Infection of female BWF1 lupus mice with malaria parasite attenuates B cell autoreactivity by modulating the CXCL12/CXCR4 axis and its downstream signals PI3K/AKT, NFκB and ERK

PLoS ONE

Volumn 10, Issue 4, 2015, Pages

  Badr, Gamal ^a   Sayed, Ayat ^b   Abdel Maksoud, Mostafa A ^c,d   Mohamed, Amany O ^b   El Amir, Azza ^c   Abdel Ghaffar, Fathy A ^c   Al Quraishy, Saleh ^d   Mahmoud, Mohamed H ^e,f  

^a Assiut University   (Egypt)

^b Assiut University Faculty of Medicine   (Egypt)

^c CAIRO UNIVERSITY   (Egypt)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

^f NATIONAL RESEARCH CENTRE   (Egypt)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; APRIL PROTEIN; AUTOANTIBODY; B CELL ACTIVATING FACTOR; CHEMOKINE RECEPTOR CXCR4; DOUBLE STRANDED DNA ANTIBODY; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G2A ANTIBODY; IMMUNOGLOBULIN G3 ANTIBODY; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 7; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSFORMING GROWTH FACTOR BETA; CXCL12 PROTEIN, MOUSE; CXCR4 PROTEIN, MOUSE; IMMUNOGLOBULIN G; INTERLEUKIN DERIVATIVE; STROMAL CELL DERIVED FACTOR 1; TNFSF13 PROTEIN, MOUSE; TNFSF13B PROTEIN, MOUSE;

ALPHA INTERFERON BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APRIL PROTEIN BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; B CELL ACTIVATING FACTOR BLOOD LEVEL; B LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENZYME ACTIVATION; GAMMA INTERFERON BLOOD LEVEL; HOST PARASITE INTERACTION; HUMORAL IMMUNITY; IMMUNOMODULATION; IMMUNOPATHOGENESIS; INTERLEUKIN 12 BLOOD LEVEL; INTERLEUKIN 17 BLOOD LEVEL; INTERLEUKIN 4 BLOOD LEVEL; INTERLEUKIN 6 BLOOD LEVEL; INTERLEUKIN 7 BLOOD LEVEL; LYMPHOCYTE FUNCTION; LYMPHOCYTE PROLIFERATION; MALARIA; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSFORMING GROWTH FACTOR BETA BLOOD LEVEL; ANIMAL; CELL PROLIFERATION; DISEASE MODEL; FEMALE; IMMUNOLOGY; PARASITE; PARASITOLOGY; PHYSIOLOGY;

MUS;

ANIMALS; AUTOANTIBODIES; B-CELL ACTIVATING FACTOR; B-LYMPHOCYTES; CELL PROLIFERATION; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOGLOBULIN G; INTERFERON-ALPHA; INTERFERON-GAMMA; INTERLEUKINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALARIA; MAP KINASE SIGNALING SYSTEM; MICE; NF-KAPPA B; PARASITES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13;

EID: 84929340580     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0125340     Document Type: Article

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