The biomarkers of fetal growth in intrauterine growth retardation and large for gestational age cases: From adipocytokines to a metabolomic all-in-one tool

Expert Review of Proteomics

Volumn 12, Issue 3, 2015, Pages 309-316

  Dessì, Angelica ^a   Pravettoni, Chiara ^a   Cesare Marincola, Flaminia ^b   Schirru, Andrea ^a   Fanos, Vassilios ^a  

^a Neonatal Intensive Care Unit   (Italy)

^b UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

biomarkers; fetal growth; intrauterine growth retardation; large for gestational age; metabolomics

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; APELIN; BIOLOGICAL MARKER; GHRELIN; INTERLEUKIN 6; LEPTIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROTEIN S100B; TUMOR NECROSIS FACTOR;

EARLY DIAGNOSIS; FETUS GROWTH; HOLISTIC CARE; HUMAN; INTRAUTERINE GROWTH RETARDATION; LARGE FOR GESTATIONAL AGE; MEDICAL RESEARCH; METABOLIC SYNDROME X; METABOLOMICS; NONHUMAN; PEDIATRICS; REVIEW; ANIMAL; FETUS DEVELOPMENT; GESTATIONAL AGE; METABOLIC DISORDER; METABOLISM;

ADIPOKINES; ANIMALS; BIOMARKERS; FETAL DEVELOPMENT; FETAL GROWTH RETARDATION; GESTATIONAL AGE; HUMANS; METABOLIC DISEASES; METABOLOMICS;

EID: 84929575170     PISSN: 14789450     EISSN: 17448387     Source Type: Journal    
DOI: 10.1586/14789450.2015.1034694     Document Type: Review

References (56)

1. Committee on Practice Bulletins Gynecology; American College of Obstetricians and Gynecologists; Washington; DC 20090-6920; USA. Intrauterine growth restriction. Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet 2001;72:85-96
2. Ferrario M, Magenes G, Campanile M, et al. Multiparameter analysis of heart rate variability signal for the investigation of high risk fetuses. Conf Proc IEEE Eng Med Biol Soc 2009;2009:4662-5
3. Ju H, Chadha Y, Donovan T, O'Rourke P. Fetal Macrosomia and pregnancy outcomes. Aust N Z J Obstet Gynaecol 2009;49(5): 504-9
4. Dessì A, Ottonello G, Fanos V. Physiopathology of intrauterine growth retardation: from classic data to metabolomics. J Matern Fetal Neonatal Med 2012;25(5):13-18
5. Dessì A, Puddu M, Ottonello G, Fanos V. Metabolomics and fetal-neonatal nutrition: between not enough and too much. Molecules 2013;18(10):11724-32 .. This paper mainly focuses on the formulation of new hypotheses, by means of metabolomics, concerning the biological mechanisms to departure from fetal-neonatal life that may predispose to the development of chronic diseases in adulthood.
6. Bjorntorp P. Metabolic implications of body fat distribution. Diabetes Care 1991;14(12): 1132-43
7. Yajnik CS, Lubree HG, Rege SS, et al. Adiposity and hyperinsulinemia in Indians are present at birth. J Clin Endocrinol Metab 2002;87(12):5575-80
8. Ibáñez L, Lopez-Bermejo A, Suarez L, et al. Visceral adiposity without overweight in children born small for gestational age. J Clin Endocrinol Metab 2008;93(6): 2079-208
9. Eriksson JG, Lindi V, Uusitupa M, et al. The effects of the Pro12Ala polymorphism of the peroxisome proliferators-activated receptor-gamma2 gene on insulin sensitivity and insulin metabolism interact with size at birth. Diabetes 2002;51(7):2321-4
10. Hawdon J. Hypoglycemia and the neonatal brain. Eur J Pediatr 1999;158(Suppl):S9-12
11. Lukaszewski MA, Eberle- D, Vieau D, Breton C. Nutritional manipulations in the perinatal period program adipose tissue in offspring. Am J Physiol Endocrinol Metab 2013;305(10):E1195-207
12. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997;387(6636):903-8
13. Clapp JF 3rd, Kiess W. Cord blood leptin reflects fetal fat mass. J Soc Gynecol Investig 1998;5(6):300-3
14. Bertoni L, Ferretti M, Cavani F, et al. Leptin increases growth of primary ossification centers in fetal mice. J Anat 2009;215(5):577-83
15. Nezar MA, el-Baky AM, Soliman OA, et al. Endothelin-1 and leptin as markers of intrauterine growth restriction. Indian J Pediatr 2009;76(5):485-8
16. Ben X, Qin Y, Wu S, et al. Placental leptin correlates with intrauterine fetal growth and development. Chin Med J (Engl) 2001; 114(6):636-9
17. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in the central regulation of feeding. Nature 2001;409(6817):194-8
18. Farquhar J, Heiman M, Wong AC, et al. Elevated umbilical cord ghrelin concentrations in small for gestational age neonates. J Clin Endocrinol Metab 2003; 88(9):4324-7
19. Onal EE, Cinaz P, Atalay Y, et al. Umbilical cord ghrelin concentrations in small- and appropriate-for-gestational age newborn infants: relationship to anthropometric markers. J Endocrinol 2004; 180(2):267-71
20. Fernandez-Real JM, Ricart W. Insulin resistance and inflammation in an evolutionary perspective: the contribution of cytokine genotype/phenotype to thriftiness. Diabetologia 1999;42(11):1367-74
21. Cox CM, D'Agostino SL, Miller MK, et al. Apelin, the ligand for the endothelial G-protein-coupled receptor, APJ, is a potent angiogenic factor required for normal vascular development of the frog embryo. Dev Biol 2006;296(1):177-89
22. Cianfarani S, Martinez C, Maiorana A, et al. Adiponectin levels are reduced in children born small for gestational age and are inversely related to postnatal catch-up growth. J Clin Endocrinol Metab 2004; 89(3):1346-51
23. Kotani Y, Yokota I, Kitamura S, et al. Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birth weight. Clin Endocrinol (Oxf) 2004;61(4):418-23
24. Lindsay RS, Walker JD, Havel PJ, et al. Adiponectin is present in cord blood but is unrelated to birth weight. Diabetes Care 2003;26(8):2244-9
25. Ibáñez L, Sebastiani G, Lopez-Bermejo A, et al. Gender specificity of body adiposity and circulating adiponectin, visfatin, insulin, and insulin growth factor-I at term birth: relation to prenatal growth. J Clin Endocrinol Metab 2008;93(7):2774-8
26. Sancakli O, Darendeliler F, Bas F, et al. Insulin, adiponectin, IGFBP-1 levels and body composition in small for gestational age born non-obese children during prepubertal ages. Clin Endocrinol (Oxf) 2008;69(1):88-92
27. Darendeliler F, Poyrazoglu S, Sancakli O, et al. Adiponectin is an indicator of insulin resistance in non-obese prepubertal children born large for gestational age and is affected by birth weight. Clin Endocrinol (Oxf) 2009;70(5):710-16
28. Boucher J, Masri B, Daviaud D, et al. Apelin, a newly identified adipokine up-regulated by insulin and obesity. Endocrinology 2005;146(4):1764-71
29. Li L, Yang G, Li Q, et al. Changes and relations of circulating visfatin, apelin, and resistin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Exp Clin Endocrinol Diabetes 2006;114(10): 544-8
30. Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005;307(5708):426-30
31. Fukuhara A, Matsuda M, Nishizawa M, et al. Retraction. Science 2007;318(5850): 565
32. Malamitsi-Puchner A, Briana DD, Boutsikou M, et al. Perinatal circulating visfatin levels in intrauterine growth restriction. Pediatrics 2007;119:e1314-18
33. Nemeth E, Millar LK, Bryant-Greenwood G. Fetal membrane distention: II. Differentially expressed genes regulated by acute distention in vitro. Am J Obstet Gynecol 2000;182(1):60-7
34. Rothermundt M, Peters M, Prehn JH, Arolt V. S100B in brain damage and neurodegeneration. Microsc Res Tech 2003; 60(6):614-32
35. Florio P, Marinoni E, Di Iorio R, et al. Urinary S100B protein concentrations are increased in intrauterine growth-retarded newborns. Pediatrics 2006;118(3):747-54
36. Tina LG, Frigiola A, Abella R, et al. S100B protein and near infrared spectroscopy in preterm and term newborns. Front Biosci (Elite Ed) 2010;2:159-64
37. Nicholson JK, Connelly J, Lindon JC, Holmes E. Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 2002;1(2):153-61
38. McNiven EM, German JB, Slupsky CM. Analytical metabolomics: nutritional opportunities for personalized health. J Nutr Biochem 2011;22(11):995-1002
39. Lin G, Liu C, Feng C, et al. Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestation. J Nutr 2012;142(6):990-8
40. Favretto D, Cosmi E, Ragazzi E, et al. Cord blood metabolomic profiling in intrauterine growth restriction. Anal Bioanal Chem 2012;402(3):1109-21
41. van Vliet E, Eixarch E, Illa M, et al. Metabolomics reveals metabolic alterations by intrauterine growth restriction in the fetal rabbit brain. PLoS One 2013;8:e64545
42. Dessì A, Atzori L, Noto A, et al. Metabolomics in newborns with intrauterine growth retardation (IUGR): urine reveals markers of metabolic syndrome. J Matern Fetal Neonatal Med 2011;24(2):35-9 .. This is the first work described in the literature that has analyzed, with the use of metabolomics, the urine metabolic profiles in intrauterine growth retardation (IUGR) neonates and controls for the purpose of defining the metabolic patterns associated with growth retardation.
43. Kennington AS, Hill CR, Craig J, et al. Low urinary chiro-inositol excretion in non-insulin-dependent diabetes mellitus. N Engl J Med 1990;323(6):373-8
44. Dessì A, Fanos V. Myoinositol: a new marker of intrauterine growth restriction? J Obstet Gynaecol 2013;33(8):776-80
45. Dessì A, Marincola FC, Pattumelli MG, et al. Investigation of the 1H-NMR based urine metabolomic profiles of IUGR, LGA and AGA newborns on the first day of life. J Matern Fetal Neonatal Med 2014; 27(2):13-19 .. This study highlights the applicability of NMR-based metabolomics for improving the understanding of the relationship between nutrition, integrated metabolism and health in neonatology.
46. Barberini L, Noto A, Fattuoni C, et al. Urinary metabolomics (GC-MS) reveals that low and high birth weight infants share elevated inositol concentrations at birth. J Matern Fetal Neonatal Med 2014;27(2): 20-6 .. This investigation compared urine metabolic profiles of IUGR and large for gestational age neonates to controls to identify metabolic similarities between IUGR and large for gestational age and identify markers for biochemical alterations during fetal life that may lead to the onset of metabolic syndrome in adulthood.
47. Dessì A, Marincola FC, Fanos V. Metabolomics and the great obstetrical syndromes - GDM, PET, and IUGR. Best Pract Res Clin Obstet Gynaecol 2015;29(2): 156-64 . This paper focuses on the applications of metabolomic technology in the context of prenatal research, attempting to meet specific medical needs of diagnosis of the great obstetrical syndromes.
48. Dessì A, Cesare Marincola F, Masili A, et al. Clinical metabolomics and nutrition: the new frontier in neonatology and pediatrics. Biomed Res Int 2014;2014:981219 .. This review focuses on the applications of metabolomics in the context of neonatology and pediatrics with emphasis on the potential preclinical and clinical applications of this technology in the area of nutrition.
49. Palcevska-Kocevska S, Aluloska N, Krstevska M, et al. Correlation of serum adiponectin and leptin concentrations with anthropometric parameters in newborns. Srp Arh Celok Lek 2012;140(9-10):595-9
50. Jacquet D, Leger J, Levy-Marchal C, et al. Ontogeny of leptin in human fetuses and newborns: effect of intrauterine growth retardation on serum leptin concentrations. JCEM 1997;83(4):1243-6
51. Chiesa C, Osborn JF, Haass C, et al. Ghrelin, leptin, IGF-1, IGFBP-3, and insulin concentrations at birth: is there a relationship with fetal growth and neonatal anthropometry? Clin Chem 2008;54(3): 550-8
52. Kyriakakou M, Malamitsi-Puchner A, Militsi H, et al. Leptin and adiponectin concentrations in intrauterine growth restricted and appropriate for gestational age fetuses, neonates, and their mothers. Eur J Endocrinol 2008;158(3):343-8
53. Shang LX, Tang QL, Wang J, et al. Relationship of adiponectin and visfatin with fetus intrauterine growth. Zhonghua Fu Chan Ke Za Zhi 2009;44(4):246-8
54. Cekmez F, Pirgon O, Tanju A, Ipcioglu OM. Cord plasma concentrations of visfatin, adiponectin and insulin in healthy term neonates: positive correlation with birthweight. Int J Biomed Sci 2009; 5(3):257-60
55. Smerieri A, Petraroli M, Ziveri MA, et al. Effects of cord serum insulin, IGF-II, IGFBP-2, IL-6 and cortisol concentrations on human birth weight and length: pilot study. PLoS One 2011;6(12):e29562
56. Michetti F, Gazzolo D. S100B protein in biological fluids: a tool for perinatal medicine. Clin Chem 2002;48(12): 2097-104