Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 20, 2015, Pages 6491-6496

  Devanathan, Vasudharani ^a   Hagedorn, Ina ^a,b   Köhler, David ^c   Pexa, Katja ^b   Cherpokova, Deya ^a,b   Kraft, Peter ^d   Singh, Madhurendra ^b   Rosenberger, Peter ^c   Stoll, Guido ^d   Birnbaumer, Lutz ^e   Piekorz, Roland P ^b   Beer Hammer, Sandra ^a   Nieswandt, Bernhard ^a,b   Nürnberg, Bernd ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

^d HEINRICH HEINE UNIVERSITY   (Germany)

^e NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

G proteins; Ischemia reperfusion injury; P2y12 receptor; Platelets; Thrombosis

Indexed keywords

ADENOSINE DIPHOSPHATE; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA I2 SUBUNIT; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; UNCLASSIFIED DRUG; GNAI2 PROTEIN, MOUSE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY THROMBOSIS; ARTICLE; BLEEDING TIME; BLOOD CLOTTING; BRAIN INFARCTION; BRAIN ISCHEMIA; CONTROLLED STUDY; FEMALE; HEART MUSCLE ISCHEMIA; HEMOSTASIS; INFLAMMATION; MALE; MEGAKARYOCYTE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; REPERFUSION INJURY; THROMBOCYTE; TRANSIENT ISCHEMIC ATTACK; UPREGULATION; ANIMAL; CEREBRAL ARTERY DISEASE; DEFICIENCY; IMMUNOBLOTTING; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE ACTIVATION; THROMBOSIS;

MUS;

ANIMALS; BLEEDING TIME; BLOOD PLATELETS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; IMMUNOBLOTTING; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MEGAKARYOCYTES; MICE; PLATELET ACTIVATION; REPERFUSION INJURY; THROMBOSIS;

EID: 84929427684     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505887112     Document Type: Article

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