Role of urinary cathelicidin LL-37 and human β-defensin 1 in uncomplicated escherichia coli urinary tract infections

Infection and Immunity

Volumn 82, Issue 4, 2014, Pages 1572-1578

  Nielsen, Karen L ^a,b   Dynesen, Pia ^c   Larsen, Preben ^d   Jakobsen, Lotte ^a,b   Andersen, Paal S ^a   Frimodt Møller, Niels ^a,b  

^a STATENS SERUM INSTITUT   (Denmark)

^b HVIDOVRE HOSPITAL   (Denmark)

^c Haslev Lægecenter ^*  (Denmark)

^d Lægehuset Ellemarksvej   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 1; CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL VIRULENCE; BACTERIUM ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI INFECTION; FECES MICROFLORA; FEMALE; HUMAN; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN URINE LEVEL; URINALYSIS; URINARY TRACT INFECTION;

ADULT; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BETA-DEFENSINS; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FECES; FEMALE; HOST-PATHOGEN INTERACTIONS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; URINARY TRACT INFECTIONS; VIRULENCE;

EID: 84896448952     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01393-13     Document Type: Article

References (34)

1. Foxman B, Barlow R, D'Arcy H, Gillespie B, Sobel JD. 2000. Urinary tract infection: self-reported incidence and associated costs. Ann. Epidemiol. 10:509-515. http://dx.doi.org/10.1016/S1047-2797(00)00072-7.
2. Song J, Abraham SN. 2008. Innate and adaptive immune responses in the urinary tract. Eur. J. Clin. Invest. 38(Suppl 2):21-28. http://dx.doi.org/10.1111/j.1365-2362.2008.02005.x.
3. Brumfitt W, Gargan RA, Hamilton-Miller JM. 1987. Periurethral enterobacterial carriage preceding urinary infection. Lancet i:824-826.
4. Spencer JD, Hains DS, Porter E, Bevins CL, DiRosario J, Becknell B, Wang H, Schwaderer AL. 2012. Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One 7:e31712. http://dx.doi.org/10.1371/journal.pone.0031712.
5. Spencer JD, Schwaderer AL, Wang H, Bartz J, Kline J, Eichler T, DeSouza KR, Sims-Lucas S, Baker P, Hains DS. 2013. Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. Kidney Int. 83:615-625. http://dx.doi.org/10.1038/ki.2012.410.
6. Valore EV, Park CH, Quayle A, Wiles JKR, McCray PB, Ganz T. 1998. Human beta-defensin-1: an antimicrobial peptide of urogenital tissues. J. Clin. Invest. 101:1633-1642. http://dx.doi.org/10.1172/JCI1861.
7. Chromek M, Slamová Z, Bergman P, Kovács L, Podracká L, Ehrén I, Hökfelt T, Gudmundsson GH, Gallo RL, Agerberth B, Brauner A. 2006. The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection. Nat. Med. 12:636-641. http://dx.doi.org/10.1038/nm1407.
8. Bhan I, Camargo CA, Wenger J, Ricciardi C, Ye J, Borregaard N, Thadhani R. 2011. Circulating levels of 25-hydroxyvitamin D and human cathelicidin in healthy adults. J. Allergy Clin. Immunol. 127:1302-4.e1. http://dx.doi.org/10.1016/j.jaci.2010.12.1097.
9. Borregaard N, Sørensen OE, Theilgaard-Mönch K. 2007. Neutrophil granules: a library of innate immunity proteins. Trends Immunol. 28: 340-345. http://dx.doi.org/10.1016/j.it.2007.06.002.
10. Hertting O, Holm Å Lüthje P, Brauner H, Dyrdak R, Jonasson AF, Wiklund P, Chromek M, Brauner A. 2010. Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder. PLoS One 5:e15580. http://dx.doi.org/10.1371/journal.pone.0015580.
11. Reference deleted.
12. Hiratsuka T, Nakazato M, Ihi T, Minematsu T, Chino N, Nakanishi T, Shimizu A, Kangawa K, Matsukura S. 2000. Structural analysis of human beta-defensin-1 and its significance in urinary tract infection. Nephron 85:34-40. http://dx.doi.org/10.1159/000045627.
13. Morrison G, Kilanowski F, Davidson D, Dorin J. 2002. Characterization of the mouse beta defensin 1, Defb1, mutant mouse model. Infect. Immun. 70:3053-3060. http://dx.doi.org/10.1128/IAI.70.6.3053-3060.2002.
14. Tesse R, Cardinale F, Santostasi T, Polizzi A, Manca A, Mappa L, Iacoviello G, De Robertis F, Logrillo VP, Armenio L. 2008. Association of beta-defensin-1 gene polymorphisms with Pseudomonas aeruginosa airway colonization in cystic fibrosis. Genes Immun. 9:57-60. http://dx.doi.org/10.1038/sj.gene.6364440.
15. Milanese M, Segat L, Pontillo A, Arraes LC, de Lima Filho JL, Crovella S. 2006. DEFB1 gene polymorphisms and increased risk of HIV-1 infection in Brazilian children. AIDS 20:1673-1675. http://dx.doi.org/10.1097/01.aids.0000238417.05819.40.
16. Braida L, Boniotto M, Pontillo A, Tovo PA, Amoroso A, Crovella S. 2004. A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children. AIDS 18:1598-1600. http://dx.doi.org/10.1097/01.aids.0000131363.82951.fb.
17. Kocsis AK, Lakatos PL, Somogyvári F, Fuszek P, Papp J, Fischer S, Szamosi T, Lakatos L, Kovacs A, Hofner P, Mándi Y. 2008. Association of beta-defensin 1 single nucleotide polymorphisms with Crohn's disease. Scand. J. Gastroenterol. 43:299-307. http://dx.doi.org/10.1080/00365520 701682615.
18. Chen Q-X, Lv C, Huang L-X, Cheng B-L, Xie G-H, Wu S-J, Fang X-M. 2007. Genomic variations within DEFB1 are associated with the susceptibility to and the fatal outcome of severe sepsis in Chinese Han population. Genes Immun. 8:439-443. http://dx.doi.org/10.1038/sj.gene.6364401.
19. Levy H, Raby BA, Lake S, Tantisira KG, Kwiatkowski D, Lazarus R, Silverman EK, Richter B, Klimecki WT, Vercelli D, Martinez FD, Weiss ST. 2005. Association of defensin beta-1 gene polymorphisms with asthma. J. Allergy Clin. Immunol. 115:252-258. http://dx.doi.org/10.1016/j.jaci.2004.11.013.
20. Dörk T, Stuhrmann M. 1998. Polymorphisms of the human β-defensin-1 gene. Mol. Cell. Probes 12:171-173. http://dx.doi.org/10.1006/mcpr.1998.0165.
21. Larrick JW, Hirata M, Zhong J, Wright SC. 1995. Anti-microbial activity of human CAP18 peptides. Immunotechnology 1:65-72. http://dx.doi.org/10.1016/1380-2933(95)00006-2.
22. Foschiatti M, Cescutti P, Tossi A, Rizzo R. 2009. Inhibition of cathelicidin activity by bacterial exopolysaccharides. Mol. Microbiol. 72:1137-1146. http://dx.doi.org/10.1111/j.1365-2958.2009.06707.x.
23. Johansson J, Gudmundsson GH, Rottenberg ME, Berndt KD, Agerberth B. 1998. Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37. J. Biol. Chem. 273:3718-3724. http://dx.doi.org/10.1074/jbc.273.6.3718.
24. Kai-Larsen Y, Lüthje P, Chromek M, Peters V, Wang X, Holm A, Kádas L, Hedlund K-O, Johansson J, Chapman MR, Jacobson SH, Römling U, Agerberth B, Brauner A. 2010. Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37. PLoS Pathog. 6:e1001010. http://dx.doi.org/10.1371/journal.ppat.1001010.
25. Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J. 2011. Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature 469:419-423. http://dx.doi.org/10.1038/nature09674.
26. Venieri D, Vantarakis A, Komninou G, Papapetropoulou M. 2004. Differentiation of faecal Escherichia coli from human and animal sources by random amplified polymorphic DNA-PCR (RAPD-PCR). Water Sci. Technol. 50:193-198.
27. Galland JC, Hyatt DR, Crupper SS, Acheson DW. 2001. Prevalence, antibiotic susceptibility, and diversity of Escherichia coli O157:H7 isolates from a longitudinal study of beef cattle feedlots. Appl. Environ. Microbiol. 67:1619-1627. http://dx.doi.org/10.1128/AEM.67.4.1619-1627.2001.
28. Clermont O, Bonacorsi S, Bingen E. 2000. Rapid and simple determination of the Escherichia coli phylogenetic group. Appl. Environ. Microbiol. 66:4555-4558. http://dx.doi.org/10.1128/AEM.66.10.4555-4558.2000.
29. Gordon DM, Clermont O, Tolley H, Denamur E. 2008. Assigning Escherichia coli strains to phylogenetic groups: multi-locus sequence typing versus the PCR triplex method. Environ. Microbiol. 10:2484-2496. http://dx.doi.org/10.1111/j.1462-2920.2008.01669.x.
30. Turner J, Cho Y, Dinh NN, Waring A, Lehrer JRI. 1998. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob. Agents Chemother. 42:2206-2214.
31. Hvidberg H, Struve C, Krogfelt KA, Christensen N, Rasmussen SN, Frimodt-Møller N. 2000. Development of a long-term ascending urinary tract infection mouse model for antibiotic treatment studies. Antimicrob. Agents Chemother. 44:156-163. http://dx.doi.org/10.1128/AAC.44.1.156-163.2000.
32. Jakobsen L, Garneau P, Bruant G, Harel J, Olsen SS, Porsbo LJ, Hammerum A, Frimodt-Møller N. 2011. Is Escherichia coli urinary tract infection a zoonosis? Proof of direct link with production animals and meat. Eur. J. Clin. Microbiol. Infect. Dis. 31:1121-1129. http://dx.doi.org/10.1007/s10096-011-1417-5.
33. Finer G, Landau D. 2004. Pathogenesis of urinary tract infections with normal female anatomy. Lancet Infect. Dis. 4:631-635. http://dx.doi.org/10.1016/S1473-3099(04)01147-8.
34. Sabaté M, Prats G, Moreno E, Ballesté E, Blanch AR, Andreu A. 2008. Virulence and antimicrobial resistance profiles among Escherichia coli strains isolated from human and animal wastewater. Res. Microbiol. 159: 288-293. http://dx.doi.org/10.1016/j.resmic.2008.02.001.