MicroRNA-29c Correlates with Neuroprotection Induced by FNS by Targeting Both Birc2 and Bak1 in Rat Brain after Stroke

CNS Neuroscience and Therapeutics

Volumn 21, Issue 6, 2015, Pages 496-503

  Huang, Li Gang ^a   Li, Jin Pin ^a   Pang, Xiao Min ^a   Chen, Chun Yong ^a   Xiang, Hui Yao ^a   Feng, Ling Bo ^a   Su, Sheng You ^a   Li, Sheng Hua ^a   Zhang, Lei ^a   Liu, Jing Li ^a  

^a GUANGXI MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Cerebral ischemia; Electrical fastigial nucleus stimulation; MicroRNA

Indexed keywords

ANTAGOMIR; MESSENGER RNA; MICRORNA; MICRORNA 29C; PROTEIN; PROTEIN BAK1; PROTEIN BIRC2; UNCLASSIFIED DRUG; ANTISENSE OLIGONUCLEOTIDE; BAK1 PROTEIN, RAT; BIRC3 PROTEIN, RAT; INHIBITOR OF APOPTOSIS PROTEIN; MIRN29 MICRORNA, RAT; PROTEIN BAK;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BAK1 GENE; BIRC2 GENE; BRAIN DEPTH STIMULATION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN PROTECTION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DETERIORATION; DOWN REGULATION; FASTIGIAL NUCLEUS; GENE; GENE EXPRESSION; LUCIFERASE ASSAY; MALE; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; RAT MODEL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANALYSIS OF VARIANCE; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN; BRAIN INFARCTION; CEREBELLUM NUCLEUS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; NERVOUS SYSTEM DISEASES; PATHOLOGY; PHYSIOLOGY; PROCEDURES; SPRAGUE DAWLEY RAT; STROKE; TUNEL ASSAY;

ANALYSIS OF VARIANCE; ANIMALS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BRAIN; BRAIN INFARCTION; CEREBELLAR NUCLEI; DEEP BRAIN STIMULATION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; IN SITU NICK-END LABELING; INHIBITOR OF APOPTOSIS PROTEINS; MALE; MICRORNAS; MUTATION; NERVOUS SYSTEM DISEASES; OLIGONUCLEOTIDES, ANTISENSE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STROKE;

EID: 84929502525     PISSN: 17555930     EISSN: 17555949     Source Type: Journal    
DOI: 10.1111/cns.12383     Document Type: Article

References (29)

1. Biller JLB, Schneck MJ Vascular diseases of the nervous system. In: Bradly WG, Daroff RB, editors. Neurology in clinical practice. 5th edn. Philadelphia: Butterworth-Heinemann, 2008.
2. Goldstein LB, Jones MR, Matchar DB, et al. Improving the reliability of stroke subgroup classification using the trial of org 10172 in acute stroke treatment (toast) criteria. Stroke 2001;32:1091-1098.
3. Miura M, Reis DJ. Cerebellum: a pressor response elicited from the fastigial nucleus and its efferent pathway in brainstem. Brain Res 1969;13:595-599.
4. Wang J, Dong WW, Zhang WH, Zheng J, Wang X. Electrical stimulation of cerebellar fastigial nucleus: mechanism of neuroprotection and prospects for clinical application against cerebral ischemia. CNS Neurosci Ther 2014;20:710-716.
5. Vera J, Lai X, Schmitz U, Wolkenhauer O. MicroRNA-regulated networks: the perfect storm for classical molecular biology, the ideal scenario for systems biology. Adv Exp Med Biol 2013;774:55-76.
6. Griffiths-Jones S. The microRNA registry. Nucleic Acids Res 2004;32:D109-D111.
7. Pandi G, Nakka VP, Dharap A, Roopra A, Vemuganti R. Microrna mir-29c down-regulation leading to de-repression of its target DNA methyltransferase 3a promotes ischemic brain damage. PLoS ONE 2013;8:e58039.
8. Zhu F, Liu JL, Li JP, Xiao F, Zhang ZX, Zhang L. Microrna-124 (mir-124) regulates ku70 expression and is correlated with neuronal death induced by ischemia/reperfusion. J Mol Neurosci 2014;52:148-155.
9. Paxinos GWC. The rat brain in stereotaxic coordinates. Sydney: Academic Press, 1986;7-84.
10. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20:84-91.
11. Yin KJ, Deng Z, Huang H, et al. Mir-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia. Neurobiol Dis 2010;38:17-26.
12. Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab 1990;10:290-293.
13. Mandel M, Talamoni Fonoff E, Bor-Seng-Shu E, Teixeira MJ, Chadi G. Neurogenic neuroprotection: clinical perspectives. Funct Neurol 2012;27:207-216.
14. Liu B, Li J, Li L, Yu L, Li C. Electrical stimulation of cerebellar fastigial nucleus promotes the expression of growth arrest and DNA damage inducible gene beta and motor function recovery in cerebral ischemia/reperfusion rats. Neurosci Lett 2012;520:110-114.
15. Zhou P, Qian L, Zhou T, Iadecola C. Mitochondria are involved in the neurogenic neuroprotection conferred by stimulation of cerebellar fastigial nucleus. J Neurochem 2005;95:221-229.
16. Zhang S, Zhang Q, Zhang JH, Qin X. Electro-stimulation of cerebellar fastigial nucleus (fns) improves axonal regeneration. Front Biosci 2008;13:6999-7007.
17. Liu J, Li J, Yang Y, Wang X, Zhang Z, Zhang L. Neuronal apoptosis in cerebral ischemia/reperfusion area following electrical stimulation of fastigial nucleus. Neural Regen Res 2014;9:727-734.
18. Kim VN, Han J, Siomi MC. Biogenesis of small rnas in animals. Nat Rev Mol Cell Biol 2009;10:126-139.
19. Williams AE. Functional aspects of animal microRNAs. Cell Mol Life Sci 2008;65:545-562.
20. Dharap A, Bowen K, Place R, Li LC, Vemuganti R. Transient focal ischemia induces extensive temporal changes in rat cerebral microRNAome. J Cereb Blood Flow Metab 2009;29:675-687.
21. Liu DZ, Tian Y, Ander BP, et al. Brain and blood microRNA expression profiling of ischemic stroke, intracerebral hemorrhage, and kainate seizures. J Cereb Blood Flow Metab 2010;30:92-101.
22. Kriegel AJ, Liu Y, Fang Y, Ding X, Liang M. The mir-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury. Physiol Genomics 2012;44:237-244.
23. Presneau N, Eskandarpour M, Shemais T, et al. Microrna profiling of peripheral nerve sheath tumours identifies mir-29c as a tumour suppressor gene involved in tumour progression. Br J Cancer 2013;108:964-972.
24. Matsuo M, Nakada C, Tsukamoto Y, et al. Mir-29c is downregulated in gastric carcinomas and regulates cell proliferation by targeting rcc2. Mol Cancer 2013;12:15.
25. Warnakulasuriyarachchi D, Cerquozzi S, Cheung HH, Holcik M. Translational induction of the inhibitor of apoptosis protein hiap2 during endoplasmic reticulum stress attenuates cell death and is mediated via an inducible internal ribosome entry site element. J Biol Chem 2004;279:17148-17157.
26. Hamanaka RB, Bobrovnikova-Marjon E, Ji X, Liebhaber SA, Diehl JA. Perk-dependent regulation of iap translation during er stress. Oncogene 2009;28:910-920.
27. Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic bak. Proc Natl Acad Sci USA 2013;110:E986-E995.
28. Jane EP, Premkumar DR, Morales A, Foster KA, Pollack IF. Inhibition of phosphatidylinositol 3-kinase/akt signaling by nvp-bkm120 promotes abt-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells. J Pharmacol Exp Ther 2014;350:22-35.
29. Lin ML, Chen SS, Huang RY, et al. Suppression of pi3k/akt signaling by synthetic bichalcone analog tswu-cd4 induces er stress- and bax/bak-mediated apoptosis of cancer cells. Apoptosis 2014;19:1637-1653.