A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis

Journal of Biological Chemistry

Volumn 290, Issue 18, 2015, Pages 11749-11761

  Bagheri Yarmand, Rozita ^a   Sinha, Krishna M ^a   Gururaj, Anupama E ^b   Ahmed, Zamal ^b   Rizvi, Yasmeen Q ^a   Huang, Su Chen ^a   Ladbury, John E ^b   Bogler, Oliver ^b   Williams, Michelle D ^a   Cote, Gilbert J ^a   Gagel, Robert F ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b Center for Biomolecular Structure and Function   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL DEATH; CHEMICAL ACTIVATION; DISEASES; GENE EXPRESSION; TRANSCRIPTION;

ACTIVATING TRANSCRIPTION FACTOR; KINASE FUNCTION; PRO-APOPTOTIC GENES; PROTO-ONCOGENES; RECEPTOR TYROSINE KINASE; THYROID CANCERS;

ENZYMES;

ACTIVATING TRANSCRIPTION FACTOR 4; CISPLATIN; EEYARESTATIN; PROTEIN INHIBITOR; PROTEIN NOXA; PROTEIN RET; PUMA PROTEIN; SUNITINIB; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BBC3 PROTEIN, HUMAN; ONCOPROTEIN; PMAIP1 PROTEIN, HUMAN; PROTEIN BCL 2; PROTEIN KINASE INHIBITOR; THREONINE;

APOPTOSIS; ARTICLE; CELL LINE; CELL SURVIVAL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION REGULATION; GENE INTERACTION; GENE LOCATION; GENE REPRESSION; GENETIC TRANSCRIPTION; H1993 CELL LINE; HCC2935 CELL LINE; HEK293T CELL LINE; IN VITRO STUDY; IN VIVO STUDY; NOXA GENE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTO ONCOGENE; PUMA GENE; RET PROTO ONCOGENE; THYROID CANCER; TRANSCRIPTION REGULATION; TT CELL LINE; ACTIVE TRANSPORT; CELL NUCLEUS; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; PHOSPHORYLATION; PROMOTER REGION; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL NUCLEUS; CISPLATIN; GENE EXPRESSION REGULATION; HUMANS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN KINASE INHIBITORS; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-RET; THREONINE; TRANSCRIPTION, GENETIC;

EID: 84929493812     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.619833     Document Type: Article

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