Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection

PLoS Pathogens

Volumn 11, Issue 4, 2015, Pages

  Lin, Ann E ^a   Beasley, Federico C ^a   Olson, Joshua ^a   Keller, Nadia ^a   Shalwitz, Robert A ^b   Hannan, Thomas J ^c   Hultgren, Scott J ^c   Nizet, Victor ^a,d,e  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Aerpio Therapeutics Inc   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e RADY CHILDREN'S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AKB 4924; BETA DEFENSIN 2; CATHELICIDIN; GASTROINTESTINAL AGENT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; NITRIC OXIDE; PAXILLIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; VASCULOTROPIN; AKB-4924; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; HIF1A PROTEIN, HUMAN; HIF1A PROTEIN, MOUSE; MESSENGER RNA; PIPERAZINE DERIVATIVE; PYRIDONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL LOAD; CELL ADHESION; CELL DEATH; CELL INVASION; COLONY FORMING UNIT; CONTROLLED STUDY; CYTOKINE RELEASE; ESCHERICHIA COLI INFECTION; FEMALE; GENE DELETION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INNATE IMMUNITY; MOUSE; NEUTROPHIL; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; UROPATHOGENIC ESCHERICHIA COLI; WESTERN BLOTTING; AGONISTS; ANIMAL; BACTERIUM ADHERENCE; C57BL MOUSE; CELL LINE; DRUG EFFECTS; ESCHERICHIA COLI INFECTIONS; GENETICS; HOST PATHOGEN INTERACTION; IMMUNOLOGY; INTRAVESICAL DRUG ADMINISTRATION; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PROTEIN STABILITY; URINARY TRACT INFECTIONS; UROTHELIUM;

ESCHERICHIA COLI; MURINAE; MUS;

ADMINISTRATION, INTRAVESICAL; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL ADHESION; CELL LINE; ESCHERICHIA COLI INFECTIONS; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNITY, INNATE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; PIPERAZINES; PROTEIN STABILITY; PYRIDONES; RNA, MESSENGER; URINARY TRACT INFECTIONS; UROPATHOGENIC ESCHERICHIA COLI; UROTHELIUM;

EID: 84929485232     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1004818     Document Type: Article

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