Single-molecule analysis of RAG-mediated V(D)J DNA cleavage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 14, 2015, Pages E1715-E1723

  Lovely, Geoffrey A ^a,b   Brewster, Robert C ^b,c   Schatz, David G ^d   Baltimore, David ^b   Phillips, Rob ^a,b,c  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b California Institute of Technology   (United States)

^c California Institute of Technology   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Recombination activating gene; Single molecule; V(D)J recombination

Indexed keywords

DNA; HIGH MOBILITY GROUP B1 PROTEIN; RAG1 PROTEIN; RAG2 PROTEIN; SIGNAL PEPTIDE; DNA BINDING PROTEIN; HMGB1 PROTEIN, HUMAN; HOMEODOMAIN PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEAR PROTEIN; PROTEIN BINDING; RAG-1 PROTEIN; RAG2 PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; BINDING KINETICS; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA CLEAVAGE; DNA PROTEIN COMPLEX; HYDRODYNAMICS; IN VITRO STUDY; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN FUNCTION; SINGLE MOLECULE ASSAY; SYNAPSE; TURNOVER NUMBER; VDJ RECOMBINATION; CHEMISTRY; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGICAL SYNAPSE; METABOLISM; MOTION; MUTATION; NORMAL DISTRIBUTION;

SYNAPSIS;

DNA; DNA-BINDING PROTEINS; HEK293 CELLS; HMGB1 PROTEIN; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOLOGICAL SYNAPSES; MOTION; MUTATION; NORMAL DISTRIBUTION; NUCLEAR PROTEINS; PROTEIN BINDING; RECEPTORS, ANTIGEN; V(D)J RECOMBINATION;

EID: 84929493074     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503477112     Document Type: Article

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