcinogenesis of methyl carbamate in F344/N rats and B6C3F1 mice
    • National Toxicology Program (NTP). (1987) Toxicology and carcinogenesis of methyl carbamate in F344/N rats and B6C3F1 mice. Natl Toxicol. Program Tech. Rep. Ser., 328, 1-176.
    • (1987) Natl Toxicol. Program Tech. Rep. Ser. , vol.328 , pp. 1-176
    • National Toxicology Program (NTP)1
  • 13
    • 0025830253 scopus 로고
    • Genotoxicity data supporting the proposed metabolic activation of ethyl carbamate (urethane) to a carcinogen: The problem now posed by methyl carbamate
    • Ashby, J. (1991) Genotoxicity data supporting the proposed metabolic activation of ethyl carbamate (urethane) to a carcinogen: The problem now posed by methyl carbamate. Mutat. Res., 260, 307-308.
    • (1991) Mutat. Res. , vol.260 , pp. 307-308
    • Ashby, J.1
  • 14
    • 0025775523 scopus 로고
    • Methyl carbamate: Negative results in mouse bone-marrow micronucleus test
    • Shelby, M. D. and Tice, R. R. (1991) Methyl carbamate: negative results in mouse bone-marrow micronucleus test. Mutat. Res., 260, 311.
    • (1991) Mutat. Res. , vol.260 , pp. 311
    • Shelby, M.D.1    Tice, R.R.2
  • 15
    • 49649113454 scopus 로고    scopus 로고
    • Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop
    • Kirkland, D., Kasper, P., Müller, L., Corvi, R. and Speit, G. (2008) Recommended lists of genotoxic and non-genotoxic chemicals for assessment of the performance of new or improved genotoxicity tests: A follow-up to an ECVAM workshop. Mutat. Res., 653, 99-108.
    • (2008) Mutat. Res. , vol.653 , pp. 99-108
    • Kirkland, D.1    Kasper, P.2    Müller, L.3    Corvi, R.4    Speit, G.5
  • 16
    • 77954067514 scopus 로고    scopus 로고
    • Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies
    • Dertinger, S. D., Phonethepswath, S., Franklin, D. et al. (2010) Integration of mutation and chromosomal damage endpoints into 28-day repeat dose toxicology studies. Toxicol. Sci., 115, 401-411.
    • (2010) Toxicol. Sci. , vol.115 , pp. 401-411
    • Dertinger, S.D.1    Phonethepswath, S.2    Et Al., F.D.3
  • 17
    • 80155189083 scopus 로고    scopus 로고
    • Integration of Pig-A, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide
    • Stankowski, L. F. Jr, Roberts, D. J., Chen, H., Lawlor, T., McKeon, M., Murli, H., Thakur, A. and Xu, Y. (2011) Integration of Pig-a, micronucleus, chromosome aberration, and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide. Environ. Mol. Mutagen., 52, 738-747.
    • (2011) Environ. Mol. Mutagen. , vol.52 , pp. 738-747
    • Stankowski, L.F.1    Roberts, D.J.2    Chen, H.3    Lawlor, T.4    McKeon, M.5    Murli, H.6    Thakur, A.7    Xu, Y.8
  • 19
    • 80155154404 scopus 로고    scopus 로고
    • Manifestation and persistence of Pig-A mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea
    • Bhalli, J. A., Pearce, M. G., Dobrovolsky, V. N. and Heflich, R. H. (2011) Manifestation and persistence of Pig-A mutant red blood cells in C57BL/6 mice following single and split doses of N-ethyl-N-nitrosourea. Environ. Mol. Mutagen., 52, 766-773.
    • (2011) Environ. Mol. Mutagen. , vol.52 , pp. 766-773
    • Bhalli, J.A.1    Pearce, M.G.2    Dobrovolsky, V.N.3    Heflich, R.H.4
  • 20
    • 0034011427 scopus 로고    scopus 로고
    • Significance of multiple mutations in cancer
    • Loeb, K. R. and Loeb, L. A. (2000) Significance of multiple mutations in cancer. Carcinogenesis, 21, 379-385.
    • (2000) Carcinogenesis , vol.21 , pp. 379-385
    • Loeb, K.R.1    Loeb, L.A.2
  • 21
    • 84875594981 scopus 로고    scopus 로고
    • Test Guideline 407: Repeated Dose 28-Day Oral Toxicity Study in Rodents
    • OECD Publishing (accessed December 3, 2014)
    • OECD. (2008) Test Guideline 407: Repeated Dose 28-Day Oral Toxicity Study in Rodents. OECD Guidelines for the Testing of Chemicals, Section 4. OECD Publishing. http://www.oecd-ilibrary.org/ environment/test-no-407-repeated-dose-28-day-oral-toxicity-study-inrodents-9789264070684-en (accessed December 3, 2014).
    • (2008) OECD Guidelines for the Testing of Chemicals, Section , vol.4
  • 22
    • 0004389169 scopus 로고
    • What about other intervals?
    • Vardeman, S.B. (1992) What about other intervals? Am. Stat., 46, 193-197.
    • (1992) Am. Stat. , vol.46 , pp. 193-197
    • Vardeman, S.B.1
  • 23
    • 0042591389 scopus 로고    scopus 로고
    • Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy
    • Torous, D. K., Hall, N. E., Murante, F. G., Gleason, S. E., Tometsko, C. R. and Dertinger, S. D. (2003) Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicol. Sci., 74, 309-314.
    • (2003) Toxicol. Sci. , vol.74 , pp. 309-314
    • Torous, D.K.1    Hall, N.E.2    Murante, F.G.3    Gleason, S.E.4    Tometsko, C.R.5    Dertinger, S.D.6
  • 24
    • 19944434262 scopus 로고    scopus 로고
    • Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood
    • Dertinger, S. D., Camphausen, K., Macgregor, J. T. et al. (2004) Three-color labeling method for flow cytometric measurement of cytogenetic damage in rodent and human blood. Environ. Mol. Mutagen., 44, 427-435.
    • (2004) Environ. Mol. Mutagen. , vol.44 , pp. 427-435
    • Dertinger, S.D.1    Camphausen, K.2    Et Al., T.M.J.3
  • 25
    • 0027292604 scopus 로고
    • Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model
    • Tometsko, A. M., Torous, D. K. and Dertinger, S. D. (1993) Analysis of micronucleated cells by flow cytometry. 1. Achieving high resolution with a malaria model. Mutat. Res., 292, 129-135.
    • (1993) Mutat. Res. , vol.292 , pp. 129-135
    • Tometsko, A.M.1    Torous, D.K.2    Dertinger, S.D.3
  • 26
    • 0033978261 scopus 로고    scopus 로고
    • Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry
    • Dertinger, S. D., Torous, D. K., Hall, N. E., Tometsko, C. R. and Gasiewicz, T. A. (2000) Malaria-infected erythrocytes serve as biological standards to ensure reliable and consistent scoring of micronucleated erythrocytes by flow cytometry. Mutat. Res., 464, 195-200.
    • (2000) Mutat. Res. , vol.464 , pp. 195-200
    • Dertinger, S.D.1    Torous, D.K.2    Hall, N.E.3    Tometsko, C.R.4    Gasiewicz, T.A.5
  • 27
    • 84869753046 scopus 로고    scopus 로고
    • Efficient monitoring of in vivo pig-A gene mutation and chromosomal damage: Summary of 7 published studies and results from 11 new reference compounds
    • Dertinger, S. D., Phonethepswath, S., Avlasevich, S. L. et al. (2012) Efficient monitoring of in vivo pig-A gene mutation and chromosomal damage: summary of 7 published studies and results from 11 new reference compounds. Toxicol. Sci., 130, 328-348.
    • (2012) Toxicol. Sci. , vol.130 , pp. 328-348
    • Dertinger, S.D.1    Phonethepswath, S.2    Et Al., L.A.S.3
  • 28
    • 84898057850 scopus 로고    scopus 로고
    • Pig-A gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone
    • Dertinger, S. D., Phonethepswath, S., Avlasevich, S. L., Torous, D. K., Mereness, J., Cottom, J., Bemis, J. C. and Macgregor, J. T. (2014) Pig-A gene mutation and micronucleated reticulocyte induction in rats exposed to tumorigenic doses of the leukemogenic agents chlorambucil, thiotepa, melphalan, and 1,3-propane sultone. Environ. Mol. Mutagen., 55, 299-308.
    • (2014) Environ. Mol. Mutagen. , vol.55 , pp. 299-308
    • Dertinger, S.D.1    Phonethepswath, S.2    Avlasevich, S.L.3    Torous, D.K.4    Mereness, J.5    Cottom, J.6    Bemis, J.C.7    Macgregor, J.T.8
  • 29
    • 77951556618 scopus 로고    scopus 로고
    • Pig-A mutation: Kinetics in rat erythrocytes following exposure to five prototypical mutagens
    • Phonethepswath, S., Franklin, D., Torous, D. K. et al. (2010) Pig-A mutation: kinetics in rat erythrocytes following exposure to five prototypical mutagens. Toxicol. Sci., 114, 59-70.
    • (2010) Toxicol. Sci. , vol.114 , pp. 59-70
    • Phonethepswath, S.1    Franklin, D.2    Et Al., K.T.D.3
  • 30
    • 84928810972 scopus 로고    scopus 로고
    • The in vivo Pig-A assay: A report of the international workshop on genotoxicity testing (IWGT) workgroup
    • in press
    • Gollapudi, B. B., Lynch, A. M., Heflich, R. H. et al. (2014) The in vivo Pig-A assay: A report of the International Workshop on Genotoxicity Testing (IWGT) Workgroup, Mutat. Res., in press. doi: 10.1016.j.mrgentox. 2014.09.007.
    • (2014) Mutat. Res.
    • Gollapudi, B.B.1    Lynch, A.M.2    Et Al., H.H.R.3
  • 32
    • 72449195675 scopus 로고    scopus 로고
    • Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities-Report from an ECVAM workshop
    • Pfuhler, S., Kirkland, D., Kasper, P. et al. (2009) Reduction of use of animals in regulatory genotoxicity testing: identification and implementation opportunities-Report from an ECVAM workshop. Mutat. Res., 680, 31-42.
    • (2009) Mutat. Res. , vol.680 , pp. 31-42
    • Pfuhler, S.1    Kirkland, D.2    Et Al., K.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.