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Volumn 44, Issue 4, 2011, Pages 271-281

Reactive animation: From piecemeal experimentation to reactive biological systems

Author keywords

complex systems; computational models; pancreas; Reactive animation; simulation; statecharts; systems biology; T cell activation; thymus

Indexed keywords

CCL25 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR9; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 2 RECEPTOR; MACROPHAGE DERIVED CHEMOKINE; SECONDARY LYMPHOID TISSUE CHEMOKINE; STROMAL CELL DERIVED FACTOR 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 79954461933     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2010.523260     Document Type: Article
Times cited : (6)

References (41)
  • 1
    • 34047105227 scopus 로고    scopus 로고
    • Explaining a complex living system: Dynamics, multi-scaling and emergence
    • DOI 10.1098/rsif.2006.0173
    • Cohen IR, Harel D. Explaining a complex living system: Dynamics, multi-scaling and emergence. J R Soc Interface 2007;4:175-182. (Pubitemid 46513049)
    • (2007) Journal of the Royal Society Interface , vol.4 , Issue.13 , pp. 175-182
    • Cohen, I.R.1    Harel, D.2
  • 2
    • 17844384842 scopus 로고    scopus 로고
    • Reactive animation: Realistic modeling of complex dynamic systems
    • DOI 10.1109/MC.2005.31
    • Efroni S, Harel D, Cohen IR. Reactive animation: Realistic modeling of complex dynamic systems. IEEE Comput 2005; 38:38-47. (Pubitemid 40583541)
    • (2005) Computer , vol.38 , Issue.1 , pp. 38-47
    • Efroni, S.1    Harel, D.2    Cohen, I.R.3
  • 4
    • 0023365727 scopus 로고
    • A statecharts: Visual formalism for complex systems
    • DOI 10.1016/0167-6423(87)90035-9
    • Harel D. A Statecharts: Visual formalism for complex systems. Sci Comput Program 1987;8:231-274. (Pubitemid 17617706)
    • (1987) Science of Computer Programming , vol.8 , Issue.3 , pp. 231-274
    • Harel, D.1
  • 5
    • 61449214048 scopus 로고    scopus 로고
    • Agent-based modeling of host-pathogen systems: The successes and challenges
    • Bauer AL, Beauchemin CA, Perelson AS. Agent-based modeling of host-pathogen systems: The successes and challenges. Inf Sci (NY) 2009;179:1379-1389.
    • (2009) Inf. Sci NY , vol.179 , pp. 1379-1389
    • Bauer, A.L.1    Beauchemin, C.A.2    Perelson, A.S.3
  • 6
    • 0242574975 scopus 로고    scopus 로고
    • Toward rigorous comprehension of biological complexity: Modeling, execution, and visualization of thymic T-cell maturation
    • DOI 10.1101/gr.1215303
    • Efroni S, Harel D, Cohen IR. Toward rigorous comprehension of biological complexity: Modeling, execution, and visualization of thymic T-cell maturation. Genome Res 2003;13: 2485-2497. (Pubitemid 37428273)
    • (2003) Genome Research , vol.13 , Issue.11 , pp. 2485-2497
    • Efroni, S.1    Harel, D.2    Cohen, I.R.3
  • 7
    • 33846542982 scopus 로고    scopus 로고
    • Emergent dynamics of thymocyte development and lineage determination
    • Efroni S, Harel D, Cohen IR. Emergent dynamics of thymocyte development and lineage determination. PLoS Comput Biol 2007;3:e13.
    • (2007) PLoS Comput. Biol. , vol.3
    • Efroni, S.1    Harel, D.2    Cohen, I.R.3
  • 8
    • 36049044199 scopus 로고    scopus 로고
    • Executable cell biology
    • DOI 10.1038/nbt1356, PII NBT1356
    • Fisher J, Henzinger TA. Executable cell biology. Nat Biotechnol 2007;25:1239-1249. (Pubitemid 350089829)
    • (2007) Nature Biotechnology , vol.25 , Issue.11 , pp. 1239-1249
    • Fisher, J.1    Henzinger, T.A.2
  • 9
    • 77950347868 scopus 로고    scopus 로고
    • The executable pathway to biological networks
    • Fisher J, Piterman N. The executable pathway to biological networks. Brief Funct Genomics 2010;9:79-92.
    • (2010) Brief. Funct. Genomics , vol.9 , pp. 79-92
    • Fisher, J.1    Piterman, N.2
  • 12
    • 0035790856 scopus 로고    scopus 로고
    • The immune system as a reactive system: Modeling T cell activation with statecharts proceedings of visual languages and formal methods VLFM 01 part
    • Kam N, Cohen IR, Harel D. The immune system as a reactive system: Modeling T cell activation with Statecharts, Proceedings of Visual Languages and Formal Methods (VLFM'01), part of IEEE Symposium on Human-Centric Computing (HCC'01). 2001;15-22.
    • (2001) IEEE Symposium on Human-Centric Computing HCC01 , pp. 15-22
    • Kam, N.1    Cohen, I.R.2    Harel, D.3
  • 13
    • 58149511982 scopus 로고    scopus 로고
    • Four-dimensional realistic modeling of pancreatic organogenesis
    • USA
    • Setty Y, Cohen IR, Dor Y, Harel D. Four-dimensional realistic modeling of pancreatic organogenesis. Proc Natl Acad Sci USA 2008;105:20374-20379.
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 20374-20379
    • Setty, Y.1    Cohen, I.R.2    Dor, Y.3    Harel, D.4
  • 19
    • 0021928572 scopus 로고
    • Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats
    • Holoshitz J, Matitiau A, Cohen IR. Role of the thymus in induction and transfer of vaccination against adjuvant arthritis with a T lymphocyte line in rats. J Clin Invest 1985;75: 472-477. (Pubitemid 15143487)
    • (1985) Journal of Clinical Investigation , vol.75 , Issue.2 , pp. 472-477
    • Holoshitz, J.1    Matitiau, A.2    Cohen, I.R.3
  • 20
    • 0035496231 scopus 로고    scopus 로고
    • Lymphostromal interactions in thymic development and function
    • Anderson G, Jenkinson EJ. Lymphostromal interactions in thymic development and function. Nat Rev Immunol 2001;1: 31-40. (Pubitemid 33741973)
    • (2001) Nature Reviews Immunology , vol.1 , Issue.1 , pp. 31-40
    • Anderson, G.1    Jenkinson, E.J.2
  • 21
    • 0036582215 scopus 로고    scopus 로고
    • T-cell development and the CD4-CD8 lineage decision
    • Germain RN. T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol 2002;2:309-322. (Pubitemid 37328754)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.5 , pp. 309-322
    • Germain, R.N.1
  • 23
    • 2542497114 scopus 로고    scopus 로고
    • The interleukin (IL)-2 family cytokines: Survival and proliferation signaling pathways in T lymphocytes
    • Benczik M, Gaffen SL. The interleukin (IL)-2 family cytokines: Survival and proliferation signaling pathways in T lymphocytes. Immunol Invest 2004;33:109-142. (Pubitemid 38685927)
    • (2004) Immunological Investigations , vol.33 , Issue.2 , pp. 109-142
    • Benczik, M.1    Gaffen, S.L.2
  • 25
    • 0028920919 scopus 로고
    • The positively selected T cell repertoire: Is it exclusively restricted to the selecting MHC
    • Nanda NK, Sercarz EE. The positively selected T cell repertoire: Is it exclusively restricted to the selecting MHC? Int Immunol 1995;7:353-358.
    • (1995) Int. Immunol. , vol.7 , pp. 353-358
    • Nanda, N.K.1    Sercarz, E.E.2
  • 26
    • 0034665493 scopus 로고    scopus 로고
    • TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type
    • Yasutomo K, Lucas B, Germain RN. TCR signaling for initiation and completion of thymocyte positive selection has distinct requirements for ligand quality and presenting cell type. J Immunol 2000;165:3015-3022.
    • (2000) J. Immunol. , vol.165 , pp. 3015-3022
    • Yasutomo, K.1    Lucas, B.2    Germain, R.N.3
  • 27
    • 0142149043 scopus 로고    scopus 로고
    • Critical Role for CXCR4 Signaling in Progenitor Localization and T Cell Differentiation in the Postnatal Thymus
    • Plotkin J, Prockop SE, Lepique A, Petrie HT. Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J Immunol 2003;171: 4521-4527. (Pubitemid 37310567)
    • (2003) Journal of Immunology , vol.171 , Issue.9 , pp. 4521-4527
    • Plotkin, J.1    Prockop, S.E.2    Lepique, A.3    Petrie, H.T.4
  • 29
    • 0015446766 scopus 로고
    • An ultrastructural analysis of the developing embryonic pancreas
    • Pictet RL, Clark WR, Williams RH, Rutter WJ. An ultrastructural analysis of the developing embryonic pancreas. Dev Biol 1972;29:436-467.
    • (1972) Dev. Biol. , vol.29 , pp. 436-467
    • Pictet, R.L.1    Clark, W.R.2    Williams, R.H.3    Rutter, W.J.4
  • 30
    • 0348047628 scopus 로고    scopus 로고
    • Gene Regulatory Factors in Pancreatic Development
    • DOI 10.1002/dvdy.10460
    • Jensen J. Gene regulatory factors in pancreatic development. Dev Dyn 2004;229:176-200. (Pubitemid 38036833)
    • (2004) Developmental Dynamics , vol.229 , Issue.1 , pp. 176-200
    • Jensen, J.1
  • 31
    • 16644375545 scopus 로고    scopus 로고
    • Blood Vessel Patterning at the Embryonic Midline
    • DOI 10.1016/S0070-2153(04)62003-5, PII S0070215304620035, Developmental Vascular Biology
    • Hogan KA, Bautch VL. Blood vessel patterning at the embryonic midline. Curr Top Dev Biol 2004;62:55-85. (Pubitemid 39752375)
    • (2004) Current Topics in Developmental Biology , vol.62 , pp. 55-85
    • Hogan, K.A.1    Bautch, V.L.2
  • 32
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • DOI 10.1126/science.1064344
    • Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001; 294:564-567. (Pubitemid 32999547)
    • (2001) Science , vol.294 , Issue.5542 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 33
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000;127:2317-2322. (Pubitemid 30386571)
    • (2000) Development , vol.127 , Issue.11 , pp. 2317-2322
    • Herrera, P.L.1
  • 34
    • 0036777339 scopus 로고    scopus 로고
    • Signaling and transcriptional control of pancreatic organogenesis
    • DOI 10.1016/S0959-437X(02)00338-6
    • Kim SK, MacDonald RJ. Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev 2002;12: 540-547. (Pubitemid 35013536)
    • (2002) Current Opinion in Genetics and Development , vol.12 , Issue.5 , pp. 540-547
    • Kim, S.K.1    MacDonald, R.J.2
  • 35
    • 74049099391 scopus 로고    scopus 로고
    • Computational modeling of signaling networks for eukaryotic chemosensing
    • Meier-Schellersheim M, Klauschen F, Angermann B. Computational modeling of signaling networks for eukaryotic chemosensing. Methods Mol Biol 2009;571:507-526.
    • (2009) Methods Mol. Biol. , vol.571 , pp. 507-526
    • Meier-Schellersheim, M.1    Klauschen, F.2    Angermann, B.3
  • 38
    • 0026556477 scopus 로고
    • A computer model of cellular interactions in the immune system
    • Celada F, Seiden PE. A computer model of cellular interactions in the immune system. Immunol Today 1992; 13:56-62.
    • (1992) Immunol. Today , vol.13 , pp. 56-62
    • Celada, F.1    Seiden, P.E.2
  • 39
    • 58249107138 scopus 로고    scopus 로고
    • A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses
    • Cheng Y, Ghersi D, Calcagno C, Selin LK, Puzone R, Celada F. A discrete computer model of the immune system reveals competitive interactions between the humoral and cellular branch and between cross-reacting memory and naïve responses. Vaccine 2008;27:833-845.
    • (2008) Vaccine , vol.27 , pp. 833-845
    • Cheng, Y.1    Ghersi, D.2    Calcagno, C.3    Selin, L.K.4    Puzone, R.5    Celada, F.6
  • 40
    • 0026459891 scopus 로고
    • A model for simulating cognate recognition and response in the immune system
    • Seiden PE, Celada F. A model for simulating cognate recognition and response in the immune system. J Theor Biol 1992;158:329-357.
    • (1992) J. Theor. Biol. , vol.158 , pp. 329-357
    • Seiden, P.E.1    Celada, F.2
  • 41
    • 34948874342 scopus 로고    scopus 로고
    • Qualitative networks: A symbolic approach to analyze biological signaling networks
    • Schaub MA, Henzinger TA, Fisher J. Qualitative networks: A symbolic approach to analyze biological signaling networks. BMC Syst Biol 2007;1:4.
    • (2007) BMC Syst. Biol. , vol.1 , pp. 4
    • Schaub, M.A.1    Henzinger, T.A.2    Fisher, J.3


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