Protective role of PGC-1α in diabetic nephropathy is associated with the inhibition of ROS through mitochondrial dynamic remodeling

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Guo, Kaifeng ^a   Lu, Junxi ^a   Huang, Yan ^a   Wu, Mian ^a   Zhang, Lei ^a   Yu, Haoyong ^a   Zhang, Mingliang ^a   Bao, Yuqian ^a   He, John Cijiang ^b   Chen, Haibing ^a   Jia, Weiping ^a  

^a Shanghai Diabetes Institute   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; GLUCOSE; MITOCHONDRIAL PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN DRP1; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 8-OXO-7-HYDRODEOXYGUANOSINE; BIOLOGICAL MARKER; DEOXYGUANOSINE; DRP1 PROTEIN, RAT; DYNAMIN; PPARGC1A PROTEIN, RAT; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GENE OVEREXPRESSION; HYPERGLYCEMIA; IN VITRO STUDY; INCUBATION TIME; KIDNEY CORTEX; KIDNEY HYPERTROPHY; MALE; MESANGIUM CELL; METABOLIC INHIBITION; MITOCHONDRIAL DYNAMIC REMODELING; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PLASMID; PROTEIN EXPRESSION; PROTEINURIA; RAT; RENAL PROTECTION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; PATHOLOGY; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; BIOMARKERS; DEOXYGUANOSINE; DIABETIC NEPHROPATHIES; DYNAMINS; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; HYPERGLYCEMIA; MALE; MESANGIAL CELLS; MITOCHONDRIA; MITOCHONDRIAL DYNAMICS; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PLASMIDS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 84929492282     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125176     Document Type: Article

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