Biophysical and Biological Characterization of Hairpin and Molecular Beacon RNase H Active Antisense Oligonucleotides

ACS Chemical Biology

Volumn 10, Issue 5, 2015, Pages 1227-1233

  Østergaard, Michael E ^a   Thomas, George ^a   Koller, Erich ^a   Southwell, Amber L ^b   Hayden, Michael R ^b   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CELL PROTEIN; COMPLEMENTARY RNA; HUNTINGTIN; NUCLEOTIDE; OLIGONUCLEOTIDE; RIBONUCLEASE H; RNA; SCAVENGER RECEPTOR B; SINGLE STRANDED RNA; VIRUS LARGE T ANTIGEN; HTT PROTEIN, HUMAN; NERVE PROTEIN;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOPHYSICS; CAG REPEAT; CELL CULTURE; CELL INTERACTION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CLINICAL EVALUATION; CONTROLLED STUDY; DNA HAIRPIN; DOWN REGULATION; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HAIRPIN STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR BEACON; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; RNA BINDING; RNA CONFORMATION; RNA PROBE; RNA STABILITY; RNA STRUCTURE; SIMIAN VIRUS 40; SINGLE NUCLEOTIDE POLYMORPHISM; CELL LINE; CHEMISTRY; GENETICS;

ANIMALIA; MUS;

ALLELES; BIOPHYSICAL PHENOMENA; CELL LINE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROSCOPY, FLUORESCENCE; NERVE TISSUE PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; RIBONUCLEASE H;

EID: 84929576881     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500880f     Document Type: Article

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