Metabolomics and fetal-neonatal nutrition: Between "not enough" and "too much"

Molecules

Volumn 18, Issue 10, 2013, Pages 11724-11732

  Dessì, Angelica ^a   Puddu, Melania ^a   Ottonello, Giovanni ^a   Fanos, Vassilios ^a  

^a DEPARTMENT OF RADIOLOGY   (Italy)

Author keywords

LGA; Metabolomics; Nutrition; SGA

Indexed keywords

ANIMAL; FEMALE; FETAL MALNUTRITION; HUMAN; METABOLISM; METABOLOME; METABOLOMICS; NEWBORN; NUTRITIONAL DISORDER; OVERNUTRITION; PREGNANCY; PRENATAL EXPOSURE; REVIEW; RISK FACTOR; COMPLICATION; ETIOLOGY;

ANIMALS; FEMALE; FETAL NUTRITION DISORDERS; HUMANS; INFANT NUTRITION DISORDERS; INFANT, NEWBORN; METABOLOME; METABOLOMICS; OVERNUTRITION; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RISK FACTORS;

EID: 84886604201     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules181011724     Document Type: Review

References (37)

1. Nicholson, J.K.; Connelly, J.; Lindon, J.C.; Holmes, E. Metabonomics: A platform for studying drug toxicity and gene function. Nat. Rev. Drug. Discov. 2002, 1, 153-161.
2. Ellis, D.I.; Dunn, W.B.; Griffin, J.L.; Allwood, J.W.; Goodacre, R. Metabolic fingerprinting as a diagnostic tool. Pharmacogenomics 2007, 8, 1243-1266.
3. Kim, O.Y.; Lee, J.H. Sweeney G. Metabolomic profiling as a useful tool for diagnosis and treatment of chronic disease: Focus on obesity, diabetes and cardiovascular diseases. Expert. Rev. Cardiovasc. Ther. 2013, 11, 61-68.
4. Smith, S.C., Jr.; Collins, A.; Ferrari, R.; Holmes, D.R., Jr.; Logstrup, S.; McGhie, D.V.; Ralston, J.; Sacco, R.L.; Stam, H.; Taubert, K.; et al. Our time: A call to save preventable death from cardiovascular disease (heart disease and stroke). J. Am. Coll. Cardiol. 2012, 60, 2343-2348.
5. Bozzola, M.; Bozzola, E.; Abela, S.; Amato, S. Childhood obesity: Know it to prevent it. Ig. Sanita Pubbl. 2012, 68, 473-482.
6. Chambers, J.C.; Elliott, P.; Zabaneh, D.; Zhang, W.; Li, Y.; Froguel, P.; Balding, D.; Scott, J.; Kooner, J.S. Common genetic variation near MC4R is associated with waist circumference and insulin resistance. Nat. Genet. 2008, 40, 716-718.
7. Hindorff, L.A.; Sethupathy, P.; Junkins, H.A.; Ramos, E.M.; Mehta, J.P.; Collins, F.S.; Manolio, T.A. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc. Natl. Acad. Sci. USA 2009, 106, 9362-9367.
8. Cai, G.; Cole, S.A.; Butte, N.; Bacino, C.; Diego, V.; Tan, K.; Göring, H.H.; O'Rahilly, S.; Farooqi, I.S.; Comuzzie, A.G. A quantitative trait locus on chromosome 18q for physical activity and dietary intake in Hispanic children. Obesity (Silver Spring) 2006, 14, 1596-1604.
9. Meng, Q.; Mäkinen, V.P.; Luk, H.; Yang, X. Systems biology approaches and applications in obesity, diabetes, and cardiovascular diseases. Curr. Cardiovasc. Risk. Rep. 2013, 7, 73-83.
10. Barker, D.J. Fetal origins of coronary heart disease. BMJ 1995, 311, 171-174.
11. Hales, C.N.; Barker, D.J. Type 2 (non insulin dipendent) diabetes mellitus: The trifty phenotype hypothesis. Diabetologia 2003, 35, 395-601.
12. Dessì, A.; Ottonello, G.; Fanos, V. Physiopathology of intrauterine growth retardation: From classic data to metabolomics. J. Matern. Fetal. Neonatal. Med. 2012, 25, 13-18.
13. Dyck, R.F.; Klomp, H.; Tan, L. From "thrifty genotype" to "hefty fetal phenotype": The relationship between high birthweight and diabetes in Saskatchewan Registered Indians. Can. J. Public Health 2001, 92, 340-344.
14. Harder, T.; Rodekamp. E.; Schellong, K.; Dudenhausen, J.W.; Plagemann, A. Birth weight and subsequent risk of type 2 diabetes: A meta-analysis. Am. J. Epidemiol. 2007, 165, 849-857.
15. Diderholm, B. Perinatal energy metabolism with reference to IUGR & SGA: Studies in pregnant women & newborn infants. Indian J. Med. Res. 2009, 130, 612-617.
16. Committee on Practice Bulletins Gynecology. American College of Obstetricians and Gynecologists. Intrauterine growth restriction. Clinical management guidelines for obstetrician-gynecologists. Int. J. Gynaecol. Obstet. 2001, 72, 85-96.
17. Fanos, V.; Puddu, M.; Reali, A.; Atzei, A.; Zaffanello, M. Perinatal nutrient restriction reduces nephron endowment increasing renal morbidity in adulthood: A review. Early Hum. Dev. 2010, 86, 37-42.
18. Ju, H.; Chadha, Y.; Donovan, T.; O'Rourke, P. Fetal Macrosomia and pregnancy outcomes. Aust. N. Z. J. Obstet. Gynaecol. 2009, 49, 504-509.
19. King, J.C. Physiology of pregnancy and nutrient metabolism. Am. J. Clin. Nutr. 2000, 7, 1218-1225.
20. Lam, Y.Y.; Hatzinikolas, G.; Weir, J.M.; Janovská, A.; McAinch, A.J.; Game, P.; Meikle, P.J.; Wittert, G.A. Insulin-stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. Biochim. Biophys. Acta 2011, 1811, 468-475.
21. Holemans, K.; Aerts, L.; van Assche, F.A. Lifetime consequences of abnormal fetal pancreatic development. J. Physiol. 2003, 547, 11-20.
22. Fernandez-Twinn, D.S.; Ozanne, S.E. Mechanisms by which poor early growth programs type-2 diabetes, obesity and the metabolic syndrome. Physiol. Behav. 2006, 88, 234-243.
23. Plagemann, A.; Harder, T.; Rake, A.; Voits, M.; Fink, H.; Rohde, W.; Dörner, G. Perinatal elevation of hypothalamic insulin, acquired malformation of hypothalamic galaninergic neurons, and syndrome X-like alterations in adulthood of neonatally overfed rats. Brain Res. 1999, 836, 146-155.
24. Pantaleão, L.C.; Teodoro, G.F.; Torres-Leal, F.L.; Vianna, D.; de Paula, T.D.; de Matos-Neto, E.M.; Trindade, M.C.; Rogero, M.M.; Bueno, C.R., Jr.; Tirapegui, J. Maternal postnatal high-fat diet, rather than gestational diet, affects morphology and mTOR pathway in skeletal muscle of weaning rat. J. Nutr. Biochem. 2013, 24, 1340-1348.
25. Persson, B.; Westgren, M.; Celsi, G.; Nord, E.; Ortqvist, E. Leptin concentrations in cord blood in normal newborn infants and offspring of diabetic mothers. Horm. Metab. Res. 1999, 3, 467-471.
26. Ibáñez, L.; Sebastiani, G.; Diaz, M.; Gómez-Roig, M.D.; Lopez-Bermejo, A.; de Zegher, F. Low body adiposity and high leptinemia in breast-fed infants born small-for-gestational-age. J. Pediatr. 2010, 156, 145-147.
27. Heltemes, A.; Gingery, A.; Soldner, E.L.; Bozadjieva, N.; Jahr, K.N.; Johnson, B.K.; Gilbert, J.S. Chronic placental ischemia alters amniotic fluid milieu and results in impaired glucose tolerance, insulin resistance and hyperleptinemia in young rats. Exp. Biol. Med. (Maywood) 2010, 235, 892-899.
28. Logan, K.M.; Wijeyesekera, A.D.; Perez, I.G.; Hyde, M.J.; Romero, M.G.; Jeffries, S.; Andreas, N.; Gale, C.; Holmes, E.; Modi, N. Infants of mothers with diabetes have altered urinary metabolic profile at birth. Available online: http://www.neonatalsociety.ac.uk/abstracts/logank- 2012-diabeticurinaryprofile. shtml/ (accessed on 1 July 2013).
29. Oresic, M.; Simell, S.; Sysi-Aho, M.; Näntö-Salonen, K.; Seppänen-Laakso, T.; Parikka, V.; Katajamaa, M.; Hekkala, A.; Mattila. I.; Keskinen, P.; et al. Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes. J. Exp. Med. 2008, 205, 2975-2984.
30. Sysi-Aho, M.; Ermolov, A.; Gopalacharyulu, P.V.; Tripathi, A.; Seppänen-Laakso, T.; Maukonen, J.; Mattila, I.; Ruohonen, S.T.; Vähätalo, L.; Yetukuri, L.; et al. Metabolic regulation in progression to autoimmune diabetes. PLoS Comput. Biol. 2011, 7, e1002257.
31. Zhang, X.; Wang, Y.; Hao, F.; Zhou, X.; Han, X.; Tang, H.; Ji, L. Human serum metabonomic analysis reveals progression axes for glucose intolerance and insulin resistance statuses. J. Proteome Res. 2009, 8, 5188-5195.
32. Van Vliet, E.; Eixarch, E.; Illa, M.; Arbat-Plana, A.; González-Tendero, A.; Hogberg, H.T.; Zhao, L.; Hartung, T.; Gratacos, E. Metabolomics reveals metabolic alterations by intrauterine growth restriction in the fetal rabbit brain. PLoS One 2013, 8, e64545.
33. Lin, G.; Liu, C.; Feng, C.; Fan, Z.; Dai, Z.; Lai, C.; Li, Z.; Wu, G.; Wang, J. Metabolomic analysis reveals differences in umbilical vein plasma metabolites between normal and growth-restricted fetal pigs during late gestation. J. Nutr. 2012, 142, 990-998.
34. Favretto, D.; Cosmi, E.; Ragazzi, E.; Visentin, S.; Tucci, M.; Fais, P.; Cecchetto, G.; Zanardo, V.; Viel, G.; Ferrara, S.D. Cord blood metabolomic profiling in intrauterine growth restriction. Anal. Bioanal. Chem. 2012, 402, 1109-1121.
35. Dessì, A.; Atzori, L.; Noto, A.; Visser, G.H.; Gazzolo, D.; Zanardo, V.; Barberini, L.; Puddu, M.; Ottonello, G.; Atzei, A.; et al. Metabolomics in newborns with intrauterine growth retardation (IUGR): Urine reveals markers of metabolic syndrome. J. Matern. Fetal. Neonatal. Med. 2011, 2, 35-39.
36. Horgan, R.P.; Broadhurst, D.I.; Dunn, W.B.; Brown, M.; Heazell, A.E., Kell, D.B.; Baker, P.N.; Kenny, L.C. Changes in the metabolic footprint of placental explant-conditioned medium cultured in different oxygen tensions from placentas of small for gestational age and normal pregnancies. Placenta 2010, 31, 893-901.
37. Nissen, P.M.; Nebel, C.; Oksbjerg, N.; Bertram, H.C. Metabolomics reveals relationship between plasma inositols and birth weight: Possible markers for fetal programming of type 2 diabetes. J. Biomed. Biotechnol. 2011, 2011, 1147-1155.